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P51903

- PGK_CHICK

UniProt

P51903 - PGK_CHICK

Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei220 – 2201ATPBy similarity
    Binding sitei313 – 3131ATP; via carbonyl oxygenBy similarity
    Binding sitei344 – 3441ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi373 – 3764ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. gluconeogenesis Source: Reactome
    3. glycolytic process Source: Reactome
    4. phosphorylation Source: UniProtKB
    5. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_115534. Gluconeogenesis.
    REACT_115767. Glycolysis.
    SABIO-RKP51903.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase (EC:2.7.2.3)
    Gene namesi
    Name:PGK
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. chromosome Source: AgBase
    2. cytosol Source: Reactome

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 417416Phosphoglycerate kinasePRO_0000145841Add
    BLAST

    Proteomic databases

    PaxDbiP51903.
    PRIDEiP51903.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi676107. 2 interactions.
    IntActiP51903. 1 interaction.
    STRINGi9031.ENSGALP00000012878.

    Structurei

    3D structure databases

    ProteinModelPortaliP51903.
    SMRiP51903. Positions 2-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    HOVERGENiHBG008177.
    InParanoidiP51903.
    KOiK00927.
    PhylomeDBiP51903.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51903-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLSNKLTLD KVDVKGKRVV MRVDFNVPMK DHKITNNQRI KAAVPTIKHC    50
    LDHGAKSVVL MSHLGRPDGV PMPDKFSFSP VAVELKALLG REVSFLKDCV 100
    GPEVEKACAN PANGSVILLE NLRFHVEEEG KGKDASGNKI KADAAKVEAF 150
    RASLSKLGDV YVNDAFGTAH RAHSSMVGVH LPQKAAGFLM KKELDYFAKA 200
    LESPERPFLA ILGGAKVQDK IQLISNMLDK VNEMIIGGGM AFTFLKVLNN 250
    MQIGNSLFDE EGSKIVKDLM AKAEKNGVKI TLPVDFITAD KFDEHAQTGE 300
    ATVASGIPAG WMGLDCGPES VKKFVEVVGR AKQIVWNGPV GVFEWDKFSK 350
    GTKALMDKVV EVTGKGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
    ELLEGKVLPG VDALSSV 417
    Length:417
    Mass (Da):44,717
    Last modified:January 23, 2007 - v2
    Checksum:iD4C3BEC9D40D5FDA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37101 mRNA. Translation: AAC42219.1.
    PIRiI50407.
    RefSeqiNP_990316.1. NM_204985.2.
    UniGeneiGga.8606.

    Genome annotation databases

    GeneIDi395833.
    KEGGigga:395833.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37101 mRNA. Translation: AAC42219.1 .
    PIRi I50407.
    RefSeqi NP_990316.1. NM_204985.2.
    UniGenei Gga.8606.

    3D structure databases

    ProteinModelPortali P51903.
    SMRi P51903. Positions 2-417.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 676107. 2 interactions.
    IntActi P51903. 1 interaction.
    STRINGi 9031.ENSGALP00000012878.

    Proteomic databases

    PaxDbi P51903.
    PRIDEi P51903.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 395833.
    KEGGi gga:395833.

    Organism-specific databases

    CTDi 5230.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    HOVERGENi HBG008177.
    InParanoidi P51903.
    KOi K00927.
    PhylomeDBi P51903.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    Reactomei REACT_115534. Gluconeogenesis.
    REACT_115767. Glycolysis.
    SABIO-RK P51903.

    Miscellaneous databases

    NextBioi 20815901.
    PROi P51903.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Localization of the chicken PgK gene to chromosome 4p by fluorescence in situ hybridization."
      Rauen K.A., le Ciel C.D., Abbott U.K., Hutchison N.J.
      J. Hered. 85:147-150(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiPGK_CHICK
    AccessioniPrimary (citable) accession number: P51903
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3