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P51892

- DNLI1_XENLA

UniProt

P51892 - DNLI1_XENLA

Protein

DNA ligase 1

Gene

lig1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).PROSITE-ProRule annotation

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei458 – 4581Interaction with target DNABy similarity
    Binding sitei719 – 7191ATPBy similarity
    Active sitei721 – 7211N6-AMP-lysine intermediatePROSITE-ProRule annotation
    Binding sitei726 – 7261ATPBy similarity
    Binding sitei742 – 7421ATPBy similarity
    Sitei743 – 7431Interaction with target DNABy similarity
    Metal bindingi774 – 7741Magnesium 1By similarity
    Metal bindingi873 – 8731Magnesium 2By similarity
    Binding sitei878 – 8781ATPBy similarity
    Binding sitei891 – 8911ATPBy similarity
    Binding sitei897 – 8971ATPBy similarity
    Sitei923 – 9231Interaction with target DNABy similarity
    Sitei948 – 9481Interaction with target DNABy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-KW
    5. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligase 1 (EC:6.5.1.1)
    Alternative name(s):
    DNA ligase I
    Polydeoxyribonucleotide synthase [ATP] 1
    Gene namesi
    Name:lig1
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-1009783. lig1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10701070DNA ligase 1PRO_0000059573Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP51892.
    SMRiP51892. Positions 419-1053.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni602 – 61110Interaction with target DNABy similarity
    Regioni795 – 7973Interaction with target DNABy similarity

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.Curated

    Phylogenomic databases

    HOVERGENiHBG005514.
    KOiK10747.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51892-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRTIKSFFQ PKLGAEVKTK EEKVKNDVQK EKEEPEKSVP ERPLKERNGR     50
    ALCGDTESPV KRVSKKSARV LESDSEEEEE NSKVQATPEK MNNESDPKND 100
    VKETPPSARK ETPPSARKET PPSARKETPQ SARKETPPSA RKDAKSEGAS 150
    EMNTSQDFVS PCSSKSIDSP LCSDSPGISP SGIPKRKTAR KQLPKRKLEI 200
    SPSESNPPKD DFDVKGAVKR QKKEAEGDIQ QEEPMETSHN ISMEEECPIK 250
    KETNPDVVQE TISNADDPNI ELVDQKDVVS GEKQSEPKCQ EQPQPKLTSP 300
    TVEPKASKGK ARKKNSPLPK KVKFSDKVSF KDNDSEEKSN EEKSDEEPQK 350
    KADSAKPVKQ ISSFFAPRKP AIKTEKREEN LNEKNVTETS LEESPKPKKN 400
    VGSFFGASKQ EATEEQTEYN PSKSKYHPID DACWCNGQKV PYLAVARTFE 450
    RIEEESARLK NVETLSNFLR SVIALTPEDL LPCIYLCLNR LGPAYEGLEL 500
    GIGETILMKA VAQATGRQLE KIKAEAQEKG DLGLVAESSR SNQRTMFTPP 550
    KLMASGVFGK LKDIARMTGN ASMNKKIDII KGLFVACRHS EARYIARSLG 600
    GKLRIGLAEQ SVLSSIAQAV CLTPPGRDAP PTVMDAGKGM SADARKSWIE 650
    EKAMILKQTF CELPNYDAII PILLEHGIDD LPKHCRLTPG IPLKPMLAHP 700
    TKGIGEVLKR FDEAAFTCEY KYDGERAQIH ILENGEVHVY SRNQENNTTK 750
    YPDIISRIPK IKKESVKSCI LDTEAVAGDA EKKQIQPFQV LTTRKRKDVD 800
    ASEIKVQVCV YAFDMLYLNG ESLVKEPFAK RRQLLRDSFL ETEGQFMFAT 850
    YMDKSNTDEI SEFLDQSIKD SCEGLMVKTL EQDATYEIAK RSHNWLKLKK 900
    DYLEGVGDTL DLVVIGAYLG KGKRTGIYGG FLLASYDEES EEYQTICKIG 950
    TGFTDDDLEK HYNFLKDHVI ENPRSYYRWD SATEPDHWFD PVQVWEVKCA 1000
    DLSISPVHKA ALGLVEDQKG ISLRFPRFLR IRDDKKPEES TNSFQVADLY 1050
    RKQQQIQNTS STEKAEEDFY 1070
    Length:1,070
    Mass (Da):120,234
    Last modified:October 1, 1996 - v1
    Checksum:i065D6E5B8C6E4E52
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43496 mRNA. Translation: AAB37754.1.
    PIRiJC4852.
    RefSeqiNP_001081653.1. NM_001088184.1.
    UniGeneiXl.78.

    Genome annotation databases

    GeneIDi397978.
    KEGGixla:397978.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L43496 mRNA. Translation: AAB37754.1 .
    PIRi JC4852.
    RefSeqi NP_001081653.1. NM_001088184.1.
    UniGenei Xl.78.

    3D structure databases

    ProteinModelPortali P51892.
    SMRi P51892. Positions 419-1053.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397978.
    KEGGi xla:397978.

    Organism-specific databases

    CTDi 3978.
    Xenbasei XB-GENE-1009783. lig1.

    Phylogenomic databases

    HOVERGENi HBG005514.
    KOi K10747.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The cloning and characterization of a cDNA encoding Xenopus laevis DNA ligase I."
      Lepetit D., Thiebaud P., Aoufouchi S., Prigent C., Guesne R., Theze N.
      Gene 172:273-277(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDNLI1_XENLA
    AccessioniPrimary (citable) accession number: P51892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3