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P51882 (CD5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
T-cell surface glycoprotein CD5
Alternative name(s):
CD_antigen=CD5
Gene names
Name:Cd5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length491 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May act as a receptor in regulating T-cell proliferation.

Subunit structure

Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Post-translational modification

Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1 By similarity.

Sequence similarities

Contains 3 SRCR domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 491468T-cell surface glycoprotein CD5
PRO_0000033224

Regions

Topological domain25 – 368344Extracellular Potential
Transmembrane369 – 39830Helical; Potential
Topological domain399 – 49193Cytoplasmic Potential
Domain34 – 13198SRCR 1
Domain157 – 266110SRCR 2
Domain274 – 36491SRCR 3

Amino acid modifications

Modified residue4351Phosphoserine By similarity
Modified residue4491Phosphotyrosine By similarity
Modified residue4561Phosphoserine By similarity
Modified residue4791Phosphoserine By similarity
Modified residue4811Phosphoserine By similarity
Glycosylation1141N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Disulfide bond43 ↔ 84 By similarity
Disulfide bond58 ↔ 123 By similarity
Disulfide bond79 ↔ 130 By similarity
Disulfide bond105 ↔ 115 By similarity
Disulfide bond199 ↔ 265 By similarity
Disulfide bond242 ↔ 248 By similarity
Disulfide bond283 ↔ 319 By similarity
Disulfide bond299 ↔ 356 By similarity
Disulfide bond314 ↔ 363 By similarity
Disulfide bond339 ↔ 347 By similarity

Experimental info

Sequence conflict271R → RDGPGKKEHEKGR Ref.2
Sequence conflict218 – 2236GTPAPA → ELQLCS in CAA55586. Ref.2
Sequence conflict370 – 3723GLA → AW in CAA55586. Ref.2
Sequence conflict4451V → M in CAA55586. Ref.2
Sequence conflict457 – 4582RL → W in CAA55586. Ref.2
Sequence conflict4901R → K in CAA55586. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51882 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 88DD76F8E6891CDE

FASTA49153,440
        10         20         30         40         50         60 
MDSHEVLLAA TYLLGTLAAF CLGQSGRGFV GAQVMLSGSN SKCQGLVEVQ MNGMKTVCSS 

        70         80         90        100        110        120 
SWRLSQDLWK NANEASTVCQ QLGCGNPLAL GHLTLWNRPK NQILCQGPPW SFSNCSTSSL 

       130        140        150        160        170        180 
GQCLPLSLVC LEPQKTTPLP TTTLPTTMPE PTAPPRLQLV PGHEGLRCTG VVEFYNGSRG 

       190        200        210        220        230        240 
GTILYKAKAR PVDLGNLICK SLQCGSFLTH LSRIETAGTP APAELRDPRP LPIRWEAQNG 

       250        260        270        280        290        300 
SCTSLQQCFQ KTTVQEGSQA LAVVCSDFQP KVQSRLVGGS SVCEGIAEVR QRSQWAALCD 

       310        320        330        340        350        360 
SSAARGPGRW EELCQEQQCG NLISFHVMDA DRTSPGVLCT QEKLSQCYQL QKKTHCKRVF 

       370        380        390        400        410        420 
ITCKDPNPVG LAPGTVASII LTLVLLVVLM VMCGPLIYKK LVKKFRQKKQ RQWIGPTGVN 

       430        440        450        460        470        480 
QSMSFHRSHT ATVRSQVENP AASHVDNEYS QPPRNSRLSA YPALEGALHR SSTQPDNSSD 

       490 
SDYDLQVAQR L

« Hide

References

[1]"Structure and expression of the Rat Homologue of CD5."
Murakami T., Matsuura A.
Sapporo Igaku Zasshi 61:13-26(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"MRC OX19 recognizes the rat CD5 surface glycoprotein, but does not provide evidence for a population of CD5bright B cells."
Vermeer L.A., Boer de N.K., Bucci C., Bos N.A., Kroese F.G.M., Alberti S.
Eur. J. Immunol. 24:585-592(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: PVG.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		D10728 mRNA. Translation: BAA01571.1.
X78985 mRNA. Translation: CAA55586.1.
IPIIPI00206402.
PIRS43536.
RefSeqNP_062168.1. NM_019295.1.
UniGeneRn.11337.

3D structure databases

ProteinModelPortalP51882.
SMRP51882. Positions 268-365.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-4996821.
STRING10116.ENSRNOP00000028330.

Proteomic databases

PaxDbP51882.
PRIDEP51882.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000054812; ENSRNOP00000051697; ENSRNOG00000020872.
GeneID54236.
KEGGrno:54236.
UCSCRGD:2309. rat.

Organism-specific databases

CTD921.
RGD2309. Cd5.

Phylogenomic databases

eggNOGNOG86650.
GeneTreeENSGT00390000017536.
HOGENOMHOG000111490.
HOVERGENHBG005286.
InParanoidP51882.
KOK06455.
OrthoDBEOG4GB76J.

Gene expression databases

ArrayExpressP51882.
GenevestigatorP51882.
GermOnlineENSRNOG00000020872. Rattus norvegicus.

Family and domain databases

InterProIPR001190. Srcr_rcpt.
IPR017448. Srcr_rcpt-rel.
IPR003566. Tcell_CD5.
[Graphical view]
PANTHERPTHR19331:SF6. PTHR19331:SF6. 1 hit.
PfamPF00530. SRCR. 2 hits.
[Graphical view]
PRINTSPR00258. SPERACTRCPTR.
PR01409. TCELLCD5.
SMARTSM00202. SR. 1 hit.
[Graphical view]
SUPFAMSSF56487. Srcr_receptor. 2 hits.
PROSITEPS00420. SRCR_1. False negative.
PS50287. SRCR_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio610680.

Entry information

Entry nameCD5_RAT
AccessionPrimary (citable) accession number: P51882
Secondary accession number(s): Q63098
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 29, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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