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P51870 (CP4F5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4F5

EC=1.14.14.1
Alternative name(s):
CYPIVF5
Gene names
Name:Cyp4f5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

High expression in liver and kidney. Lower expression in brain.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Cytochrome P450 4F5
PRO_0000051853

Sites

Metal binding4701Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P51870 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7F0F1DED4B07EEEC

FASTA52660,681
        10         20         30         40         50         60 
MPWLTVSGLD LGSVVTSTWH LLLLGAASWI LARILAWTYS FCENCSRLRC FPQSPKRNWF 

        70         80         90        100        110        120 
LGHLGTIQSN EEGMRLVTEM GQTFRDIHLC WLGPVIPVLR LVDPAFVAPL LQAPALVAPK 

       130        140        150        160        170        180 
DTTFLRFLKP WLGDGLFLSS GDKWSRHRRL LTPAFHFDIL KPYVKIFNQS VNIMHAKWKH 

       190        200        210        220        230        240 
LCLEGSARLE MFENISLMTL DSLQKCLFGF DSNCQESPSE YISAILELSS LIIKRSQQLF 

       250        260        270        280        290        300 
LYLDFLYYRT ADGRRFRKAC DLVHNFTDAV IRERRRLLSS QGTDEFLESK TKSKSKTLDF 

       310        320        330        340        350        360 
IDVLLLAKDE HGKELSDEDI RAEADTFMFG GHDTTASALS WILYNLARHP EYQERCRQEV 

       370        380        390        400        410        420 
WELLRDREPE EIEWDDLAQL PFLTMCIKES LRLHPPAIDL LRRCTQDIVL PDGRVIPKGN 

       430        440        450        460        470        480 
ICVISIFGIH HNPSVWPDPE VFDPFRFDSE NRQKRSPLSF IPFSAGPRNC IGQTFAMNEM 

       490        500        510        520 
KVVVALTLLR FRVLPDDKEP RRKPEIILRA EGGLWLRMEP LSTDTQ 

« Hide

References

[1]"cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
Kawashima H., Strobel H.W.
Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39207 mRNA. Translation: AAC52359.1.
PIRJC4533.
RefSeqNP_775147.1. NM_173124.1.
UniGeneRn.10171.

3D structure databases

ProteinModelPortalP51870.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000007428.

Proteomic databases

PaxDbP51870.
PRIDEP51870.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID286905.
KEGGrno:286905.
UCSCRGD:708364. rat.

Organism-specific databases

CTD286905.
RGD708364. Cyp4f5.

Phylogenomic databases

eggNOGCOG2124.
HOGENOMHOG000233833.
HOVERGENHBG000182.
InParanoidP51870.
KOK00490.

Gene expression databases

GenevestigatorP51870.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002403. Cyt_P450_E_grp-IV.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00465. EP450IV.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio625004.

Entry information

Entry nameCP4F5_RAT
AccessionPrimary (citable) accession number: P51870
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 19, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families