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P51919 (GON1_SPAAU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Progonadoliberin-1
Alternative name(s):
Progonadoliberin I

Cleaved into the following 2 chains:

  1. Gonadoliberin-1
    Alternative name(s):
    Gonadoliberin I
    Gonadotropin-releasing hormone I
    Short name=GnRH-I
    Luliberin I
    Luteinizing hormone-releasing hormone I
    Short name=LH-RH I
  2. GnRH-associated peptide 1
    Alternative name(s):
    GnRH-associated peptide I
Gene names
Name:gnrh1
OrganismSparus aurata (Gilthead sea bream)
Taxonomic identifier8175 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiEuteleosteiNeoteleosteiAcanthomorphaAcanthopterygiiPercomorphaPerciformesPercoideiSparidaeSparus

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Stimulates the secretion of gonadotropins.

Subcellular location

Secreted.

Sequence similarities

Belongs to the GnRH family.

Mass spectrometry

Molecular mass is 1113.6 Da from positions 26 - 35. Determined by MALDI. Ref.2

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionHormone
   PTMAmidation
Cleavage on pair of basic residues
Pyrrolidone carboxylic acid
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Ref.2
Chain26 – 9570Progonadoliberin-1
PRO_0000012444
Peptide26 – 3510Gonadoliberin-1 Ref.2
PRO_0000012445
Peptide39 – 9557GnRH-associated peptide 1 Potential
PRO_0000012446

Amino acid modifications

Modified residue261Pyrrolidone carboxylic acid
Modified residue351Glycine amide

Sequences

Sequence LengthMass (Da)Tools
P51919 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 49313FD6FD6B87DA

FASTA9510,753
        10         20         30         40         50         60 
MAPQTSNLWI LLLLVVVMMM SQGCCQHWSY GLSPGGKRDL DSLSDTLGNI IERFPHVDSP 

        70         80         90 
CSVLGCVEEP HVPRMYRMKG FIGSERDIGH RMYKK 

« Hide

References

[1]"Molecular cloning and characterization of a novel gonadotropin-releasing hormone from the gilthead seabream (Sparus aurata)."
Gothilf Y., Elizur A., Chow M., Chen T.T., Zohar Y.
Mol. Mar. Biol. Biotechnol. 4:27-35(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Three forms of gonadotropin-releasing hormone characterized from brains of one species."
Powell J.F.F., Zohar Y., Elizur A., Park M., Fischer W.H., Craig A.G., Rivier J.E., Lovejoy D.A., Sherwood N.M.
Proc. Natl. Acad. Sci. U.S.A. 91:12081-12085(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 26-35, MASS SPECTROMETRY.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U30320 mRNA. Translation: AAA75469.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG014746.

Family and domain databases

InterProIPR002012. GnRH.
IPR019792. Gonadoliberin_I.
[Graphical view]
PANTHERPTHR10522. PTHR10522. 1 hit.
PROSITEPS00473. GNRH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGON1_SPAAU
AccessionPrimary (citable) accession number: P51919
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families