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P51871

- CP4F6_RAT

UniProt

P51871 - CP4F6_RAT

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Protein

Cytochrome P450 4F6

Gene

Cyp4f6

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi468 – 4681Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. inflammatory response Source: RGD
  2. leukotriene metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F6 (EC:1.14.14.1)
Alternative name(s):
CYPIVF6
Gene namesi
Name:Cyp4f6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi708365. Cyp4f6.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Cytochrome P450 4F6PRO_0000051854Add
BLAST

Proteomic databases

PaxDbiP51871.
PRIDEiP51871.

PTM databases

PhosphoSiteiP51871.

Expressioni

Tissue specificityi

High expression in liver and kidney. Lower expression in brain.

Gene expression databases

ExpressionAtlasiP51871. baseline.
GenevestigatoriP51871.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006335.

Structurei

3D structure databases

ProteinModelPortaliP51871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP51871.
KOiK17726.
OMAiIPKDMFF.
OrthoDBiEOG7CNZFK.
PhylomeDBiP51871.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQLSLSRLG MGSLTASPWH LLLLGGASWI LARILAWIYT FYDNCCRLRC
60 70 80 90 100
FPQPPKPSWF WGHLTLMKNN EEGMQFIAHL GRNFRDIHLS WVGPVYPILR
110 120 130 140 150
LVHPNVIAPL LQASAAVAPK EMTLYGFLKP WLGDGLLMSA GEKWNHHRRL
160 170 180 190 200
LTPAFHFDIL KSYVKIFNKS VNTMHAKWQR LTAKGSARLD MFEHISLMTL
210 220 230 240 250
DSLQKCIFSF DSNCQESNSE YIAAILELSS LIVKRQRQPF LYLDFLYYLT
260 270 280 290 300
ADGRRFRKAC DVVHNFTDAV IRERRSTLNT QGVDEFLKAR AKTKTLDFID
310 320 330 340 350
VLLLAKDEHG KGLSDVDIRA EADTFMFGGH DTTASALSWI LYNLARHPEY
360 370 380 390 400
QERCRQEVRE LLRDREPEEI EWDDLAQLPF LTMCIKESLR LHPPVLLISR
410 420 430 440 450
CCSQDIVLPD GRVIPKGNIC VISIFGVHHN PSVWPDPEVY NPFRFDPENP
460 470 480 490 500
QKRSPLAFIP FSAGPRNCIG QTFAMSEIKV ALALTLLRFC VLPDDKEPRR
510 520 530
KPELILRAEG GLWLRVEPLS TVTSQLPWDL LAHPPTS
Length:537
Mass (Da):61,541
Last modified:October 1, 1996 - v1
Checksum:i4D96D761A2BEA7E9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39208 mRNA. Translation: AAC52360.1.
PIRiJC4534.
RefSeqiNP_695230.1. NM_153318.1.
XP_006241111.1. XM_006241049.1.
UniGeneiRn.11269.

Genome annotation databases

EnsembliENSRNOT00000006335; ENSRNOP00000006335; ENSRNOG00000034157.
GeneIDi266689.
KEGGirno:266689.
UCSCiRGD:708365. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39208 mRNA. Translation: AAC52360.1 .
PIRi JC4534.
RefSeqi NP_695230.1. NM_153318.1.
XP_006241111.1. XM_006241049.1.
UniGenei Rn.11269.

3D structure databases

ProteinModelPortali P51871.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000006335.

PTM databases

PhosphoSitei P51871.

Proteomic databases

PaxDbi P51871.
PRIDEi P51871.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000006335 ; ENSRNOP00000006335 ; ENSRNOG00000034157 .
GeneIDi 266689.
KEGGi rno:266689.
UCSCi RGD:708365. rat.

Organism-specific databases

CTDi 266689.
RGDi 708365. Cyp4f6.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118816.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi P51871.
KOi K17726.
OMAi IPKDMFF.
OrthoDBi EOG7CNZFK.
PhylomeDBi P51871.
TreeFami TF105088.

Miscellaneous databases

NextBioi 624504.

Gene expression databases

ExpressionAtlasi P51871. baseline.
Genevestigatori P51871.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00465. EP450IV.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
    Kawashima H., Strobel H.W.
    Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCP4F6_RAT
AccessioniPrimary (citable) accession number: P51871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3