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Protein

Apolipoprotein D

Gene

Apod

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein D
Short name:
Apo-D
Short name:
ApoD
Gene namesi
Name:Apod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:88056. Apod.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 189169Apolipoprotein DPRO_0000017874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Pyrrolidone carboxylic acidBy similarity
Disulfide bondi28 ↔ 134By similarity
Disulfide bondi61 ↔ 185By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP51910.
PaxDbiP51910.
PeptideAtlasiP51910.
PRIDEiP51910.

PTM databases

iPTMnetiP51910.
PhosphoSiteiP51910.

Expressioni

Tissue specificityi

Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen.

Gene expression databases

BgeeiENSMUSG00000022548.
CleanExiMM_APOD.
GenevisibleiP51910. MM.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110885.

Structurei

3D structure databases

ProteinModelPortaliP51910.
SMRiP51910. Positions 23-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4824. Eukaryota.
COG3040. LUCA.
GeneTreeiENSGT00510000046981.
HOGENOMiHOG000061525.
HOVERGENiHBG018734.
InParanoidiP51910.
KOiK03098.
OMAiANFKIVW.
OrthoDBiEOG091G11BU.
PhylomeDBiP51910.
TreeFamiTF324836.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR026222. ApoD_vertbrte.
IPR002969. ApolipopD.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR02058. APODVERTBRTE.
PR01219. APOLIPOPROTD.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51910-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTMLMFLAT LAGLFTTAKG QNFHLGKCPS PPVQENFDVK KYLGRWYEIE
60 70 80 90 100
KIPASFEKGN CIQANYSLME NGNIEVLNKE LSPDGTMNQV KGEAKQSNVS
110 120 130 140 150
EPAKLEVQFF PLMPPAPYWI LATDYENYAL VYSCTTFFWL FHVDFVWILG
160 170 180
RNPYLPPETI TYLKDILTSN GIDIEKMTTT DQANCPDFL
Length:189
Mass (Da):21,530
Last modified:October 1, 1996 - v1
Checksum:iC10109F1D56D69A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461V → F in strain: Swiss Webster.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39123 Genomic DNA. Translation: AAA67892.1.
X82648 mRNA. Translation: CAA57974.1.
AK135046 mRNA. Translation: BAE22397.1.
AK157917 mRNA. Translation: BAE34262.1.
AK158118 mRNA. Translation: BAE34364.1.
AK158405 mRNA. Translation: BAE34491.1.
AK160729 mRNA. Translation: BAE35974.1.
AK162392 mRNA. Translation: BAE36889.1.
BC145907 mRNA. Translation: AAI45908.1.
BC145909 mRNA. Translation: AAI45910.1.
CCDSiCCDS28105.1.
PIRiS49581.
RefSeqiNP_001288282.1. NM_001301353.1.
NP_001288283.1. NM_001301354.1.
NP_031496.2. NM_007470.4.
UniGeneiMm.2082.
Mm.416437.

Genome annotation databases

EnsembliENSMUST00000115230; ENSMUSP00000110885; ENSMUSG00000022548.
ENSMUST00000130560; ENSMUSP00000119827; ENSMUSG00000022548.
GeneIDi11815.
KEGGimmu:11815.
UCSCiuc007yxf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39123 Genomic DNA. Translation: AAA67892.1.
X82648 mRNA. Translation: CAA57974.1.
AK135046 mRNA. Translation: BAE22397.1.
AK157917 mRNA. Translation: BAE34262.1.
AK158118 mRNA. Translation: BAE34364.1.
AK158405 mRNA. Translation: BAE34491.1.
AK160729 mRNA. Translation: BAE35974.1.
AK162392 mRNA. Translation: BAE36889.1.
BC145907 mRNA. Translation: AAI45908.1.
BC145909 mRNA. Translation: AAI45910.1.
CCDSiCCDS28105.1.
PIRiS49581.
RefSeqiNP_001288282.1. NM_001301353.1.
NP_001288283.1. NM_001301354.1.
NP_031496.2. NM_007470.4.
UniGeneiMm.2082.
Mm.416437.

3D structure databases

ProteinModelPortaliP51910.
SMRiP51910. Positions 23-186.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110885.

PTM databases

iPTMnetiP51910.
PhosphoSiteiP51910.

Proteomic databases

MaxQBiP51910.
PaxDbiP51910.
PeptideAtlasiP51910.
PRIDEiP51910.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115230; ENSMUSP00000110885; ENSMUSG00000022548.
ENSMUST00000130560; ENSMUSP00000119827; ENSMUSG00000022548.
GeneIDi11815.
KEGGimmu:11815.
UCSCiuc007yxf.2. mouse.

Organism-specific databases

CTDi347.
MGIiMGI:88056. Apod.

Phylogenomic databases

eggNOGiKOG4824. Eukaryota.
COG3040. LUCA.
GeneTreeiENSGT00510000046981.
HOGENOMiHOG000061525.
HOVERGENiHBG018734.
InParanoidiP51910.
KOiK03098.
OMAiANFKIVW.
OrthoDBiEOG091G11BU.
PhylomeDBiP51910.
TreeFamiTF324836.

Miscellaneous databases

ChiTaRSiApod. mouse.
PROiP51910.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022548.
CleanExiMM_APOD.
GenevisibleiP51910. MM.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR026222. ApoD_vertbrte.
IPR002969. ApolipopD.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR02058. APODVERTBRTE.
PR01219. APOLIPOPROTD.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOD_MOUSE
AccessioniPrimary (citable) accession number: P51910
Secondary accession number(s): Q3TZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.