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P51911

- CNN1_HUMAN

UniProt

P51911 - CNN1_HUMAN

Protein

Calponin-1

Gene

CNN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity By similarity.By similarity

    GO - Biological processi

    1. actomyosin structure organization Source: InterPro
    2. regulation of smooth muscle contraction Source: UniProtKB

    Keywords - Ligandi

    Actin-binding, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calponin-1
    Alternative name(s):
    Basic calponin
    Calponin H1, smooth muscle
    Gene namesi
    Name:CNN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:2155. CNN1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoskeleton Source: MGI

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26665.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 297297Calponin-1PRO_0000204767Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei170 – 1701Phosphothreonine; by ROCK2By similarity
    Modified residuei175 – 1751Phosphoserine; by ROCK2By similarity
    Modified residuei180 – 1801Phosphothreonine; by ROCK2By similarity
    Modified residuei184 – 1841Phosphothreonine; by ROCK2By similarity
    Modified residuei259 – 2591Phosphothreonine; by ROCK2By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP51911.
    PaxDbiP51911.
    PeptideAtlasiP51911.
    PRIDEiP51911.

    PTM databases

    PhosphoSiteiP51911.

    Expressioni

    Tissue specificityi

    Smooth muscle, and tissues containing significant amounts of smooth muscle.

    Gene expression databases

    ArrayExpressiP51911.
    BgeeiP51911.
    CleanExiHS_CNN1.
    GenevestigatoriP51911.

    Organism-specific databases

    HPAiCAB000007.
    HPA014263.

    Interactioni

    Subunit structurei

    Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1.By similarity

    Protein-protein interaction databases

    BioGridi107664. 9 interactions.
    IntActiP51911. 2 interactions.
    STRINGi9606.ENSP00000252456.

    Structurei

    Secondary structure

    1
    297
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi28 – 4114
    Helixi52 – 554
    Helixi58 – 6710
    Beta strandi71 – 733
    Helixi82 – 9817
    Helixi102 – 1043
    Helixi108 – 1125
    Helixi118 – 13417

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WYPNMR-A20-142[»]
    ProteinModelPortaliP51911.
    SMRiP51911. Positions 13-142.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP51911.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 131104CHPROSITE-ProRule annotationAdd
    BLAST
    Repeati164 – 18926Calponin-like 1Add
    BLAST
    Repeati204 – 22926Calponin-like 2Add
    BLAST
    Repeati243 – 26826Calponin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the calponin family.Curated
    Contains 3 calponin-like repeats.PROSITE-ProRule annotation
    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5199.
    HOGENOMiHOG000232113.
    HOVERGENiHBG005186.
    InParanoidiP51911.
    OMAiAGMAKSK.
    OrthoDBiEOG71P2B3.
    PhylomeDBiP51911.
    TreeFamiTF313921.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    InterProiIPR001997. Calponin.
    IPR000557. Calponin_repeat.
    IPR001715. CH-domain.
    IPR003096. SM22_calponin.
    [Graphical view]
    PfamiPF00402. Calponin. 3 hits.
    PF00307. CH. 1 hit.
    [Graphical view]
    PRINTSiPR00889. CALPONIN.
    PR00888. SM22CALPONIN.
    SMARTiSM00033. CH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    PROSITEiPS01052. CALPONIN_1. 3 hits.
    PS51122. CALPONIN_2. 3 hits.
    PS50021. CH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51911-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF    50
    MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV 100
    KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER 150
    KFEPGKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD 200
    QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN 250
    KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSA 297
    Length:297
    Mass (Da):33,170
    Last modified:November 1, 1997 - v2
    Checksum:iA949573543BC246C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti57 – 571G → S in BAA12983. 1 PublicationCurated
    Sequence conflicti149 – 1491E → G in BAA12983. 1 PublicationCurated
    Sequence conflicti170 – 1701T → S in AAC51780. (PubMed:9332369)Curated
    Sequence conflicti266 – 2661Q → P in BAA12983. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80560 mRNA. Translation: AAB35751.1.
    U37019 mRNA. Translation: AAC51780.1.
    D17408 mRNA. Translation: BAA04231.1.
    AK313255 mRNA. Translation: BAG36065.1.
    CH471106 Genomic DNA. Translation: EAW84229.1.
    BC022015 mRNA. Translation: AAH22015.1.
    BC036307 mRNA. Translation: AAH36307.2.
    D86058 mRNA. Translation: BAA12983.1.
    D85611 Genomic DNA. Translation: BAA19538.1.
    CCDSiCCDS12263.1.
    PIRiG02142.
    JC4500.
    RefSeqiNP_001290.2. NM_001299.4.
    UniGeneiHs.465929.

