UniProtKB - P51886 (LUM_RAT)
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Protein
Lumican
Gene
Lum
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- collagen binding Source: RGD
GO - Biological processi
- cartilage development Source: RGD
- collagen fibril organization Source: InterPro
- positive regulation of transcription by RNA polymerase II Source: RGD
- positive regulation of transforming growth factor beta1 production Source: RGD
- response to growth factor Source: RGD
- response to organic cyclic compound Source: RGD
- visual perception Source: InterPro
Enzyme and pathway databases
Reactomei | R-RNO-2022854 Keratan sulfate biosynthesis R-RNO-2022857 Keratan sulfate degradation R-RNO-216083 Integrin cell surface interactions |
Names & Taxonomyi
Protein namesi | Recommended name: LumicanAlternative name(s): Keratan sulfate proteoglycan lumican Short name: KSPG lumican |
Gene namesi | Name:Lum Synonyms:Lcn, Ldc |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620984 Lum |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | By similarityAdd BLAST | 18 | |
ChainiPRO_0000032735 | 19 – 338 | LumicanAdd BLAST | 320 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Pyrrolidone carboxylic acidBy similarity | 1 | |
Modified residuei | 20 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 21 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 23 | SulfotyrosineBy similarity | 1 | |
Modified residuei | 30 | SulfotyrosineBy similarity | 1 | |
Glycosylationi | 88 | N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis | 1 | |
Glycosylationi | 127 | N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis | 1 | |
Glycosylationi | 160 | N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis | 1 | |
Glycosylationi | 252 | N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis | 1 | |
Disulfide bondi | 295 ↔ 328 | By similarity | ||
Modified residuei | 304 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid, SulfationProteomic databases
PaxDbi | P51886 |
PRIDEi | P51886 |
PTM databases
iPTMneti | P51886 |
PhosphoSitePlusi | P51886 |
Interactioni
Subunit structurei
Binds to laminin.By similarity
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006109 |
Structurei
3D structure databases
ProteinModelPortali | P51886 |
SMRi | P51886 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 66 | LRRNTAdd BLAST | 39 | |
Repeati | 67 – 88 | LRR 1Add BLAST | 22 | |
Repeati | 91 – 114 | LRR 2Add BLAST | 24 | |
Repeati | 117 – 137 | LRR 3Add BLAST | 21 | |
Repeati | 138 – 159 | LRR 4Add BLAST | 22 | |
Repeati | 160 – 181 | LRR 5Add BLAST | 22 | |
Repeati | 185 – 205 | LRR 6Add BLAST | 21 | |
Repeati | 206 – 227 | LRR 7Add BLAST | 22 | |
Repeati | 230 – 250 | LRR 8Add BLAST | 21 | |
Repeati | 255 – 276 | LRR 9Add BLAST | 22 | |
Repeati | 277 – 296 | LRR 10Add BLAST | 20 | |
Repeati | 305 – 326 | LRR 11Add BLAST | 22 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 37 – 53 | Cys-richAdd BLAST | 17 |
Sequence similaritiesi
Keywords - Domaini
Leucine-rich repeat, Repeat, SignalPhylogenomic databases
eggNOGi | KOG0619 Eukaryota COG4886 LUCA |
GeneTreei | ENSGT00760000118969 |
HOGENOMi | HOG000234447 |
HOVERGENi | HBG108061 |
InParanoidi | P51886 |
KOi | K08122 |
OMAi | KKLHINY |
OrthoDBi | EOG091G09XE |
PhylomeDBi | P51886 |
TreeFami | TF334562 |
Family and domain databases
Gene3Di | 3.80.10.102 hits |
InterProi | View protein in InterPro IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR000372 LRRNT IPR027219 Lumican |
PANTHERi | PTHR24373:SF119 PTHR24373:SF119, 1 hit |
Pfami | View protein in Pfam PF13516 LRR_6, 1 hit PF13855 LRR_8, 3 hits PF01462 LRRNT, 1 hit |
SMARTi | View protein in SMART SM00369 LRR_TYP, 9 hits SM00013 LRRNT, 1 hit |
PROSITEi | View protein in PROSITE PS51450 LRR, 10 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P51886-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA
60 70 80 90 100
MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN
110 120 130 140 150
LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLANNKIS
160 170 180 190 200
KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL KGLKSLEYLD LSFNQMSKLP
210 220 230 240 250
AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE LADSGVPGNS
260 270 280 290 300
FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP
310 320 330
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84039 mRNA Translation: CAA58858.1 BC061878 mRNA Translation: AAH61878.1 |
PIRi | S52284 |
RefSeqi | NP_112312.1, NM_031050.1 |
UniGenei | Rn.3087 |
Genome annotation databases
Ensembli | ENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610 |
GeneIDi | 81682 |
KEGGi | rno:81682 |
UCSCi | RGD:620984 rat |
Similar proteinsi
Entry informationi
Entry namei | LUM_RAT | |
Accessioni | P51886Primary (citable) accession number: P51886 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | March 28, 2018 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |