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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Receptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-BTA-3371378 Regulation by c-FLIP
R-BTA-5213460 RIPK1-mediated regulated necrosis
R-BTA-5218900 CASP8 activity is inhibited
R-BTA-69416 Dimerization of procaspase-8
R-BTA-75157 FasL/ CD95L signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 26

Organism-specific databases

VGNCiVGNC:28869 FAS

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 170ExtracellularSequence analysisAdd BLAST148
Transmembranei171 – 188HelicalSequence analysisAdd BLAST18
Topological domaini189 – 323CytoplasmicSequence analysisAdd BLAST135

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000003456123 – 323Tumor necrosis factor receptor superfamily member 6Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi45 ↔ 56PROSITE-ProRule annotation
Disulfide bondi57 ↔ 70PROSITE-ProRule annotation
Disulfide bondi60 ↔ 79PROSITE-ProRule annotation
Disulfide bondi82 ↔ 98PROSITE-ProRule annotation
Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 140PROSITE-ProRule annotation
Disulfide bondi143 ↔ 154PROSITE-ProRule annotation
Disulfide bondi146 ↔ 162PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51867
PRIDEiP51867

Expressioni

Gene expression databases

BgeeiENSBTAG00000010785

Interactioni

Subunit structurei

Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD (By similarity). Binds RIPK1 and FAIM2. Interacts with BABAM2 and FEM1B. Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity). Interacts with CALM (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000014282

Structurei

3D structure databases

ProteinModelPortaliP51867
SMRiP51867
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati45 – 80TNFR-Cys 1Add BLAST36
Repeati81 – 124TNFR-Cys 2Add BLAST44
Repeati125 – 163TNFR-Cys 3Add BLAST39
Domaini238 – 306DeathPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 305Interaction with HIPK3By similarityAdd BLAST102
Regioni222 – 246Interaction with CALMBy similarityAdd BLAST25

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J23A Eukaryota
ENOG4112ADB LUCA
GeneTreeiENSGT00730000111280
HOGENOMiHOG000139681
HOVERGENiHBG004091
InParanoidiP51867
KOiK04390
OMAiCTTCEHG
OrthoDBiEOG091G0DU6
TreeFamiTF333916

Family and domain databases

CDDicd08316 Death_FAS_TNFRSF6, 1 hit
cd10579 TNFRSF6, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR008063 Fas_rcpt
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR033998 TNFRSF6_death
IPR033999 TNFRSF6_N
PANTHERiPTHR23097:SF114 PTHR23097:SF114, 2 hits
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PRINTSiPR01680 TNFACTORR6
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 3 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIWVHLSL IFISVSGPLS KGENAHMAGI NSEGLKLNIT EANSCQEGLY
60 70 80 90 100
REHQFCCQPC PPGKRKNGDC KRDGDTPECV LCSEGNEYTD KSHHSDKCIR
110 120 130 140 150
CSICDEEHGL EVEQNCTRTR NTKCRCKSNF FCNSSPCEHC NPCTTCEHGI
160 170 180 190 200
IEKCTPTSNT KCKGSRSHAN SLWALLILLI PIVLIIYKVV KSRERNKKND
210 220 230 240 250
YCNSAASNDE GRQLNLTDVD LGKYIPSIAE QMRITEVKEF VRKNGMEEAK
260 270 280 290 300
IDDIMHDNVH ETAEQKVQLL RNWYQSHGKK NAYCTLTKSL PKALAEKICD
310 320
IVMKDITNER ENANLQNENE NLV
Length:323
Mass (Da):36,445
Last modified:October 1, 1996 - v1
Checksum:i4D88A90E9E1F4892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34794 mRNA Translation: AAC48546.1
RefSeqiNP_777087.1, NM_174662.2
UniGeneiBt.4345

Genome annotation databases

EnsembliENSBTAT00000014282; ENSBTAP00000014282; ENSBTAG00000010785
GeneIDi282488
KEGGibta:282488

Similar proteinsi

Entry informationi

Entry nameiTNR6_BOVIN
AccessioniPrimary (citable) accession number: P51867
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health