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Protein

Fatty acid-binding protein, brain

Gene

Fabp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.

GO - Molecular functioni

  1. fatty acid binding Source: BHF-UCL
  2. transporter activity Source: InterPro

GO - Biological processi

  1. cell proliferation in forebrain Source: MGI
  2. epithelial cell proliferation Source: Ensembl
  3. neurogenesis Source: MGI
  4. prepulse inhibition Source: MGI
  5. startle response Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid-binding protein, brain
Alternative name(s):
Brain lipid-binding protein
Short name:
BLBP
Brain-type fatty acid-binding protein
Short name:
B-FABP
Fatty acid-binding protein 7
Gene namesi
Name:Fabp7
Synonyms:Blbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:101916. Fabp7.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: MGI
  2. cell projection Source: MGI
  3. cytosol Source: BHF-UCL
  4. neuronal cell body Source: MGI
  5. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Fatty acid-binding protein, brainPRO_0000067374Add
BLAST

Proteomic databases

MaxQBiP51880.
PaxDbiP51880.
PRIDEiP51880.

PTM databases

PhosphoSiteiP51880.

Expressioni

Tissue specificityi

Expressed in brain and other neural tissues.

Gene expression databases

BgeeiP51880.
CleanExiMM_FABP7.
ExpressionAtlasiP51880. baseline and differential.
GenevestigatoriP51880.

Structurei

3D structure databases

ProteinModelPortaliP51880.
SMRiP51880. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid bindingBy similarity

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG241430.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP51880.
KOiK08756.
OMAiPTIVISH.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP51880.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDAFCATWK LTDSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGGKV
60 70 80 90 100
VIRTQCTFKN TEINFQLGEE FEETSIDDRN CKSVVRLDGD KLIHVQKWDG
110 120 130
KETNCTREIK DGKMVVTLTF GDIVAVRCYE KA
Length:132
Mass (Da):14,893
Last modified:January 23, 2007 - v2
Checksum:i13D8970E7D8D9C57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04827 Genomic DNA. Translation: AAA81904.1.
S69799 mRNA. Translation: AAB30595.1.
AK002955 mRNA. Translation: BAB22478.1.
AK021271 mRNA. Translation: BAB32356.1.
CT010401 mRNA. Translation: CAJ18607.1.
BC055280 mRNA. Translation: AAH55280.1.
BC057090 mRNA. Translation: AAH57090.1.
CCDSiCCDS23856.1.
PIRiI48923.
RefSeqiNP_067247.1. NM_021272.3.
UniGeneiMm.3644.

Genome annotation databases

EnsembliENSMUST00000020024; ENSMUSP00000020024; ENSMUSG00000019874.
GeneIDi12140.
KEGGimmu:12140.
UCSCiuc007fct.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04827 Genomic DNA. Translation: AAA81904.1.
S69799 mRNA. Translation: AAB30595.1.
AK002955 mRNA. Translation: BAB22478.1.
AK021271 mRNA. Translation: BAB32356.1.
CT010401 mRNA. Translation: CAJ18607.1.
BC055280 mRNA. Translation: AAH55280.1.
BC057090 mRNA. Translation: AAH57090.1.
CCDSiCCDS23856.1.
PIRiI48923.
RefSeqiNP_067247.1. NM_021272.3.
UniGeneiMm.3644.

3D structure databases

ProteinModelPortaliP51880.
SMRiP51880. Positions 2-132.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP51880.

Proteomic databases

MaxQBiP51880.
PaxDbiP51880.
PRIDEiP51880.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020024; ENSMUSP00000020024; ENSMUSG00000019874.
GeneIDi12140.
KEGGimmu:12140.
UCSCiuc007fct.1. mouse.

Organism-specific databases

CTDi2173.
MGIiMGI:101916. Fabp7.

Phylogenomic databases

eggNOGiNOG241430.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP51880.
KOiK08756.
OMAiPTIVISH.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP51880.
TreeFamiTF316894.

Miscellaneous databases

NextBioi280461.
PROiP51880.
SOURCEiSearch...

Gene expression databases

BgeeiP51880.
CleanExiMM_FABP7.
ExpressionAtlasiP51880. baseline and differential.
GenevestigatoriP51880.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The expression pattern of a novel gene encoding brain-fatty acid binding protein correlates with neuronal and glial cell development."
    Kurtz A., Zimmer A., Schnuetgen F., Bruening G., Spener F., Mueller T.
    Development 120:2637-2649(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ICR X Swiss Webster.
    Tissue: Liver.
  2. "Brain lipid-binding protein (BLBP): a novel signaling system in the developing mammalian CNS."
    Feng L., Hatten M.E., Heintz N.
    Neuron 12:895-908(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Spinal cord.
  4. "Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)."
    Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Heterologous expression and characterisation of mouse brain fatty acid binding protein."
    Schnutgen F., Borchers T., Muller T., Spener F.
    Biol. Chem. Hoppe-Seyler 377:211-215(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-10.

Entry informationi

Entry nameiFABP7_MOUSE
AccessioniPrimary (citable) accession number: P51880
Secondary accession number(s): Q4FJK4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.