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Protein

Gap junction Cx32.2 protein

Gene
N/A
Organism
Micropogonias undulatus (Atlantic croaker)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May be involved in ovarian follicular maturation.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction Cx32.2 protein
Alternative name(s):
Connexin-32.2
OrganismiMicropogonias undulatus (Atlantic croaker)
Taxonomic identifieri29154 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaSciaenidaeMicropogonias

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 19CytoplasmicSequence analysisAdd BLAST18
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 148CytoplasmicSequence analysisAdd BLAST49
Transmembranei149 – 171HelicalSequence analysisAdd BLAST23
Topological domaini172 – 194ExtracellularSequence analysisAdd BLAST23
Transmembranei195 – 217HelicalSequence analysisAdd BLAST23
Topological domaini218 – 285CytoplasmicSequence analysisAdd BLAST68

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000578772 – 285Gap junction Cx32.2 proteinAdd BLAST284

Expressioni

Inductioni

In ovaries, hormonally induced at the onset of oocyte maturation.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Structurei

3D structure databases

SMRiP51915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLGFLSKL LDQVQSHSTV IGKIWMTVLF LFRIMVLGAG AESVWGDEQS
60 70 80 90 100
DFTCNTQQPG CENVCYDWTF PISHIRFWVL QIIFVSTPTL IYLGHAMHII
110 120 130 140 150
QQETKLRARL SSPGGSRLCK QPKYTNEQGK VKIKGNLLGS YLTQLVFKII
160 170 180 190 200
IEAAFIVGQY YLYGFIMVPM FPCSKKPCPF TVECYMSRPT EKTIFIIFML
210 220 230 240 250
VVACVSLLLN VIEVFYLICT RVRCGSRAHS HKITSAENPA SLSSPRWPTV
260 270 280
EDSLKQNKMN MELETSQSIG GSLDGAKEEK RLLSH
Length:285
Mass (Da):32,166
Last modified:January 23, 2007 - v2
Checksum:i8805BA7E2F5C7B82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31542 mRNA. Translation: AAA66969.1.
PIRiI50995.

Similar proteinsi

Entry informationi

Entry nameiCX32_MICUN
AccessioniPrimary (citable) accession number: P51915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 62 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families