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Protein

Progonadoliberin-1

Gene

gnrh1

Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the secretion of gonadotropins.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
GnRH-associated peptide I
Gene namesi
Name:gnrh1
OrganismiSparus aurata (Gilthead sea bream)
Taxonomic identifieri8175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeSparus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 25251 PublicationAdd
BLAST
Chaini26 – 9570Progonadoliberin-1PRO_0000012444Add
BLAST
Peptidei26 – 3510Gonadoliberin-1PRO_0000012445
Peptidei39 – 9557GnRH-associated peptide 1Sequence AnalysisPRO_0000012446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261Pyrrolidone carboxylic acid
Modified residuei35 – 351Glycine amide

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG014746.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI
60 70 80 90
IERFPHVDSP CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK
Length:95
Mass (Da):10,753
Last modified:October 1, 1996 - v1
Checksum:i49313FD6FD6B87DA
GO

Mass spectrometryi

Molecular mass is 1113.6 Da from positions 26 - 35. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30320 mRNA. Translation: AAA75469.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30320 mRNA. Translation: AAA75469.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG014746.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and characterization of a novel gonadotropin-releasing hormone from the gilthead seabream (Sparus aurata)."
    Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y.
    Mol. Mar. Biol. Biotechnol. 4:27-35(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Three forms of gonadotropin-releasing hormone characterized from brains of one species."
    Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M.
    Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-35, MASS SPECTROMETRY.
    Tissue: Brain.

Entry informationi

Entry nameiGON1_SPAAU
AccessioniPrimary (citable) accession number: P51919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.