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P51869 (CP4F4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 4F4

EC=1.14.14.1
Alternative name(s):
CYPIVF4
Gene names
Name:Cyp4f4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length522 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

High expression in liver and kidney. Lower expression in brain.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 522522Cytochrome P450 4F4
PRO_0000051852

Sites

Metal binding4681Iron (heme axial ligand)
Binding site3281Heme (covalent; via 1 link)

Sequences

Sequence LengthMass (Da)Tools
P51869 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 193EA8E7CE8864D6

FASTA52260,050
        10         20         30         40         50         60 
MPQLDLSWLG LRLETSLPWL LLLLIGASWL LVRVLTQTYI FYRTYQHLCD FPQPPKWNWF 

        70         80         90        100        110        120 
LGHLGMITPT EQGLKQVTKL VATYPQGFMT WLGPILPIIT LCHPDVIRSV LSASASVALK 

       130        140        150        160        170        180 
EVIFYSFLKP WLGDGLLLSD GDKWSCHRRM LTPAFHFNIL KPYVKIFNDS TNIMHAKWQD 

       190        200        210        220        230        240 
LASGGSARLD MFKNISLMTL DSLQKCVFSF DSNCQEKPSE YISAILELSA LVAKRYQQLL 

       250        260        270        280        290        300 
LHTDSLYQLT HNGRRFHKAC KLVHNFTDAV IQGRRRALPS QHEDDILKAK ARSKTLDFID 

       310        320        330        340        350        360 
VLLLTKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWI LYNLARHPEY QERCRQEVRE 

       370        380        390        400        410        420 
LLRDRESTEI EWDDLAQLPF LTMCIKESLR LHPPVTVISR RCTQDIVLPD GRVIPKGVIC 

       430        440        450        460        470        480 
IINIFATHHN PTVWPDPEVY DPFRFDPENI KDRSPLAFIP FSAGPRNCIG QTFAMNEMKV 

       490        500        510        520 
ALALTLLRFR VLPDDKEPRR KPELILRAEG GLWLRVEPLS TQ 

« Hide

References

[1]"cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
Kawashima H., Strobel H.W.
Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
[2]"Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family."
LeBrun L.A., Xu F., Kroetz D.L., Ortiz de Montellano P.R.
Biochemistry 41:5931-5937(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: COVALENT HEME ATTACHMENT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U39206 mRNA. Translation: AAC52358.1.
PIRJC4532.
RefSeqNP_775146.1. NM_173123.1.
UniGeneRn.10170.

3D structure databases

ProteinModelPortalP51869.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4570522.
STRING10116.ENSRNOP00000032609.

Proteomic databases

PaxDbP51869.
PRIDEP51869.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000041034; ENSRNOP00000039545; ENSRNOG00000032895.
GeneID286904.
KEGGrno:286904.
UCSCRGD:708363. rat.

Organism-specific databases

CTD286904.
RGD708363. Cyp4f4.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00730000110562.
HOGENOMHOG000233833.
HOVERGENHBG000182.
KOK00490.
OMAGMITPTE.
OrthoDBEOG7CNZFK.

Gene expression databases

GenevestigatorP51869.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio625000.

Entry information

Entry nameCP4F4_RAT
AccessionPrimary (citable) accession number: P51869
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families