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P51911

- CNN1_HUMAN

UniProt

P51911 - CNN1_HUMAN

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Protein

Calponin-1

Gene

CNN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).By similarity

GO - Biological processi

  1. actomyosin structure organization Source: InterPro
  2. regulation of smooth muscle contraction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-1
Alternative name(s):
Basic calponin
Calponin H1, smooth muscle
Gene namesi
Name:CNN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:2155. CNN1.

Subcellular locationi

GO - Cellular componenti

  1. cytoskeleton Source: MGI
  2. focal adhesion Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26665.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 297297Calponin-1PRO_0000204767Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei170 – 1701Phosphothreonine; by ROCK2By similarity
Modified residuei175 – 1751Phosphoserine; by ROCK2By similarity
Modified residuei180 – 1801Phosphothreonine; by ROCK2By similarity
Modified residuei184 – 1841Phosphothreonine; by ROCK2By similarity
Modified residuei259 – 2591Phosphothreonine; by ROCK2By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP51911.
PaxDbiP51911.
PeptideAtlasiP51911.
PRIDEiP51911.

PTM databases

PhosphoSiteiP51911.

Expressioni

Tissue specificityi

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Gene expression databases

BgeeiP51911.
CleanExiHS_CNN1.
ExpressionAtlasiP51911. baseline and differential.
GenevestigatoriP51911.

Organism-specific databases

HPAiCAB000007.
HPA014263.

Interactioni

Subunit structurei

Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.By similarity

Protein-protein interaction databases

BioGridi107664. 9 interactions.
IntActiP51911. 2 interactions.
STRINGi9606.ENSP00000252456.

Structurei

Secondary structure

1
297
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi28 – 4114Combined sources
Helixi52 – 554Combined sources
Helixi58 – 6710Combined sources
Beta strandi71 – 733Combined sources
Helixi82 – 9817Combined sources
Helixi102 – 1043Combined sources
Helixi108 – 1125Combined sources
Helixi118 – 13417Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WYPNMR-A20-142[»]
ProteinModelPortaliP51911.
SMRiP51911. Positions 13-142.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51911.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 131104CHPROSITE-ProRule annotationAdd
BLAST
Repeati164 – 18926Calponin-like 1Add
BLAST
Repeati204 – 22926Calponin-like 2Add
BLAST
Repeati243 – 26826Calponin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 3 calponin-like repeats.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5199.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiP51911.
OMAiAGMAKSK.
OrthoDBiEOG71P2B3.
PhylomeDBiP51911.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51911-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF
60 70 80 90 100
MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV
110 120 130 140 150
KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER
160 170 180 190 200
KFEPGKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD
210 220 230 240 250
QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN
260 270 280 290
KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA
Length:297
Mass (Da):33,170
Last modified:November 1, 1997 - v2
Checksum:iA949573543BC246C
GO
Isoform 2 (identifier: P51911-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MSSAHFNRGPAYGLSAEVKNK → M

Note: No experimental confirmation available

Show »
Length:277
Mass (Da):31,055
Checksum:i4FD53B7974B60AC5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti57 – 571G → S in BAA12983. 1 PublicationCurated
Sequence conflicti149 – 1491E → G in BAA12983. 1 PublicationCurated
Sequence conflicti170 – 1701T → S in AAC51780. (PubMed:9332369)Curated
Sequence conflicti266 – 2661Q → P in BAA12983. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2121MSSAH…EVKNK → M in isoform 2. 1 PublicationVSP_056948Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80560 mRNA. Translation: AAB35751.1.
U37019 mRNA. Translation: AAC51780.1.
D17408 mRNA. Translation: BAA04231.1.
AK300837 mRNA. Translation: BAG62488.1.
AK313255 mRNA. Translation: BAG36065.1.
AC008481 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84229.1.
BC022015 mRNA. Translation: AAH22015.1.
BC036307 mRNA. Translation: AAH36307.2.
D86058 mRNA. Translation: BAA12983.1.
D85611 Genomic DNA. Translation: BAA19538.1.
CCDSiCCDS12263.1.
PIRiG02142.
JC4500.
RefSeqiNP_001290.2. NM_001299.4.
UniGeneiHs.465929.

Genome annotation databases

EnsembliENST00000252456; ENSP00000252456; ENSG00000130176. [P51911-1]
GeneIDi1264.
KEGGihsa:1264.
UCSCiuc002msc.1. human. [P51911-1]

Polymorphism databases

DMDMi2829431.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80560 mRNA. Translation: AAB35751.1 .
U37019 mRNA. Translation: AAC51780.1 .
D17408 mRNA. Translation: BAA04231.1 .
AK300837 mRNA. Translation: BAG62488.1 .
AK313255 mRNA. Translation: BAG36065.1 .
AC008481 Genomic DNA. No translation available.
CH471106 Genomic DNA. Translation: EAW84229.1 .
BC022015 mRNA. Translation: AAH22015.1 .
BC036307 mRNA. Translation: AAH36307.2 .
D86058 mRNA. Translation: BAA12983.1 .
D85611 Genomic DNA. Translation: BAA19538.1 .
CCDSi CCDS12263.1.
PIRi G02142.
JC4500.
RefSeqi NP_001290.2. NM_001299.4.
UniGenei Hs.465929.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WYP NMR - A 20-142 [» ]
ProteinModelPortali P51911.
SMRi P51911. Positions 13-142.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107664. 9 interactions.
IntActi P51911. 2 interactions.
STRINGi 9606.ENSP00000252456.

PTM databases

PhosphoSitei P51911.

Polymorphism databases

DMDMi 2829431.

Proteomic databases

MaxQBi P51911.
PaxDbi P51911.
PeptideAtlasi P51911.
PRIDEi P51911.

Protocols and materials databases

DNASUi 1264.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252456 ; ENSP00000252456 ; ENSG00000130176 . [P51911-1 ]
GeneIDi 1264.
KEGGi hsa:1264.
UCSCi uc002msc.1. human. [P51911-1 ]

Organism-specific databases

CTDi 1264.
GeneCardsi GC19P011649.
HGNCi HGNC:2155. CNN1.
HPAi CAB000007.
HPA014263.
MIMi 600806. gene.
neXtProti NX_P51911.
PharmGKBi PA26665.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5199.
HOGENOMi HOG000232113.
HOVERGENi HBG005186.
InParanoidi P51911.
OMAi AGMAKSK.
OrthoDBi EOG71P2B3.
PhylomeDBi P51911.
TreeFami TF313921.

Miscellaneous databases

ChiTaRSi CNN1. human.
EvolutionaryTracei P51911.
GenomeRNAii 1264.
NextBioi 5115.
PROi P51911.
SOURCEi Search...

Gene expression databases

Bgeei P51911.
CleanExi HS_CNN1.
ExpressionAtlasi P51911. baseline and differential.
Genevestigatori P51911.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
InterProi IPR001997. Calponin.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view ]
Pfami PF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view ]
PRINTSi PR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTi SM00033. CH. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
PROSITEi PS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and gene mapping of human basic and acidic calponins."
    Maguchi M., Nishida W., Kohara K., Kuwano A., Kondo I., Hiwada K.
    Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Aorta.
  2. "Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene."
    Miano J.M., Krahe R., Garcia E., Elliott J.M., Olson E.N.
    Gene 197:215-224(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Takahashi K.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Aorta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pericardium and Small intestine.
  5. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Testis.
  8. "Systematic RLGS-M screening and identification of genes on chromosome 21 regulated by the dosage compensation in Down syndrome."
    Kuromitsu J., Hayashizaki Y.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-297 (ISOFORM 1).
    Tissue: Placenta.
  9. Takahashi K.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  10. "Solution structure of the CH domain of human calponin 1."
    RIKEN structural genomics initiative (RSGI)
    Submitted (AUG-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 20-142.

Entry informationi

Entry nameiCNN1_HUMAN
AccessioniPrimary (citable) accession number: P51911
Secondary accession number(s): B2R868
, B4DUX6, O00638, Q15416, Q8IY93, Q99438
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3