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P51906

- EAA3_MOUSE

UniProt

P51906 - EAA3_MOUSE

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Protein

Excitatory amino acid transporter 3

Gene

Slc1a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5.

GO - Molecular functioni

  1. glutamate:sodium symporter activity Source: MGI
  2. glutamate binding Source: Ensembl
  3. L-glutamate transmembrane transporter activity Source: MGI
  4. sodium:dicarboxylate symporter activity Source: InterPro

GO - Biological processi

  1. D-aspartate import Source: Ensembl
  2. L-glutamate import Source: Ensembl
  3. L-glutamate transport Source: MGI
  4. protein homooligomerization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 3
Alternative name(s):
Excitatory amino-acid carrier 1
Sodium-dependent glutamate/aspartate transporter 3
Solute carrier family 1 member 1
Gene namesi
Name:Slc1a1
Synonyms:Eaac1, Eaat3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:105083. Slc1a1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Excitatory amino acid transporter 3PRO_0000202066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi194 – 1941N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP51906.
PaxDbiP51906.
PRIDEiP51906.

PTM databases

PhosphoSiteiP51906.

Expressioni

Tissue specificityi

Expressed in brain, lung, kidney and skeletal muscle.

Gene expression databases

BgeeiP51906.
ExpressionAtlasiP51906. baseline and differential.
GenevestigatoriP51906.

Interactioni

Subunit structurei

Interacts with ARL6IP5/PRAF3.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HccsP537025EBI-8580001,EBI-8579982

Protein-protein interaction databases

IntActiP51906. 1 interaction.
MINTiMINT-2839452.
STRINGi10090.ENSMUSP00000025875.

Structurei

3D structure databases

ProteinModelPortaliP51906.
SMRiP51906. Positions 28-119, 211-463.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini115 – 20894ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3820HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Transmembranei209 – 22820HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27220HelicalSequence AnalysisAdd
BLAST
Transmembranei289 – 30820HelicalSequence AnalysisAdd
BLAST
Transmembranei315 – 33420HelicalSequence AnalysisAdd
BLAST
Transmembranei361 – 38020HelicalSequence AnalysisAdd
BLAST
Transmembranei391 – 41020HelicalSequence AnalysisAdd
BLAST
Transmembranei419 – 43820HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1301.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP51906.
KOiK05612.
OMAiCIFLAQA.
OrthoDBiEOG7RV9G2.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51906-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKPTSSGCD WRRFLRNHWL LLSTVAAVVL GIVLGVVVRG HSELSNLDKF
60 70 80 90 100
YFAFPGEILM RMLKLVILPL IVSSMITGVA ALDSNVSGKI GLRAVVYYFS
110 120 130 140 150
TTVIAVILGI VLVVSIKPGV TQKVNDINRT GKTPEVSTMD AMLDLIRNMF
160 170 180 190 200
PENLVQACFQ QYKTKREEVK PVGDPGGNAT EVSVTTAMTT MSENKTKEYK
210 220 230 240 250
IVGLYSDGIN VLGLIIFCLV FGLVIGKMGE KGQILVDFFN ALSDATMKIV
260 270 280 290 300
QIIMCYMPIG ILFLIAGKII EVEDWEIFRK LGLYMATVLS GLAIHSLIVL
310 320 330 340 350
PLLYFIVVRK NPFRFALGMA QALLTALMIS SSSATLPVTF RCAEEKNQVD
360 370 380 390 400
KRITRFVLPV GATINMDGTA LYEAVAAVFI AQLNGLDLSI GQIVTISITA
410 420 430 440 450
TAASIGAAGV PQAGLVTMVI VLSAVGLPAE DVTLIIAVDW LLDRFRTMVN
460 470 480 490 500
VLGDAFGTGI VEKLSKKELE QMDVSSEVNI VNPFALEPTT LDNEDSDTKK
510 520
SYVNGGFAVD KSDTISFTQT SQF
Length:523
Mass (Da):56,694
Last modified:July 27, 2011 - v2
Checksum:i46F35480465E5A82
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211T → A in AAB71742. 1 PublicationCurated
Sequence conflicti139 – 1391M → I in BAA07855. (PubMed:7766664)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43797 mRNA. Translation: BAA07855.1.
U73521 mRNA. Translation: AAB80694.1.
U75217 Genomic DNA. Translation: AAB71742.1.
CH466534 Genomic DNA. Translation: EDL41660.1.
BC065099 mRNA. Translation: AAH65099.1.
CCDSiCCDS29727.1.
PIRiS55677.
RefSeqiNP_033225.1. NM_009199.2.
UniGeneiMm.246670.

Genome annotation databases

EnsembliENSMUST00000025875; ENSMUSP00000025875; ENSMUSG00000024935.
GeneIDi20510.
KEGGimmu:20510.
UCSCiuc008hcl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D43797 mRNA. Translation: BAA07855.1 .
U73521 mRNA. Translation: AAB80694.1 .
U75217 Genomic DNA. Translation: AAB71742.1 .
CH466534 Genomic DNA. Translation: EDL41660.1 .
BC065099 mRNA. Translation: AAH65099.1 .
CCDSi CCDS29727.1.
PIRi S55677.
RefSeqi NP_033225.1. NM_009199.2.
UniGenei Mm.246670.

3D structure databases

ProteinModelPortali P51906.
SMRi P51906. Positions 28-119, 211-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P51906. 1 interaction.
MINTi MINT-2839452.
STRINGi 10090.ENSMUSP00000025875.

PTM databases

PhosphoSitei P51906.

Proteomic databases

MaxQBi P51906.
PaxDbi P51906.
PRIDEi P51906.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025875 ; ENSMUSP00000025875 ; ENSMUSG00000024935 .
GeneIDi 20510.
KEGGi mmu:20510.
UCSCi uc008hcl.1. mouse.

Organism-specific databases

CTDi 6505.
MGIi MGI:105083. Slc1a1.

Phylogenomic databases

eggNOGi COG1301.
GeneTreei ENSGT00760000119117.
HOGENOMi HOG000208776.
HOVERGENi HBG000080.
InParanoidi P51906.
KOi K05612.
OMAi CIFLAQA.
OrthoDBi EOG7RV9G2.
TreeFami TF315206.

Miscellaneous databases

NextBioi 298699.
PROi P51906.
SOURCEi Search...

Gene expression databases

Bgeei P51906.
ExpressionAtlasi P51906. baseline and differential.
Genevestigatori P51906.

Family and domain databases

Gene3Di 1.10.3860.10. 2 hits.
InterProi IPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view ]
PANTHERi PTHR11958. PTHR11958. 1 hit.
Pfami PF00375. SDF. 1 hit.
[Graphical view ]
PRINTSi PR00173. EDTRNSPORT.
SUPFAMi SSF118215. SSF118215. 2 hits.
PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of two glutamate transporter subtypes from mouse brain."
    Mukainaka Y., Tanaka K., Hagiwara T., Wada K.
    Biochim. Biophys. Acta 1244:233-237(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: JCL:ICR.
    Tissue: Cerebellum.
  2. "Molecular cloning of a mouse glutamate transporter."
    Peng J.-B., Guo L.-H.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Brain.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  5. "Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18."
    Butchbach M.E.R., Lai L., Lin C.-L.G.
    Gene 292:81-90(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ARL6IP5.
    Strain: C57BL/6J.
    Tissue: Brain.

Entry informationi

Entry nameiEAA3_MOUSE
AccessioniPrimary (citable) accession number: P51906
Secondary accession number(s): O35869, O35875, Q6P1F7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3