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P51878

- CASP5_HUMAN

UniProt

P51878 - CASP5_HUMAN

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Protein

Caspase-5

Gene

CASP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Mediator of programmed cell death (apoptosis).

Catalytic activityi

Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei267 – 2671By similarity
Active sitei315 – 3151

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome
  2. cysteine-type peptidase activity Source: ProtInc

GO - Biological processi

  1. apoptotic process Source: ProtInc
  2. cellular response to mechanical stimulus Source: UniProtKB
  3. execution phase of apoptosis Source: RefGenome
  4. proteolysis Source: ProtInc
  5. regulation of apoptotic process Source: InterPro
  6. regulation of inflammatory response Source: RefGenome
  7. substantia nigra development Source: UniProt
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BRENDAi3.4.22.58. 2681.
SABIO-RKP51878.

Protein family/group databases

MEROPSiC14.008.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-5 (EC:3.4.22.58)
Short name:
CASP-5
Alternative name(s):
ICE(rel)-III
Protease ICH-3
Protease TY
Cleaved into the following 2 chains:
Gene namesi
Name:CASP5
Synonyms:ICH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:1506. CASP5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. NLRP1 inflammasome complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26089.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 136136Sequence AnalysisPRO_0000004604Add
BLAST
Chaini137 – 327191Caspase-5 subunit p20PRO_0000004605Add
BLAST
Propeptidei328 – 34619Sequence AnalysisPRO_0000004606Add
BLAST
Chaini347 – 43488Caspase-5 subunit p10PRO_0000004607Add
BLAST

Post-translational modificationi

The two subunits are derived from the precursor sequence by an autocatalytic mechanism.

Keywords - PTMi

Zymogen

Proteomic databases

PaxDbiP51878.
PRIDEiP51878.

PTM databases

PhosphoSiteiP51878.

Expressioni

Tissue specificityi

Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle.

Inductioni

Up-regulated by bacterial lipopolysaccharides (LPS).1 Publication

Gene expression databases

BgeeiP51878.
CleanExiHS_CASP5.
ExpressionAtlasiP51878. baseline and differential.
GenevestigatoriP51878.

Organism-specific databases

HPAiHPA040937.

Interactioni

Subunit structurei

Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 10 kDa (p10) subunits. Interacts with MEFV.1 Publication

Protein-protein interaction databases

BioGridi107288. 1 interaction.
DIPiDIP-40038N.
IntActiP51878. 1 interaction.
MINTiMINT-245149.
STRINGi9606.ENSP00000376849.

Structurei

3D structure databases

ProteinModelPortaliP51878.
SMRiP51878. Positions 163-434.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini56 – 14893CARDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C14A family.Curated
Contains 1 CARD domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG326166.
GeneTreeiENSGT00760000118912.
HOVERGENiHBG076981.
InParanoidiP51878.
KOiK04395.
OMAiHDEIYPI.
PhylomeDBiP51878.
TreeFamiTF102023.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProiIPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view]
PIRSFiPIRSF038001. Caspase_ICE. 1 hit.
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform 1 (identifier: P51878) [UniParc]FASTAAdd to Basket

Also known as: caspase-5/a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEDSGKKKR RKNFEAMFKG ILQSGLDNFV INHMLKNNVA GQTSIQTLVP
60 70 80 90 100
NTDQKSTSVK KDNHKKKTVK MLEYLGKDVL HGVFNYLAKH DVLTLKEEEK
110 120 130 140 150
KKYYDTKIED KALILVDSLR KNRVAHQMFT QTLLNMDQKI TSVKPLLQIE
160 170 180 190 200
AGPPESAEST NILKLCPREE FLRLCKKNHD EIYPIKKRED RRRLALIICN
210 220 230 240 250
TKFDHLPARN GAHYDIVGMK RLLQGLGYTV VDEKNLTARD MESVLRAFAA
260 270 280 290 300
RPEHKSSDST FLVLMSHGIL EGICGTAHKK KKPDVLLYDT IFQIFNNRNC
310 320 330 340 350
LSLKDKPKVI IVQACRGEKH GELWVRDSPA SLALISSQSS ENLEADSVCK
360 370 380 390 400
IHEEKDFIAF CSSTPHNVSW RDRTRGSIFI TELITCFQKY SCCCHLMEIF
410 420 430
RKVQKSFEVP QAKAQMPTIE RATLTRDFYL FPGN

Note: Most abundant isoform.

