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P51867

- TNR6_BOVIN

UniProt

P51867 - TNR6_BOVIN

Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both By similarity.By similarity

    GO - Molecular functioni

    1. transmembrane signaling receptor activity Source: InterPro

    GO - Biological processi

    1. activation-induced cell death of T cells Source: Ensembl
    2. B cell mediated immunity Source: Ensembl
    3. cellular response to hyperoxia Source: Ensembl
    4. cellular response to lithium ion Source: Ensembl
    5. cellular response to mechanical stimulus Source: Ensembl
    6. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    7. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
    8. gene expression Source: Ensembl
    9. immunoglobulin production Source: Ensembl
    10. inflammatory cell apoptotic process Source: Ensembl
    11. motor neuron apoptotic process Source: Ensembl
    12. negative regulation of apoptotic process Source: Ensembl
    13. negative regulation of B cell activation Source: Ensembl
    14. negative thymic T cell selection Source: Ensembl
    15. positive regulation of apoptotic process Source: Ensembl
    16. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    17. positive regulation of necrotic cell death Source: Ensembl
    18. positive regulation of protein homooligomerization Source: Ensembl
    19. protein homooligomerization Source: Ensembl
    20. regulation of lymphocyte differentiation Source: Ensembl
    21. regulation of myeloid cell differentiation Source: Ensembl
    22. renal system process Source: Ensembl
    23. response to glucocorticoid Source: Ensembl
    24. response to toxic substance Source: Ensembl
    25. spleen development Source: Ensembl
    26. transformed cell apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_206178. Caspase-8 activation.
    REACT_211787. FasL/ CD95L signaling.
    REACT_213884. Regulation by c-FLIP.
    REACT_226577. Dimerization of procaspase-8.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor receptor superfamily member 6
    Alternative name(s):
    Apo-1 antigen
    Apoptosis-mediating surface antigen FAS
    FASLG receptor
    CD_antigen: CD95
    Gene namesi
    Name:FAS
    Synonyms:APT1, TNFRSF6
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 26

    Subcellular locationi

    GO - Cellular componenti

    1. CD95 death-inducing signaling complex Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. external side of plasma membrane Source: Ensembl
    4. extracellular region Source: Ensembl
    5. integral component of membrane Source: UniProtKB-KW
    6. membrane raft Source: Ensembl
    7. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 323301Tumor necrosis factor receptor superfamily member 6PRO_0000034561Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi45 ↔ 56PROSITE-ProRule annotation
    Disulfide bondi57 ↔ 70PROSITE-ProRule annotation
    Disulfide bondi60 ↔ 79PROSITE-ProRule annotation
    Disulfide bondi82 ↔ 98PROSITE-ProRule annotation
    Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
    Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi126 ↔ 140PROSITE-ProRule annotation
    Disulfide bondi143 ↔ 154PROSITE-ProRule annotation
    Disulfide bondi146 ↔ 162PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP51867.

    Interactioni

    Subunit structurei

    Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B By similarity. Interacts with FADD By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP51867.
    SMRiP51867. Positions 214-323.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 170148ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 323135CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei171 – 18818HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati45 – 8036TNFR-Cys 1Add
    BLAST
    Repeati81 – 12444TNFR-Cys 2Add
    BLAST
    Repeati125 – 16339TNFR-Cys 3Add
    BLAST
    Domaini238 – 30669DeathPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni204 – 305102Interaction with HIPK3By similarityAdd
    BLAST

    Domaini

    Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

    Sequence similaritiesi

    Contains 1 death domain.PROSITE-ProRule annotation
    Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45364.
    GeneTreeiENSGT00730000111280.
    HOGENOMiHOG000139681.
    HOVERGENiHBG004091.
    InParanoidiP51867.
    KOiK04390.
    OMAiCEHCNPC.
    OrthoDBiEOG7DVDC8.
    TreeFamiTF333916.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 2 hits.
    [Graphical view]
    PRINTSiPR01680. TNFACTORR6.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 3 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51867-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGIWVHLSL IFISVSGPLS KGENAHMAGI NSEGLKLNIT EANSCQEGLY    50
    REHQFCCQPC PPGKRKNGDC KRDGDTPECV LCSEGNEYTD KSHHSDKCIR 100
    CSICDEEHGL EVEQNCTRTR NTKCRCKSNF FCNSSPCEHC NPCTTCEHGI 150
    IEKCTPTSNT KCKGSRSHAN SLWALLILLI PIVLIIYKVV KSRERNKKND 200
    YCNSAASNDE GRQLNLTDVD LGKYIPSIAE QMRITEVKEF VRKNGMEEAK 250
    IDDIMHDNVH ETAEQKVQLL RNWYQSHGKK NAYCTLTKSL PKALAEKICD 300
    IVMKDITNER ENANLQNENE NLV 323
    Length:323
    Mass (Da):36,445
    Last modified:October 1, 1996 - v1
    Checksum:i4D88A90E9E1F4892
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34794 mRNA. Translation: AAC48546.1.
    RefSeqiNP_777087.1. NM_174662.2.
    UniGeneiBt.4345.

    Genome annotation databases

    EnsembliENSBTAT00000014282; ENSBTAP00000014282; ENSBTAG00000010785.
    GeneIDi282488.
    KEGGibta:282488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U34794 mRNA. Translation: AAC48546.1 .
    RefSeqi NP_777087.1. NM_174662.2.
    UniGenei Bt.4345.

    3D structure databases

    ProteinModelPortali P51867.
    SMRi P51867. Positions 214-323.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P51867.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000014282 ; ENSBTAP00000014282 ; ENSBTAG00000010785 .
    GeneIDi 282488.
    KEGGi bta:282488.

    Organism-specific databases

    CTDi 355.

    Phylogenomic databases

    eggNOGi NOG45364.
    GeneTreei ENSGT00730000111280.
    HOGENOMi HOG000139681.
    HOVERGENi HBG004091.
    InParanoidi P51867.
    KOi K04390.
    OMAi CEHCNPC.
    OrthoDBi EOG7DVDC8.
    TreeFami TF333916.

    Enzyme and pathway databases

    Reactomei REACT_206178. Caspase-8 activation.
    REACT_211787. FasL/ CD95L signaling.
    REACT_213884. Regulation by c-FLIP.
    REACT_226577. Dimerization of procaspase-8.

    Miscellaneous databases

    NextBioi 20806250.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR008063. Fas_rcpt.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 2 hits.
    [Graphical view ]
    PRINTSi PR01680. TNFACTORR6.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 2 hits.
    PS50050. TNFR_NGFR_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the bovine Fas."
      Yoo J., Stone R.T., Beattie C.W.
      DNA Cell Biol. 15:227-234(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiTNR6_BOVIN
    AccessioniPrimary (citable) accession number: P51867
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3