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Protein

Prolargin

Gene

PRELP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May anchor basement membranes to the underlying connective tissue.By similarity

GO - Molecular functioni

  • extracellular matrix structural constituent Source: ProtInc
  • heparin binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:G66-31380-MONOMER.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-3656225. Defective CHST6 causes MCDC1.
R-HSA-3656243. Defective ST3GAL3 causes MCT12 and EIEE15.
R-HSA-3656244. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).

Names & Taxonomyi

Protein namesi
Recommended name:
Prolargin
Alternative name(s):
Proline-arginine-rich end leucine-rich repeat protein
Gene namesi
Name:PRELP
Synonyms:SLRR2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:9357. PRELP.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: GO_Central
  • extracellular vesicle Source: UniProtKB
  • Golgi lumen Source: Reactome
  • lysosomal lumen Source: Reactome
  • proteinaceous extracellular matrix Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5549.
OpenTargetsiENSG00000188783.
PharmGKBiPA33729.

Polymorphism and mutation databases

BioMutaiPRELP.
DMDMi1709586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003274421 – 382ProlarginAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi124N-linked (GlcNAc...)1 Publication1
Glycosylationi289N-linked (GlcNAc...)Sequence analysis1
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1
Glycosylationi327N-linked (GlcNAc...)1 Publication1
Disulfide bondi332 ↔ 373By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP51888.
PaxDbiP51888.
PeptideAtlasiP51888.
PRIDEiP51888.
TopDownProteomicsiP51888.

PTM databases

iPTMnetiP51888.
PhosphoSitePlusiP51888.

Miscellaneous databases

PMAP-CutDBP51888.

Expressioni

Tissue specificityi

Connective tissue.

Gene expression databases

BgeeiENSG00000188783.
CleanExiHS_PRELP.
GenevisibleiP51888. HS.

Organism-specific databases

HPAiHPA062623.

Interactioni

Subunit structurei

Binds the basement membrane heparan sulfate proteoglycan perlecan and triple helical collagens type I and type II.By similarity

Protein-protein interaction databases

BioGridi111540. 15 interactors.
IntActiP51888. 2 interactors.
STRINGi9606.ENSP00000343924.

Structurei

3D structure databases

ProteinModelPortaliP51888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati95 – 114LRR 1Add BLAST20
Repeati115 – 138LRR 2Add BLAST24
Repeati139 – 162LRR 3Add BLAST24
Repeati163 – 183LRR 4Add BLAST21
Repeati184 – 207LRR 5Add BLAST24
Repeati208 – 233LRR 6Add BLAST26
Repeati234 – 254LRR 7Add BLAST21
Repeati255 – 278LRR 8Add BLAST24
Repeati279 – 303LRR 9Add BLAST25
Repeati304 – 323LRR 10Add BLAST20
Repeati324 – 362LRR 11Add BLAST39
Repeati363 – 382LRR 12Add BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi73 – 89Cys-richAdd BLAST17
Compositional biasi197 – 202Poly-Leu6

Domaini

The basic N-terminal Arg/Pro-rich region binds heparin and heparan sulfate. Binds collagens type I and type II through its leucine-rich repeat domain (By similarity).By similarity

