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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei171 – 1711SubstrateBy similarity
Binding sitei220 – 2201ATPBy similarity
Binding sitei313 – 3131ATP; via carbonyl oxygenBy similarity
Binding sitei344 – 3441ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi373 – 3764ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB
  2. phosphoglycerate kinase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. gluconeogenesis Source: Reactome
  3. glycolytic process Source: Reactome
  4. phosphorylation Source: UniProtKB
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.
SABIO-RKP51903.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. chromosome Source: AgBase
  2. cytosol Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 417416Phosphoglycerate kinasePRO_0000145841Add
BLAST

Proteomic databases

PaxDbiP51903.
PRIDEiP51903.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi676107. 2 interactions.
IntActiP51903. 1 interaction.
STRINGi9031.ENSGALP00000012878.

Structurei

3D structure databases

ProteinModelPortaliP51903.
SMRiP51903. Positions 2-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
HOVERGENiHBG008177.
InParanoidiP51903.
KOiK00927.
PhylomeDBiP51903.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51903-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSNKLTLD KVDVKGKRVV MRVDFNVPMK DHKITNNQRI KAAVPTIKHC
60 70 80 90 100
LDHGAKSVVL MSHLGRPDGV PMPDKFSFSP VAVELKALLG REVSFLKDCV
110 120 130 140 150
GPEVEKACAN PANGSVILLE NLRFHVEEEG KGKDASGNKI KADAAKVEAF
160 170 180 190 200
RASLSKLGDV YVNDAFGTAH RAHSSMVGVH LPQKAAGFLM KKELDYFAKA
210 220 230 240 250
LESPERPFLA ILGGAKVQDK IQLISNMLDK VNEMIIGGGM AFTFLKVLNN
260 270 280 290 300
MQIGNSLFDE EGSKIVKDLM AKAEKNGVKI TLPVDFITAD KFDEHAQTGE
310 320 330 340 350
ATVASGIPAG WMGLDCGPES VKKFVEVVGR AKQIVWNGPV GVFEWDKFSK
360 370 380 390 400
GTKALMDKVV EVTGKGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL
410
ELLEGKVLPG VDALSSV
Length:417
Mass (Da):44,717
Last modified:January 23, 2007 - v2
Checksum:iD4C3BEC9D40D5FDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37101 mRNA. Translation: AAC42219.1.
PIRiI50407.
RefSeqiNP_990316.1. NM_204985.2.
UniGeneiGga.8606.

Genome annotation databases

GeneIDi395833.
KEGGigga:395833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37101 mRNA. Translation: AAC42219.1.
PIRiI50407.
RefSeqiNP_990316.1. NM_204985.2.
UniGeneiGga.8606.

3D structure databases

ProteinModelPortaliP51903.
SMRiP51903. Positions 2-417.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi676107. 2 interactions.
IntActiP51903. 1 interaction.
STRINGi9031.ENSGALP00000012878.

Proteomic databases

PaxDbiP51903.
PRIDEiP51903.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395833.
KEGGigga:395833.

Organism-specific databases

CTDi5230.

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227107.
HOVERGENiHBG008177.
InParanoidiP51903.
KOiK00927.
PhylomeDBiP51903.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
ReactomeiREACT_115534. Gluconeogenesis.
REACT_115767. Glycolysis.
SABIO-RKP51903.

Miscellaneous databases

NextBioi20815901.
PROiP51903.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Localization of the chicken PgK gene to chromosome 4p by fluorescence in situ hybridization."
    Rauen K.A., le Ciel C.D., Abbott U.K., Hutchison N.J.
    J. Hered. 85:147-150(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiPGK_CHICK
AccessioniPrimary (citable) accession number: P51903
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.