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P51912

- AAAT_MOUSE

UniProt

P51912 - AAAT_MOUSE

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Protein

Neutral amino acid transporter B(0)

Gene
Slc1a5, Aaat, Asct2, Slc1a7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin.

GO - Molecular functioni

  1. neutral amino acid transmembrane transporter activity Source: MGI
  2. sodium:dicarboxylate symporter activity Source: InterPro

GO - Biological processi

  1. neutral amino acid transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.23.3.2. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
ASC-like Na(+)-dependent neutral amino acid transporter ASCT2
Insulin-activated amino acid transporter
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:Slc1a5
Synonyms:Aaat, Asct2, Slc1a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:105305. Slc1a5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5151Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei52 – 7221Helical; Reviewed predictionAdd
BLAST
Transmembranei98 – 11821Helical; Reviewed predictionAdd
BLAST
Transmembranei132 – 15221Helical; Reviewed predictionAdd
BLAST
Topological domaini153 – 23684Extracellular Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Reviewed predictionAdd
BLAST
Transmembranei278 – 29821Helical; Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Reviewed predictionAdd
BLAST
Transmembranei348 – 36821Helical; Reviewed predictionAdd
BLAST
Transmembranei389 – 40921Helical; Reviewed predictionAdd
BLAST
Transmembranei411 – 43121Helical; Reviewed predictionAdd
BLAST
Transmembranei438 – 45821Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. melanosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Neutral amino acid transporter B(0)PRO_0000202083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine By similarity
Glycosylationi165 – 1651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi228 – 2281N-linked (GlcNAc...) Reviewed prediction
Modified residuei505 – 5051Phosphoserine By similarity
Modified residuei506 – 5061Phosphoserine1 Publication
Modified residuei518 – 5181Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP51912.
PaxDbiP51912.
PRIDEiP51912.

PTM databases

PhosphoSiteiP51912.

Expressioni

Tissue specificityi

Highly expressed in adipose tissue, lower levels seen in lung. Not expressed in brain, kidney, liver or heart and only traces are detected in spleen, thymus and skeletal muscle.

Developmental stagei

Expressed is induced during differentiation of preadipocytes into adipocytes.

Gene expression databases

GenevestigatoriP51912.

Structurei

3D structure databases

ProteinModelPortaliP51912.
SMRiP51912. Positions 92-494.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1301.
HOVERGENiHBG000080.
InParanoidiP51912.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51912-1 [UniParc]FASTAAdd to Basket

« Hide

MAVDPPKADP KGVAVDSSRR CPALGSREDQ SAKAGGCCGS RDRVRRCIRA    50
NLLVLLTVAA VVAGVGLGLG VSAAGGADAL GPARLTRFAF PGELLLRLLK 100
MIILPLVVCS LIGGAASLDP SALGRVGAWA LLFFLVTTLL ASALGVGLAL 150
ALKPGAAVTA ITSINDSVVD PCARSAPTKE ALDSFLDLVR NIFPSNLVSA 200
AFRSFATSYE PKDNSCKIPQ SCIQREINST MVQLLCEVEG MNILGLVVFA 250
IVFGVALRKL GPEGELLIRF FNSFNDATMV LVSWIMWYAP VGILFLVASK 300
IVEMKDVRQL FISLGKYILC CLLGHAIHGL LVLPLIYFLF TRKNPYRFLW 350
GIMTPLATAF GTSSSSATLP LMMKCVEEKN GVAKHISRFI LPIGATVNMD 400
GAALFQCVAA VFIAQLNGVS LDFVKIITIL VTATASSVGA AGIPAGGVLT 450
LAIILEAVSL PVKDISLILA VDWLVDRSCT VLNVEGDAFG AGLLQSYVDR 500
TKMPSSEPEL IQVKNEVSLN PLPLATEEGN PLLKQYQGPT GDSSATFEKE 550
SVM 553
Length:553
Mass (Da):58,483
Last modified:July 15, 1998 - v2
Checksum:iD25EBC982FBDE158
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 219VAVDSSRRC → SSGGFHRNGG in AAA66264. 1 Publication
Sequence conflicti131 – 15424LLFFL…LALKP → ALFPGHHTARVGARRGFGPG AEA in AAA66264. 1 PublicationAdd
BLAST
Sequence conflicti181 – 1811A → V in AAA66264. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42115 mRNA. Translation: AAA66264.1.
D85044 mRNA. Translation: BAA12716.1.
PIRiJC4149.
UniGeneiMm.1056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42115 mRNA. Translation: AAA66264.1 .
D85044 mRNA. Translation: BAA12716.1 .
PIRi JC4149.
UniGenei Mm.1056.

3D structure databases

ProteinModelPortali P51912.
SMRi P51912. Positions 92-494.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 2.A.23.3.2. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

PhosphoSitei P51912.

Proteomic databases

MaxQBi P51912.
PaxDbi P51912.
PRIDEi P51912.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:105305. Slc1a5.

Phylogenomic databases

eggNOGi COG1301.
HOVERGENi HBG000080.
InParanoidi P51912.

Miscellaneous databases

PROi P51912.
SOURCEi Search...

Gene expression databases

Genevestigatori P51912.

Family and domain databases

Gene3Di 1.10.3860.10. 2 hits.
InterProi IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view ]
PANTHERi PTHR11958. PTHR11958. 1 hit.
Pfami PF00375. SDF. 1 hit.
[Graphical view ]
PRINTSi PR00173. EDTRNSPORT.
SUPFAMi SSF118215. SSF118215. 2 hits.
PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel insulin-activated amino acid transporter gene during differentiation of 3T3-L1 preadipocytes into adipocytes."
    Liao K., Lane M.D.
    Biochem. Biophys. Res. Commun. 208:1008-1015(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Tissue: Adipose tissue.
  2. "Cloning and functional characterization of a system ASC-like Na+-dependent neutral amino acid transporter."
    Utsunomiya-Tate N., Endou H., Kanai Y.
    J. Biol. Chem. 271:14883-14890(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: JCL:ICR.
    Tissue: Testis.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-506 AND SER-518, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAAAT_MOUSE
AccessioniPrimary (citable) accession number: P51912
Secondary accession number(s): Q61326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi