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P51911 (CNN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calponin-1
Alternative name(s):
Basic calponin
Calponin H1, smooth muscle
Gene names
Name:CNN1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity By similarity.

Subunit structure

Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 By similarity.

Tissue specificity

Smooth muscle, and tissues containing significant amounts of smooth muscle.

Sequence similarities

Belongs to the calponin family.

Contains 3 calponin-like repeats.

Contains 1 CH (calponin-homology) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 297297Calponin-1
PRO_0000204767

Regions

Domain28 – 131104CH
Repeat164 – 18926Calponin-like 1
Repeat204 – 22926Calponin-like 2
Repeat243 – 26826Calponin-like 3

Amino acid modifications

Modified residue1701Phosphothreonine; by ROCK2 By similarity
Modified residue1751Phosphoserine; by ROCK2 By similarity
Modified residue1801Phosphothreonine; by ROCK2 By similarity
Modified residue1841Phosphothreonine; by ROCK2 By similarity
Modified residue2591Phosphothreonine; by ROCK2 By similarity

Experimental info

Sequence conflict571G → S in BAA12983. Ref.7
Sequence conflict1491E → G in BAA12983. Ref.7
Sequence conflict1701T → S in AAC51780. Ref.2
Sequence conflict2661Q → P in BAA12983. Ref.7

Secondary structure

................. 297
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P51911 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: A949573543BC246C

FASTA29733,170
        10         20         30         40         50         60 
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL 

        70         80         90        100        110        120 
CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV 

       130        140        150        160        170        180 
QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT 

       190        200        210        220        230        240 
AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT 

       250        260        270        280        290 
LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and gene mapping of human basic and acidic calponins."
Maguchi M., Nishida W., Kohara K., Kuwano A., Kondo I., Hiwada K.
Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aorta.
[2]"Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene."
Miano J.M., Krahe R., Garcia E., Elliott J.M., Olson E.N.
Gene 197:215-224(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]Takahashi K.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Aorta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pericardium.
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Testis.
[7]"Systematic RLGS-M screening and identification of genes on chromosome 21 regulated by the dosage compensation in Down syndrome."
Kuromitsu J., Hayashizaki Y.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-297.
Tissue: Placenta.
[8]Takahashi K.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
[9]"Solution structure of the CH domain of human calponin 1."
RIKEN structural genomics initiative (RSGI)
Submitted (AUG-2005) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 20-142.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S80560 mRNA. Translation: AAB35751.1.
U37019 mRNA. Translation: AAC51780.1.
D17408 mRNA. Translation: BAA04231.1.
AK313255 mRNA. Translation: BAG36065.1.
CH471106 Genomic DNA. Translation: EAW84229.1.
BC022015 mRNA. Translation: AAH22015.1.
BC036307 mRNA. Translation: AAH36307.2.
D86058 mRNA. Translation: BAA12983.1.
D85611 Genomic DNA. Translation: BAA19538.1.
PIRG02142.
JC4500.
RefSeqNP_001290.2. NM_001299.4.
UniGeneHs.465929.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1WYPNMR-A20-142[»]
ProteinModelPortalP51911.
SMRP51911. Positions 13-142.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107664. 8 interactions.
IntActP51911. 2 interactions.
STRING9606.ENSP00000252456.

PTM databases

PhosphoSiteP51911.

Polymorphism databases

DMDM2829431.

Proteomic databases

PaxDbP51911.
PeptideAtlasP51911.
PRIDEP51911.

Protocols and materials databases

DNASU1264.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000252456; ENSP00000252456; ENSG00000130176.
GeneID1264.
KEGGhsa:1264.
UCSCuc002msc.1. human.

Organism-specific databases

CTD1264.
GeneCardsGC19P011649.
HGNCHGNC:2155. CNN1.
HPACAB000007.
HPA014263.
MIM600806. gene.
neXtProtNX_P51911.
PharmGKBPA26665.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5199.
HOGENOMHOG000232113.
HOVERGENHBG005186.
InParanoidP51911.
OMAAGMAKSK.
OrthoDBEOG71P2B3.
PhylomeDBP51911.
TreeFamTF313921.

Gene expression databases

ArrayExpressP51911.
BgeeP51911.
CleanExHS_CNN1.
GenevestigatorP51911.

Family and domain databases

Gene3D1.10.418.10. 1 hit.
InterProIPR001997. Calponin.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTSM00033. CH. 1 hit.
[Graphical view]
SUPFAMSSF47576. SSF47576. 1 hit.
PROSITEPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCNN1. human.
EvolutionaryTraceP51911.
GenomeRNAi1264.
NextBio5115.
PROP51911.
SOURCESearch...

Entry information

Entry nameCNN1_HUMAN
AccessionPrimary (citable) accession number: P51911
Secondary accession number(s): B2R868 expand/collapse secondary AC list , O00638, Q15416, Q8IY93, Q99438
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: February 19, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM