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P51886 (LUM_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name=KSPG lumican
Gene names
Name:Lum
Synonyms:Lcn, Ldc
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Binds to laminin By similarity.

Subcellular location

Secreted › extracellular space › extracellular matrix By similarity.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Contains 11 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Chain19 – 338320Lumican
PRO_0000032735

Regions

Domain28 – 6639LRRNT
Repeat67 – 8822LRR 1
Repeat91 – 11424LRR 2
Repeat117 – 13721LRR 3
Repeat138 – 15922LRR 4
Repeat160 – 18122LRR 5
Repeat185 – 20521LRR 6
Repeat206 – 22722LRR 7
Repeat230 – 25021LRR 8
Repeat255 – 27622LRR 9
Repeat277 – 29620LRR 10
Repeat305 – 32622LRR 11
Compositional bias37 – 5317Cys-rich

Amino acid modifications

Modified residue191Pyrrolidone carboxylic acid By similarity
Modified residue201Sulfotyrosine By similarity
Modified residue211Sulfotyrosine By similarity
Modified residue231Sulfotyrosine By similarity
Modified residue301Sulfotyrosine By similarity
Glycosylation881N-linked (GlcNAc...) (keratan sulfate) Potential
Glycosylation1271N-linked (GlcNAc...) (keratan sulfate) Potential
Glycosylation1601N-linked (GlcNAc...) (keratan sulfate) Potential
Glycosylation2521N-linked (GlcNAc...) (keratan sulfate) Potential
Disulfide bond295 ↔ 328 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51886 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 13442BAECC905585

FASTA33838,279
        10         20         30         40         50         60 
MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA MYCDDLKLKS 

        70         80         90        100        110        120 
VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGK VFSKLKQLKK 

       130        140        150        160        170        180 
LHINYNNLTE SVGPLPKSLQ DLQLANNKIS KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL 

       190        200        210        220        230        240 
KGLKSLEYLD LSFNQMSKLP AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE 

       250        260        270        280        290        300 
LADSGVPGNS FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP 

       310        320        330 
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN

« Hide

References

« Hide 'large scale' references
[1]Krull N.B.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Eye.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X84039 mRNA. Translation: CAA58858.1.
BC061878 mRNA. Translation: AAH61878.1.
IPIIPI00206403.
PIRS52284.
RefSeqNP_112312.1. NM_031050.1.
UniGeneRn.3087.

3D structure databases

ProteinModelPortalP51886.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006109.

Proteomic databases

PaxDbP51886.
PRIDEP51886.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610.
GeneID81682.
KEGGrno:81682.
UCSCRGD:620984. rat.

Organism-specific databases

CTD4060.
RGD620984. Lum.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00600000084286.
HOGENOMHOG000234447.
HOVERGENHBG108061.
InParanoidP51886.
KOK08122.
OMALHINYNN.
OrthoDBEOG4CZBGK.

Gene expression databases

GenevestigatorP51886.
GermOnlineENSRNOG00000004610. Rattus norvegicus.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027219. Lumican.
[Graphical view]
PANTHERPTHR24371:SF1. PTHR24371:SF1. 1 hit.
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio615304.

Entry information

Entry nameLUM_RAT
AccessionPrimary (citable) accession number: P51886
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 1, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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