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P51881

- ADT2_MOUSE

UniProt

P51881 - ADT2_MOUSE

Protein

ADP/ATP translocase 2

Gene

Slc25a5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801NucleotideBy similarity

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. chromosome segregation Source: UniProtKB-KW
    2. negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway Source: UniProtKB
    3. positive regulation of cell proliferation Source: UniProtKB
    4. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Chromosome partition, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP/ATP translocase 2
    Alternative name(s):
    ADP,ATP carrier protein 2
    Adenine nucleotide translocator 2
    Short name:
    ANT 2
    Solute carrier family 25 member 5
    Cleaved into the following chain:
    Gene namesi
    Name:Slc25a5
    Synonyms:Ant2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1353496. Slc25a5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: MGI
    3. mitochondrial nucleoid Source: Ensembl
    4. mitochondrion Source: MGI
    5. MMXD complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 298298ADP/ATP translocase 2PRO_0000423221Add
    BLAST
    Initiator methioninei1 – 11Removed; alternate1 Publication
    Chaini2 – 298297ADP/ATP translocase 2, N-terminally processedPRO_0000090580Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processed1 Publication
    Modified residuei23 – 231N6-acetyllysine; alternateCurated
    Modified residuei23 – 231N6-malonyllysine; alternateBy similarity
    Modified residuei43 – 431N6-succinyllysine1 Publication
    Modified residuei52 – 521N6,N6-dimethyllysine; alternateBy similarity
    Modified residuei52 – 521N6-methyllysine; alternateBy similarity
    Modified residuei92 – 921N6-acetyllysine; alternateCurated
    Modified residuei92 – 921N6-malonyllysine; alternateBy similarity
    Modified residuei96 – 961N6-malonyllysineBy similarity
    Modified residuei105 – 1051N6-acetyllysine; alternate2 Publications
    Modified residuei105 – 1051N6-succinyllysine; alternate1 Publication
    Modified residuei147 – 1471N6-acetyllysine; alternate1 Publication
    Modified residuei147 – 1471N6-malonyllysine; alternateBy similarity
    Modified residuei147 – 1471N6-succinyllysine; alternate1 Publication
    Modified residuei155 – 1551N6-acetyllysine; alternate1 Publication
    Modified residuei155 – 1551N6-succinyllysine; alternate1 Publication
    Modified residuei163 – 1631N6-acetyllysine1 Publication
    Modified residuei166 – 1661N6-acetyllysine1 Publication
    Modified residuei268 – 2681N6-acetyllysine; alternate1 Publication
    Modified residuei268 – 2681N6-succinyllysine; alternate1 Publication

    Keywords - PTMi

    Acetylation, Methylation

    Proteomic databases

    MaxQBiP51881.
    PaxDbiP51881.
    PRIDEiP51881.

    PTM databases

    PhosphoSiteiP51881.

    Expressioni

    Gene expression databases

    BgeeiP51881.
    GenevestigatoriP51881.

    Interactioni

    Subunit structurei

    Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi198106. 12 interactions.
    DIPiDIP-31399N.
    IntActiP51881. 11 interactions.
    MINTiMINT-1839032.

    Structurei

    3D structure databases

    ProteinModelPortaliP51881.
    SMRiP51881. Positions 2-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 3935Helical; Name=1By similarityAdd
    BLAST
    Transmembranei75 – 10026Helical; Name=2By similarityAdd
    BLAST
    Transmembranei109 – 14335Helical; Name=3By similarityAdd
    BLAST
    Transmembranei176 – 20227Helical; Name=4By similarityAdd
    BLAST
    Transmembranei207 – 24135Helical; Name=5By similarityAdd
    BLAST
    Transmembranei273 – 29826Helical; Name=6By similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati6 – 9893Solcar 1Add
    BLAST
    Repeati111 – 20191Solcar 2Add
    BLAST
    Repeati212 – 29786Solcar 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi235 – 2406Substrate recognitionBy similarity

