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Protein

Lumican

Gene

Lum

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.
R-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name:
KSPG lumican
Gene namesi
Name:Lum
Synonyms:Lcn, Ldc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109347. Lum.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000003273419 – 338LumicanAdd BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Modified residuei20Sulfotyrosine1 Publication1
Modified residuei21Sulfotyrosine1 Publication1
Modified residuei23Sulfotyrosine1 Publication1
Modified residuei30Sulfotyrosine1 Publication1
Glycosylationi88N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Glycosylationi127N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Glycosylationi160N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Glycosylationi252N-linked (GlcNAc...) (keratan sulfate)Sequence analysis1
Disulfide bondi295 ↔ 328By similarity
Modified residuei304PhosphoserineBy similarity1

Post-translational modificationi

Cys-37, Cys-41, Cys-43 and Cys-53 are involved in disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

MaxQBiP51885.
PaxDbiP51885.
PeptideAtlasiP51885.
PRIDEiP51885.

PTM databases

PhosphoSitePlusiP51885.

Expressioni

Tissue specificityi

Cornea and other tissues.

Gene expression databases

BgeeiENSMUSG00000036446.
CleanExiMM_LUM.
GenevisibleiP51885. MM.

Interactioni

Subunit structurei

Binds to laminin.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP51885. 1 interactor.
MINTiMINT-4100731.
STRINGi10090.ENSMUSP00000040877.

Structurei

3D structure databases

ProteinModelPortaliP51885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 66LRRNTAdd BLAST39
Repeati67 – 88LRR 1Add BLAST22
Repeati91 – 114LRR 2Add BLAST24
Repeati117 – 137LRR 3Add BLAST21
Repeati138 – 159LRR 4Add BLAST22
Repeati160 – 181LRR 5Add BLAST22
Repeati185 – 205LRR 6Add BLAST21
Repeati206 – 227LRR 7Add BLAST22
Repeati230 – 250LRR 8Add BLAST21
Repeati255 – 276LRR 9Add BLAST22
Repeati277 – 296LRR 10Add BLAST20
Repeati305 – 326LRR 11Add BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 53Cys-richAdd BLAST17

Sequence similaritiesi

Contains 11 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51885.
KOiK08122.
OMAiKKLHINY.
OrthoDBiEOG091G09XE.
PhylomeDBiP51885.
TreeFamiTF334562.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027219. Lumican.
[Graphical view]
PANTHERiPTHR24373:SF119. PTHR24373:SF119. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51885-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVCAFSLAL ALVGSVSGQY YDYDIPLFMY GQISPNCAPE CNCPHSYPTA
60 70 80 90 100
MYCDDLKLKS VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN
110 120 130 140 150
LLENSKIKGK VFSKLKQLKK LHINYNNLTE SVGPLPKSLQ DLQLTNNKIS
160 170 180 190 200
KLGSFDGLVN LTFIYLQHNQ LKEDAVSASL KGLKSLEYLD LSFNQMSKLP
210 220 230 240 250
AGLPTSLLTL YLDNNKISNI PDEYFKRFTG LQYLRLSHNE LADSGVPGNS
260 270 280 290 300
FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNELEKFD VKSFCKILGP
310 320 330
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN
Length:338
Mass (Da):38,265
Last modified:June 20, 2002 - v2
Checksum:iFF1E050C89779140
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57K → M in BAB29264 (PubMed:16141072).Curated1
Sequence conflicti109G → E (PubMed:7558724).Curated1
Sequence conflicti109G → E (Ref. 2) Curated1
Sequence conflicti293S → T (PubMed:7558724).Curated1
Sequence conflicti293S → T (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79461 mRNA. Translation: AAB35361.1.
AF013262 Genomic DNA. Translation: AAB87767.1.
AK014312 mRNA. Translation: BAB29264.1.
AK075737 mRNA. Translation: BAC35919.1.
AK164774 mRNA. Translation: BAE37912.1.
BC005550 mRNA. Translation: AAH05550.1.
CCDSiCCDS24142.1.
RefSeqiNP_032550.2. NM_008524.2.
UniGeneiMm.18888.

Genome annotation databases

EnsembliENSMUST00000038160; ENSMUSP00000040877; ENSMUSG00000036446.
GeneIDi17022.
KEGGimmu:17022.
UCSCiuc007gwz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79461 mRNA. Translation: AAB35361.1.
AF013262 Genomic DNA. Translation: AAB87767.1.
AK014312 mRNA. Translation: BAB29264.1.
AK075737 mRNA. Translation: BAC35919.1.
AK164774 mRNA. Translation: BAE37912.1.
BC005550 mRNA. Translation: AAH05550.1.
CCDSiCCDS24142.1.
RefSeqiNP_032550.2. NM_008524.2.
UniGeneiMm.18888.

3D structure databases

ProteinModelPortaliP51885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51885. 1 interactor.
MINTiMINT-4100731.
STRINGi10090.ENSMUSP00000040877.

PTM databases

PhosphoSitePlusiP51885.

Proteomic databases

MaxQBiP51885.
PaxDbiP51885.
PeptideAtlasiP51885.
PRIDEiP51885.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038160; ENSMUSP00000040877; ENSMUSG00000036446.
GeneIDi17022.
KEGGimmu:17022.
UCSCiuc007gwz.2. mouse.

Organism-specific databases

CTDi4060.
MGIiMGI:109347. Lum.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118969.
HOGENOMiHOG000234447.
HOVERGENiHBG108061.
InParanoidiP51885.
KOiK08122.
OMAiKKLHINY.
OrthoDBiEOG091G09XE.
PhylomeDBiP51885.
TreeFamiTF334562.

Enzyme and pathway databases

ReactomeiR-MMU-2022854. Keratan sulfate biosynthesis.
R-MMU-2022857. Keratan sulfate degradation.
R-MMU-216083. Integrin cell surface interactions.

Miscellaneous databases

PROiP51885.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036446.
CleanExiMM_LUM.
GenevisibleiP51885. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR027219. Lumican.
[Graphical view]
PANTHERiPTHR24373:SF119. PTHR24373:SF119. 1 hit.
PfamiPF13516. LRR_6. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 9 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLUM_MOUSE
AccessioniPrimary (citable) accession number: P51885
Secondary accession number(s): Q3TP25, Q99JZ3, Q9CXK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: November 2, 2016
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.