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Protein

Neutral amino acid transporter B(0)

Gene

Slc1a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids.2 Publications

GO - Molecular functioni

  • neutral amino acid transmembrane transporter activity Source: MGI
  • symporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Protein family/group databases

TCDBi2.A.23.3.2. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Neutral amino acid transporter B(0)
Short name:
ATB(0)
Alternative name(s):
ASC-like Na(+)-dependent neutral amino acid transporter ASCT2
Insulin-activated amino acid transporter
Sodium-dependent neutral amino acid transporter type 2
Solute carrier family 1 member 5
Gene namesi
Name:Slc1a5
Synonyms:Aaat, Asct2, Slc1a7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:105305. Slc1a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 51CytoplasmicSequence analysisAdd BLAST51
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Transmembranei132 – 152HelicalSequence analysisAdd BLAST21
Topological domaini153 – 236ExtracellularSequence analysisAdd BLAST84
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Transmembranei348 – 368HelicalSequence analysisAdd BLAST21
Transmembranei389 – 409HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020831 – 553Neutral amino acid transporter B(0)Add BLAST553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi165N-linked (GlcNAc...)Sequence analysis1
Glycosylationi228N-linked (GlcNAc...)Sequence analysis1
Modified residuei505PhosphoserineBy similarity1
Modified residuei506PhosphoserineCombined sources1
Modified residuei518PhosphoserineCombined sources1
Modified residuei543PhosphoserineCombined sources1
Modified residuei551PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP51912.
MaxQBiP51912.
PaxDbiP51912.
PeptideAtlasiP51912.
PRIDEiP51912.

PTM databases

iPTMnetiP51912.
PhosphoSitePlusiP51912.
SwissPalmiP51912.

Expressioni

Tissue specificityi

Highly expressed in adipose tissue, lower levels seen in lung. Not expressed in brain, kidney, liver or heart and only traces are detected in spleen, thymus and skeletal muscle.

Developmental stagei

Expressed is induced during differentiation of preadipocytes into adipocytes.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104136.

Structurei

3D structure databases

ProteinModelPortaliP51912.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOVERGENiHBG000080.
InParanoidiP51912.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51912-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVDPPKADP KGVAVDSSRR CPALGSREDQ SAKAGGCCGS RDRVRRCIRA
60 70 80 90 100
NLLVLLTVAA VVAGVGLGLG VSAAGGADAL GPARLTRFAF PGELLLRLLK
110 120 130 140 150
MIILPLVVCS LIGGAASLDP SALGRVGAWA LLFFLVTTLL ASALGVGLAL
160 170 180 190 200
ALKPGAAVTA ITSINDSVVD PCARSAPTKE ALDSFLDLVR NIFPSNLVSA
210 220 230 240 250
AFRSFATSYE PKDNSCKIPQ SCIQREINST MVQLLCEVEG MNILGLVVFA
260 270 280 290 300
IVFGVALRKL GPEGELLIRF FNSFNDATMV LVSWIMWYAP VGILFLVASK
310 320 330 340 350
IVEMKDVRQL FISLGKYILC CLLGHAIHGL LVLPLIYFLF TRKNPYRFLW
360 370 380 390 400
GIMTPLATAF GTSSSSATLP LMMKCVEEKN GVAKHISRFI LPIGATVNMD
410 420 430 440 450
GAALFQCVAA VFIAQLNGVS LDFVKIITIL VTATASSVGA AGIPAGGVLT
460 470 480 490 500
LAIILEAVSL PVKDISLILA VDWLVDRSCT VLNVEGDAFG AGLLQSYVDR
510 520 530 540 550
TKMPSSEPEL IQVKNEVSLN PLPLATEEGN PLLKQYQGPT GDSSATFEKE

SVM
Length:553
Mass (Da):58,483
Last modified:July 15, 1998 - v2
Checksum:iD25EBC982FBDE158
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13 – 21VAVDSSRRC → SSGGFHRNGG in AAA66264 (PubMed:7702599).Curated9
Sequence conflicti131 – 154LLFFL…LALKP → ALFPGHHTARVGARRGFGPG AEA in AAA66264 (PubMed:7702599).CuratedAdd BLAST24
Sequence conflicti181A → V in AAA66264 (PubMed:7702599).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42115 mRNA. Translation: AAA66264.1.
D85044 mRNA. Translation: BAA12716.1.
PIRiJC4149.
UniGeneiMm.1056.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L42115 mRNA. Translation: AAA66264.1.
D85044 mRNA. Translation: BAA12716.1.
PIRiJC4149.
UniGeneiMm.1056.

3D structure databases

ProteinModelPortaliP51912.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104136.

Protein family/group databases

TCDBi2.A.23.3.2. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

iPTMnetiP51912.
PhosphoSitePlusiP51912.
SwissPalmiP51912.

Proteomic databases

EPDiP51912.
MaxQBiP51912.
PaxDbiP51912.
PeptideAtlasiP51912.
PRIDEiP51912.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:105305. Slc1a5.

Phylogenomic databases

eggNOGiKOG3787. Eukaryota.
COG1301. LUCA.
HOVERGENiHBG000080.
InParanoidiP51912.

Miscellaneous databases

PROiP51912.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAAT_MOUSE
AccessioniPrimary (citable) accession number: P51912
Secondary accession number(s): Q61326
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: November 30, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.