ID   GON1_HAPBU              Reviewed;          94 AA.
AC   P51918; O93387;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   05-MAY-2009, entry version 53.
DE   RecName: Full=Progonadoliberin-1;
DE   AltName: Full=Progonadoliberin I;
DE   Contains:
DE     RecName: Full=Gonadoliberin-1;
DE     AltName: Full=Gonadoliberin I;
DE     AltName: Full=Luteinizing hormone-releasing hormone I;
DE              Short=LH-RH I;
DE     AltName: Full=Gonadotropin-releasing hormone I;
DE              Short=GnRH-I;
DE     AltName: Full=Luliberin I;
DE   Contains:
DE     RecName: Full=GnRH-associated peptide 1;
DE     AltName: Full=GnRH-associated peptide I;
DE   Flags: Precursor;
GN   Name=gnrh1;
OS   Haplochromis burtoni (Burton's mouthbrooder).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei;
OC   Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Labroidei;
OC   Cichlidae; African cichlids; Pseudocrenilabrinae; Haplochromini;
OC   Haplochromis.
OX   NCBI_TaxID=8153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=95396797; PubMed=7667296; DOI=10.1073/pnas.92.18.8363;
RA   White S.A., Kasten T.L., Bond C.T., Adelman J.P., Fernald R.D.;
RT   "Three gonadotropin-releasing hormone genes in one organism suggest
RT   novel roles for an ancient peptide.";
RL   Proc. Natl. Acad. Sci. U.S.A. 92:8363-8367(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=99061842; PubMed=9843638; DOI=10.1006/gcen.1998.7142;
RA   White R.B., Fernald R.D.;
RT   "Ontogeny of gonadotropin-releasing hormone (GnRH) gene expression
RT   reveals a distinct origin for GnRH-containing neurons in the
RT   midbrain.";
RL   Gen. Comp. Endocrinol. 112:322-329(1998).
RN   [3]
RP   PROTEIN SEQUENCE OF 23-32, AND MASS SPECTROMETRY.
RC   TISSUE=Pituitary;
RX   MEDLINE=95372591; PubMed=7644702; DOI=10.1016/0167-0115(95)00014-3;
RA   Powell J.F.F., Fischer W.H., Park M., Craig A.G., Rivier J.E.,
RA   White S.A., Francis R.C., Fernald R.D., Licht P., Warby C.,
RA   Sherwood N.M.;
RT   "Primary structure of solitary form of gonadotropin-releasing hormone
RT   (GnRH) in cichlid pituitary; three forms of GnRH in brain of cichlid
RT   and pumpkinseed fish.";
RL   Regul. Pept. 57:43-53(1995).
CC   -!- FUNCTION: Stimulates the secretion of gonadotropins. May be
CC       responsible for the regulation of the hypothalamic-pituitary-
CC       gonadal axis.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Synthesized in preoptic neurons and is
CC       transported to the pituitary in the preoptic-hypophyseal axons.
CC   -!- MASS SPECTROMETRY: Mass=1113.9; Method=MALDI; Range=23-32;
CC       Source=PubMed:7644702;
CC   -!- SIMILARITY: Belongs to the GnRH family.
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DR   EMBL; U31865; AAC59691.1; -; mRNA.
DR   EMBL; AF076961; AAC27716.1; -; Genomic_DNA.
DR   PIR; I50739; I50739.
DR   HOVERGEN; P51918; -.
DR   GO; GO:0005576; C:extracellular region; NAS:UniProtKB.
DR   GO; GO:0005183; F:gonadotropin hormone-releasing hormone acti...; NAS:UniProtKB.
DR   GO; GO:0007275; P:multicellular organismal development; IDA:UniProtKB.
DR   InterPro; IPR002012; GnRH.
DR   InterPro; IPR019792; Gonadoliberin_I.
DR   InterPro; IPR004079; Gonadoliberin_I_precursor.
DR   PANTHER; PTHR10522; GnRH; 1.
DR   Pfam; PF00446; GnRH; 1.
DR   PRINTS; PR01541; GONADOLIBRNI.
DR   PROSITE; PS00473; GNRH; 1.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues;
KW   Direct protein sequencing; Hormone; Pyrrolidone carboxylic acid;
KW   Secreted; Signal.
FT   SIGNAL        1     22
FT   CHAIN        23     94       Progonadoliberin-1.
FT                                /FTId=PRO_0000012432.
FT   PEPTIDE      23     32       Gonadoliberin-1.
FT                                /FTId=PRO_0000012433.
FT   PEPTIDE      36     94       GnRH-associated peptide 1 (Potential).
FT                                /FTId=PRO_0000012434.
FT   MOD_RES      23     23       Pyrrolidone carboxylic acid.
FT   MOD_RES      32     32       Glycine amide.
FT   CONFLICT     86     94       ENGHRTFKK -> KMDTGHSRNERFL (in Ref. 1;
FT                                AAC59691).
SQ   SEQUENCE   94 AA;  10382 MW;  E57DBA83333278D7 CRC64;
     MAAKILALWL LLAGTVFPQG CCQHWSYGLS PGGKRDLDNF SDTLGNMVEE FPRVEAPCSV
     FGCAEESPFA KMYRVKGLLA SVAERENGHR TFKK
//