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P51880

- FABP7_MOUSE

UniProt

P51880 - FABP7_MOUSE

Protein

Fatty acid-binding protein, brain

Gene

Fabp7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

    GO - Molecular functioni

    1. fatty acid binding Source: BHF-UCL
    2. transporter activity Source: InterPro

    GO - Biological processi

    1. cell proliferation in forebrain Source: MGI
    2. epithelial cell proliferation Source: Ensembl
    3. neurogenesis Source: MGI
    4. prepulse inhibition Source: MGI
    5. startle response Source: MGI

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty acid-binding protein, brain
    Alternative name(s):
    Brain lipid-binding protein
    Short name:
    BLBP
    Brain-type fatty acid-binding protein
    Short name:
    B-FABP
    Fatty acid-binding protein 7
    Gene namesi
    Name:Fabp7
    Synonyms:Blbp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:101916. Fabp7.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: MGI
    2. cell projection Source: MGI
    3. cytosol Source: BHF-UCL
    4. neuronal cell body Source: MGI
    5. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 132131Fatty acid-binding protein, brainPRO_0000067374Add
    BLAST

    Proteomic databases

    MaxQBiP51880.
    PaxDbiP51880.
    PRIDEiP51880.

    PTM databases

    PhosphoSiteiP51880.

    Expressioni

    Tissue specificityi

    Expressed in brain and other neural tissues.

    Gene expression databases

    ArrayExpressiP51880.
    BgeeiP51880.
    CleanExiMM_FABP7.
    GenevestigatoriP51880.

    Structurei

    3D structure databases

    ProteinModelPortaliP51880.
    SMRiP51880. Positions 2-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 1293Fatty acid bindingBy similarity

    Domaini

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG241430.
    GeneTreeiENSGT00750000117272.
    HOGENOMiHOG000004829.
    HOVERGENiHBG005633.
    InParanoidiQ4FJK4.
    KOiK08756.
    OMAiPTIVISH.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiP51880.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51880-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDAFCATWK LTDSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGGKV    50
    VIRTQCTFKN TEINFQLGEE FEETSIDDRN CKSVVRLDGD KLIHVQKWDG 100
    KETNCTREIK DGKMVVTLTF GDIVAVRCYE KA 132
    Length:132
    Mass (Da):14,893
    Last modified:January 23, 2007 - v2
    Checksum:i13D8970E7D8D9C57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04827 Genomic DNA. Translation: AAA81904.1.
    S69799 mRNA. Translation: AAB30595.1.
    AK002955 mRNA. Translation: BAB22478.1.
    AK021271 mRNA. Translation: BAB32356.1.
    CT010401 mRNA. Translation: CAJ18607.1.
    BC055280 mRNA. Translation: AAH55280.1.
    BC057090 mRNA. Translation: AAH57090.1.
    CCDSiCCDS23856.1.
    PIRiI48923.
    RefSeqiNP_067247.1. NM_021272.3.
    UniGeneiMm.3644.

    Genome annotation databases

    EnsembliENSMUST00000020024; ENSMUSP00000020024; ENSMUSG00000019874.
    GeneIDi12140.
    KEGGimmu:12140.
    UCSCiuc007fct.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U04827 Genomic DNA. Translation: AAA81904.1 .
    S69799 mRNA. Translation: AAB30595.1 .
    AK002955 mRNA. Translation: BAB22478.1 .
    AK021271 mRNA. Translation: BAB32356.1 .
    CT010401 mRNA. Translation: CAJ18607.1 .
    BC055280 mRNA. Translation: AAH55280.1 .
    BC057090 mRNA. Translation: AAH57090.1 .
    CCDSi CCDS23856.1.
    PIRi I48923.
    RefSeqi NP_067247.1. NM_021272.3.
    UniGenei Mm.3644.

    3D structure databases

    ProteinModelPortali P51880.
    SMRi P51880. Positions 2-132.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P51880.

    Proteomic databases

    MaxQBi P51880.
    PaxDbi P51880.
    PRIDEi P51880.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020024 ; ENSMUSP00000020024 ; ENSMUSG00000019874 .
    GeneIDi 12140.
    KEGGi mmu:12140.
    UCSCi uc007fct.1. mouse.

    Organism-specific databases

    CTDi 2173.
    MGIi MGI:101916. Fabp7.

    Phylogenomic databases

    eggNOGi NOG241430.
    GeneTreei ENSGT00750000117272.
    HOGENOMi HOG000004829.
    HOVERGENi HBG005633.
    InParanoidi Q4FJK4.
    KOi K08756.
    OMAi PTIVISH.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi P51880.
    TreeFami TF316894.

    Miscellaneous databases

    NextBioi 280461.
    PROi P51880.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51880.
    Bgeei P51880.
    CleanExi MM_FABP7.
    Genevestigatori P51880.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development."
      Kurtz A., Zimmer A., Schnuetgen F., Bruening G., Spener F., Mueller T.
      Development 120:2637-2649(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ICR X Swiss Webster.
      Tissue: Liver.
    2. "Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS."
      Feng L., Hatten M.E., Heintz N.
      Neuron 12:895-908(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain and Spinal cord.
    4. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
      Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Heterologous expression and characterisation of mouse brain fatty acid binding protein."
      Schnutgen F., Borchers T., Muller T., Spener F.
      Biol. Chem. Hoppe-Seyler 377:211-215(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-10.

    Entry informationi

    Entry nameiFABP7_MOUSE
    AccessioniPrimary (citable) accession number: P51880
    Secondary accession number(s): Q4FJK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 117 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3