Sequence similaritiesi

Contains 12 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51888.
KOiK08125.
OMAiRKMPPKV.
OrthoDBiEOG091G09Q0.
PhylomeDBiP51888.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027216. Prolargin.
[Graphical view]
PANTHERiPTHR24373:SF152. PTHR24373:SF152. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSPLCWLLP LLILASVAQG QPTRRPRPGT GPGRRPRPRP RPTPSFPQPD
60 70 80 90 100
EPAEPTDLPP PLPPGPPSIF PDCPRECYCP PDFPSALYCD SRNLRKVPVI
110 120 130 140 150
PPRIHYLYLQ NNFITELPVE SFQNATGLRW INLDNNRIRK IDQRVLEKLP
160 170 180 190 200
GLVFLYMEKN QLEEVPSALP RNLEQLRLSQ NHISRIPPGV FSKLENLLLL
210 220 230 240 250
DLQHNRLSDG VFKPDTFHGL KNLMQLNLAH NILRKMPPRV PTAIHQLYLD
260 270 280 290 300
SNKIETIPNG YFKSFPNLAF IRLNYNKLTD RGLPKNSFNI SNLLVLHLSH
310 320 330 340 350
NRISSVPAIN NRLEHLYLNN NSIEKINGTQ ICPNDLVAFH DFSSDLENVP
360 370 380
HLRYLRLDGN YLKPPIPLDL MMCFRLLQSV VI
Length:382
Mass (Da):43,810
Last modified:October 1, 1996 - v1
Checksum:iA1C4E166B7515695
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06180433G → R.Corresponds to variant rs41313926dbSNPEnsembl.1
Natural variantiVAR_052012157M → V.Corresponds to variant rs2233726dbSNPEnsembl.1
Natural variantiVAR_052013334N → S.Corresponds to variant rs2233732dbSNPEnsembl.1
Natural variantiVAR_011976348N → H.Corresponds to variant rs9439dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29089 mRNA. Translation: AAC50230.1.
U41344, U41343 Genomic DNA. Translation: AAC18782.1.
CR542270 mRNA. Translation: CAG47066.1.
AL391817 Genomic DNA. Translation: CAI17033.1.
CH471067 Genomic DNA. Translation: EAW91481.1.
BC032498 mRNA. Translation: AAH32498.1.
CCDSiCCDS1438.1.
PIRiI39068.
RefSeqiNP_002716.1. NM_002725.3.
NP_958505.1. NM_201348.1.
UniGeneiHs.632481.

Genome annotation databases

EnsembliENST00000343110; ENSP00000343924; ENSG00000188783.
GeneIDi5549.
KEGGihsa:5549.
UCSCiuc001gzs.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29089 mRNA. Translation: AAC50230.1.
U41344, U41343 Genomic DNA. Translation: AAC18782.1.
CR542270 mRNA. Translation: CAG47066.1.
AL391817 Genomic DNA. Translation: CAI17033.1.
CH471067 Genomic DNA. Translation: EAW91481.1.
BC032498 mRNA. Translation: AAH32498.1.
CCDSiCCDS1438.1.
PIRiI39068.
RefSeqiNP_002716.1. NM_002725.3.
NP_958505.1. NM_201348.1.
UniGeneiHs.632481.

3D structure databases

ProteinModelPortaliP51888.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111540. 15 interactors.
IntActiP51888. 2 interactors.
STRINGi9606.ENSP00000343924.

PTM databases

iPTMnetiP51888.
PhosphoSitePlusiP51888.

Polymorphism and mutation databases

BioMutaiPRELP.
DMDMi1709586.

Proteomic databases

EPDiP51888.
PaxDbiP51888.
PeptideAtlasiP51888.
PRIDEiP51888.
TopDownProteomicsiP51888.

Protocols and materials databases

DNASUi5549.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343110; ENSP00000343924; ENSG00000188783.
GeneIDi5549.
KEGGihsa:5549.
UCSCiuc001gzs.4. human.

Organism-specific databases

CTDi5549.
DisGeNETi5549.
GeneCardsiPRELP.
HGNCiHGNC:9357. PRELP.
HPAiHPA062623.
MIMi601914. gene.
neXtProtiNX_P51888.
OpenTargetsiENSG00000188783.
PharmGKBiPA33729.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51888.
KOiK08125.
OMAiRKMPPKV.
OrthoDBiEOG091G09Q0.
PhylomeDBiP51888.
TreeFamiTF334562.

Enzyme and pathway databases

BioCyciZFISH:G66-31380-MONOMER.
ReactomeiR-HSA-2022854. Keratan sulfate biosynthesis.
R-HSA-2022857. Keratan sulfate degradation.
R-HSA-3656225. Defective CHST6 causes MCDC1.
R-HSA-3656243. Defective ST3GAL3 causes MCT12 and EIEE15.
R-HSA-3656244. Defective B4GALT1 causes B4GALT1-CDG (CDG-2d).

Miscellaneous databases

ChiTaRSiPRELP. human.
GeneWikiiPRELP.
GenomeRNAii5549.
PMAP-CutDBP51888.
PROiP51888.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188783.
CleanExiHS_PRELP.
GenevisibleiP51888. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027216. Prolargin.
[Graphical view]
PANTHERiPTHR24373:SF152. PTHR24373:SF152. 1 hit.
PfamiPF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 11 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRELP_HUMAN
AccessioniPrimary (citable) accession number: P51888
Secondary accession number(s): Q6FG38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 152 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.