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P51867

- TNR6_BOVIN

UniProt

P51867 - TNR6_BOVIN

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Protein
Tumor necrosis factor receptor superfamily member 6
Gene
FAS, APT1, TNFRSF6
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. B cell mediated immunity Source: Ensembl
  2. activation-induced cell death of T cells Source: Ensembl
  3. cellular response to hyperoxia Source: Ensembl
  4. cellular response to lithium ion Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  7. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  8. gene expression Source: Ensembl
  9. immunoglobulin production Source: Ensembl
  10. inflammatory cell apoptotic process Source: Ensembl
  11. motor neuron apoptotic process Source: Ensembl
  12. negative regulation of B cell activation Source: Ensembl
  13. negative regulation of apoptotic process Source: Ensembl
  14. negative thymic T cell selection Source: Ensembl
  15. positive regulation of apoptotic process Source: Ensembl
  16. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  17. positive regulation of necrotic cell death Source: Ensembl
  18. positive regulation of protein homooligomerization Source: Ensembl
  19. protein homooligomerization Source: Ensembl
  20. regulation of lymphocyte differentiation Source: Ensembl
  21. regulation of myeloid cell differentiation Source: Ensembl
  22. renal system process Source: Ensembl
  23. response to glucocorticoid Source: Ensembl
  24. response to toxic substance Source: Ensembl
  25. spleen development Source: Ensembl
  26. transformed cell apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_206178. Caspase-8 activation.
REACT_211787. FasL/ CD95L signaling.
REACT_213884. Regulation by c-FLIP.
REACT_226577. Dimerization of procaspase-8.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 26

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 170148Extracellular Reviewed prediction
Add
BLAST
Transmembranei171 – 18818Helical; Reviewed prediction
Add
BLAST
Topological domaini189 – 323135Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular region Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. membrane raft Source: Ensembl
  7. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed prediction
Add
BLAST
Chaini23 – 323301Tumor necrosis factor receptor superfamily member 6
PRO_0000034561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi45 ↔ 56 By similarity
Disulfide bondi57 ↔ 70 By similarity
Disulfide bondi60 ↔ 79 By similarity
Disulfide bondi82 ↔ 98 By similarity
Disulfide bondi101 ↔ 116 By similarity
Disulfide bondi104 ↔ 124 By similarity
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi126 ↔ 140 By similarity
Disulfide bondi143 ↔ 154 By similarity
Disulfide bondi146 ↔ 162 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP51867.

Interactioni

Subunit structurei

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B By similarity. Interacts with FADD By similarity.

Structurei

3D structure databases

ProteinModelPortaliP51867.
SMRiP51867. Positions 214-323.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 8036TNFR-Cys 1
Add
BLAST
Repeati81 – 12444TNFR-Cys 2
Add
BLAST
Repeati125 – 16339TNFR-Cys 3
Add
BLAST
Domaini238 – 30669Death
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 305102Interaction with HIPK3 By similarity
Add
BLAST

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similaritiesi

Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45364.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiP51867.
KOiK04390.
OMAiCEHCNPC.
OrthoDBiEOG7DVDC8.
TreeFamiTF333916.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51867-1 [UniParc]FASTAAdd to Basket

« Hide

MSGIWVHLSL IFISVSGPLS KGENAHMAGI NSEGLKLNIT EANSCQEGLY    50
REHQFCCQPC PPGKRKNGDC KRDGDTPECV LCSEGNEYTD KSHHSDKCIR 100
CSICDEEHGL EVEQNCTRTR NTKCRCKSNF FCNSSPCEHC NPCTTCEHGI 150
IEKCTPTSNT KCKGSRSHAN SLWALLILLI PIVLIIYKVV KSRERNKKND 200
YCNSAASNDE GRQLNLTDVD LGKYIPSIAE QMRITEVKEF VRKNGMEEAK 250
IDDIMHDNVH ETAEQKVQLL RNWYQSHGKK NAYCTLTKSL PKALAEKICD 300
IVMKDITNER ENANLQNENE NLV 323
Length:323
Mass (Da):36,445
Last modified:October 1, 1996 - v1
Checksum:i4D88A90E9E1F4892
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34794 mRNA. Translation: AAC48546.1.
RefSeqiNP_777087.1. NM_174662.2.
UniGeneiBt.4345.

Genome annotation databases

EnsembliENSBTAT00000014282; ENSBTAP00000014282; ENSBTAG00000010785.
GeneIDi282488.
KEGGibta:282488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U34794 mRNA. Translation: AAC48546.1 .
RefSeqi NP_777087.1. NM_174662.2.
UniGenei Bt.4345.

3D structure databases

ProteinModelPortali P51867.
SMRi P51867. Positions 214-323.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P51867.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000014282 ; ENSBTAP00000014282 ; ENSBTAG00000010785 .
GeneIDi 282488.
KEGGi bta:282488.

Organism-specific databases

CTDi 355.

Phylogenomic databases

eggNOGi NOG45364.
GeneTreei ENSGT00730000111280.
HOGENOMi HOG000139681.
HOVERGENi HBG004091.
InParanoidi P51867.
KOi K04390.
OMAi CEHCNPC.
OrthoDBi EOG7DVDC8.
TreeFami TF333916.

Enzyme and pathway databases

Reactomei REACT_206178. Caspase-8 activation.
REACT_211787. FasL/ CD95L signaling.
REACT_213884. Regulation by c-FLIP.
REACT_226577. Dimerization of procaspase-8.

Miscellaneous databases

NextBioi 20806250.

Family and domain databases

Gene3Di 1.10.533.10. 1 hit.
InterProi IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view ]
Pfami PF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view ]
PRINTSi PR01680. TNFACTORR6.
SMARTi SM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view ]
SUPFAMi SSF47986. SSF47986. 1 hit.
PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the bovine Fas."
    Yoo J., Stone R.T., Beattie C.W.
    DNA Cell Biol. 15:227-234(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTNR6_BOVIN
AccessioniPrimary (citable) accession number: P51867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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