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Protein

Gap junction alpha-4 protein

Gene

gja4

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-4 protein
Alternative name(s):
Connexin-41
Short name:
Cx41
Gene namesi
Name:gja4
Synonyms:cx41
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6464391. gja4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 23CytoplasmicSequence analysisAdd BLAST22
Transmembranei24 – 46HelicalSequence analysisAdd BLAST23
Topological domaini47 – 76ExtracellularSequence analysisAdd BLAST30
Transmembranei77 – 99HelicalSequence analysisAdd BLAST23
Topological domaini100 – 153CytoplasmicSequence analysisAdd BLAST54
Transmembranei154 – 176HelicalSequence analysisAdd BLAST23
Topological domaini177 – 208ExtracellularSequence analysisAdd BLAST32
Transmembranei209 – 231HelicalSequence analysisAdd BLAST23
Topological domaini232 – 352CytoplasmicSequence analysisAdd BLAST121

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000578452 – 352Gap junction alpha-4 proteinAdd BLAST351

Expressioni

Tissue specificityi

Expressed in ovarian somatic cells, heart, leg muscle, liver and eye but not in brain.1 Publication

Developmental stagei

Maternal protein whose levels decrease in late stages of oocyte maturation.1 Publication

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07613.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWEFLEKL LDQVQEHSTS IGKIWLMVLF IFRILILGLA GESVWGDEQS
60 70 80 90 100
DFTCNTEQPG CTNVCYDKAF PISHVRYWVL QFLFVSTPTL FYLGHVIYLS
110 120 130 140 150
RKEEKLKQKE SELRALDDKE QVEQAIAIIE KKKLKLYIQE DGTVKIKGAL
160 170 180 190 200
MYTYLTSVIF KSIFEAGFLL GQWYLYGFVM TPIYVCERVP CPHKVDCFVS
210 220 230 240 250
RPMEKTIFII FMLVVSLISL FLNVLELIHL ICKSMIHALK KYSQYIPANR
260 270 280 290 300
YPKNEDTYPE KTSETATAPF QDKSYIYLPM NENISYPQYK MPNEQNWVNF
310 320 330 340 350
NTEQQLAISG NTQSPLGHYS LSAFLPVSPK THSTVEKAST RASSSASKKQ

YV
Length:352
Mass (Da):40,633
Last modified:January 23, 2007 - v2
Checksum:i016023F7483D6D90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26256 mRNA. Translation: AAA93235.1.
RefSeqiNP_001165443.1. NM_001171972.1.

Genome annotation databases

GeneIDi100335149.
KEGGixla:100335149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26256 mRNA. Translation: AAA93235.1.
RefSeqiNP_001165443.1. NM_001171972.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100335149.
KEGGixla:100335149.

Organism-specific databases

CTDi100335149.
XenbaseiXB-GENE-6464391. gja4.

Phylogenomic databases

HOVERGENiHBG009576.
KOiK07613.

Family and domain databases

InterProiIPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiPF00029. Connexin. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXA4_XENLA
AccessioniPrimary (citable) accession number: P51914
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.