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P51870

- CP4F5_RAT

UniProt

P51870 - CP4F5_RAT

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Protein

Cytochrome P450 4F5

Gene

Cyp4f5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi470 – 4701Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. inflammatory response Source: RGD
  2. leukotriene metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4F5 (EC:1.14.14.1)
Alternative name(s):
CYPIVF5
Gene namesi
Name:Cyp4f5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi708364. Cyp4f5.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Cytochrome P450 4F5PRO_0000051853Add
BLAST

Proteomic databases

PaxDbiP51870.
PRIDEiP51870.

Expressioni

Tissue specificityi

High expression in liver and kidney. Lower expression in brain.

Gene expression databases

GenevestigatoriP51870.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007428.

Structurei

3D structure databases

ProteinModelPortaliP51870.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiP51870.
KOiK00490.
PhylomeDBiP51870.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00465. EP450IV.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51870-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWLTVSGLD LGSVVTSTWH LLLLGAASWI LARILAWTYS FCENCSRLRC
60 70 80 90 100
FPQSPKRNWF LGHLGTIQSN EEGMRLVTEM GQTFRDIHLC WLGPVIPVLR
110 120 130 140 150
LVDPAFVAPL LQAPALVAPK DTTFLRFLKP WLGDGLFLSS GDKWSRHRRL
160 170 180 190 200
LTPAFHFDIL KPYVKIFNQS VNIMHAKWKH LCLEGSARLE MFENISLMTL
210 220 230 240 250
DSLQKCLFGF DSNCQESPSE YISAILELSS LIIKRSQQLF LYLDFLYYRT
260 270 280 290 300
ADGRRFRKAC DLVHNFTDAV IRERRRLLSS QGTDEFLESK TKSKSKTLDF
310 320 330 340 350
IDVLLLAKDE HGKELSDEDI RAEADTFMFG GHDTTASALS WILYNLARHP
360 370 380 390 400
EYQERCRQEV WELLRDREPE EIEWDDLAQL PFLTMCIKES LRLHPPAIDL
410 420 430 440 450
LRRCTQDIVL PDGRVIPKGN ICVISIFGIH HNPSVWPDPE VFDPFRFDSE
460 470 480 490 500
NRQKRSPLSF IPFSAGPRNC IGQTFAMNEM KVVVALTLLR FRVLPDDKEP
510 520
RRKPEIILRA EGGLWLRMEP LSTDTQ
Length:526
Mass (Da):60,681
Last modified:October 1, 1996 - v1
Checksum:i7F0F1DED4B07EEEC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39207 mRNA. Translation: AAC52359.1.
PIRiJC4533.
RefSeqiNP_775147.1. NM_173124.1.
UniGeneiRn.10171.

Genome annotation databases

GeneIDi286905.
KEGGirno:286905.
UCSCiRGD:708364. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U39207 mRNA. Translation: AAC52359.1 .
PIRi JC4533.
RefSeqi NP_775147.1. NM_173124.1.
UniGenei Rn.10171.

3D structure databases

ProteinModelPortali P51870.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000007428.

Proteomic databases

PaxDbi P51870.
PRIDEi P51870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 286905.
KEGGi rno:286905.
UCSCi RGD:708364. rat.

Organism-specific databases

CTDi 286905.
RGDi 708364. Cyp4f5.

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi P51870.
KOi K00490.
PhylomeDBi P51870.

Miscellaneous databases

NextBioi 625004.

Gene expression databases

Genevestigatori P51870.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00465. EP450IV.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
    Kawashima H., Strobel H.W.
    Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCP4F5_RAT
AccessioniPrimary (citable) accession number: P51870
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3