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P51910

- APOD_MOUSE

UniProt

P51910 - APOD_MOUSE

Protein

Apolipoprotein D

Gene

Apod

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

    GO - Molecular functioni

    1. cholesterol binding Source: UniProtKB
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. aging Source: UniProtKB
    2. brain development Source: UniProtKB
    3. glucose metabolic process Source: UniProtKB
    4. lipid metabolic process Source: UniProtKB
    5. negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
    6. negative regulation of focal adhesion assembly Source: UniProtKB
    7. negative regulation of lipoprotein lipid oxidation Source: UniProtKB
    8. negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
    9. negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
    10. negative regulation of protein import into nucleus Source: UniProtKB
    11. negative regulation of smooth muscle cell-matrix adhesion Source: UniProtKB
    12. negative regulation of smooth muscle cell proliferation Source: UniProtKB
    13. negative regulation of T cell migration Source: UniProtKB
    14. peripheral nervous system axon regeneration Source: UniProtKB
    15. response to axon injury Source: UniProtKB
    16. response to drug Source: UniProtKB
    17. response to reactive oxygen species Source: UniProtKB
    18. tissue regeneration Source: UniProtKB

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein D
    Short name:
    Apo-D
    Short name:
    ApoD
    Gene namesi
    Name:Apod
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:88056. Apod.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosolic ribosome Source: UniProtKB
    2. dendrite Source: UniProtKB
    3. endoplasmic reticulum Source: UniProtKB
    4. extracellular space Source: UniProtKB
    5. intracellular Source: MGI
    6. neuronal cell body Source: UniProtKB
    7. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020By similarityAdd
    BLAST
    Chaini21 – 189169Apolipoprotein DPRO_0000017874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei21 – 211Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi28 ↔ 134By similarity
    Disulfide bondi61 ↔ 185By similarity
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP51910.
    PaxDbiP51910.
    PRIDEiP51910.

    PTM databases

    PhosphoSiteiP51910.

    Expressioni

    Tissue specificityi

    Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen.

    Gene expression databases

    BgeeiP51910.
    CleanExiMM_APOD.
    GenevestigatoriP51910.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000119827.

    Structurei

    3D structure databases

    ProteinModelPortaliP51910.
    SMRiP51910. Positions 23-186.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the calycin superfamily. Lipocalin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG3040.
    GeneTreeiENSGT00510000046981.
    HOGENOMiHOG000061525.
    HOVERGENiHBG018734.
    InParanoidiQ3TZE7.
    KOiK03098.
    OMAiSGMANAD.
    OrthoDBiEOG77T169.
    PhylomeDBiP51910.
    TreeFamiTF324836.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR026222. ApoD_vertbrte.
    IPR002969. ApolipopD.
    IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR002345. Lipocalin.
    IPR022271. Lipocalin_ApoD.
    IPR022272. Lipocalin_CS.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF08212. Lipocalin_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
    PRINTSiPR02058. APODVERTBRTE.
    PR01219. APOLIPOPROTD.
    PR00179. LIPOCALIN.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00213. LIPOCALIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51910-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTMLMFLAT LAGLFTTAKG QNFHLGKCPS PPVQENFDVK KYLGRWYEIE    50
    KIPASFEKGN CIQANYSLME NGNIEVLNKE LSPDGTMNQV KGEAKQSNVS 100
    EPAKLEVQFF PLMPPAPYWI LATDYENYAL VYSCTTFFWL FHVDFVWILG 150
    RNPYLPPETI TYLKDILTSN GIDIEKMTTT DQANCPDFL 189
    Length:189
    Mass (Da):21,530
    Last modified:October 1, 1996 - v1
    Checksum:iC10109F1D56D69A0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461V → F in strain: Swiss Webster.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39123 Genomic DNA. Translation: AAA67892.1.
    X82648 mRNA. Translation: CAA57974.1.
    AK135046 mRNA. Translation: BAE22397.1.
    AK157917 mRNA. Translation: BAE34262.1.
    AK158118 mRNA. Translation: BAE34364.1.
    AK158405 mRNA. Translation: BAE34491.1.
    AK160729 mRNA. Translation: BAE35974.1.
    AK162392 mRNA. Translation: BAE36889.1.
    BC145907 mRNA. Translation: AAI45908.1.
    BC145909 mRNA. Translation: AAI45910.1.
    CCDSiCCDS28105.1.
    PIRiS49581.
    RefSeqiNP_031496.2. NM_007470.3.
    XP_006521779.1. XM_006521716.1.
    XP_006521780.1. XM_006521717.1.
    UniGeneiMm.2082.

