Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ADP/ATP translocase 2

Gene

Slc25a5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei80NucleotideBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processChromosome partition, Transport

Enzyme and pathway databases

ReactomeiR-MMU-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 2
Alternative name(s):
ADP,ATP carrier protein 2
Adenine nucleotide translocator 2
Short name:
ANT 2
Solute carrier family 25 member 5
Cleaved into the following chain:
Gene namesi
Name:Slc25a5
Synonyms:Ant2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1353496 Slc25a5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232211 – 298ADP/ATP translocase 2Add BLAST298
Initiator methionineiRemoved; alternate1 Publication
ChainiPRO_00000905802 – 298ADP/ATP translocase 2, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 2, N-terminally processed1 Publication1
Modified residuei7PhosphoserineBy similarity1
Modified residuei23N6-malonyllysineBy similarity1
Modified residuei43N6-succinyllysineCombined sources1
Modified residuei52N6,N6,N6-trimethyllysine; alternateBy similarity1
Modified residuei52N6,N6-dimethyllysine; alternateBy similarity1
Modified residuei52N6-methyllysine; alternateBy similarity1
Modified residuei92N6-malonyllysineBy similarity1
Modified residuei96N6-malonyllysineBy similarity1
Modified residuei105N6-acetyllysine; alternateCombined sources1
Modified residuei105N6-succinyllysine; alternateCombined sources1
Modified residuei147N6-acetyllysine; alternateCombined sources1
Modified residuei147N6-malonyllysine; alternateBy similarity1
Modified residuei147N6-methyllysine; alternateBy similarity1
Modified residuei147N6-succinyllysine; alternateCombined sources1
Modified residuei155N6-acetyllysine; alternateCombined sources1
Modified residuei155N6-succinyllysine; alternateCombined sources1
Modified residuei163N6-acetyllysineCombined sources1
Modified residuei166N6-acetyllysineCombined sources1
Modified residuei268N6-acetyllysine; alternateCombined sources1
Modified residuei268N6-succinyllysine; alternateCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP51881
PaxDbiP51881
PeptideAtlasiP51881
PRIDEiP51881
TopDownProteomicsiP51881

PTM databases

iPTMnetiP51881
PhosphoSitePlusiP51881
SwissPalmiP51881

Expressioni

Gene expression databases

BgeeiENSMUSG00000016319
ExpressionAtlasiP51881 baseline and differential
GenevisibleiP51881 MM

Interactioni

Subunit structurei

Homodimer. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198106, 9 interactors
DIPiDIP-31399N
IntActiP51881, 22 interactors
MINTiP51881
STRINGi10090.ENSMUSP00000016463

Structurei

3D structure databases

ProteinModelPortaliP51881
SMRiP51881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOGENOMiHOG000165727
HOVERGENiHBG108348
InParanoidiP51881
KOiK05863
OMAiFRGIHHF
OrthoDBiEOG091G0ULB
PhylomeDBiP51881
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKAGA
160 170 180 190 200
EREFKGLGDC LVKIYKSDGI KGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI FISWMIAQSV TAVAGLTSYP FDTVRRRMMM QSGRKGTDIM
260 270 280 290
YTGTLDCWRK IARDEGSKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT
Length:298
Mass (Da):32,931
Last modified:January 23, 2007 - v3
Checksum:i0798E04B987EFE20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27316 mRNA Translation: AAC52838.1
U10404 mRNA Translation: AAA19009.1
X70847 mRNA Translation: CAA50196.1
AF240003 Genomic DNA Translation: AAF64471.1
BC004570 mRNA Translation: AAH04570.1
BC086756 mRNA Translation: AAH86756.1
CCDSiCCDS30062.1
PIRiS31814
RefSeqiNP_031477.1, NM_007451.4
UniGeneiMm.371544

Genome annotation databases

EnsembliENSMUST00000016463; ENSMUSP00000016463; ENSMUSG00000016319
GeneIDi11740
KEGGimmu:11740
UCSCiuc009sxs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiADT2_MOUSE
AccessioniPrimary (citable) accession number: P51881
Secondary accession number(s): Q61311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 165 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health