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Protein

Lumican

Gene

Lum

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-2022854. Keratan sulfate biosynthesis.
R-RNO-2022857. Keratan sulfate degradation.
R-RNO-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name:
KSPG lumican
Gene namesi
Name:Lum
Synonyms:Lcn, Ldc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi620984. Lum.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18By similarityAdd BLAST18
ChainiPRO_000003273519 – 338LumicanAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acidBy similarity1
Modified residuei20SulfotyrosineBy similarity1
Modified residuei21SulfotyrosineBy similarity1
Modified residuei23SulfotyrosineBy similarity1
Modified residuei30SulfotyrosineBy similarity1
Glycosylationi88N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Glycosylationi160N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Disulfide bondi295 ↔ 328By similarity
Modified residuei304PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP51886.
PRIDEiP51886.

PTM databases

iPTMnetiP51886.
PhosphoSitePlusiP51886.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004610.
GenevisibleiP51886. RN.

Interactioni

Subunit structurei

Binds to laminin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006109.

Structurei

3D structure databases

ProteinModelPortaliP51886.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 66LRRNTAdd BLAST39
Repeati67 – 88LRR 1Add BLAST22
Repeati91 – 114LRR 2Add BLAST24
Repeati117 – 137LRR 3Add BLAST21
Repeati138 – 159LRR 4Add BLAST22
Repeati160 – 181LRR 5Add BLAST22
Repeati185 – 205LRR 6Add BLAST21
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 250LRR 8Add BLAST21
Repeati255 – 276LRR 9Add BLAST22
Repeati277 – 296LRR 10Add BLAST20
Repeati305 – 326LRR 11Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 53Cys-richAdd BLAST17

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51886.
KOiK08122.
OMAiKKLHINY.
OrthoDBiEOG091G09XE.
PhylomeDBiP51886.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027219. Lumican.
[Graphical view]
PANTHERiPTHR24373:SF119. PTHR24373:SF119. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51886-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA
60 70 80 90 100
MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN
110 120 130 140 150
LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLANNKIS
160 170 180 190 200
KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL KGLKSLEYLD LSFNQMSKLP
210 220 230 240 250
AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE LADSGVPGNS
260 270 280 290 300
FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP
310 320 330
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN
Length:338
Mass (Da):38,279
Last modified:October 1, 1996 - v1
Checksum:i13442BAECC905585
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84039 mRNA. Translation: CAA58858.1.
BC061878 mRNA. Translation: AAH61878.1.
PIRiS52284.
RefSeqiNP_112312.1. NM_031050.1.
UniGeneiRn.3087.

Genome annotation databases

EnsembliENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610.
GeneIDi81682.
KEGGirno:81682.
UCSCiRGD:620984. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84039 mRNA. Translation: CAA58858.1.
BC061878 mRNA. Translation: AAH61878.1.
PIRiS52284.
RefSeqiNP_112312.1. NM_031050.1.
UniGeneiRn.3087.

3D structure databases

ProteinModelPortaliP51886.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006109.

PTM databases

iPTMnetiP51886.
PhosphoSitePlusiP51886.

Proteomic databases

PaxDbiP51886.
PRIDEiP51886.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610.
GeneIDi81682.
KEGGirno:81682.
UCSCiRGD:620984. rat.

Organism-specific databases

CTDi4060.
RGDi620984. Lum.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51886.
KOiK08122.
OMAiKKLHINY.
OrthoDBiEOG091G09XE.
PhylomeDBiP51886.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-RNO-2022854. Keratan sulfate biosynthesis.
R-RNO-2022857. Keratan sulfate degradation.
R-RNO-216083. Integrin cell surface interactions.

Miscellaneous databases

PROiP51886.

Gene expression databases

BgeeiENSRNOG00000004610.
GenevisibleiP51886. RN.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027219. Lumican.
[Graphical view]
PANTHERiPTHR24373:SF119. PTHR24373:SF119. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUM_RAT
AccessioniPrimary (citable) accession number: P51886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.