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P51919

- GON1_SPAAU

UniProt

P51919 - GON1_SPAAU

Protein

Progonadoliberin-1

Gene

gnrh1

Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Stimulates the secretion of gonadotropins.

    GO - Biological processi

    1. multicellular organismal development Source: InterPro

    Keywords - Molecular functioni

    Hormone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Progonadoliberin-1
    Alternative name(s):
    Progonadoliberin I
    Cleaved into the following 2 chains:
    Alternative name(s):
    Gonadoliberin I
    Gonadotropin-releasing hormone I
    Short name:
    GnRH-I
    Luliberin I
    Luteinizing hormone-releasing hormone I
    Short name:
    LH-RH I
    Alternative name(s):
    GnRH-associated peptide I
    Gene namesi
    Name:gnrh1
    OrganismiSparus aurata (Gilthead sea bream)
    Taxonomic identifieri8175 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataPercomorphariaSpariformesSparidaeSparus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 25251 PublicationAdd
    BLAST
    Chaini26 – 9570Progonadoliberin-1PRO_0000012444Add
    BLAST
    Peptidei26 – 3510Gonadoliberin-1PRO_0000012445
    Peptidei39 – 9557GnRH-associated peptide 1Sequence AnalysisPRO_0000012446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei26 – 261Pyrrolidone carboxylic acid
    Modified residuei35 – 351Glycine amide

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GnRH family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG014746.

    Family and domain databases

    InterProiIPR002012. GnRH.
    IPR019792. Gonadoliberin_I.
    [Graphical view]
    PANTHERiPTHR10522. PTHR10522. 1 hit.
    PROSITEiPS00473. GNRH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51919-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI   50
    IERFPHVDSP CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK 95
    Length:95
    Mass (Da):10,753
    Last modified:October 1, 1996 - v1
    Checksum:i49313FD6FD6B87DA
    GO

    Mass spectrometryi

    Molecular mass is 1113.6 Da from positions 26 - 35. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30320 mRNA. Translation: AAA75469.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30320 mRNA. Translation: AAA75469.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG014746.

    Family and domain databases

    InterProi IPR002012. GnRH.
    IPR019792. Gonadoliberin_I.
    [Graphical view ]
    PANTHERi PTHR10522. PTHR10522. 1 hit.
    PROSITEi PS00473. GNRH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel gonadotropin-releasing hormone from the gilthead seabream (Sparus aurata)."
      Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y.
      Mol. Mar. Biol. Biotechnol. 4:27-35(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Three forms of gonadotropin-releasing hormone characterized from brains of one species."
      Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M.
      Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-35, MASS SPECTROMETRY.
      Tissue: Brain.

    Entry informationi

    Entry nameiGON1_SPAAU
    AccessioniPrimary (citable) accession number: P51919
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3