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P51910

- APOD_MOUSE

UniProt

P51910 - APOD_MOUSE

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Protein

Apolipoprotein D

Gene

Apod

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

APOD occurs in the macromolecular complex with lecithin-transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts.

GO - Molecular functioni

  1. cholesterol binding Source: UniProtKB
  2. transporter activity Source: InterPro

GO - Biological processi

  1. aging Source: UniProtKB
  2. brain development Source: UniProtKB
  3. glucose metabolic process Source: UniProtKB
  4. lipid metabolic process Source: UniProtKB
  5. negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
  6. negative regulation of focal adhesion assembly Source: UniProtKB
  7. negative regulation of lipoprotein lipid oxidation Source: UniProtKB
  8. negative regulation of monocyte chemotactic protein-1 production Source: UniProtKB
  9. negative regulation of platelet-derived growth factor receptor signaling pathway Source: UniProtKB
  10. negative regulation of protein import into nucleus Source: UniProtKB
  11. negative regulation of smooth muscle cell-matrix adhesion Source: UniProtKB
  12. negative regulation of smooth muscle cell proliferation Source: UniProtKB
  13. negative regulation of T cell migration Source: UniProtKB
  14. peripheral nervous system axon regeneration Source: UniProtKB
  15. response to axon injury Source: UniProtKB
  16. response to drug Source: UniProtKB
  17. response to reactive oxygen species Source: UniProtKB
  18. tissue regeneration Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein D
Short name:
Apo-D
Short name:
ApoD
Gene namesi
Name:Apod
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:88056. Apod.

Subcellular locationi

GO - Cellular componenti

  1. cytosolic ribosome Source: UniProtKB
  2. dendrite Source: UniProtKB
  3. endoplasmic reticulum Source: UniProtKB
  4. extracellular space Source: UniProtKB
  5. extracellular vesicular exosome Source: Ensembl
  6. intracellular Source: MGI
  7. neuronal cell body Source: UniProtKB
  8. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020By similarityAdd
BLAST
Chaini21 – 189169Apolipoprotein DPRO_0000017874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei21 – 211Pyrrolidone carboxylic acidBy similarity
Disulfide bondi28 ↔ 134By similarity
Disulfide bondi61 ↔ 185By similarity
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

MaxQBiP51910.
PaxDbiP51910.
PRIDEiP51910.

PTM databases

PhosphoSiteiP51910.

Expressioni

Tissue specificityi

Highest levels of expression in brain, testis, virgin mammary gland and salivary gland. Moderate levels in skeletal muscle, lactating mammary gland and thymus. Low levels in lung and lymph node. No expression in kidney, pancreas, liver or spleen.

Gene expression databases

BgeeiP51910.
CleanExiMM_APOD.
GenevestigatoriP51910.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000119827.

Structurei

3D structure databases

ProteinModelPortaliP51910.
SMRiP51910. Positions 23-186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3040.
GeneTreeiENSGT00510000046981.
HOGENOMiHOG000061525.
HOVERGENiHBG018734.
InParanoidiP51910.
KOiK03098.
OMAiSGMANAD.
OrthoDBiEOG77T169.
PhylomeDBiP51910.
TreeFamiTF324836.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR026222. ApoD_vertbrte.
IPR002969. ApolipopD.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF08212. Lipocalin_2. 1 hit.
[Graphical view]
PIRSFiPIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSiPR02058. APODVERTBRTE.
PR01219. APOLIPOPROTD.
PR00179. LIPOCALIN.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00213. LIPOCALIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51910-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTMLMFLAT LAGLFTTAKG QNFHLGKCPS PPVQENFDVK KYLGRWYEIE
60 70 80 90 100
KIPASFEKGN CIQANYSLME NGNIEVLNKE LSPDGTMNQV KGEAKQSNVS
110 120 130 140 150
EPAKLEVQFF PLMPPAPYWI LATDYENYAL VYSCTTFFWL FHVDFVWILG
160 170 180
RNPYLPPETI TYLKDILTSN GIDIEKMTTT DQANCPDFL
Length:189
Mass (Da):21,530
Last modified:October 1, 1996 - v1
Checksum:iC10109F1D56D69A0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461V → F in strain: Swiss Webster.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39123 Genomic DNA. Translation: AAA67892.1.
X82648 mRNA. Translation: CAA57974.1.
AK135046 mRNA. Translation: BAE22397.1.
AK157917 mRNA. Translation: BAE34262.1.
AK158118 mRNA. Translation: BAE34364.1.
AK158405 mRNA. Translation: BAE34491.1.
AK160729 mRNA. Translation: BAE35974.1.
AK162392 mRNA. Translation: BAE36889.1.
BC145907 mRNA. Translation: AAI45908.1.
BC145909 mRNA. Translation: AAI45910.1.
CCDSiCCDS28105.1.
PIRiS49581.
RefSeqiNP_031496.2. NM_007470.4.
UniGeneiMm.2082.

Genome annotation databases

EnsembliENSMUST00000115230; ENSMUSP00000110885; ENSMUSG00000022548.
ENSMUST00000130560; ENSMUSP00000119827; ENSMUSG00000022548.
GeneIDi11815.
KEGGimmu:11815.
UCSCiuc007yxf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L39123 Genomic DNA. Translation: AAA67892.1 .
X82648 mRNA. Translation: CAA57974.1 .
AK135046 mRNA. Translation: BAE22397.1 .
AK157917 mRNA. Translation: BAE34262.1 .
AK158118 mRNA. Translation: BAE34364.1 .
AK158405 mRNA. Translation: BAE34491.1 .
AK160729 mRNA. Translation: BAE35974.1 .
AK162392 mRNA. Translation: BAE36889.1 .
BC145907 mRNA. Translation: AAI45908.1 .
BC145909 mRNA. Translation: AAI45910.1 .
CCDSi CCDS28105.1.
PIRi S49581.
RefSeqi NP_031496.2. NM_007470.4.
UniGenei Mm.2082.

3D structure databases

ProteinModelPortali P51910.
SMRi P51910. Positions 23-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000119827.

PTM databases

PhosphoSitei P51910.

Proteomic databases

MaxQBi P51910.
PaxDbi P51910.
PRIDEi P51910.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000115230 ; ENSMUSP00000110885 ; ENSMUSG00000022548 .
ENSMUST00000130560 ; ENSMUSP00000119827 ; ENSMUSG00000022548 .
GeneIDi 11815.
KEGGi mmu:11815.
UCSCi uc007yxf.1. mouse.

Organism-specific databases

CTDi 347.
MGIi MGI:88056. Apod.

Phylogenomic databases

eggNOGi COG3040.
GeneTreei ENSGT00510000046981.
HOGENOMi HOG000061525.
HOVERGENi HBG018734.
InParanoidi P51910.
KOi K03098.
OMAi SGMANAD.
OrthoDBi EOG77T169.
PhylomeDBi P51910.
TreeFami TF324836.

Miscellaneous databases

ChiTaRSi APOD. mouse.
NextBioi 279699.
PROi P51910.
SOURCEi Search...

Gene expression databases

Bgeei P51910.
CleanExi MM_APOD.
Genevestigatori P51910.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR026222. ApoD_vertbrte.
IPR002969. ApolipopD.
IPR012674. Calycin.
IPR011038. Calycin-like.
IPR002345. Lipocalin.
IPR022271. Lipocalin_ApoD.
IPR022272. Lipocalin_CS.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF08212. Lipocalin_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF036893. Lipocalin_ApoD. 1 hit.
PRINTSi PR02058. APODVERTBRTE.
PR01219. APOLIPOPROTD.
PR00179. LIPOCALIN.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00213. LIPOCALIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and differential mRNA tissue distribution of mouse apolipoprotein D."
    Seguin D., Desforges M., Rassart E.
    Brain Res. Mol. Brain Res. 30:242-250(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The murine gene encoding apolipoprotein D exhibits a unique expression pattern as compared to other species."
    Cofer S., Ross R.R.
    Gene 171:261-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster.
    Tissue: Mammary gland.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Diencephalon, Embryonic head, Inner ear and Olfactory bulb.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiAPOD_MOUSE
AccessioniPrimary (citable) accession number: P51910
Secondary accession number(s): Q3TZE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3