Reviewed,
UniProtKB/Swiss-Prot P51878 (CASP5_HUMAN)
Last modified
November 25, 2008.
Version 76.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Caspase-5 Short name=CASP-5 EC=3.4.22.58 Alternative name(s): ICH-3 protease TY protease ICE(rel)-III Cleaved into the following 2 chains: 1- Recommended name: Caspase-5 subunit p20 2- Recommended name: Caspase-5 subunit p10 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 418 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Mediator of programmed cell death (apoptosis). |
| Catalytic activity | Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. |
| Subunit structure | Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. |
| Tissue specificity | Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. |
| Post-translational modification | The two subunits are derived from the precursor sequence by an autocatalytic mechanism. |
| Sequence similarities | Belongs to the peptidase C14 family. Contains 1 CARD domain. |
Ontologies
Keywords | |
|---|---|
| Biological process | Apoptosis |
| Coding sequence diversity | Polymorphism |
| Molecular function | Hydrolase Protease Thiol protease |
| PTM | Zymogen |
Gene Ontology (GO) | |
| Biological process | proteolysis Ref.1 Traceable author statement. Source: ProtInc regulation of apoptosisInferred from electronic annotation. Source: InterPro |
| Cellular component | intracellular Inferred from electronic annotation. Source: InterPro |
| Molecular function | cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Propeptide | 1 – 120 | 120 | Potential | PRO_0000004604 | |||||
| Chain | 121 – 311 | 191 | Caspase-5 subunit p20 | PRO_0000004605 | |||||
| Propeptide | 312 – 330 | 19 | Potential | PRO_0000004606 | |||||
| Chain | 331 – 418 | 88 | Caspase-5 subunit p10 | PRO_0000004607 | |||||
Regions | |||||||||
| Domain | 40 – 132 | 93 | CARD | ||||||
Sites | |||||||||
| Active site | 251 | 1 | By similarity | ||||||
| Active site | 299 | 1 | |||||||
Natural variations | |||||||||
| Natural variant | 3 | 1 | K → N: dbSNP rs45483102. | VAR_047216 | |||||
| Natural variant | 10 | 1 | L → W: dbSNP rs1792778. | VAR_047217 | |||||
| Natural variant | 13 | 1 | F → L: dbSNP rs3181320. | VAR_024403 | |||||
| Natural variant | 90 | 1 | T → A: dbSNP rs507879. | VAR_047218 | |||||
| Natural variant | 152 | 1 | R → H: dbSNP rs3181179. | VAR_024404 | |||||
| Natural variant | 201 | 1 | V → L: dbSNP rs3181326. | VAR_024405 | |||||
| Natural variant | 318 | 1 | L → V: dbSNP rs523104. | VAR_047219 | |||||
| Natural variant | 337 | 1 | E → K: dbSNP rs45619739. | VAR_047220 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases." Munday N.A., Vaillancourt J.P., Ali A., Casano F.J., Miller D.K., Molineaux S.M., Yamin T.-T., Yu V.L., Nicholson D.W. J. Biol. Chem. 270:15870-15876(1995) [PubMed: 7797592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS ALA-90 AND VAL-318. |
| [2] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme." Faucheu C., Blanchet A.-M., Collard-Dutilleul V., Lalanne J.-L., Diu-Hercend A. Eur. J. Biochem. 236:207-213(1996) [PubMed: 8617266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-418, VARIANT ALA-90. Tissue: Placenta and Spleen. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| U28015 mRNA. Translation: AAA75172.1. AP001153 Genomic DNA. No translation available. X94993 mRNA. Translation: CAA64450.1. Different initiation. | |
| PIR | B57511. |
| RefSeq | NP_004338.2. |
| UniGene | Hs.213327 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ICE based on UniProtKB P29466. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | P51878. |
Protein family/group databases | |
| MEROPS | C14.008. |
PTM databases | |
| PhosphoSite | P51878. |
Genome annotation databases | |
| Ensembl | ENSG00000137757. Homo sapiens. [Contig view] |
| GeneID | 838. |
Organism-specific databases | |
| HGNC | HGNC:1506. CASP5. |
| MIM | 602665. gene. |
| PharmGKB | PA26089. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOVERGEN | P51878. |
Gene expression databases | |
| ArrayExpress | P51878. |
| CleanEx | HS_CASP5. |
| GermOnline | ENSG00000137757. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001315. CARD. IPR017350. Caspase_IL-1_beta. IPR011029. DEATH_like. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view] |
| Gene3D | G3DSA:1.10.533.10. DEATH_like. 1 hit. |
| PANTHER | PTHR10454. Pept_C14_p45. 1 hit. |
| Pfam | PF00619. CARD. 1 hit. PF00656. Peptidase_C14. 1 hit. [Graphical view] |
| PIRSF | PIRSF038001. Caspase_ICE. 1 hit. |
| PRINTS | PR00376. IL1BCENZYME. |
| SMART | SM00114. CARD. 1 hit. SM00115. CASc. 1 hit. [Graphical view] |
| PROSITE | PS50209. CARD. 1 hit. PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| BindingDB | P51878. |
| SOURCE | Search... |
Entry information
| Entry name | CASP5_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51878 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


