Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein D

Gene

Apod

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-804914 Transport of fatty acids

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein D
Short name:
Apo-D
Short name:
ApoD
Gene namesi
Name:Apod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:88056 Apod

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001787421 – 189Apolipoprotein DAdd BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi28 ↔ 134By similarity
Disulfide bondi61 ↔ 185By similarity
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP51910
PaxDbiP51910
PeptideAtlasiP51910
PRIDEiP51910

PTM databases

iPTMnetiP51910
PhosphoSitePlusiP51910

Expressioni

Tissue specificityi

Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen.

Gene expression databases

BgeeiENSMUSG00000022548
CleanExiMM_APOD
GenevisibleiP51910 MM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110885

Structurei

3D structure databases

ProteinModelPortaliP51910
SMRiP51910
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4824 Eukaryota
COG3040 LUCA
GeneTreeiENSGT00510000046981
HOGENOMiHOG000061525
HOVERGENiHBG018734
InParanoidiP51910
KOiK03098
OMAiCGPDKSY
OrthoDBiEOG091G11BU
PhylomeDBiP51910
TreeFamiTF324836

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR026222 ApoD_vertbrte
IPR002969 ApolipopD
IPR012674 Calycin
IPR022271 Lipocalin_ApoD
IPR022272 Lipocalin_CS
IPR000566 Lipocln_cytosolic_FA-bd_dom
PfamiView protein in Pfam
PF08212 Lipocalin_2, 1 hit
PIRSFiPIRSF036893 Lipocalin_ApoD, 1 hit
PRINTSiPR02058 APODVERTBRTE
PR01219 APOLIPOPROTD
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTMLMFLAT LAGLFTTAKG QNFHLGKCPS PPVQENFDVK KYLGRWYEIE
60 70 80 90 100
KIPASFEKGN CIQANYSLME NGNIEVLNKE LSPDGTMNQV KGEAKQSNVS
110 120 130 140 150
EPAKLEVQFF PLMPPAPYWI LATDYENYAL VYSCTTFFWL FHVDFVWILG
160 170 180
RNPYLPPETI TYLKDILTSN GIDIEKMTTT DQANCPDFL
Length:189
Mass (Da):21,530
Last modified:October 1, 1996 - v1
Checksum:iC10109F1D56D69A0
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti146V → F in strain: Swiss Webster. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39123 Genomic DNA Translation: AAA67892.1
X82648 mRNA Translation: CAA57974.1
AK135046 mRNA Translation: BAE22397.1
AK157917 mRNA Translation: BAE34262.1
AK158118 mRNA Translation: BAE34364.1
AK158405 mRNA Translation: BAE34491.1
AK160729 mRNA Translation: BAE35974.1
AK162392 mRNA Translation: BAE36889.1
BC145907 mRNA Translation: AAI45908.1
BC145909 mRNA Translation: AAI45910.1
CCDSiCCDS28105.1
PIRiS49581
RefSeqiNP_001288282.1, NM_001301353.1
NP_001288283.1, NM_001301354.1
NP_031496.2, NM_007470.4
UniGeneiMm.2082
Mm.416437

Genome annotation databases

EnsembliENSMUST00000115230; ENSMUSP00000110885; ENSMUSG00000022548
ENSMUST00000130560; ENSMUSP00000119827; ENSMUSG00000022548
GeneIDi11815
KEGGimmu:11815
UCSCiuc007yxf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAPOD_MOUSE
AccessioniPrimary (citable) accession number: P51910
Secondary accession number(s): Q3TZE7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health