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P51885 (LUM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lumican
Alternative name(s):
Keratan sulfate proteoglycan lumican
Short name=KSPG lumican
Gene names
Name:Lum
Synonyms:Lcn, Ldc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Binds to laminin By similarity.

Subcellular location

Secretedextracellular spaceextracellular matrix By similarity.

Tissue specificity

Cornea and other tissues.

Post-translational modification

Cys-37, Cys-41, Cys-43 and Cys-53 are involved in disulfide bonds.

Sequence similarities

Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Contains 11 LRR (leucine-rich) repeats.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 338320Lumican
PRO_0000032734

Regions

Domain28 – 6639LRRNT
Repeat67 – 8822LRR 1
Repeat91 – 11424LRR 2
Repeat117 – 13721LRR 3
Repeat138 – 15922LRR 4
Repeat160 – 18122LRR 5
Repeat185 – 20521LRR 6
Repeat206 – 22722LRR 7
Repeat230 – 25021LRR 8
Repeat255 – 27622LRR 9
Repeat277 – 29620LRR 10
Repeat305 – 32622LRR 11
Compositional bias37 – 5317Cys-rich

Amino acid modifications

Modified residue191Pyrrolidone carboxylic acid
Modified residue201Sulfotyrosine Ref.5
Modified residue211Sulfotyrosine Ref.5
Modified residue231Sulfotyrosine Ref.5
Modified residue301Sulfotyrosine Ref.5
Glycosylation881N-linked (GlcNAc...) (keratan sulfate) Potential
Glycosylation1271N-linked (GlcNAc...) (keratan sulfate) Potential
Glycosylation1601N-linked (GlcNAc...) (keratan sulfate) Potential
Glycosylation2521N-linked (GlcNAc...) (keratan sulfate) Potential
Disulfide bond295 ↔ 328 By similarity

Experimental info

Sequence conflict571K → M in BAB29264. Ref.3
Sequence conflict1091G → E Ref.1
Sequence conflict1091G → E Ref.2
Sequence conflict2931S → T Ref.1
Sequence conflict2931S → T Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51885 [UniParc].

Last modified June 20, 2002. Version 2.
Checksum: FF1E050C89779140

FASTA33838,265
        10         20         30         40         50         60 
MNVCAFSLAL ALVGSVSGQY YDYDIPLFMY GQISPNCAPE CNCPHSYPTA MYCDDLKLKS 

        70         80         90        100        110        120 
VPMVPPGIKY LYLRNNQIDH IDEKAFENVT DLQWLILDHN LLENSKIKGK VFSKLKQLKK 

       130        140        150        160        170        180 
LHINYNNLTE SVGPLPKSLQ DLQLTNNKIS KLGSFDGLVN LTFIYLQHNQ LKEDAVSASL 

       190        200        210        220        230        240 
KGLKSLEYLD LSFNQMSKLP AGLPTSLLTL YLDNNKISNI PDEYFKRFTG LQYLRLSHNE 

       250        260        270        280        290        300 
LADSGVPGNS FNISSLLELD LSYNKLKSIP TVNENLENYY LEVNELEKFD VKSFCKILGP 

       310        320        330 
LSYSKIKHLR LDGNPLTQSS LPPDMYECLR VANEITVN 

« Hide

References

« Hide 'large scale' references
[1]"Sequence, molecular properties, and chromosomal mapping of mouse lumican."
Funderburgh J.L., Funderburgh M.L., Hevelone N.D., Stech M.E., Justice M.J., Liu C.-Y., Kao W.W.-Y., Conrad G.W.
Invest. Ophthalmol. Vis. Sci. 36:2296-2303(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cornea.
[2]Ying S., Shiraishi A., Kao C.W.-C., Converse R.L., Funderburgh J.L., Swiergiel J., Roth M.R., Kao W.W.-Y.
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum, Embryonic head and Mammary gland.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
[5]"Determination of the sites of tyrosine O-sulfation in peptides and proteins."
Yu Y., Hoffhines A.J., Moore K.L., Leary J.A.
Nat. Methods 4:583-588(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 29-52, SULFATION AT TYR-20; TYR-21; TYR-23 AND TYR-30, PYROGLUTAMATE FORMATION AT GLN-19, DISULFIDE BONDS, IDENTIFICATION BY MASS SPECTROMETRY.
[6]"Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127.
Strain: C57BL/6.
Tissue: Plasma.
[7]"Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides."
Bernhard O.K., Kapp E.A., Simpson R.J.
J. Proteome Res. 6:987-995(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-127 AND ASN-160.
Strain: C57BL/6.
Tissue: Plasma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
S79461 mRNA. Translation: AAB35361.1.
AF013262 Genomic DNA. Translation: AAB87767.1.
AK014312 mRNA. Translation: BAB29264.1.
AK075737 mRNA. Translation: BAC35919.1.
AK164774 mRNA. Translation: BAE37912.1.
BC005550 mRNA. Translation: AAH05550.1.
RefSeqNP_032550.2. NM_008524.2.
UniGeneMm.18888.

3D structure databases

ProteinModelPortalP51885.
SMRP51885. Positions 9-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP51885. 1 interaction.
MINTMINT-4100731.

PTM databases

PhosphoSiteP51885.

Proteomic databases

PaxDbP51885.
PRIDEP51885.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038160; ENSMUSP00000040877; ENSMUSG00000036446.
GeneID17022.
KEGGmmu:17022.
UCSCuc007gwz.2. mouse.

Organism-specific databases

CTD4060.
MGIMGI:109347. Lum.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00600000084286.
HOGENOMHOG000234447.
HOVERGENHBG108061.
InParanoidP51885.
KOK08122.
OMALHINYNN.
OrthoDBEOG75F4DF.
PhylomeDBP51885.
TreeFamTF334562.

Gene expression databases

BgeeP51885.
CleanExMM_LUM.
GenevestigatorP51885.

Family and domain databases

InterProIPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR027219. Lumican.
[Graphical view]
PANTHERPTHR24371:SF1. PTHR24371:SF1. 1 hit.
PfamPF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00369. LRR_TYP. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS51450. LRR. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio291134.
PROP51885.
SOURCESearch...

Entry information

Entry nameLUM_MOUSE
AccessionPrimary (citable) accession number: P51885
Secondary accession number(s): Q3TP25, Q99JZ3, Q9CXK0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 20, 2002
Last modified: April 16, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot