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P51878

- CASP5_HUMAN

UniProt

P51878 - CASP5_HUMAN

Protein

Caspase-5

Gene

CASP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 3 (20 Apr 2010)
      Previous versions | rss
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    Functioni

    Mediator of programmed cell death (apoptosis).

    Catalytic activityi

    Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei267 – 2671By similarity
    Active sitei315 – 3151

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: RefGenome
    2. cysteine-type peptidase activity Source: ProtInc

    GO - Biological processi

    1. apoptotic process Source: ProtInc
    2. cellular response to mechanical stimulus Source: UniProtKB
    3. execution phase of apoptosis Source: RefGenome
    4. proteolysis Source: ProtInc
    5. regulation of apoptotic process Source: InterPro
    6. regulation of inflammatory response Source: RefGenome
    7. substantia nigra development Source: UniProt

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    BRENDAi3.4.22.58. 2681.
    SABIO-RKP51878.

    Protein family/group databases

    MEROPSiC14.008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caspase-5 (EC:3.4.22.58)
    Short name:
    CASP-5
    Alternative name(s):
    ICE(rel)-III
    Protease ICH-3
    Protease TY
    Cleaved into the following 2 chains:
    Gene namesi
    Name:CASP5
    Synonyms:ICH3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:1506. CASP5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome
    2. NLRP1 inflammasome complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26089.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 136136Sequence AnalysisPRO_0000004604Add
    BLAST
    Chaini137 – 327191Caspase-5 subunit p20PRO_0000004605Add
    BLAST
    Propeptidei328 – 34619Sequence AnalysisPRO_0000004606Add
    BLAST
    Chaini347 – 43488Caspase-5 subunit p10PRO_0000004607Add
    BLAST

    Post-translational modificationi

    The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

    Keywords - PTMi

    Zymogen

    Proteomic databases

    PaxDbiP51878.
    PRIDEiP51878.

    PTM databases

    PhosphoSiteiP51878.

    Expressioni

    Tissue specificityi

    Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

    Inductioni

    Up-regulated by bacterial lipopolysaccharides (LPS).1 Publication

    Gene expression databases

    ArrayExpressiP51878.
    BgeeiP51878.
    CleanExiHS_CASP5.
    GenevestigatoriP51878.

    Organism-specific databases

    HPAiHPA040937.

    Interactioni

    Subunit structurei

    Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.1 Publication

    Protein-protein interaction databases

    BioGridi107288. 1 interaction.
    DIPiDIP-40038N.
    IntActiP51878. 1 interaction.
    MINTiMINT-245149.
    STRINGi9606.ENSP00000376849.

    Structurei

    3D structure databases

    ProteinModelPortaliP51878.
    SMRiP51878. Positions 163-434.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini56 – 14893CARDPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C14A family.Curated
    Contains 1 CARD domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG326166.
    HOVERGENiHBG076981.
    InParanoidiP51878.
    KOiK04395.
    OMAiHDEIYPI.
    PhylomeDBiP51878.
    TreeFamiTF102023.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProiIPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view]
    PfamiPF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
    PRINTSiPR00376. IL1BCENZYME.
    SMARTiSM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing and alternative initiation. Align

    Isoform 1 (identifier: P51878-1) [UniParc]FASTAAdd to Basket

    Also known as: caspase-5/a

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP    50
    NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK 100
    KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE 150
    AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN 200
    TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA 250
    RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC 300
    LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK 350
    IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF 400
    RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN 434

    Note: Most abundant isoform.

    Length:434
    Mass (Da):49,736
    Last modified:April 20, 2010 - v3
    Checksum:iC5257C2BF15EB6D5
    GO
    Isoform 2 (identifier: P51878-2) [UniParc]FASTAAdd to Basket

    Also known as: Caspase-5/b

    The sequence of this isoform differs from the canonical sequence as follows:
         5-62: Missing.

    Note: Most abundant isoform.

    Show »
    Length:376
    Mass (Da):43,261
    Checksum:i7D3035A84418FE31
    GO
    Isoform 3 (identifier: P51878-3) [UniParc]FASTAAdd to Basket

    Also known as: Caspase-5/c

    The sequence of this isoform differs from the canonical sequence as follows:
         1-145: MAEDSGKKKR...MDQKITSVKP → MAA

    Show »
    Length:292
    Mass (Da):33,304
    Checksum:iFD1D1199CB76E857
    GO
    Isoform 4 (identifier: P51878-4) [UniParc]FASTAAdd to Basket

    Also known as: Caspase-5/e

    The sequence of this isoform differs from the canonical sequence as follows:
         5-62: Missing.
         145-166: PLLQIEAGPPESAESTNILKLC → HLSNKKERGPQTPGSHHMQYKV
         167-434: Missing.

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Show »
    Length:108
    Mass (Da):12,694
    Checksum:i2A441B191C453A3C
    GO
    Isoform 5 (identifier: P51878-5) [UniParc]FASTAAdd to Basket

    Also known as: Caspase-5/f

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2: MA → MAAVPRVEGVFIFLI

    Show »
    Length:447
    Mass (Da):51,177
    Checksum:i39D5955FA0419B68
    GO
    Isoform 6 (identifier: P51878-6) [UniParc]FASTAAdd to Basket

    Also known as: Caspase-5-S

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.

    Note: Produced by alternative initiation at Met-71 of isoform 1.

    Show »
    Length:364
    Mass (Da):41,851
    Checksum:i64533BAB7E528B37
    GO

    Sequence cautioni

    The sequence BAG59257.1 differs from that shown. Reason: Frameshift at position 10.
    The sequence AAA75172.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAH74994.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI13407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence ABF47103.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA64450.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191K → N.1 Publication
    Corresponds to variant rs45483102 [ dbSNP | Ensembl ].
    VAR_047216
    Natural varianti26 – 261L → W.
    Corresponds to variant rs1792778 [ dbSNP | Ensembl ].
    VAR_047217
    Natural varianti29 – 291F → L.2 Publications
    Corresponds to variant rs3181320 [ dbSNP | Ensembl ].
    VAR_024403
    Natural varianti75 – 751L → R.1 Publication
    Corresponds to variant rs45585331 [ dbSNP | Ensembl ].
    VAR_054480
    Natural varianti106 – 1061T → A.7 Publications
    Corresponds to variant rs507879 [ dbSNP | Ensembl ].
    VAR_047218
    Natural varianti168 – 1681R → H.2 Publications
    Corresponds to variant rs3181179 [ dbSNP | Ensembl ].
    VAR_024404
    Natural varianti217 – 2171V → L.2 Publications
    Corresponds to variant rs3181326 [ dbSNP | Ensembl ].
    VAR_024405
    Natural varianti298 – 2981R → H.1 Publication
    Corresponds to variant rs45464699 [ dbSNP | Ensembl ].
    VAR_054481
    Natural varianti334 – 3341L → V.4 Publications
    Corresponds to variant rs523104 [ dbSNP | Ensembl ].
    VAR_047219
    Natural varianti353 – 3531E → K.1 Publication
    Corresponds to variant rs45619739 [ dbSNP | Ensembl ].
    VAR_047220
    Natural varianti382 – 3821E → Q.1 Publication
    Corresponds to variant rs45458695 [ dbSNP | Ensembl ].
    VAR_054482

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 145145MAEDS…TSVKP → MAA in isoform 3. 1 PublicationVSP_038990Add
    BLAST
    Alternative sequencei1 – 7070Missing in isoform 6. CuratedVSP_038991Add
    BLAST
    Alternative sequencei1 – 22MA → MAAVPRVEGVFIFLI in isoform 5. 1 PublicationVSP_038992
    Alternative sequencei5 – 6258Missing in isoform 2 and isoform 4. 2 PublicationsVSP_038993Add
    BLAST
    Alternative sequencei145 – 16622PLLQI…ILKLC → HLSNKKERGPQTPGSHHMQY KV in isoform 4. 1 PublicationVSP_038994Add
    BLAST
    Alternative sequencei167 – 434268Missing in isoform 4. 1 PublicationVSP_038995Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ228672 mRNA. Translation: ABB58698.1.
    DQ228673 mRNA. Translation: ABB58699.1.
    DQ228674 mRNA. Translation: ABB58700.1.
    DQ228676 mRNA. Translation: ABB58702.1.
    DQ228677 mRNA. Translation: ABB58703.1.
    AK296660 mRNA. Translation: BAG59257.1. Frameshift.
    AP001153 Genomic DNA. No translation available.
    U28015 mRNA. Translation: AAA75172.1. Different initiation.
    BC074994 mRNA. Translation: AAH74994.1. Different initiation.
    BC113406 mRNA. Translation: AAI13407.1. Different initiation.
    X94993 mRNA. Translation: CAA64450.1. Different initiation.
    DQ508420 Genomic DNA. Translation: ABF47103.1. Different initiation.
    CH471065 Genomic DNA. Translation: EAW67054.1.
    CCDSiCCDS44718.1. [P51878-3]
    CCDS44719.1. [P51878-2]
    CCDS44720.1. [P51878-5]
    CCDS8328.2. [P51878-1]
    PIRiB57511.
    RefSeqiNP_001129581.1. NM_001136109.1. [P51878-2]
    NP_001129582.1. NM_001136110.1. [P51878-3]
    NP_001129584.1. NM_001136112.1. [P51878-5]
    NP_004338.3. NM_004347.3. [P51878-1]
    UniGeneiHs.213327.

    Genome annotation databases

    EnsembliENST00000260315; ENSP00000260315; ENSG00000137757. [P51878-1]
    ENST00000393141; ENSP00000376849; ENSG00000137757. [P51878-5]
    ENST00000418434; ENSP00000398130; ENSG00000137757. [P51878-3]
    ENST00000444749; ENSP00000388365; ENSG00000137757. [P51878-2]
    ENST00000456200; ENSP00000408455; ENSG00000137757. [P51878-4]
    ENST00000526056; ENSP00000436877; ENSG00000137757. [P51878-5]
    ENST00000531367; ENSP00000434471; ENSG00000137757. [P51878-3]
    GeneIDi838.
    KEGGihsa:838.
    UCSCiuc009yxh.2. human. [P51878-3]
    uc010ruz.1. human. [P51878-5]
    uc010rva.1. human. [P51878-1]
    uc010rvb.1. human. [P51878-2]

    Polymorphism databases

    DMDMi294862523.

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ228672 mRNA. Translation: ABB58698.1 .
    DQ228673 mRNA. Translation: ABB58699.1 .
    DQ228674 mRNA. Translation: ABB58700.1 .
    DQ228676 mRNA. Translation: ABB58702.1 .
    DQ228677 mRNA. Translation: ABB58703.1 .
    AK296660 mRNA. Translation: BAG59257.1 . Frameshift.
    AP001153 Genomic DNA. No translation available.
    U28015 mRNA. Translation: AAA75172.1 . Different initiation.
    BC074994 mRNA. Translation: AAH74994.1 . Different initiation.
    BC113406 mRNA. Translation: AAI13407.1 . Different initiation.
    X94993 mRNA. Translation: CAA64450.1 . Different initiation.
    DQ508420 Genomic DNA. Translation: ABF47103.1 . Different initiation.
    CH471065 Genomic DNA. Translation: EAW67054.1 .
    CCDSi CCDS44718.1. [P51878-3 ]
    CCDS44719.1. [P51878-2 ]
    CCDS44720.1. [P51878-5 ]
    CCDS8328.2. [P51878-1 ]
    PIRi B57511.
    RefSeqi NP_001129581.1. NM_001136109.1. [P51878-2 ]
    NP_001129582.1. NM_001136110.1. [P51878-3 ]
    NP_001129584.1. NM_001136112.1. [P51878-5 ]
    NP_004338.3. NM_004347.3. [P51878-1 ]
    UniGenei Hs.213327.

    3D structure databases

    ProteinModelPortali P51878.
    SMRi P51878. Positions 163-434.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107288. 1 interaction.
    DIPi DIP-40038N.
    IntActi P51878. 1 interaction.
    MINTi MINT-245149.
    STRINGi 9606.ENSP00000376849.

    Chemistry

    BindingDBi P51878.
    ChEMBLi CHEMBL3131.
    GuidetoPHARMACOLOGYi 1621.

    Protein family/group databases

    MEROPSi C14.008.

    PTM databases

    PhosphoSitei P51878.

    Polymorphism databases

    DMDMi 294862523.

