Lum

Functionⁱ

GO - Molecular functionⁱ

collagen binding
Source: RGD
Inferred from sequence orthologyⁱ
- 10892350

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cartilage development
Source: RGD
Inferred from expression patternⁱ
- 19746167
collagen fibril organization Source: InterPro
positive regulation of transcription by RNA polymerase II
Source: RGD
Inferred from sequence orthologyⁱ
- 15849191
positive regulation of transforming growth factor beta1 production
Source: RGD
Inferred from sequence orthologyⁱ
- 21931815
response to growth factor
Source: RGD
Inferred from expression patternⁱ
- 18482974
response to organic cyclic compound
Source: RGD
Inferred from expression patternⁱ
- 18602130
visual perception Source: InterPro

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2022854 Keratan sulfate biosynthesis R-RNO-2022857 Keratan sulfate degradation R-RNO-216083 Integrin cell surface interactions

Reactomeⁱ

R-RNO-2022854 Keratan sulfate biosynthesis
R-RNO-2022857 Keratan sulfate degradation
R-RNO-216083 Integrin cell surface interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Lumican Alternative name(s): Keratan sulfate proteoglycan lumican Short name: KSPG lumican
Gene namesⁱ	Name:Lum Synonyms:Lcn, Ldc
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	620984 Lum

RGDⁱ

620984 Lum

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	By similarityAdd BLAST		18
ChainⁱPRO_0000032735	19 – 338	LumicanAdd BLAST		320

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	Pyrrolidone carboxylic acidBy similarity	1
Modified residueⁱ	20	SulfotyrosineBy similarity	1
Modified residueⁱ	21	SulfotyrosineBy similarity	1
Modified residueⁱ	23	SulfotyrosineBy similarity	1
Modified residueⁱ	30	SulfotyrosineBy similarity	1
Glycosylationⁱ	88	N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis	1
Glycosylationⁱ	127	N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis	1
Glycosylationⁱ	160	N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis	1
Glycosylationⁱ	252	N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis	1
Disulfide bondⁱ	295 ↔ 328	By similarity
Modified residueⁱ	304	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbⁱ	P51886
PRIDEⁱ	P51886

PTM databases

iPTMnetⁱ	P51886
PhosphoSitePlusⁱ	P51886

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000004610
Genevisibleⁱ	P51886 RN

Interactionⁱ

Subunit structureⁱ

Binds to laminin.By similarity

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000006109

STRINGⁱ

10116.ENSRNOP00000006109

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51886
SMRⁱ	P51886
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 66	LRRNTAdd BLAST	39
Repeatⁱ	67 – 88	LRR 1Add BLAST	22
Repeatⁱ	91 – 114	LRR 2Add BLAST	24
Repeatⁱ	117 – 137	LRR 3Add BLAST	21
Repeatⁱ	138 – 159	LRR 4Add BLAST	22
Repeatⁱ	160 – 181	LRR 5Add BLAST	22
Repeatⁱ	185 – 205	LRR 6Add BLAST	21
Repeatⁱ	206 – 227	LRR 7Add BLAST	22
Repeatⁱ	230 – 250	LRR 8Add BLAST	21
Repeatⁱ	255 – 276	LRR 9Add BLAST	22
Repeatⁱ	277 – 296	LRR 10Add BLAST	20
Repeatⁱ	305 – 326	LRR 11Add BLAST	22

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	37 – 53	Cys-richAdd BLAST		17

Sequence similaritiesⁱ

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118969
HOGENOMⁱ	HOG000234447
HOVERGENⁱ	HBG108061
InParanoidⁱ	P51886
KEGG Orthology (KO) More...KOⁱ	K08122
OMAⁱ	KKLHINY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XE
PhylomeDBⁱ	P51886
TreeFamⁱ	TF334562

Family and domain databases

Gene3Dⁱ	3.80.10.102 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR000372 LRRNT IPR027219 Lumican
PANTHERⁱ	PTHR24373:SF119 PTHR24373:SF119, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516 LRR_6, 1 hit PF13855 LRR_8, 3 hits PF01462 LRRNT, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 9 hits SM00013 LRRNT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 10 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P51886-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA 
        60         70         80         90        100
MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN 
       110        120        130        140        150
LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLANNKIS 
       160        170        180        190        200
KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL KGLKSLEYLD LSFNQMSKLP 
       210        220        230        240        250
AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE LADSGVPGNS 
       260        270        280        290        300
FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP 
       310        320        330 
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN

