Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P51919

- GON1_SPAAU

UniProt

P51919 - GON1_SPAAU

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Progonadoliberin-1

Gene

gnrh1

Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Stimulates the secretion of gonadotropins.

GO - Biological processi

  1. multicellular organismal development Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
GnRH-associated peptide I
Gene namesi
Name:gnrh1
OrganismiSparus aurata (Gilthead sea bream)
Taxonomic identifieri8175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeSparus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 9570Progonadoliberin-1PRO_0000012444Add
BLAST
Peptidei26 – 3510Gonadoliberin-1PRO_0000012445
Peptidei39 – 9557GnRH-associated peptide 1Sequence AnalysisPRO_0000012446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Pyrrolidone carboxylic acid
Modified residuei35 – 351Glycine amide

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG014746.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51919-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI
60 70 80 90
IERFPHVDSP CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK
Length:95
Mass (Da):10,753
Last modified:October 1, 1996 - v1
Checksum:i49313FD6FD6B87DA
GO

Mass spectrometryi

Molecular mass is 1113.6 Da from positions 26 - 35. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U30320 mRNA. Translation: AAA75469.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U30320 mRNA. Translation: AAA75469.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG014746.

Family and domain databases

InterProi IPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view ]
PANTHERi PTHR10522. PTHR10522. 1 hit.
PROSITEi PS00473. GNRH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and characterization of a novel gonadotropin-releasing hormone from the gilthead seabream (Sparus aurata)."
    Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y.
    Mol. Mar. Biol. Biotechnol. 4:27-35(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Three forms of gonadotropin-releasing hormone characterized from brains of one species."
    Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M.
    Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-35, MASS SPECTROMETRY.
    Tissue: Brain.

Entry informationi

Entry nameiGON1_SPAAU
AccessioniPrimary (citable) accession number: P51919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3