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238123.
    HOGENOMiHOG000165727.
    HOVERGENiHBG108348.
    InParanoidiP51881.
    KOiK05863.
    OMAiSSYSAMN.
    OrthoDBiEOG7T1RBR.
    PhylomeDBiP51881.
    TreeFamiTF300743.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51881-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ    50
    YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 100
    GGVDKRTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA 150
    EREFKGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG 200
    MLPDPKNTHI FISWMIAQSV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM 250
    YTGTLDCWRK IARDEGSKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT 298
    Length:298
    Mass (Da):32,931
    Last modified:January 23, 2007 - v3
    Checksum:i0798E04B987EFE20
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27316 mRNA. Translation: AAC52838.1.
    U10404 mRNA. Translation: AAA19009.1.
    X70847 mRNA. Translation: CAA50196.1.
    AF240003 Genomic DNA. Translation: AAF64471.1.
    BC004570 mRNA. Translation: AAH04570.1.
    BC086756 mRNA. Translation: AAH86756.1.
    CCDSiCCDS30062.1.
    PIRiS31814.
    RefSeqiNP_031477.1. NM_007451.3.
    UniGeneiMm.371544.

    Genome annotation databases

    EnsembliENSMUST00000016463; ENSMUSP00000016463; ENSMUSG00000016319.
    GeneIDi11740.
    KEGGimmu:11740.
    UCSCiuc009sxs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U27316 mRNA. Translation: AAC52838.1 .
    U10404 mRNA. Translation: AAA19009.1 .
    X70847 mRNA. Translation: CAA50196.1 .
    AF240003 Genomic DNA. Translation: AAF64471.1 .
    BC004570 mRNA. Translation: AAH04570.1 .
    BC086756 mRNA. Translation: AAH86756.1 .
    CCDSi CCDS30062.1.
    PIRi S31814.
    RefSeqi NP_031477.1. NM_007451.3.
    UniGenei Mm.371544.

    3D structure databases

    ProteinModelPortali P51881.
    SMRi P51881. Positions 2-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198106. 12 interactions.
    DIPi DIP-31399N.
    IntActi P51881. 11 interactions.
    MINTi MINT-1839032.

    PTM databases

    PhosphoSitei P51881.

    Proteomic databases

    MaxQBi P51881.
    PaxDbi P51881.
    PRIDEi P51881.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000016463 ; ENSMUSP00000016463 ; ENSMUSG00000016319 .
    GeneIDi 11740.
    KEGGi mmu:11740.
    UCSCi uc009sxs.1. mouse.

    Organism-specific databases

    CTDi 292.
    MGIi MGI:1353496. Slc25a5.

    Phylogenomic databases

    eggNOGi NOG238123.
    HOGENOMi HOG000165727.
    HOVERGENi HBG108348.
    InParanoidi P51881.
    KOi K05863.
    OMAi SSYSAMN.
    OrthoDBi EOG7T1RBR.
    PhylomeDBi P51881.
    TreeFami TF300743.

    Miscellaneous databases

    NextBioi 279467.
    PROi P51881.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51881.
    Genevestigatori P51881.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rapid evolution of human pseudoautosomal genes and their mouse homologs."
      Ellison J.W., Li X., Francke U., Shapiro L.J.
      Mamm. Genome 7:25-30(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. Sheldon J.G.
      Thesis (1995), University of Cambridge, United Kingdom
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Skeletal muscle.
    3. Costet P., Laplace C.
      Submitted (FEB-1993) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/Sv.
    4. Laplace C.
      Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    5. "Expression and sequence analysis of the mouse adenine nucleotide translocase 1 and 2 genes."
      Levy S.E., Chen Y.-S., Graham B.H., Wallace D.C.
      Gene 254:57-66(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Mammary gland.
    7. Bienvenut W.V.
      Submitted (JUL-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2-31; 34-43; 64-72; 81-92; 97-106 AND 189-199, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT THR-2, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Liver.
    8. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    9. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-43; LYS-105; LYS-147; LYS-155 AND LYS-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast and Liver.
    10. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-105; LYS-147; LYS-155; LYS-163; LYS-166 AND LYS-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiADT2_MOUSE
    AccessioniPrimary (citable) accession number: P51881
    Secondary accession number(s): Q61311
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.By similarity

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3