Length:338

Mass (Da):38,279

Last modified:October 1, 1996 - v1

Checksum:ⁱ13442BAECC905585

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X84039 mRNA Translation: CAA58858.1 BC061878 mRNA Translation: AAH61878.1
PIRⁱ	S52284
NCBI Reference Sequences More...RefSeqⁱ	NP_112312.1, NM_031050.1
UniGeneⁱ	Rn.3087

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610
GeneIDⁱ	81682
KEGGⁱ	rno:81682
UCSC genome browser More...UCSCⁱ	RGD:620984 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P51886	P51885 G3HJG5 I3MCI8 A0A1A6FWH2 UPI00038C37E0 UPI00076255C6 UPI00042AD3A1 UPI000A31860D UPI0004ED107B A0A1U7Q4A8 +2	Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Neotoma lepida (Desert woodrat) Microtus ochrogaster (Prairie vole) Marmota marmota marmota (Alpine marmot) Peromyscus maniculatus bairdii (Prairie deer mouse) Mus caroli (Ryukyu mouse) (Ricefield mouse) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Mesocricetus auratus (Golden hamster) And more	338	UniRef90_P51885	Cluster: Lumican	13

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P51886	P51885 G3HJG5 I3MCI8 UPI00042AD3A1 A0A1U7Q4A8 A0A1A6FWH2 UPI00038C37E0 UPI0004ED107B UPI000B4F8A5C UPI00076255C6 +172	Mus musculus (Mouse) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus tridecemlineatus) Peromyscus maniculatus bairdii (Prairie deer mouse) Mesocricetus auratus (Golden hamster) Neotoma lepida (Desert woodrat) Microtus ochrogaster (Prairie vole) Nannospalax galili (Northern Israeli blind subterranean mole rat) (Spalax galili) Meriones unguiculatus (Mongolian jird) (Mongolian gerbil) Marmota marmota marmota (Alpine marmot) And more	338	UniRef50_P51885	Cluster: Lumican	183

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X84039 mRNA Translation: CAA58858.1 BC061878 mRNA Translation: AAH61878.1
PIRⁱ	S52284
NCBI Reference Sequences More...RefSeqⁱ	NP_112312.1, NM_031050.1
UniGeneⁱ	Rn.3087

3D structure databases

ProteinModelPortalⁱ	P51886
SMRⁱ	P51886
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000006109

STRINGⁱ

10116.ENSRNOP00000006109

PTM databases

iPTMnetⁱ	P51886
PhosphoSitePlusⁱ	P51886

Proteomic databases

PaxDbⁱ	P51886
PRIDEⁱ	P51886

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610
GeneIDⁱ	81682
KEGGⁱ	rno:81682
UCSC genome browser More...UCSCⁱ	RGD:620984 rat

Organism-specific databases

CTDⁱ	4060
Rat genome database More...RGDⁱ	620984 Lum

Phylogenomic databases

eggNOGⁱ	KOG0619 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118969
HOGENOMⁱ	HOG000234447
HOVERGENⁱ	HBG108061
InParanoidⁱ	P51886
KEGG Orthology (KO) More...KOⁱ	K08122
OMAⁱ	KKLHINY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09XE
PhylomeDBⁱ	P51886
TreeFamⁱ	TF334562

Enzyme and pathway databases

Reactomeⁱ	R-RNO-2022854 Keratan sulfate biosynthesis R-RNO-2022857 Keratan sulfate degradation R-RNO-216083 Integrin cell surface interactions

Reactomeⁱ

R-RNO-2022854 Keratan sulfate biosynthesis
R-RNO-2022857 Keratan sulfate degradation
R-RNO-216083 Integrin cell surface interactions

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P51886

PROⁱ

PR:P51886

Gene expression databases

Bgeeⁱ	ENSRNOG00000004610
Genevisibleⁱ	P51886 RN

Family and domain databases

Gene3Dⁱ	3.80.10.102 hits
InterProⁱ	View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR000372 LRRNT IPR027219 Lumican
PANTHERⁱ	PTHR24373:SF119 PTHR24373:SF119, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13516 LRR_6, 1 hit PF13855 LRR_8, 3 hits PF01462 LRRNT, 1 hit
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 9 hits SM00013 LRRNT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 10 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LUM_RAT
Accessionⁱ	P51886Primary (citable) accession number: P51886
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	March 28, 2018
	This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51886 (LUM_RAT)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Lumican

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