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P51892

- DNLI1_XENLA

UniProt

P51892 - DNLI1_XENLA

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Protein
DNA ligase 1
Gene
lig1
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

Cofactori

Magnesium By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei458 – 4581Interaction with target DNA By similarity
Binding sitei719 – 7191ATP By similarity
Active sitei721 – 7211N6-AMP-lysine intermediate By similarity
Binding sitei726 – 7261ATP By similarity
Binding sitei742 – 7421ATP By similarity
Sitei743 – 7431Interaction with target DNA By similarity
Metal bindingi774 – 7741Magnesium 1 By similarity
Metal bindingi873 – 8731Magnesium 2 By similarity
Binding sitei878 – 8781ATP By similarity
Binding sitei891 – 8911ATP By similarity
Binding sitei897 – 8971ATP By similarity
Sitei923 – 9231Interaction with target DNA By similarity
Sitei948 – 9481Interaction with target DNA By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 1 (EC:6.5.1.1)
Alternative name(s):
DNA ligase I
Polydeoxyribonucleotide synthase [ATP] 1
Gene namesi
Name:lig1
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-1009783. lig1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10701070DNA ligase 1
PRO_0000059573Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP51892.
SMRiP51892. Positions 419-1053.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni602 – 61110Interaction with target DNA By similarity
Regioni795 – 7973Interaction with target DNA By similarity

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG005514.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51892-1 [UniParc]FASTAAdd to Basket

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MQRTIKSFFQ PKLGAEVKTK EEKVKNDVQK EKEEPEKSVP ERPLKERNGR     50
ALCGDTESPV KRVSKKSARV LESDSEEEEE NSKVQATPEK MNNESDPKND 100
VKETPPSARK ETPPSARKET PPSARKETPQ SARKETPPSA RKDAKSEGAS 150
EMNTSQDFVS PCSSKSIDSP LCSDSPGISP SGIPKRKTAR KQLPKRKLEI 200
SPSESNPPKD DFDVKGAVKR QKKEAEGDIQ QEEPMETSHN ISMEEECPIK 250
KETNPDVVQE TISNADDPNI ELVDQKDVVS GEKQSEPKCQ EQPQPKLTSP 300
TVEPKASKGK ARKKNSPLPK KVKFSDKVSF KDNDSEEKSN EEKSDEEPQK 350
KADSAKPVKQ ISSFFAPRKP AIKTEKREEN LNEKNVTETS LEESPKPKKN 400
VGSFFGASKQ EATEEQTEYN PSKSKYHPID DACWCNGQKV PYLAVARTFE 450
RIEEESARLK NVETLSNFLR SVIALTPEDL LPCIYLCLNR LGPAYEGLEL 500
GIGETILMKA VAQATGRQLE KIKAEAQEKG DLGLVAESSR SNQRTMFTPP 550
KLMASGVFGK LKDIARMTGN ASMNKKIDII KGLFVACRHS EARYIARSLG 600
GKLRIGLAEQ SVLSSIAQAV CLTPPGRDAP PTVMDAGKGM SADARKSWIE 650
EKAMILKQTF CELPNYDAII PILLEHGIDD LPKHCRLTPG IPLKPMLAHP 700
TKGIGEVLKR FDEAAFTCEY KYDGERAQIH ILENGEVHVY SRNQENNTTK 750
YPDIISRIPK IKKESVKSCI LDTEAVAGDA EKKQIQPFQV LTTRKRKDVD 800
ASEIKVQVCV YAFDMLYLNG ESLVKEPFAK RRQLLRDSFL ETEGQFMFAT 850
YMDKSNTDEI SEFLDQSIKD SCEGLMVKTL EQDATYEIAK RSHNWLKLKK 900
DYLEGVGDTL DLVVIGAYLG KGKRTGIYGG FLLASYDEES EEYQTICKIG 950
TGFTDDDLEK HYNFLKDHVI ENPRSYYRWD SATEPDHWFD PVQVWEVKCA 1000
DLSISPVHKA ALGLVEDQKG ISLRFPRFLR IRDDKKPEES TNSFQVADLY 1050
RKQQQIQNTS STEKAEEDFY 1070
Length:1,070
Mass (Da):120,234
Last modified:October 1, 1996 - v1
Checksum:i065D6E5B8C6E4E52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43496 mRNA. Translation: AAB37754.1.
PIRiJC4852.
RefSeqiNP_001081653.1. NM_001088184.1.
UniGeneiXl.78.

Genome annotation databases

GeneIDi397978.
KEGGixla:397978.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L43496 mRNA. Translation: AAB37754.1 .
PIRi JC4852.
RefSeqi NP_001081653.1. NM_001088184.1.
UniGenei Xl.78.

3D structure databases

ProteinModelPortali P51892.
SMRi P51892. Positions 419-1053.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397978.
KEGGi xla:397978.

Organism-specific databases

CTDi 3978.
Xenbasei XB-GENE-1009783. lig1.

Phylogenomic databases

HOVERGENi HBG005514.
KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The cloning and characterization of a cDNA encoding Xenopus laevis DNA ligase I."
    Lepetit D., Thiebaud P., Aoufouchi S., Prigent C., Guesne R., Theze N.
    Gene 172:273-277(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDNLI1_XENLA
AccessioniPrimary (citable) accession number: P51892
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 16, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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