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Protein

Lumican

Gene

Lum

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-2022854 Keratan sulfate biosynthesis
R-MMU-2022857 Keratan sulfate degradation
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name:
KSPG lumican
Gene namesi
Name:Lum
Synonyms:Lcn, Ldc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:109347 Lum

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000003273419 – 338LumicanAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Modified residuei20Sulfotyrosine1 Publication1
Modified residuei21Sulfotyrosine1 Publication1
Modified residuei23Sulfotyrosine1 Publication1
Modified residuei30Sulfotyrosine1 Publication1
Glycosylationi88N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi127N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi160N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Glycosylationi252N-linked (GlcNAc...) (keratan sulfate) asparagineSequence analysis1
Disulfide bondi295 ↔ 328By similarity
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

Cys-37, Cys-41, Cys-43 and Cys-53 are involved in disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiP51885
PaxDbiP51885
PeptideAtlasiP51885
PRIDEiP51885

PTM databases

PhosphoSitePlusiP51885

Expressioni

Tissue specificityi

Cornea and other tissues.

Gene expression databases

BgeeiENSMUSG00000036446
CleanExiMM_LUM
GenevisibleiP51885 MM

Interactioni

Subunit structurei

Binds to laminin.By similarity

Protein-protein interaction databases

IntActiP51885, 1 interactor
MINTiP51885
STRINGi10090.ENSMUSP00000040877

Structurei

3D structure databases

ProteinModelPortaliP51885
SMRiP51885
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 66LRRNTAdd BLAST39
Repeati67 – 88LRR 1Add BLAST22
Repeati91 – 114LRR 2Add BLAST24
Repeati117 – 137LRR 3Add BLAST21
Repeati138 – 159LRR 4Add BLAST22
Repeati160 – 181LRR 5Add BLAST22
Repeati185 – 205LRR 6Add BLAST21
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 250LRR 8Add BLAST21
Repeati255 – 276LRR 9Add BLAST22
Repeati277 – 296LRR 10Add BLAST20
Repeati305 – 326LRR 11Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 53Cys-richAdd BLAST17

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiP51885
KOiK08122
OMAiKKLHINY
OrthoDBiEOG091G09XE
PhylomeDBiP51885
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR027219 Lumican
PANTHERiPTHR24373:SF119 PTHR24373:SF119, 1 hit
PfamiView protein in Pfam
PF13516 LRR_6, 1 hit
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVCAFSLAL ALVGSVSGQY YDYDIPLFMY GQISPNCAPE CNCPHSYPTA
60 70 80 90 100
MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN
110 120 130 140 150
LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLTNNKIS
160 170 180 190 200
KLGSFDGLVN LTFIYLQHNQ LKEDAVSASL KGLKSLEYLD LSFNQMSKLP
210 220 230 240 250
AGLPTSLLTL YLDNNKISNI PDEYFKRFTG LQYLRLSHNE LADSGVPGNS
260 270 280 290 300
FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNELEKFD VKSFCKILGP
310 320 330
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN
Length:338
Mass (Da):38,265
Last modified:June 20, 2002 - v2
Checksum:iFF1E050C89779140
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57K → M in BAB29264 (PubMed:16141072).Curated1
Sequence conflicti109G → E (PubMed:7558724).Curated1
Sequence conflicti109G → E (Ref. 2) Curated1
Sequence conflicti293S → T (PubMed:7558724).Curated1
Sequence conflicti293S → T (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79461 mRNA Translation: AAB35361.1
AF013262 Genomic DNA Translation: AAB87767.1
AK014312 mRNA Translation: BAB29264.1
AK075737 mRNA Translation: BAC35919.1
AK164774 mRNA Translation: BAE37912.1
BC005550 mRNA Translation: AAH05550.1
CCDSiCCDS24142.1
RefSeqiNP_032550.2, NM_008524.2
UniGeneiMm.18888

Genome annotation databases

EnsembliENSMUST00000038160; ENSMUSP00000040877; ENSMUSG00000036446
GeneIDi17022
KEGGimmu:17022
UCSCiuc007gwz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLUM_MOUSE
AccessioniPrimary (citable) accession number: P51885
Secondary accession number(s): Q3TP25, Q99JZ3, Q9CXK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: May 23, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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