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P51867 (TNR6_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen=CD95
Gene names
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.

Subunit structure

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B By similarity. Interacts with FADD By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Domain

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similarities

Contains 1 death domain.

Contains 3 TNFR-Cys repeats.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentMembrane
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell mediated immunity

Inferred from electronic annotation. Source: Ensembl

activation-induced cell death of T cells

Inferred from electronic annotation. Source: Ensembl

cellular response to hyperoxia

Inferred from electronic annotation. Source: Ensembl

cellular response to lithium ion

Inferred from electronic annotation. Source: Ensembl

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway via death domain receptors

Inferred from electronic annotation. Source: Ensembl

gene expression

Inferred from electronic annotation. Source: Ensembl

immunoglobulin production

Inferred from electronic annotation. Source: Ensembl

inflammatory cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

motor neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of B cell activation

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative thymic T cell selection

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Inferred from electronic annotation. Source: Ensembl

positive regulation of necrotic cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

protein homooligomerization

Inferred from electronic annotation. Source: Ensembl

regulation of lymphocyte differentiation

Inferred from electronic annotation. Source: Ensembl

regulation of myeloid cell differentiation

Inferred from electronic annotation. Source: Ensembl

renal system process

Inferred from electronic annotation. Source: Ensembl

response to glucocorticoid

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from electronic annotation. Source: Ensembl

spleen development

Inferred from electronic annotation. Source: Ensembl

transformed cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentCD95 death-inducing signaling complex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from electronic annotation. Source: Ensembl

extracellular region

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

membrane raft

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiontransmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 323301Tumor necrosis factor receptor superfamily member 6
PRO_0000034561

Regions

Topological domain23 – 170148Extracellular Potential
Transmembrane171 – 18818Helical; Potential
Topological domain189 – 323135Cytoplasmic Potential
Repeat45 – 8036TNFR-Cys 1
Repeat81 – 12444TNFR-Cys 2
Repeat125 – 16339TNFR-Cys 3
Domain238 – 30669Death
Region204 – 305102Interaction with HIPK3 By similarity

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation1151N-linked (GlcNAc...) Potential
Disulfide bond45 ↔ 56 By similarity
Disulfide bond57 ↔ 70 By similarity
Disulfide bond60 ↔ 79 By similarity
Disulfide bond82 ↔ 98 By similarity
Disulfide bond101 ↔ 116 By similarity
Disulfide bond104 ↔ 124 By similarity
Disulfide bond126 ↔ 140 By similarity
Disulfide bond143 ↔ 154 By similarity
Disulfide bond146 ↔ 162 By similarity

Sequences

Sequence LengthMass (Da)Tools
P51867 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4D88A90E9E1F4892

FASTA32336,445
        10         20         30         40         50         60 
MSGIWVHLSL IFISVSGPLS KGENAHMAGI NSEGLKLNIT EANSCQEGLY REHQFCCQPC 

        70         80         90        100        110        120 
PPGKRKNGDC KRDGDTPECV LCSEGNEYTD KSHHSDKCIR CSICDEEHGL EVEQNCTRTR 

       130        140        150        160        170        180 
NTKCRCKSNF FCNSSPCEHC NPCTTCEHGI IEKCTPTSNT KCKGSRSHAN SLWALLILLI 

       190        200        210        220        230        240 
PIVLIIYKVV KSRERNKKND YCNSAASNDE GRQLNLTDVD LGKYIPSIAE QMRITEVKEF 

       250        260        270        280        290        300 
VRKNGMEEAK IDDIMHDNVH ETAEQKVQLL RNWYQSHGKK NAYCTLTKSL PKALAEKICD 

       310        320 
IVMKDITNER ENANLQNENE NLV 

« Hide

References

[1]"Cloning and characterization of the bovine Fas."
Yoo J., Stone R.T., Beattie C.W.
DNA Cell Biol. 15:227-234(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U34794 mRNA. Translation: AAC48546.1.
RefSeqNP_777087.1. NM_174662.2.
UniGeneBt.4345.

3D structure databases

ProteinModelPortalP51867.
SMRP51867. Positions 214-323.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP51867.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000014282; ENSBTAP00000014282; ENSBTAG00000010785.
GeneID282488.
KEGGbta:282488.

Organism-specific databases

CTD355.

Phylogenomic databases

eggNOGNOG45364.
GeneTreeENSGT00730000111280.
HOGENOMHOG000139681.
HOVERGENHBG004091.
InParanoidP51867.
KOK04390.
OMAKPNFFCN.
OrthoDBEOG7DVDC8.
TreeFamTF333916.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSPR01680. TNFACTORR6.
SMARTSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806250.

Entry information

Entry nameTNR6_BOVIN
AccessionPrimary (citable) accession number: P51867
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 19, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families