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P51886

- LUM_RAT

UniProt

P51886 - LUM_RAT

Protein

Lumican

Gene

Lum

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cartilage development Source: RGD
    2. collagen fibril organization Source: InterPro
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. response to growth factor Source: RGD
    5. response to organic cyclic compound Source: RGD
    6. visual perception Source: InterPro

    Enzyme and pathway databases

    ReactomeiREACT_196475. Keratan sulfate biosynthesis.
    REACT_198617. Keratan sulfate degradation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lumican
    Alternative name(s):
    Keratan sulfate proteoglycan lumican
    Short name:
    KSPG lumican
    Gene namesi
    Name:Lum
    Synonyms:Lcn, Ldc
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi620984. Lum.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. fibrillar collagen trimer Source: Ensembl
    3. proteinaceous extracellular matrix Source: RGD

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818By similarityAdd
    BLAST
    Chaini19 – 338320LumicanPRO_0000032735Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191Pyrrolidone carboxylic acidBy similarity
    Modified residuei20 – 201SulfotyrosineBy similarity
    Modified residuei21 – 211SulfotyrosineBy similarity
    Modified residuei23 – 231SulfotyrosineBy similarity
    Modified residuei30 – 301SulfotyrosineBy similarity
    Glycosylationi88 – 881N-linked (GlcNAc...) (keratan sulfate)Sequence Analysis
    Glycosylationi127 – 1271N-linked (GlcNAc...) (keratan sulfate)Sequence Analysis
    Glycosylationi160 – 1601N-linked (GlcNAc...) (keratan sulfate)Sequence Analysis
    Glycosylationi252 – 2521N-linked (GlcNAc...) (keratan sulfate)Sequence Analysis
    Disulfide bondi295 ↔ 328By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

    Proteomic databases

    PaxDbiP51886.
    PRIDEiP51886.

    Expressioni

    Gene expression databases

    GenevestigatoriP51886.

    Interactioni

    Subunit structurei

    Binds to laminin.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006109.

    Structurei

    3D structure databases

    ProteinModelPortaliP51886.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 6639LRRNTAdd
    BLAST
    Repeati67 – 8822LRR 1Add
    BLAST
    Repeati91 – 11424LRR 2Add
    BLAST
    Repeati117 – 13721LRR 3Add
    BLAST
    Repeati138 – 15922LRR 4Add
    BLAST
    Repeati160 – 18122LRR 5Add
    BLAST
    Repeati185 – 20521LRR 6Add
    BLAST
    Repeati206 – 22722LRR 7Add
    BLAST
    Repeati230 – 25021LRR 8Add
    BLAST
    Repeati255 – 27622LRR 9Add
    BLAST
    Repeati277 – 29620LRR 10Add
    BLAST
    Repeati305 – 32622LRR 11Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 5317Cys-richAdd
    BLAST

    Sequence similaritiesi

    Contains 11 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00600000084286.
    HOGENOMiHOG000234447.
    HOVERGENiHBG108061.
    InParanoidiP51886.
    KOiK08122.
    OMAiKKLHINY.
    OrthoDBiEOG75F4DF.
    PhylomeDBiP51886.
    TreeFamiTF334562.

    Family and domain databases

    InterProiIPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR027219. Lumican.
    [Graphical view]
    PANTHERiPTHR24371:SF54. PTHR24371:SF54. 1 hit.
    PfamiPF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS51450. LRR. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51886-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA    50
    MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN 100
    LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLANNKIS 150
    KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL KGLKSLEYLD LSFNQMSKLP 200
    AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE LADSGVPGNS 250
    FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP 300
    LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN 338
    Length:338
    Mass (Da):38,279
    Last modified:October 1, 1996 - v1
    Checksum:i13442BAECC905585
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84039 mRNA. Translation: CAA58858.1.
    BC061878 mRNA. Translation: AAH61878.1.
    PIRiS52284.
    RefSeqiNP_112312.1. NM_031050.1.
    UniGeneiRn.3087.

    Genome annotation databases

    EnsembliENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610.
    GeneIDi81682.
    KEGGirno:81682.
    UCSCiRGD:620984. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84039 mRNA. Translation: CAA58858.1 .
    BC061878 mRNA. Translation: AAH61878.1 .
    PIRi S52284.
    RefSeqi NP_112312.1. NM_031050.1.
    UniGenei Rn.3087.

    3D structure databases

    ProteinModelPortali P51886.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006109.

    Proteomic databases

    PaxDbi P51886.
    PRIDEi P51886.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006109 ; ENSRNOP00000006109 ; ENSRNOG00000004610 .
    GeneIDi 81682.
    KEGGi rno:81682.
    UCSCi RGD:620984. rat.

    Organism-specific databases

    CTDi 4060.
    RGDi 620984. Lum.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00600000084286.
    HOGENOMi HOG000234447.
    HOVERGENi HBG108061.
    InParanoidi P51886.
    KOi K08122.
    OMAi KKLHINY.
    OrthoDBi EOG75F4DF.
    PhylomeDBi P51886.
    TreeFami TF334562.

    Enzyme and pathway databases

    Reactomei REACT_196475. Keratan sulfate biosynthesis.
    REACT_198617. Keratan sulfate degradation.

    Miscellaneous databases

    NextBioi 615304.
    PROi P51886.

    Gene expression databases

    Genevestigatori P51886.

    Family and domain databases

    InterProi IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR027219. Lumican.
    [Graphical view ]
    PANTHERi PTHR24371:SF54. PTHR24371:SF54. 1 hit.
    Pfami PF13855. LRR_8. 3 hits.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS51450. LRR. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Krull N.B.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Eye.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiLUM_RAT
    AccessioniPrimary (citable) accession number: P51886
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3