P51919 (GON1_SPAAU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Progonadoliberin-1

Alternative name(s):
Progonadoliberin I

Cleaved into the following 2 chains:

1. Gonadoliberin-1
   Alternative name(s):
   Gonadoliberin I
   Gonadotropin-releasing hormone I
   Short name=GnRH-I
   Luliberin I
   Luteinizing hormone-releasing hormone I
   Short name=LH-RH I
2. GnRH-associated peptide 1
   Alternative name(s):
   GnRH-associated peptide I

Gene names

Name:

gnrh1

Organism

Sparus aurata (Gilthead sea bream)

Taxonomic identifier

8175 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Actinopterygii › Actinopteri › Neopterygii › Teleostei › Elopocephala › Clupeocephala › Euteleostei › Neognathi › Neoteleostei › Eurypterygii › Ctenosquamata › Acanthomorpha › Euacanthomorpha › Holacanthopterygii › Acanthopterygii › Euacanthopterygii › Percomorpha › Perciformes › Percoidei › Sparidae › Sparus

Protein attributes

Sequence length	95 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Stimulates the secretion of gonadotropins.
Subcellular location	Secreted.
Sequence similarities	Belongs to the GnRH family.
Mass spectrometry	Molecular mass is 1113.6 Da from positions 26 - 35. Determined by MALDI. Ref.2

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hormone
PTM	Amidation Cleavage on pair of basic residues Pyrrolidone carboxylic acid
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Ref.2
	Chain	26 – 95	70	Progonadoliberin-1		PRO_0000012444
	Peptide	26 – 35	10	Gonadoliberin-1 Ref.2		PRO_0000012445
	Peptide	39 – 95	57	GnRH-associated peptide 1 Potential		PRO_0000012446
Amino acid modifications
	Modified residue	26	1	Pyrrolidone carboxylic acid
	Modified residue	35	1	Glycine amide

Sequences

	Sequence		Length	Mass (Da)
	P51919 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 49313FD6FD6B87DA	FASTA	95	10,753
	10 20 30 40 50 60 MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI IERFPHVDSP 70 80 90 CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK

References

[1]	"Molecular cloning and characterization of a novel gonadotropin-releasing hormone from the gilthead seabream (Sparus aurata)." Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y. Mol. Mar. Biol. Biotechnol. 4:27-35(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Three forms of gonadotropin-releasing hormone characterized from brains of one species." Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M. Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 26-35, MASS SPECTROMETRY. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U30320 mRNA. Translation: AAA75469.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG014746.
Family and domain databases
InterPro	IPR002012. GnRH. IPR019792. Gonadoliberin_I. [Graphical view]
PANTHER	PTHR10522. PTHR10522. 1 hit.
PROSITE	PS00473. GNRH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GON1_SPAAU

Accession

Primary (citable) accession number: P51919

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program