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P51871

- CP4F6_RAT

UniProt

P51871 - CP4F6_RAT

Protein

Cytochrome P450 4F6

Gene

Cyp4f6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi468 – 4681Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: RGD
    2. leukotriene metabolic process Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4F6 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVF6
    Gene namesi
    Name:Cyp4f6
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi708365. Cyp4f6.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Cytochrome P450 4F6PRO_0000051854Add
    BLAST

    Proteomic databases

    PaxDbiP51871.
    PRIDEiP51871.

    PTM databases

    PhosphoSiteiP51871.

    Expressioni

    Tissue specificityi

    High expression in liver and kidney. Lower expression in brain.

    Gene expression databases

    GenevestigatoriP51871.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006335.

    Structurei

    3D structure databases

    ProteinModelPortaliP51871.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110562.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiP51871.
    KOiK17726.
    OMAiIPKDMFF.
    OrthoDBiEOG7CNZFK.
    PhylomeDBiP51871.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51871-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLQLSLSRLG MGSLTASPWH LLLLGGASWI LARILAWIYT FYDNCCRLRC    50
    FPQPPKPSWF WGHLTLMKNN EEGMQFIAHL GRNFRDIHLS WVGPVYPILR 100
    LVHPNVIAPL LQASAAVAPK EMTLYGFLKP WLGDGLLMSA GEKWNHHRRL 150
    LTPAFHFDIL KSYVKIFNKS VNTMHAKWQR LTAKGSARLD MFEHISLMTL 200
    DSLQKCIFSF DSNCQESNSE YIAAILELSS LIVKRQRQPF LYLDFLYYLT 250
    ADGRRFRKAC DVVHNFTDAV IRERRSTLNT QGVDEFLKAR AKTKTLDFID 300
    VLLLAKDEHG KGLSDVDIRA EADTFMFGGH DTTASALSWI LYNLARHPEY 350
    QERCRQEVRE LLRDREPEEI EWDDLAQLPF LTMCIKESLR LHPPVLLISR 400
    CCSQDIVLPD GRVIPKGNIC VISIFGVHHN PSVWPDPEVY NPFRFDPENP 450
    QKRSPLAFIP FSAGPRNCIG QTFAMSEIKV ALALTLLRFC VLPDDKEPRR 500
    KPELILRAEG GLWLRVEPLS TVTSQLPWDL LAHPPTS 537
    Length:537
    Mass (Da):61,541
    Last modified:October 1, 1996 - v1
    Checksum:i4D96D761A2BEA7E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39208 mRNA. Translation: AAC52360.1.
    PIRiJC4534.
    RefSeqiNP_695230.1. NM_153318.1.
    XP_006241111.1. XM_006241049.1.
    UniGeneiRn.11269.

    Genome annotation databases

    EnsembliENSRNOT00000006335; ENSRNOP00000006335; ENSRNOG00000034157.
    GeneIDi266689.
    KEGGirno:266689.
    UCSCiRGD:708365. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39208 mRNA. Translation: AAC52360.1 .
    PIRi JC4534.
    RefSeqi NP_695230.1. NM_153318.1.
    XP_006241111.1. XM_006241049.1.
    UniGenei Rn.11269.

    3D structure databases

    ProteinModelPortali P51871.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006335.

    PTM databases

    PhosphoSitei P51871.

    Proteomic databases

    PaxDbi P51871.
    PRIDEi P51871.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000006335 ; ENSRNOP00000006335 ; ENSRNOG00000034157 .
    GeneIDi 266689.
    KEGGi rno:266689.
    UCSCi RGD:708365. rat.

    Organism-specific databases

    CTDi 266689.
    RGDi 708365. Cyp4f6.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110562.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi P51871.
    KOi K17726.
    OMAi IPKDMFF.
    OrthoDBi EOG7CNZFK.
    PhylomeDBi P51871.
    TreeFami TF105088.

    Miscellaneous databases

    NextBioi 624504.

    Gene expression databases

    Genevestigatori P51871.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
      Kawashima H., Strobel H.W.
      Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCP4F6_RAT
    AccessioniPrimary (citable) accession number: P51871
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3