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P51871 (CP4F6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4F6

EC=1.14.14.1
Alternative name(s):
CYPIVF6
Gene names
Name:Cyp4f6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

High expression in liver and kidney. Lower expression in brain.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 537537Cytochrome P450 4F6
PRO_0000051854

Sites

Metal binding4681Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P51871 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4D96D761A2BEA7E9

FASTA53761,541
        10         20         30         40         50         60 
MLQLSLSRLG MGSLTASPWH LLLLGGASWI LARILAWIYT FYDNCCRLRC FPQPPKPSWF 

        70         80         90        100        110        120 
WGHLTLMKNN EEGMQFIAHL GRNFRDIHLS WVGPVYPILR LVHPNVIAPL LQASAAVAPK 

       130        140        150        160        170        180 
EMTLYGFLKP WLGDGLLMSA GEKWNHHRRL LTPAFHFDIL KSYVKIFNKS VNTMHAKWQR 

       190        200        210        220        230        240 
LTAKGSARLD MFEHISLMTL DSLQKCIFSF DSNCQESNSE YIAAILELSS LIVKRQRQPF 

       250        260        270        280        290        300 
LYLDFLYYLT ADGRRFRKAC DVVHNFTDAV IRERRSTLNT QGVDEFLKAR AKTKTLDFID 

       310        320        330        340        350        360 
VLLLAKDEHG KGLSDVDIRA EADTFMFGGH DTTASALSWI LYNLARHPEY QERCRQEVRE 

       370        380        390        400        410        420 
LLRDREPEEI EWDDLAQLPF LTMCIKESLR LHPPVLLISR CCSQDIVLPD GRVIPKGNIC 

       430        440        450        460        470        480 
VISIFGVHHN PSVWPDPEVY NPFRFDPENP QKRSPLAFIP FSAGPRNCIG QTFAMSEIKV 

       490        500        510        520        530 
ALALTLLRFC VLPDDKEPRR KPELILRAEG GLWLRVEPLS TVTSQLPWDL LAHPPTS 

« Hide

References

[1]"cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
Kawashima H., Strobel H.W.
Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39208 mRNA. Translation: AAC52360.1.
PIRJC4534.
RefSeqNP_695230.1. NM_153318.1.
XP_006241111.1. XM_006241049.1.
UniGeneRn.11269.

3D structure databases

ProteinModelPortalP51871.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006335.

PTM databases

PhosphoSiteP51871.

Proteomic databases

PaxDbP51871.
PRIDEP51871.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000006335; ENSRNOP00000006335; ENSRNOG00000034157.
GeneID266689.
KEGGrno:266689.
UCSCRGD:708365. rat.

Organism-specific databases

CTD266689.
RGD708365. Cyp4f6.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110562.
HOGENOMHOG000233833.
HOVERGENHBG000182.
InParanoidP51871.
KOK17726.
OMAMIEDLGH.
OrthoDBEOG7CNZFK.
PhylomeDBP51871.
TreeFamTF105088.

Gene expression databases

GenevestigatorP51871.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00465. EP450IV.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio624504.

Entry information

Entry nameCP4F6_RAT
AccessionPrimary (citable) accession number: P51871
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families