P51903 (PGK_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:

PGK

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gluconeogenesis Traceable author statement. Source: Reactome glycolysis Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome
Cellular_component	chromosome Traceable author statement PubMed 10198428. Source: AgBase cytosol Traceable author statement. Source: Reactome
Molecular_function	ATP binding Inferred from sequence or structural similarity. Source: UniProtKB phosphoglycerate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 417	416	Phosphoglycerate kinase		PRO_0000145841
Regions
	Nucleotide binding	373 – 376	4	ATP By similarity
	Region	24 – 26	3	Substrate binding By similarity
	Region	63 – 66	4	Substrate binding By similarity
Sites
	Binding site	39	1	Substrate By similarity
	Binding site	123	1	Substrate By similarity
	Binding site	171	1	Substrate By similarity
	Binding site	220	1	ATP By similarity
	Binding site	313	1	ATP; via carbonyl oxygen By similarity
	Binding site	344	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51903 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: D4C3BEC9D40D5FDA	FASTA	417	44,717
	10 20 30 40 50 60 MSLSNKLTLD KVDVKGKRVV MRVDFNVPMK DHKITNNQRI KAAVPTIKHC LDHGAKSVVL 70 80 90 100 110 120 MSHLGRPDGV PMPDKFSFSP VAVELKALLG REVSFLKDCV GPEVEKACAN PANGSVILLE 130 140 150 160 170 180 NLRFHVEEEG KGKDASGNKI KADAAKVEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVH 190 200 210 220 230 240 LPQKAAGFLM KKELDYFAKA LESPERPFLA ILGGAKVQDK IQLISNMLDK VNEMIIGGGM 250 260 270 280 290 300 AFTFLKVLNN MQIGNSLFDE EGSKIVKDLM AKAEKNGVKI TLPVDFITAD KFDEHAQTGE 310 320 330 340 350 360 ATVASGIPAG WMGLDCGPES VKKFVEVVGR AKQIVWNGPV GVFEWDKFSK GTKALMDKVV 370 380 390 400 410 EVTGKGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VDALSSV

References

[1]	"Localization of the chicken PgK gene to chromosome 4p by fluorescence in situ hybridization." Rauen K.A., le Ciel C.D., Abbott U.K., Hutchison N.J. J. Hered. 85:147-150(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L37101 mRNA. Translation: AAC42219.1.
IPI	IPI00574153.
PIR	I50407.
RefSeq	NP_990316.1. NM_204985.1.
UniGene	Gga.8606.
3D structure databases
ProteinModelPortal	P51903.
SMR	P51903. Positions 2-417.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51903. 1 interaction.
STRING	9031.ENSGALP00000012878.
Proteomic databases
PaxDb	P51903.
PRIDE	P51903.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	395833.
KEGG	gga:395833.
Organism-specific databases
CTD	5230.
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
HOVERGEN	HBG008177.
InParanoid	P51903.
KO	K00927.
OrthoDB	EOG44MXS6.
Enzyme and pathway databases
Reactome	REACT_115655. Metabolism.
SABIO-RK	P51903.
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815901.

Entry information

Entry name

PGK_CHICK

Accession

Primary (citable) accession number: P51903

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program