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P51869

- CP4F4_RAT

UniProt

P51869 - CP4F4_RAT

Protein

Cytochrome P450 4F4

Gene

Cyp4f4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei328 – 3281Heme (covalent; via 1 link)
    Metal bindingi468 – 4681Iron (heme axial ligand)

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: RGD
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4F4 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVF4
    Gene namesi
    Name:Cyp4f4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi708363. Cyp4f4.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 522522Cytochrome P450 4F4PRO_0000051852Add
    BLAST

    Proteomic databases

    PaxDbiP51869.
    PRIDEiP51869.

    Expressioni

    Tissue specificityi

    High expression in liver and kidney. Lower expression in brain.

    Gene expression databases

    GenevestigatoriP51869.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4570522.
    STRINGi10116.ENSRNOP00000032609.

    Structurei

    3D structure databases

    ProteinModelPortaliP51869.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00730000110562.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    KOiK00490.
    OMAiGMITPTE.
    OrthoDBiEOG7CNZFK.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51869-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPQLDLSWLG LRLETSLPWL LLLLIGASWL LVRVLTQTYI FYRTYQHLCD    50
    FPQPPKWNWF LGHLGMITPT EQGLKQVTKL VATYPQGFMT WLGPILPIIT 100
    LCHPDVIRSV LSASASVALK EVIFYSFLKP WLGDGLLLSD GDKWSCHRRM 150
    LTPAFHFNIL KPYVKIFNDS TNIMHAKWQD LASGGSARLD MFKNISLMTL 200
    DSLQKCVFSF DSNCQEKPSE YISAILELSA LVAKRYQQLL LHTDSLYQLT 250
    HNGRRFHKAC KLVHNFTDAV IQGRRRALPS QHEDDILKAK ARSKTLDFID 300
    VLLLTKDEDG KELSDEDIRA EADTFMFEGH DTTASGLSWI LYNLARHPEY 350
    QERCRQEVRE LLRDRESTEI EWDDLAQLPF LTMCIKESLR LHPPVTVISR 400
    RCTQDIVLPD GRVIPKGVIC IINIFATHHN PTVWPDPEVY DPFRFDPENI 450
    KDRSPLAFIP FSAGPRNCIG QTFAMNEMKV ALALTLLRFR VLPDDKEPRR 500
    KPELILRAEG GLWLRVEPLS TQ 522
    Length:522
    Mass (Da):60,050
    Last modified:October 1, 1996 - v1
    Checksum:i193EA8E7CE8864D6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39206 mRNA. Translation: AAC52358.1.
    PIRiJC4532.
    RefSeqiNP_775146.1. NM_173123.1.
    UniGeneiRn.10170.

    Genome annotation databases

    EnsembliENSRNOT00000041034; ENSRNOP00000039545; ENSRNOG00000032895.
    GeneIDi286904.
    KEGGirno:286904.
    UCSCiRGD:708363. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U39206 mRNA. Translation: AAC52358.1 .
    PIRi JC4532.
    RefSeqi NP_775146.1. NM_173123.1.
    UniGenei Rn.10170.

    3D structure databases

    ProteinModelPortali P51869.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4570522.
    STRINGi 10116.ENSRNOP00000032609.

    Proteomic databases

    PaxDbi P51869.
    PRIDEi P51869.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000041034 ; ENSRNOP00000039545 ; ENSRNOG00000032895 .
    GeneIDi 286904.
    KEGGi rno:286904.
    UCSCi RGD:708363. rat.

    Organism-specific databases

    CTDi 286904.
    RGDi 708363. Cyp4f4.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00730000110562.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    KOi K00490.
    OMAi GMITPTE.
    OrthoDBi EOG7CNZFK.

    Miscellaneous databases

    NextBioi 625000.

    Gene expression databases

    Genevestigatori P51869.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily."
      Kawashima H., Strobel H.W.
      Biochem. Biophys. Res. Commun. 217:1137-1144(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.
    2. "Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family."
      LeBrun L.A., Xu F., Kroetz D.L., Ortiz de Montellano P.R.
      Biochemistry 41:5931-5937(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: COVALENT HEME ATTACHMENT.

    Entry informationi

    Entry nameiCP4F4_RAT
    AccessioniPrimary (citable) accession number: P51869
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3