SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P51880

- FABP7_MOUSE

UniProt

P51880 - FABP7_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Fatty acid-binding protein, brain

Gene
Fabp7, Blbp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

GO - Molecular functioni

  1. fatty acid binding Source: BHF-UCL
  2. transporter activity Source: InterPro

GO - Biological processi

  1. cell proliferation in forebrain Source: MGI
  2. epithelial cell proliferation Source: Ensembl
  3. neurogenesis Source: MGI
  4. prepulse inhibition Source: MGI
  5. startle response Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain lipid-binding protein
Short name:
BLBP
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Gene namesi
Name:Fabp7
Synonyms:Blbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:101916. Fabp7.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: MGI
  2. cell projection Source: MGI
  3. cytosol Source: BHF-UCL
  4. neuronal cell body Source: MGI
  5. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 132131Fatty acid-binding protein, brainPRO_0000067374Add
BLAST

Proteomic databases

MaxQBiP51880.
PaxDbiP51880.
PRIDEiP51880.

PTM databases

PhosphoSiteiP51880.

Expressioni

Tissue specificityi

Expressed in brain and other neural tissues.

Gene expression databases

ArrayExpressiP51880.
BgeeiP51880.
CleanExiMM_FABP7.
GenevestigatoriP51880.

Structurei

3D structure databases

ProteinModelPortaliP51880.
SMRiP51880. Positions 2-132.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid binding By similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior By similarity.

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG241430.
GeneTreeiENSGT00750000117272.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiQ4FJK4.
KOiK08756.
OMAiPTIVISH.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP51880.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51880-1 [UniParc]FASTAAdd to Basket

« Hide

MVDAFCATWK LTDSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGGKV    50
VIRTQCTFKN TEINFQLGEE FEETSIDDRN CKSVVRLDGD KLIHVQKWDG 100
KETNCTREIK DGKMVVTLTF GDIVAVRCYE KA 132
Length:132
Mass (Da):14,893
Last modified:January 23, 2007 - v2
Checksum:i13D8970E7D8D9C57
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04827 Genomic DNA. Translation: AAA81904.1.
S69799 mRNA. Translation: AAB30595.1.
AK002955 mRNA. Translation: BAB22478.1.
AK021271 mRNA. Translation: BAB32356.1.
CT010401 mRNA. Translation: CAJ18607.1.
BC055280 mRNA. Translation: AAH55280.1.
BC057090 mRNA. Translation: AAH57090.1.
CCDSiCCDS23856.1.
PIRiI48923.
RefSeqiNP_067247.1. NM_021272.3.
UniGeneiMm.3644.

Genome annotation databases

EnsembliENSMUST00000020024; ENSMUSP00000020024; ENSMUSG00000019874.
GeneIDi12140.
KEGGimmu:12140.
UCSCiuc007fct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U04827 Genomic DNA. Translation: AAA81904.1 .
S69799 mRNA. Translation: AAB30595.1 .
AK002955 mRNA. Translation: BAB22478.1 .
AK021271 mRNA. Translation: BAB32356.1 .
CT010401 mRNA. Translation: CAJ18607.1 .
BC055280 mRNA. Translation: AAH55280.1 .
BC057090 mRNA. Translation: AAH57090.1 .
CCDSi CCDS23856.1.
PIRi I48923.
RefSeqi NP_067247.1. NM_021272.3.
UniGenei Mm.3644.

3D structure databases

ProteinModelPortali P51880.
SMRi P51880. Positions 2-132.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P51880.

Proteomic databases

MaxQBi P51880.
PaxDbi P51880.
PRIDEi P51880.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020024 ; ENSMUSP00000020024 ; ENSMUSG00000019874 .
GeneIDi 12140.
KEGGi mmu:12140.
UCSCi uc007fct.1. mouse.

Organism-specific databases

CTDi 2173.
MGIi MGI:101916. Fabp7.

Phylogenomic databases

eggNOGi NOG241430.
GeneTreei ENSGT00750000117272.
HOGENOMi HOG000004829.
HOVERGENi HBG005633.
InParanoidi Q4FJK4.
KOi K08756.
OMAi PTIVISH.
OrthoDBi EOG7NW6BZ.
PhylomeDBi P51880.
TreeFami TF316894.

Miscellaneous databases

NextBioi 280461.
PROi P51880.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51880.
Bgeei P51880.
CleanExi MM_FABP7.
Genevestigatori P51880.

Family and domain databases

Gene3Di 2.40.128.20. 1 hit.
InterProi IPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view ]
Pfami PF00061. Lipocalin. 1 hit.
[Graphical view ]
PRINTSi PR00178. FATTYACIDBP.
SUPFAMi SSF50814. SSF50814. 1 hit.
PROSITEi PS00214. FABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development."
    Kurtz A., Zimmer A., Schnuetgen F., Bruening G., Spener F., Mueller T.
    Development 120:2637-2649(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  2. "Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS."
    Feng L., Hatten M.E., Heintz N.
    Neuron 12:895-908(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Spinal cord.
  4. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Heterologous expression and characterisation of mouse brain fatty acid binding protein."
    Schnutgen F., Borchers T., Muller T., Spener F.
    Biol. Chem. Hoppe-Seyler 377:211-215(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10.

Entry informationi

Entry nameiFABP7_MOUSE
AccessioniPrimary (citable) accession number: P51880
Secondary accession number(s): Q4FJK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi