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Protein

Cytochrome P450 4F6

Gene

Cyp4f6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi468 – 4681Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. inflammatory response Source: RGD
  2. leukotriene metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F6 (EC:1.14.14.1)
Alternative name(s):
CYPIVF6
Gene namesi
Name:Cyp4f6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi708365. Cyp4f6.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Cytochrome P450 4F6PRO_0000051854Add
BLAST

Proteomic databases

PaxDbiP51871.
PRIDEiP51871.

PTM databases

PhosphoSiteiP51871.

Expressioni

Tissue specificityi

High expression in liver and kidney. Lower expression in brain.

Gene expression databases

ExpressionAtlasiP51871. baseline and differential.
GenevestigatoriP51871.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006335.

Structurei

3D structure databases

ProteinModelPortaliP51871.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP51871.
KOiK17726.
OMAiQESNSEY.
OrthoDBiEOG7CNZFK.
PhylomeDBiP51871.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51871-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLQLSLSRLG MGSLTASPWH LLLLGGASWI LARILAWIYT FYDNCCRLRC
60 70 80 90 100
FPQPPKPSWF WGHLTLMKNN EEGMQFIAHL GRNFRDIHLS WVGPVYPILR
110 120 130 140 150
LVHPNVIAPL LQASAAVAPK EMTLYGFLKP WLGDGLLMSA GEKWNHHRRL
160 170 180 190 200
LTPAFHFDIL KSYVKIFNKS VNTMHAKWQR LTAKGSARLD MFEHISLMTL
210 220 230 240 250
DSLQKCIFSF DSNCQESNSE YIAAILELSS LIVKRQRQPF LYLDFLYYLT
260 270 280 290 300
ADGRRFRKAC DVVHNFTDAV IRERRSTLNT QGVDEFLKAR AKTKTLDFID
310 320 330 340 350
VLLLAKDEHG KGLSDVDIRA EADTFMFGGH DTTASALSWI LYNLARHPEY
360 370 380 390 400
QERCRQEVRE LLRDREPEEI EWDDLAQLPF LTMCIKESLR LHPPVLLISR
410 420 430 440 450
CCSQDIVLPD GRVIPKGNIC VISIFGVHHN PSVWPDPEVY NPFRFDPENP
460 470 480 490 500
QKRSPLAFIP FSAGPRNCIG QTFAMSEIKV ALALTLLRFC VLPDDKEPRR
510 520 530
KPELILRAEG GLWLRVEPLS TVTSQLPWDL LAHPPTS
Length:537
Mass (Da):61,541
Last modified:October 1, 1996 - v1
Checksum:i4D96D761A2BEA7E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39208 mRNA. Translation: AAC52360.1.
PIRiJC4534.
RefSeqiNP_695230.1. NM_153318.1.
XP_006241111.1. XM_006241049.1.
UniGeneiRn.11269.

Genome annotation databases

EnsembliENSRNOT00000006335; ENSRNOP00000006335; ENSRNOG00000034157.
GeneIDi266689.
KEGGirno:266689.
UCSCiRGD:708365. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39208 mRNA. Translation: AAC52360.1.
PIRiJC4534.
RefSeqiNP_695230.1. NM_153318.1.
XP_006241111.1. XM_006241049.1.
UniGeneiRn.11269.

3D structure databases

ProteinModelPortaliP51871.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006335.

PTM databases

PhosphoSiteiP51871.

Proteomic databases

PaxDbiP51871.
PRIDEiP51871.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006335; ENSRNOP00000006335; ENSRNOG00000034157.
GeneIDi266689.
KEGGirno:266689.
UCSCiRGD:708365. rat.

Organism-specific databases

CTDi266689.
RGDi708365. Cyp4f6.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP51871.
KOiK17726.
OMAiQESNSEY.
OrthoDBiEOG7CNZFK.
PhylomeDBiP51871.
TreeFamiTF105088.

Miscellaneous databases

NextBioi624504.

Gene expression databases

ExpressionAtlasiP51871. baseline and differential.
GenevestigatoriP51871.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
    Kawashima H., Strobel H.W.
    Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCP4F6_RAT
AccessioniPrimary (citable) accession number: P51871
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 4, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.