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Protein

T-cell surface glycoprotein CD5

Gene

Cd5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May act as a receptor in regulating T-cell proliferation.

GO - Molecular functioni

  • glycoprotein binding Source: RGD
  • scavenger receptor activity Source: InterPro

GO - Biological processi

  • regulation of signal transduction Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
CD_antigen: CD5
Gene namesi
Name:Cd5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2309. Cd5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 368344ExtracellularSequence analysisAdd
BLAST
Transmembranei369 – 39830HelicalSequence analysisAdd
BLAST
Topological domaini399 – 49193CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • spanning component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 491468T-cell surface glycoprotein CD5PRO_0000033224Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 84PROSITE-ProRule annotation
Disulfide bondi58 ↔ 123PROSITE-ProRule annotation
Disulfide bondi79 ↔ 130PROSITE-ProRule annotation
Disulfide bondi105 ↔ 115PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Disulfide bondi199 ↔ 265PROSITE-ProRule annotation
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence analysis
Disulfide bondi242 ↔ 248PROSITE-ProRule annotation
Disulfide bondi283 ↔ 319PROSITE-ProRule annotation
Disulfide bondi299 ↔ 356PROSITE-ProRule annotation
Disulfide bondi314 ↔ 363PROSITE-ProRule annotation
Disulfide bondi339 ↔ 347PROSITE-ProRule annotation
Modified residuei435 – 4351PhosphoserineBy similarity
Modified residuei449 – 4491PhosphotyrosineBy similarity
Modified residuei456 – 4561PhosphoserineBy similarity
Modified residuei479 – 4791PhosphoserineBy similarity
Modified residuei481 – 4811PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51882.
PRIDEiP51882.

PTM databases

iPTMnetiP51882.
PhosphoSiteiP51882.

Expressioni

Gene expression databases

BgeeiENSRNOG00000020872.
ExpressionAtlasiP51882. baseline and differential.
GenevisibleiP51882. RN.

Interactioni

Subunit structurei

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).By similarity

GO - Molecular functioni

  • glycoprotein binding Source: RGD

Protein-protein interaction databases

MINTiMINT-4996821.
STRINGi10116.ENSRNOP00000051697.

Structurei

3D structure databases

ProteinModelPortaliP51882.
SMRiP51882. Positions 268-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini34 – 13198SRCR 1PROSITE-ProRule annotationAdd
BLAST
Domaini157 – 266110SRCR 2PROSITE-ProRule annotationAdd
BLAST
Domaini274 – 36491SRCR 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ3D. Eukaryota.
ENOG4111C54. LUCA.
GeneTreeiENSGT00390000017536.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP51882.
KOiK06455.
PhylomeDBiP51882.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSHEVLLAA TYLLGTLAAF CLGQSGRGFV GAQVMLSGSN SKCQGLVEVQ
60 70 80 90 100
MNGMKTVCSS SWRLSQDLWK NANEASTVCQ QLGCGNPLAL GHLTLWNRPK
110 120 130 140 150
NQILCQGPPW SFSNCSTSSL GQCLPLSLVC LEPQKTTPLP TTTLPTTMPE
160 170 180 190 200
PTAPPRLQLV PGHEGLRCTG VVEFYNGSRG GTILYKAKAR PVDLGNLICK
210 220 230 240 250
SLQCGSFLTH LSRIETAGTP APAELRDPRP LPIRWEAQNG SCTSLQQCFQ
260 270 280 290 300
KTTVQEGSQA LAVVCSDFQP KVQSRLVGGS SVCEGIAEVR QRSQWAALCD
310 320 330 340 350
SSAARGPGRW EELCQEQQCG NLISFHVMDA DRTSPGVLCT QEKLSQCYQL
360 370 380 390 400
QKKTHCKRVF ITCKDPNPVG LAPGTVASII LTLVLLVVLM VMCGPLIYKK
410 420 430 440 450
LVKKFRQKKQ RQWIGPTGVN QSMSFHRSHT ATVRSQVENP AASHVDNEYS
460 470 480 490
QPPRNSRLSA YPALEGALHR SSTQPDNSSD SDYDLQVAQR L
Length:491
Mass (Da):53,440
Last modified:October 1, 1996 - v1
Checksum:i88DD76F8E6891CDE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271R → RDGPGKKEHEKGR (PubMed:7510236).Curated
Sequence conflicti218 – 2236GTPAPA → ELQLCS in CAA55586 (PubMed:7510236).Curated
Sequence conflicti370 – 3723GLA → AW in CAA55586 (PubMed:7510236).Curated
Sequence conflicti445 – 4451V → M in CAA55586 (PubMed:7510236).Curated
Sequence conflicti457 – 4582RL → W in CAA55586 (PubMed:7510236).Curated
Sequence conflicti490 – 4901R → K in CAA55586 (PubMed:7510236).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10728 mRNA. Translation: BAA01571.1.
X78985 mRNA. Translation: CAA55586.1.
PIRiS43536.
RefSeqiNP_062168.1. NM_019295.1.
UniGeneiRn.11337.

Genome annotation databases

EnsembliENSRNOT00000054812; ENSRNOP00000051697; ENSRNOG00000020872.
GeneIDi54236.
KEGGirno:54236.
UCSCiRGD:2309. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10728 mRNA. Translation: BAA01571.1.
X78985 mRNA. Translation: CAA55586.1.
PIRiS43536.
RefSeqiNP_062168.1. NM_019295.1.
UniGeneiRn.11337.

3D structure databases

ProteinModelPortaliP51882.
SMRiP51882. Positions 268-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996821.
STRINGi10116.ENSRNOP00000051697.

PTM databases

iPTMnetiP51882.
PhosphoSiteiP51882.

Proteomic databases

PaxDbiP51882.
PRIDEiP51882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054812; ENSRNOP00000051697; ENSRNOG00000020872.
GeneIDi54236.
KEGGirno:54236.
UCSCiRGD:2309. rat.

Organism-specific databases

CTDi921.
RGDi2309. Cd5.

Phylogenomic databases

eggNOGiENOG410IJ3D. Eukaryota.
ENOG4111C54. LUCA.
GeneTreeiENSGT00390000017536.
HOGENOMiHOG000111490.
HOVERGENiHBG005286.
InParanoidiP51882.
KOiK06455.
PhylomeDBiP51882.

Miscellaneous databases

PROiP51882.

Gene expression databases

BgeeiENSRNOG00000020872.
ExpressionAtlasiP51882. baseline and differential.
GenevisibleiP51882. RN.

Family and domain databases

Gene3Di3.10.250.10. 1 hit.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR003566. Tcell_CD5.
[Graphical view]
PfamiPF00530. SRCR. 1 hit.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTiSM00202. SR. 1 hit.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 2 hits.
PROSITEiPS50287. SRCR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD5_RAT
AccessioniPrimary (citable) accession number: P51882
Secondary accession number(s): Q63098
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.