    Genome annotation databases

    EnsembliENSMUST00000115230; ENSMUSP00000110885; ENSMUSG00000022548.
    ENSMUST00000130560; ENSMUSP00000119827; ENSMUSG00000022548.
    GeneIDi11815.
    KEGGimmu:11815.
    UCSCiuc007yxf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L39123 Genomic DNA. Translation: AAA67892.1 .
    X82648 mRNA. Translation: CAA57974.1 .
    AK135046 mRNA. Translation: BAE22397.1 .
    AK157917 mRNA. Translation: BAE34262.1 .
    AK158118 mRNA. Translation: BAE34364.1 .
    AK158405 mRNA. Translation: BAE34491.1 .
    AK160729 mRNA. Translation: BAE35974.1 .
    AK162392 mRNA. Translation: BAE36889.1 .
    BC145907 mRNA. Translation: AAI45908.1 .
    BC145909 mRNA. Translation: AAI45910.1 .
    CCDSi CCDS28105.1.
    PIRi S49581.
    RefSeqi NP_031496.2. NM_007470.3.
    XP_006521779.1. XM_006521716.1.
    XP_006521780.1. XM_006521717.1.
    UniGenei Mm.2082.

    3D structure databases

    ProteinModelPortali P51910.
    SMRi P51910. Positions 23-186.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000119827.

    PTM databases

    PhosphoSitei P51910.

    Proteomic databases

    MaxQBi P51910.
    PaxDbi P51910.
    PRIDEi P51910.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115230 ; ENSMUSP00000110885 ; ENSMUSG00000022548 .
    ENSMUST00000130560 ; ENSMUSP00000119827 ; ENSMUSG00000022548 .
    GeneIDi 11815.
    KEGGi mmu:11815.
    UCSCi uc007yxf.1. mouse.

    Organism-specific databases

    CTDi 347.
    MGIi MGI:88056. Apod.

    Phylogenomic databases

    eggNOGi COG3040.
    GeneTreei ENSGT00510000046981.
    HOGENOMi HOG000061525.
    HOVERGENi HBG018734.
    InParanoidi Q3TZE7.
    KOi K03098.
    OMAi SGMANAD.
    OrthoDBi EOG77T169.
    PhylomeDBi P51910.
    TreeFami TF324836.

    Miscellaneous databases

    ChiTaRSi APOD. mouse.
    NextBioi 279699.
    PROi P51910.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51910.
    CleanExi MM_APOD.
    Genevestigatori P51910.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR026222. ApoD_vertbrte.
    IPR002969. ApolipopD.
    IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR002345. Lipocalin.
    IPR022271. Lipocalin_ApoD.
    IPR022272. Lipocalin_CS.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF08212. Lipocalin_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036893. Lipocalin_ApoD. 1 hit.
    PRINTSi PR02058. APODVERTBRTE.
    PR01219. APOLIPOPROTD.
    PR00179. LIPOCALIN.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00213. LIPOCALIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D."
      Seguin D., Desforges M., Rassart E.
      Brain Res. Mol. Brain Res. 30:242-250(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The murine gene encoding apolipoprotein D exhibits a unique expression pattern as compared to other species."
      Cofer S., Ross R.R.
      Gene 171:261-263(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Swiss Webster.
      Tissue: Mammary gland.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Diencephalon, Embryonic head, Inner ear and Olfactory bulb.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiAPOD_MOUSE
    AccessioniPrimary (citable) accession number: P51910
    Secondary accession number(s): Q3TZE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3