Length:434
Mass (Da):49,736
Last modified:April 20, 2010 - v3
Checksum:iC5257C2BF15EB6D5
GO
Isoform 2 (identifier: P51878-2) [UniParc]FASTAAdd to Basket

Also known as: Caspase-5/b

The sequence of this isoform differs from the canonical sequence as follows:
     5-62: Missing.

Note: Most abundant isoform.

Show »
Length:376
Mass (Da):43,261
Checksum:i7D3035A84418FE31
GO
Isoform 3 (identifier: P51878-3) [UniParc]FASTAAdd to Basket

Also known as: Caspase-5/c

The sequence of this isoform differs from the canonical sequence as follows:
     1-145: MAEDSGKKKR...MDQKITSVKP → MAA

Show »
Length:292
Mass (Da):33,304
Checksum:iFD1D1199CB76E857
GO
Isoform 4 (identifier: P51878-4) [UniParc]FASTAAdd to Basket

Also known as: Caspase-5/e

The sequence of this isoform differs from the canonical sequence as follows:
     5-62: Missing.
     145-166: PLLQIEAGPPESAESTNILKLC → HLSNKKERGPQTPGSHHMQYKV
     167-434: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »
Length:108
Mass (Da):12,694
Checksum:i2A441B191C453A3C
GO
Isoform 5 (identifier: P51878-5) [UniParc]FASTAAdd to Basket

Also known as: Caspase-5/f

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MA → MAAVPRVEGVFIFLI

Show »
Length:447
Mass (Da):51,177
Checksum:i39D5955FA0419B68
GO
Isoform 6 (identifier: P51878-6) [UniParc]FASTAAdd to Basket

Also known as: Caspase-5-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: Produced by alternative initiation at Met-71 of isoform 1.

Show »
Length:364
Mass (Da):41,851
Checksum:i64533BAB7E528B37
GO

Sequence cautioni

The sequence BAG59257.1 differs from that shown. Reason: Frameshift at position 10.
The sequence AAA75172.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAH74994.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAI13407.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence ABF47103.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA64450.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191K → N.1 Publication
Corresponds to variant rs45483102 [ dbSNP | Ensembl ].
VAR_047216
Natural varianti26 – 261L → W.
Corresponds to variant rs1792778 [ dbSNP | Ensembl ].
VAR_047217
Natural varianti29 – 291F → L.2 Publications
Corresponds to variant rs3181320 [ dbSNP | Ensembl ].
VAR_024403
Natural varianti75 – 751L → R.1 Publication
Corresponds to variant rs45585331 [ dbSNP | Ensembl ].
VAR_054480
Natural varianti106 – 1061T → A.7 Publications
Corresponds to variant rs507879 [ dbSNP | Ensembl ].
VAR_047218
Natural varianti168 – 1681R → H.2 Publications
Corresponds to variant rs3181179 [ dbSNP | Ensembl ].
VAR_024404
Natural varianti217 – 2171V → L.2 Publications
Corresponds to variant rs3181326 [ dbSNP | Ensembl ].
VAR_024405
Natural varianti298 – 2981R → H.1 Publication
Corresponds to variant rs45464699 [ dbSNP | Ensembl ].
VAR_054481
Natural varianti334 – 3341L → V.4 Publications
Corresponds to variant rs523104 [ dbSNP | Ensembl ].
VAR_047219
Natural varianti353 – 3531E → K.1 Publication
Corresponds to variant rs45619739 [ dbSNP | Ensembl ].
VAR_047220
Natural varianti382 – 3821E → Q.1 Publication
Corresponds to variant rs45458695 [ dbSNP | Ensembl ].
VAR_054482

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 145145MAEDS…TSVKP → MAA in isoform 3. 1 PublicationVSP_038990Add
BLAST
Alternative sequencei1 – 7070Missing in isoform 6. CuratedVSP_038991Add
BLAST
Alternative sequencei1 – 22MA → MAAVPRVEGVFIFLI in isoform 5. 1 PublicationVSP_038992
Alternative sequencei5 – 6258Missing in isoform 2 and isoform 4. 2 PublicationsVSP_038993Add
BLAST
Alternative sequencei145 – 16622PLLQI…ILKLC → HLSNKKERGPQTPGSHHMQY KV in isoform 4. 1 PublicationVSP_038994Add
BLAST
Alternative sequencei167 – 434268Missing in isoform 4. 1 PublicationVSP_038995Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ228672 mRNA. Translation: ABB58698.1.
DQ228673 mRNA. Translation: ABB58699.1.
DQ228674 mRNA. Translation: ABB58700.1.
DQ228676 mRNA. Translation: ABB58702.1.
DQ228677 mRNA. Translation: ABB58703.1.
AK296660 mRNA. Translation: BAG59257.1. Frameshift.
AP001153 Genomic DNA. No translation available.
U28015 mRNA. Translation: AAA75172.1. Different initiation.
BC074994 mRNA. Translation: AAH74994.1. Different initiation.
BC113406 mRNA. Translation: AAI13407.1. Different initiation.
X94993 mRNA. Translation: CAA64450.1. Different initiation.
DQ508420 Genomic DNA. Translation: ABF47103.1. Different initiation.
CH471065 Genomic DNA. Translation: EAW67054.1.
CCDSiCCDS44718.1. [P51878-3]
CCDS44719.1. [P51878-2]
CCDS44720.1. [P51878-5]
CCDS8328.2. [P51878-1]
PIRiB57511.
RefSeqiNP_001129581.1. NM_001136109.1. [P51878-2]
NP_001129582.1. NM_001136110.1. [P51878-3]
NP_001129584.1. NM_001136112.1. [P51878-5]
NP_004338.3. NM_004347.3. [P51878-1]
UniGeneiHs.213327.

Genome annotation databases

EnsembliENST00000260315; ENSP00000260315; ENSG00000137757. [P51878-1]
ENST00000393141; ENSP00000376849; ENSG00000137757. [P51878-5]
ENST00000418434; ENSP00000398130; ENSG00000137757. [P51878-3]
ENST00000444749; ENSP00000388365; ENSG00000137757. [P51878-2]
ENST00000456200; ENSP00000408455; ENSG00000137757. [P51878-4]
ENST00000526056; ENSP00000436877; ENSG00000137757. [P51878-5]
ENST00000531367; ENSP00000434471; ENSG00000137757. [P51878-3]
GeneIDi838.
KEGGihsa:838.
UCSCiuc009yxh.2. human. [P51878-3]
uc010ruz.1. human. [P51878-5]
uc010rva.1. human. [P51878-1]
uc010rvb.1. human. [P51878-2]

Polymorphism databases

DMDMi294862523.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ228672 mRNA. Translation: ABB58698.1 .
DQ228673 mRNA. Translation: ABB58699.1 .
DQ228674 mRNA. Translation: ABB58700.1 .
DQ228676 mRNA. Translation: ABB58702.1 .
DQ228677 mRNA. Translation: ABB58703.1 .
AK296660 mRNA. Translation: BAG59257.1 . Frameshift.
AP001153 Genomic DNA. No translation available.
U28015 mRNA. Translation: AAA75172.1 . Different initiation.
BC074994 mRNA. Translation: AAH74994.1 . Different initiation.
BC113406 mRNA. Translation: AAI13407.1 . Different initiation.
X94993 mRNA. Translation: CAA64450.1 . Different initiation.
DQ508420 Genomic DNA. Translation: ABF47103.1 . Different initiation.
CH471065 Genomic DNA. Translation: EAW67054.1 .
CCDSi CCDS44718.1. [P51878-3 ]
CCDS44719.1. [P51878-2 ]
CCDS44720.1. [P51878-5 ]
CCDS8328.2. [P51878-1 ]
PIRi B57511.
RefSeqi NP_001129581.1. NM_001136109.1. [P51878-2 ]
NP_001129582.1. NM_001136110.1. [P51878-3 ]
NP_001129584.1. NM_001136112.1. [P51878-5 ]
NP_004338.3. NM_004347.3. [P51878-1 ]
UniGenei Hs.213327.

3D structure databases

ProteinModelPortali P51878.
SMRi P51878. Positions 163-434.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107288. 1 interaction.
DIPi DIP-40038N.
IntActi P51878. 1 interaction.
MINTi MINT-245149.
STRINGi 9606.ENSP00000376849.

Chemistry

BindingDBi P51878.
ChEMBLi CHEMBL3131.
GuidetoPHARMACOLOGYi 1621.

Protein family/group databases

MEROPSi C14.008.

PTM databases

PhosphoSitei P51878.

Polymorphism databases

DMDMi 294862523.