    Proteomic databases

    PaxDbi P51878.
    PRIDEi P51878.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000260315 ; ENSP00000260315 ; ENSG00000137757 . [P51878-1 ]
    ENST00000393141 ; ENSP00000376849 ; ENSG00000137757 . [P51878-5 ]
    ENST00000418434 ; ENSP00000398130 ; ENSG00000137757 . [P51878-3 ]
    ENST00000444749 ; ENSP00000388365 ; ENSG00000137757 . [P51878-2 ]
    ENST00000456200 ; ENSP00000408455 ; ENSG00000137757 . [P51878-4 ]
    ENST00000526056 ; ENSP00000436877 ; ENSG00000137757 . [P51878-5 ]
    ENST00000531367 ; ENSP00000434471 ; ENSG00000137757 . [P51878-3 ]
    GeneIDi 838.
    KEGGi hsa:838.
    UCSCi uc009yxh.2. human. [P51878-3 ]
    uc010ruz.1. human. [P51878-5 ]
    uc010rva.1. human. [P51878-1 ]
    uc010rvb.1. human. [P51878-2 ]

    Organism-specific databases

    CTDi 838.
    GeneCardsi GC11M104864.
    HGNCi HGNC:1506. CASP5.
    HPAi HPA040937.
    MIMi 602665. gene.
    neXtProti NX_P51878.
    PharmGKBi PA26089.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG326166.
    HOVERGENi HBG076981.
    InParanoidi P51878.
    KOi K04395.
    OMAi HDEIYPI.
    PhylomeDBi P51878.
    TreeFami TF102023.

    Enzyme and pathway databases

    BRENDAi 3.4.22.58. 2681.
    SABIO-RK P51878.

    Miscellaneous databases

    GenomeRNAii 838.
    NextBioi 3490.
    PROi P51878.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51878.
    Bgeei P51878.
    CleanExi HS_CASP5.
    Genevestigatori P51878.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    3.40.50.1460. 1 hit.
    InterProi IPR001315. CARD.
    IPR029030. Caspase-like_dom.
    IPR017350. Caspase_ICE-type.
    IPR011029. DEATH-like_dom.
    IPR011600. Pept_C14_caspase.
    IPR001309. Pept_C14_ICE_p20.
    IPR016129. Pept_C14_ICE_p20_AS.
    IPR002138. Pept_C14_p10.
    IPR015917. Pept_C14A_p45_core.
    [Graphical view ]
    Pfami PF00619. CARD. 1 hit.
    PF00656. Peptidase_C14. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
    PRINTSi PR00376. IL1BCENZYME.
    SMARTi SM00114. CARD. 1 hit.
    SM00115. CASc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50209. CARD. 1 hit.
    PS01122. CASPASE_CYS. 1 hit.
    PS01121. CASPASE_HIS. 1 hit.
    PS50207. CASPASE_P10. 1 hit.
    PS50208. CASPASE_P20. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants."
      Eckhart L., Kittel C., Gawlas S., Gruber F., Mildner M., Jilma B., Tschachler E.
      Biochem. Biophys. Res. Commun. 348:682-688(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), ALTERNATIVE SPLICING (ISOFORM 6), VARIANTS ALA-106 AND VAL-334, INDUCTION BY LPS.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-106.
      Tissue: Colon.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases."
      Munday N.A., Vaillancourt J.P., Ali A., Casano F.J., Miller D.K., Molineaux S.M., Yamin T.-T., Yu V.L., Nicholson D.W.
      J. Biol. Chem. 270:15870-15876(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-434 (ISOFORM 1), VARIANTS ALA-106 AND VAL-334.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-434 (ISOFORM 1), VARIANTS LEU-29; ALA-106; HIS-168; LEU-217 AND VAL-334.
      Tissue: Colon.
    6. "Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme."
      Faucheu C., Blanchet A.-M., Collard-Dutilleul V., Lalanne J.-L., Diu-Hercend A.
      Eur. J. Biochem. 236:207-213(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-434, VARIANT ALA-106.
      Tissue: Placenta and Spleen.
    7. NIEHS SNPs program
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-19; LEU-29; ARG-75; ALA-106; HIS-168; LEU-217; HIS-298; VAL-334; LYS-353 AND GLN-382.
    8. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-106.
    9. "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
      Papin S., Cuenin S., Agostini L., Martinon F., Werner S., Beer H.D., Grutter C., Grutter M., Tschopp J.
      Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEFV.

    Entry informationi

    Entry nameiCASP5_HUMAN
    AccessioniPrimary (citable) accession number: P51878
    Secondary accession number(s): B4DKP5
    , Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6, Q1HBJ3, Q6DJV7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: April 20, 2010
    Last modified: October 1, 2014
    This is version 138 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Peptidase families
      Classification of peptidase families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3