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Protein

Annexin A6

Gene

ANXA6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores (By similarity).By similarity

GO - Molecular functioni

  • calcium channel activity Source: AgBase
  • calcium-dependent phospholipid binding Source: UniProtKB-KW
  • calcium ion binding Source: InterPro

GO - Biological processi

  • calcium ion homeostasis Source: AgBase
  • neural crest cell migration Source: CACAO
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
P68
P70
Protein III
Gene namesi
Name:ANXA6
Synonyms:ANX6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • calcium channel complex Source: AgBase
  • melanosome Source: UniProtKB-SubCell
  • vesicle Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Annexin A6PRO_0000067497Add
BLAST

Proteomic databases

PaxDbiP51901.
PRIDEiP51901.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006938.

Structurei

3D structure databases

ProteinModelPortaliP51901.
SMRiP51901. Positions 8-671.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati27 – 8761Annexin 1Add
BLAST
Repeati99 – 15961Annexin 2Add
BLAST
Repeati183 – 24361Annexin 3Add
BLAST
Repeati258 – 31861Annexin 4Add
BLAST
Repeati370 – 43061Annexin 5Add
BLAST
Repeati442 – 50261Annexin 6Add
BLAST
Repeati531 – 59262Annexin 7Add
BLAST
Repeati607 – 66660Annexin 8Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 8 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOVERGENiHBG061815.
InParanoidiP51901.
KOiK17094.
PhylomeDBiP51901.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PANTHERiPTHR10502:SF19. PTHR10502:SF19. 1 hit.
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51901-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPKGKVYRG SVKDFPGFNA SQDADALCNA MKGFGSDKDA ILDLITSRSN
60 70 80 90 100
KQRLEICQAY KSQYGKDLIA DLKYELTGKF ERLIVSLMRP PAYSDAKEIK
110 120 130 140 150
DAIAGIGTDE KCLIEILASR TNQEIHDLVA AYKDAYERDL EADVVGDTSG
160 170 180 190 200
HFKKMLVVLL QGAREEDDVV SEDLVEQDAK DLLEAGELKW GTDEAQFIYI
210 220 230 240 250
LGRRSKQHLR MVFDEYLKIS GKPIERSIRA ELSGDFEKLK LAVVKCVRST
260 270 280 290 300
AEYFAERLYK AMKGLGTRDN TLIHIMVSRS EIDMLDIREV FRTKYDKSLH
310 320 330 340 350
NMIKEDTSGE YKKALLKLCE GDDDAAAEFF PEAAQVAYRM WELSAVAKVE
360 370 380 390 400
LRGTVQPASN FNDDGDAQVL RKAMKGLGTD EGAIIEVLTQ RSNAQRQQIL
410 420 430 440 450
KAYKAHYGRD LLADLKSELS GSLANLILGL MLTPAQYDAK QLRKAVEGDG
460 470 480 490 500
TDESTLVEIM ATRNNQEIAA INEAYQQAYH KSLEDDLSSD TSVHFKRLLV
510 520 530 540 550
SLALGNRDEG PENLTQAHED AKVVAETLKL ADVPSNDSSD SLETRFLSIL
560 570 580 590 600
CTRSYPHLRR VFQEFVKMTN HDVEHAIRKR MSGDVRDAFV AIVRSVKNKP
610 620 630 640 650
AFFADKLYKS MKGAGTDERT LTRIMISRSE IDLLNIRGEF IDLFDKSLYQ
660 670
MIEKDSGDYC KALLALCGGD D
Length:671
Mass (Da):75,219
Last modified:October 1, 1996 - v1
Checksum:iD0E02F4311A93D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67466 mRNA. Translation: AAB29337.2.
PIRiJC2029.
S08990.
RefSeqiNP_990061.1. NM_204730.1.
UniGeneiGga.1099.

Genome annotation databases

GeneIDi395481.
KEGGigga:395481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S67466 mRNA. Translation: AAB29337.2.
PIRiJC2029.
S08990.
RefSeqiNP_990061.1. NM_204730.1.
UniGeneiGga.1099.

3D structure databases

ProteinModelPortaliP51901.
SMRiP51901. Positions 8-671.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006938.

Proteomic databases

PaxDbiP51901.
PRIDEiP51901.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi395481.
KEGGigga:395481.

Organism-specific databases

CTDi309.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
HOVERGENiHBG061815.
InParanoidiP51901.
KOiK17094.
PhylomeDBiP51901.

Miscellaneous databases

PROiP51901.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PANTHERiPTHR10502:SF19. PTHR10502:SF19. 1 hit.
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization, cloning and expression of the 67-kDa annexin from chicken growth plate cartilage matrix vesicles."
    Cao X., Genge B.R., Wu L.N., Buzzi W.R., Showman R.M., Wuthier R.E.
    Biochem. Biophys. Res. Commun. 197:556-561(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiANXA6_CHICK
AccessioniPrimary (citable) accession number: P51901
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.