Proteomic databases

PaxDbi P51878.
PRIDEi P51878.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000260315 ; ENSP00000260315 ; ENSG00000137757 . [P51878-1 ]
ENST00000393141 ; ENSP00000376849 ; ENSG00000137757 . [P51878-5 ]
ENST00000418434 ; ENSP00000398130 ; ENSG00000137757 . [P51878-3 ]
ENST00000444749 ; ENSP00000388365 ; ENSG00000137757 . [P51878-2 ]
ENST00000456200 ; ENSP00000408455 ; ENSG00000137757 . [P51878-4 ]
ENST00000526056 ; ENSP00000436877 ; ENSG00000137757 . [P51878-5 ]
ENST00000531367 ; ENSP00000434471 ; ENSG00000137757 . [P51878-3 ]
GeneIDi 838.
KEGGi hsa:838.
UCSCi uc009yxh.2. human. [P51878-3 ]
uc010ruz.1. human. [P51878-5 ]
uc010rva.1. human. [P51878-1 ]
uc010rvb.1. human. [P51878-2 ]

Organism-specific databases

CTDi 838.
GeneCardsi GC11M104864.
HGNCi HGNC:1506. CASP5.
HPAi HPA040937.
MIMi 602665. gene.
neXtProti NX_P51878.
PharmGKBi PA26089.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG326166.
GeneTreei ENSGT00760000118912.
HOVERGENi HBG076981.
InParanoidi P51878.
KOi K04395.
OMAi HDEIYPI.
PhylomeDBi P51878.
TreeFami TF102023.

Enzyme and pathway databases

BRENDAi 3.4.22.58. 2681.
SABIO-RK P51878.

Miscellaneous databases

GenomeRNAii 838.
NextBioi 3490.
PROi P51878.
SOURCEi Search...

Gene expression databases

Bgeei P51878.
CleanExi HS_CASP5.
ExpressionAtlasi P51878. baseline and differential.
Genevestigatori P51878.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
3.40.50.1460. 1 hit.
InterProi IPR001315. CARD.
IPR029030. Caspase-like_dom.
IPR017350. Caspase_ICE-type.
IPR011029. DEATH-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00619. CARD. 1 hit.
PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PIRSFi PIRSF038001. Caspase_ICE. 1 hit.
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00114. CARD. 1 hit.
SM00115. CASc. 1 hit.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50209. CARD. 1 hit.
PS01122. CASPASE_CYS. 1 hit.
PS01121. CASPASE_HIS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel exon encoding the amino-terminus of the predominant caspase-5 variants."
    Eckhart L., Kittel C., Gawlas S., Gruber F., Mildner M., Jilma B., Tschachler E.
    Biochem. Biophys. Res. Commun. 348:682-688(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5), ALTERNATIVE SPLICING (ISOFORM 6), VARIANTS ALA-106 AND VAL-334, INDUCTION BY LPS.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-106.
    Tissue: Colon.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Molecular cloning and pro-apoptotic activity of ICErelII and ICErelIII, members of the ICE/CED-3 family of cysteine proteases."
    Munday N.A., Vaillancourt J.P., Ali A., Casano F.J., Miller D.K., Molineaux S.M., Yamin T.-T., Yu V.L., Nicholson D.W.
    J. Biol. Chem. 270:15870-15876(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-434 (ISOFORM 1), VARIANTS ALA-106 AND VAL-334.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-434 (ISOFORM 1), VARIANTS LEU-29; ALA-106; HIS-168; LEU-217 AND VAL-334.
    Tissue: Colon.
  6. "Identification of a cysteine protease closely related to interleukin-1 beta-converting enzyme."
    Faucheu C., Blanchet A.-M., Collard-Dutilleul V., Lalanne J.-L., Diu-Hercend A.
    Eur. J. Biochem. 236:207-213(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 37-434, VARIANT ALA-106.
    Tissue: Placenta and Spleen.
  7. NIEHS SNPs program
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ASN-19; LEU-29; ARG-75; ALA-106; HIS-168; LEU-217; HIS-298; VAL-334; LYS-353 AND GLN-382.
  8. Cited for: PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-106.
  9. "The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing."
    Papin S., Cuenin S., Agostini L., Martinon F., Werner S., Beer H.D., Grutter C., Grutter M., Tschopp J.
    Cell Death Differ. 14:1457-1466(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEFV.

Entry informationi

Entry nameiCASP5_HUMAN
AccessioniPrimary (citable) accession number: P51878
Secondary accession number(s): B4DKP5
, Q0QVY7, Q0QVY8, Q0QVZ0, Q0QVZ1, Q0QVZ2, Q14DD6, Q1HBJ3, Q6DJV7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3