SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P51886

- LUM_RAT

UniProt

P51886 - LUM_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Lumican

Gene
Lum, Lcn, Ldc
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. cartilage development Source: RGD
  2. collagen fibril organization Source: InterPro
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. response to growth factor Source: RGD
  5. response to organic cyclic compound Source: RGD
  6. visual perception Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_196475. Keratan sulfate biosynthesis.
REACT_198617. Keratan sulfate degradation.

Names & Taxonomyi

Protein namesi
Recommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name:
KSPG lumican
Gene namesi
Name:Lum
Synonyms:Lcn, Ldc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi620984. Lum.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. fibrillar collagen trimer Source: Ensembl
  3. proteinaceous extracellular matrix Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 By similarityAdd
BLAST
Chaini19 – 338320LumicanPRO_0000032735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191Pyrrolidone carboxylic acid By similarity
Modified residuei20 – 201Sulfotyrosine By similarity
Modified residuei21 – 211Sulfotyrosine By similarity
Modified residuei23 – 231Sulfotyrosine By similarity
Modified residuei30 – 301Sulfotyrosine By similarity
Glycosylationi88 – 881N-linked (GlcNAc...) (keratan sulfate) Reviewed prediction
Glycosylationi127 – 1271N-linked (GlcNAc...) (keratan sulfate) Reviewed prediction
Glycosylationi160 – 1601N-linked (GlcNAc...) (keratan sulfate) Reviewed prediction
Glycosylationi252 – 2521N-linked (GlcNAc...) (keratan sulfate) Reviewed prediction
Disulfide bondi295 ↔ 328 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDbiP51886.
PRIDEiP51886.

Expressioni

Gene expression databases

GenevestigatoriP51886.

Interactioni

Subunit structurei

Binds to laminin By similarity.

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006109.

Structurei

3D structure databases

ProteinModelPortaliP51886.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 6639LRRNTAdd
BLAST
Repeati67 – 8822LRR 1Add
BLAST
Repeati91 – 11424LRR 2Add
BLAST
Repeati117 – 13721LRR 3Add
BLAST
Repeati138 – 15922LRR 4Add
BLAST
Repeati160 – 18122LRR 5Add
BLAST
Repeati185 – 20521LRR 6Add
BLAST
Repeati206 – 22722LRR 7Add
BLAST
Repeati230 – 25021LRR 8Add
BLAST
Repeati255 – 27622LRR 9Add
BLAST
Repeati277 – 29620LRR 10Add
BLAST
Repeati305 – 32622LRR 11Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 5317Cys-richAdd
BLAST

Sequence similaritiesi

Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00600000084286.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51886.
KOiK08122.
OMAiKKLHINY.
OrthoDBiEOG75F4DF.
PhylomeDBiP51886.
TreeFamiTF334562.

Family and domain databases

InterProiIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027219. Lumican.
[Graphical view]
PANTHERiPTHR24371:SF54. PTHR24371:SF54. 1 hit.
PfamiPF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51886-1 [UniParc]FASTAAdd to Basket

« Hide

MNVCTFTLVL ALVGSVSGQY YDYDAPLFMY GELSPNCAPE CNCPHSYPTA    50
MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN 100
LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLANNKIS 150
KLGSFDGLVN LTFIYLQHNQ LKEEAVSASL KGLKSLEYLD LSFNQMSKLP 200
AGLPTSLLTL YLDNNKITNI PDEYFNRFTG LQYLRLSHNE LADSGVPGNS 250
FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNKLEKFD VKSFCKILGP 300
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN 338
Length:338
Mass (Da):38,279
Last modified:October 1, 1996 - v1
Checksum:i13442BAECC905585
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84039 mRNA. Translation: CAA58858.1.
BC061878 mRNA. Translation: AAH61878.1.
PIRiS52284.
RefSeqiNP_112312.1. NM_031050.1.
UniGeneiRn.3087.

Genome annotation databases

EnsembliENSRNOT00000006109; ENSRNOP00000006109; ENSRNOG00000004610.
GeneIDi81682.
KEGGirno:81682.
UCSCiRGD:620984. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84039 mRNA. Translation: CAA58858.1 .
BC061878 mRNA. Translation: AAH61878.1 .
PIRi S52284.
RefSeqi NP_112312.1. NM_031050.1.
UniGenei Rn.3087.

3D structure databases

ProteinModelPortali P51886.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006109.

Proteomic databases

PaxDbi P51886.
PRIDEi P51886.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006109 ; ENSRNOP00000006109 ; ENSRNOG00000004610 .
GeneIDi 81682.
KEGGi rno:81682.
UCSCi RGD:620984. rat.

Organism-specific databases

CTDi 4060.
RGDi 620984. Lum.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00600000084286.
HOGENOMi HOG000234447.
HOVERGENi HBG108061.
InParanoidi P51886.
KOi K08122.
OMAi KKLHINY.
OrthoDBi EOG75F4DF.
PhylomeDBi P51886.
TreeFami TF334562.

Enzyme and pathway databases

Reactomei REACT_196475. Keratan sulfate biosynthesis.
REACT_198617. Keratan sulfate degradation.

Miscellaneous databases

NextBioi 615304.
PROi P51886.

Gene expression databases

Genevestigatori P51886.

Family and domain databases

InterProi IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027219. Lumican.
[Graphical view ]
PANTHERi PTHR24371:SF54. PTHR24371:SF54. 1 hit.
Pfami PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS51450. LRR. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Krull N.B.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Eye.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiLUM_RAT
AccessioniPrimary (citable) accession number: P51886
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi