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Protein

Progonadoliberin-1

Gene

gnrh1

Organism
Sparus aurata (Gilthead sea bream)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Stimulates the secretion of gonadotropins.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Names & Taxonomyi

Protein namesi
Recommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I
Cleaved into the following 2 chains:
Alternative name(s):
Gonadoliberin I
Gonadotropin-releasing hormone I
Short name:
GnRH-I
Luliberin I
Luteinizing hormone-releasing hormone I
Short name:
LH-RH I
Alternative name(s):
GnRH-associated peptide I
Gene namesi
Name:gnrh1
OrganismiSparus aurata (Gilthead sea bream)
Taxonomic identifieri8175 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSpariformesSparidaeSparus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 251 PublicationAdd BLAST25
ChainiPRO_000001244426 – 95Progonadoliberin-1Add BLAST70
PeptideiPRO_000001244526 – 35Gonadoliberin-110
PeptideiPRO_000001244639 – 95GnRH-associated peptide 1Sequence analysisAdd BLAST57

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26Pyrrolidone carboxylic acid1
Modified residuei35Glycine amide1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Pyrrolidone carboxylic acid

Family & Domainsi

Sequence similaritiesi

Belongs to the GnRH family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG014746.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI
60 70 80 90
IERFPHVDSP CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK
Length:95
Mass (Da):10,753
Last modified:October 1, 1996 - v1
Checksum:i49313FD6FD6B87DA
GO

Mass spectrometryi

Molecular mass is 1113.6 Da from positions 26 - 35. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30320 mRNA. Translation: AAA75469.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30320 mRNA. Translation: AAA75469.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG014746.

Family and domain databases

InterProiIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERiPTHR10522. PTHR10522. 1 hit.
PROSITEiPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGON1_SPAAU
AccessioniPrimary (citable) accession number: P51919
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.