P51893 (SAHHA_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenosylhomocysteinase A
Short name=AdoHcyase A
EC=3.3.1.1

Alternative name(s):
S-adenosyl-L-homocysteine hydrolase A

Gene names

Name:	ahcy-a
Synonyms:	ahcy, ahcy1

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	433 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine By similarity.
Catalytic activity	S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.
Cofactor	Binds 1 NAD per subunit By similarity.
Pathway	Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.
Sequence similarities	Belongs to the adenosylhomocysteinase family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	NAD
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 433	433	Adenosylhomocysteinase A		PRO_0000116906
Regions
	Region	184 – 351	168	NAD binding By similarity
Sites
	Binding site	57	1	Substrate By similarity
	Binding site	132	1	Substrate By similarity
	Binding site	157	1	Substrate By similarity
	Binding site	187	1	Substrate By similarity
	Binding site	191	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51893 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 28C7DB273199F2FA	FASTA	433	47,747
	10 20 30 40 50 60 MSDKLSYKVA DISLADWGRK AIEIAENEMP GLMKMREMHS ESKPLKGARI AGCLHMTLQT 70 80 90 100 110 120 AVLIETLTAL GAEVQWSSCN IFSTQDHAAA AIAKTGVPVY AWKGETDEEY IWCIEQTIYF 130 140 150 160 170 180 KDGKPLNMIL DDGGDLTNLV HSKYPQLLKG IKGISEETTT GVHNLYKMKS SGTLQVPAIN 190 200 210 220 230 240 VNDSVTKSKF DNLYGCRESL IDGIKRATDV MIAGKVAVVA GYGDVGKGCA QALRAFGARV 250 260 270 280 290 300 IITEIDPINA LQAAMEGYEV TTMDEASKEG NIFVTTTGCA DIVEGRHFEN MKDDSIVCNI 310 320 330 340 350 360 GHFDIELDVK WLNENAVKKV NIKPQVDRYL LKNGRHIILL AEGRLVNLGC AMGHPSFVMS 370 380 390 400 410 420 NSFTNQVMAQ IELWTNTDKY PVGVYFLPKK LDEAVAAAHL DKLGVKLTKL TDKQAKYLGL 430 DKEGPFKPDH YRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"S-adenosyl-L-homocysteine hydrolase from Xenopus laevis --identification, developmental expression and evolution." Seery L.T., McCabe B.D., Schoenberg D.R., Whitehead A.S. Biochem. Biophys. Res. Commun. 205:1539-1546(1994) [PubMed: 7811234] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	NIH - Xenopus Gene Collection (XGC) project Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L35559 mRNA. Translation: AAA65963.1. BC060432 mRNA. Translation: AAH60432.1. BC073400 mRNA. Translation: AAH73400.1.
PIR	JC2480.
RefSeq	NP_001089027.1. NM_001095558.1.
UniGene	Xl.937.
3D structure databases
ProteinModelPortal	P51893.
SMR	P51893. Positions 3-433.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	503669.
KEGG	xla:503669.
Organism-specific databases
CTD	503669.
Xenbase	XB-GENE-6251978. ahcy.
Phylogenomic databases
HOVERGEN	HBG005041.
Family and domain databases
InterPro	IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view]
KO	K01251.
PANTHER	PTHR23420. Ad_hcy_hydrolase. 1 hit.
Pfam	PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view]
PIRSF	PIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMART	SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00936. AhcY. 1 hit.
PROSITE	PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SAHHA_XENLA

Accession

Primary (citable) accession number: P51893
Secondary accession number(s): Q6GNV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program