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Protein

Cytochrome P450 4F5

Gene

Cyp4f5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi470Iron (heme axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

  • inflammatory response Source: RGD
  • leukotriene metabolic process Source: RGD

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F5 (EC:1.14.14.1)
Alternative name(s):
CYPIVF5
Gene namesi
Name:Cyp4f5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708364. Cyp4f5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3509598.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000518531 – 526Cytochrome P450 4F5Add BLAST526

Proteomic databases

PaxDbiP51870.
PRIDEiP51870.

PTM databases

PhosphoSitePlusiP51870.

Expressioni

Tissue specificityi

High expression in liver and kidney. Lower expression in brain.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007428.

Structurei

3D structure databases

ProteinModelPortaliP51870.
SMRiP51870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP51870.
KOiK00490.
PhylomeDBiP51870.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiView protein in InterPro
IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
IPR036396. Cyt_P450_sf.
PfamiView protein in Pfam
PF00067. p450. 1 hit.
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiView protein in PROSITE
PS00086. CYTOCHROME_P450. 1 hit.

Sequencei

Sequence statusi: Complete.

P51870-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWLTVSGLD LGSVVTSTWH LLLLGAASWI LARILAWTYS FCENCSRLRC
60 70 80 90 100
FPQSPKRNWF LGHLGTIQSN EEGMRLVTEM GQTFRDIHLC WLGPVIPVLR
110 120 130 140 150
LVDPAFVAPL LQAPALVAPK DTTFLRFLKP WLGDGLFLSS GDKWSRHRRL
160 170 180 190 200
LTPAFHFDIL KPYVKIFNQS VNIMHAKWKH LCLEGSARLE MFENISLMTL
210 220 230 240 250
DSLQKCLFGF DSNCQESPSE YISAILELSS LIIKRSQQLF LYLDFLYYRT
260 270 280 290 300
ADGRRFRKAC DLVHNFTDAV IRERRRLLSS QGTDEFLESK TKSKSKTLDF
310 320 330 340 350
IDVLLLAKDE HGKELSDEDI RAEADTFMFG GHDTTASALS WILYNLARHP
360 370 380 390 400
EYQERCRQEV WELLRDREPE EIEWDDLAQL PFLTMCIKES LRLHPPAIDL
410 420 430 440 450
LRRCTQDIVL PDGRVIPKGN ICVISIFGIH HNPSVWPDPE VFDPFRFDSE
460 470 480 490 500
NRQKRSPLSF IPFSAGPRNC IGQTFAMNEM KVVVALTLLR FRVLPDDKEP
510 520
RRKPEIILRA EGGLWLRMEP LSTDTQ
Length:526
Mass (Da):60,681
Last modified:October 1, 1996 - v1
Checksum:i7F0F1DED4B07EEEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39207 mRNA. Translation: AAC52359.1.
PIRiJC4533.
RefSeqiNP_775147.1. NM_173124.1.
UniGeneiRn.10171.

Genome annotation databases

GeneIDi286905.
KEGGirno:286905.
UCSCiRGD:708364. rat.

Similar proteinsi

Entry informationi

Entry nameiCP4F5_RAT
AccessioniPrimary (citable) accession number: P51870
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families