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P51870

- CP4F5_RAT

UniProt

P51870 - CP4F5_RAT

Protein

Cytochrome P450 4F5

Gene

Cyp4f5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi470 – 4701Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. inflammatory response Source: RGD
    2. leukotriene metabolic process Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4F5 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVF5
    Gene namesi
    Name:Cyp4f5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi708364. Cyp4f5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Cytochrome P450 4F5PRO_0000051853Add
    BLAST

    Proteomic databases

    PaxDbiP51870.
    PRIDEiP51870.

    Expressioni

    Tissue specificityi

    High expression in liver and kidney. Lower expression in brain.

    Gene expression databases

    GenevestigatoriP51870.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000007428.

    Structurei

    3D structure databases

    ProteinModelPortaliP51870.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    InParanoidiP51870.
    KOiK00490.
    PhylomeDBiP51870.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00465. EP450IV.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51870-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPWLTVSGLD LGSVVTSTWH LLLLGAASWI LARILAWTYS FCENCSRLRC    50
    FPQSPKRNWF LGHLGTIQSN EEGMRLVTEM GQTFRDIHLC WLGPVIPVLR 100
    LVDPAFVAPL LQAPALVAPK DTTFLRFLKP WLGDGLFLSS GDKWSRHRRL 150
    LTPAFHFDIL KPYVKIFNQS VNIMHAKWKH LCLEGSARLE MFENISLMTL 200
    DSLQKCLFGF DSNCQESPSE YISAILELSS LIIKRSQQLF LYLDFLYYRT 250
    ADGRRFRKAC DLVHNFTDAV IRERRRLLSS QGTDEFLESK TKSKSKTLDF 300
    IDVLLLAKDE HGKELSDEDI RAEADTFMFG GHDTTASALS WILYNLARHP 350
    EYQERCRQEV WELLRDREPE EIEWDDLAQL PFLTMCIKES LRLHPPAIDL 400
    LRRCTQDIVL PDGRVIPKGN ICVISIFGIH HNPSVWPDPE VFDPFRFDSE 450
    NRQKRSPLSF IPFSAGPRNC IGQTFAMNEM KVVVALTLLR FRVLPDDKEP 500
    RRKPEIILRA EGGLWLRMEP LSTDTQ 526
    Length:526
    Mass (Da):60,681
    Last modified:October 1, 1996 - v1
    Checksum:i7F0F1DED4B07EEEC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39207 mRNA. Translation: AAC52359.1.
    PIRiJC4533.
    RefSeqiNP_775147.1. NM_173124.1.
    UniGeneiRn.10171.

    Genome annotation databases

    GeneIDi286905.
    KEGGirno:286905.
    UCSCiRGD:708364. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39207 mRNA. Translation: AAC52359.1 .
    PIRi JC4533.
    RefSeqi NP_775147.1. NM_173124.1.
    UniGenei Rn.10171.

    3D structure databases

    ProteinModelPortali P51870.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000007428.

    Proteomic databases

    PaxDbi P51870.
    PRIDEi P51870.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 286905.
    KEGGi rno:286905.
    UCSCi RGD:708364. rat.

    Organism-specific databases

    CTDi 286905.
    RGDi 708364. Cyp4f5.

    Phylogenomic databases

    eggNOGi COG2124.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    InParanoidi P51870.
    KOi K00490.
    PhylomeDBi P51870.

    Miscellaneous databases

    NextBioi 625004.

    Gene expression databases

    Genevestigatori P51870.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002403. Cyt_P450_E_grp-IV.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00465. EP450IV.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
      Kawashima H., Strobel H.W.
      Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCP4F5_RAT
    AccessioniPrimary (citable) accession number: P51870
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3