    Genome annotation databases

    EnsembliENST00000252456; ENSP00000252456; ENSG00000130176.
    GeneIDi1264.
    KEGGihsa:1264.
    UCSCiuc002msc.1. human.

    Polymorphism databases

    DMDMi2829431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80560 mRNA. Translation: AAB35751.1 .
    U37019 mRNA. Translation: AAC51780.1 .
    D17408 mRNA. Translation: BAA04231.1 .
    AK313255 mRNA. Translation: BAG36065.1 .
    CH471106 Genomic DNA. Translation: EAW84229.1 .
    BC022015 mRNA. Translation: AAH22015.1 .
    BC036307 mRNA. Translation: AAH36307.2 .
    D86058 mRNA. Translation: BAA12983.1 .
    D85611 Genomic DNA. Translation: BAA19538.1 .
    CCDSi CCDS12263.1.
    PIRi G02142.
    JC4500.
    RefSeqi NP_001290.2. NM_001299.4.
    UniGenei Hs.465929.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WYP NMR - A 20-142 [» ]
    ProteinModelPortali P51911.
    SMRi P51911. Positions 13-142.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107664. 9 interactions.
    IntActi P51911. 2 interactions.
    STRINGi 9606.ENSP00000252456.

    PTM databases

    PhosphoSitei P51911.

    Polymorphism databases

    DMDMi 2829431.

    Proteomic databases

    MaxQBi P51911.
    PaxDbi P51911.
    PeptideAtlasi P51911.
    PRIDEi P51911.

    Protocols and materials databases

    DNASUi 1264.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252456 ; ENSP00000252456 ; ENSG00000130176 .
    GeneIDi 1264.
    KEGGi hsa:1264.
    UCSCi uc002msc.1. human.

    Organism-specific databases

    CTDi 1264.
    GeneCardsi GC19P011649.
    HGNCi HGNC:2155. CNN1.
    HPAi CAB000007.
    HPA014263.
    MIMi 600806. gene.
    neXtProti NX_P51911.
    PharmGKBi PA26665.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5199.
    HOGENOMi HOG000232113.
    HOVERGENi HBG005186.
    InParanoidi P51911.
    OMAi AGMAKSK.
    OrthoDBi EOG71P2B3.
    PhylomeDBi P51911.
    TreeFami TF313921.

    Miscellaneous databases

    ChiTaRSi CNN1. human.
    EvolutionaryTracei P51911.
    GenomeRNAii 1264.
    NextBioi 5115.
    PROi P51911.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51911.
    Bgeei P51911.
    CleanExi HS_CNN1.
    Genevestigatori P51911.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    InterProi IPR001997. Calponin.
    IPR000557. Calponin_repeat.
    IPR001715. CH-domain.
    IPR003096. SM22_calponin.
    [Graphical view ]
    Pfami PF00402. Calponin. 3 hits.
    PF00307. CH. 1 hit.
    [Graphical view ]
    PRINTSi PR00889. CALPONIN.
    PR00888. SM22CALPONIN.
    SMARTi SM00033. CH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    PROSITEi PS01052. CALPONIN_1. 3 hits.
    PS51122. CALPONIN_2. 3 hits.
    PS50021. CH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and gene mapping of human basic and acidic calponins."
      Maguchi M., Nishida W., Kohara K., Kuwano A., Kondo I., Hiwada K.
      Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aorta.
    2. "Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene."
      Miano J.M., Krahe R., Garcia E., Elliott J.M., Olson E.N.
      Gene 197:215-224(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. Takahashi K.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Aorta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pericardium.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Testis.
    7. "Systematic RLGS-M screening and identification of genes on chromosome 21 regulated by the dosage compensation in Down syndrome."
      Kuromitsu J., Hayashizaki Y.
      Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-297.
      Tissue: Placenta.
    8. Takahashi K.
      Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
    9. "Solution structure of the CH domain of human calponin 1."
      RIKEN structural genomics initiative (RSGI)
      Submitted (AUG-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 20-142.

    Entry informationi

    Entry nameiCNN1_HUMAN
    AccessioniPrimary (citable) accession number: P51911
    Secondary accession number(s): B2R868
    , O00638, Q15416, Q8IY93, Q99438
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 130 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3