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Protein

Tumor necrosis factor receptor superfamily member 6

Gene

FAS

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).By similarity

GO - Molecular functioni

  1. transmembrane signaling receptor activity Source: InterPro

GO - Biological processi

  1. activation-induced cell death of T cells Source: Ensembl
  2. B cell mediated immunity Source: Ensembl
  3. cellular response to hyperoxia Source: Ensembl
  4. cellular response to lithium ion Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. circadian rhythm Source: Ensembl
  7. extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  8. extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
  9. gene expression Source: Ensembl
  10. hepatocyte apoptotic process Source: Ensembl
  11. immunoglobulin production Source: Ensembl
  12. inflammatory cell apoptotic process Source: Ensembl
  13. motor neuron apoptotic process Source: Ensembl
  14. necroptotic signaling pathway Source: Ensembl
  15. negative regulation of apoptotic process Source: Ensembl
  16. negative regulation of B cell activation Source: Ensembl
  17. negative thymic T cell selection Source: Ensembl
  18. positive regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  19. positive regulation of protein homooligomerization Source: Ensembl
  20. protein homooligomerization Source: Ensembl
  21. regulation of lymphocyte differentiation Source: Ensembl
  22. regulation of myeloid cell differentiation Source: Ensembl
  23. renal system process Source: Ensembl
  24. response to glucocorticoid Source: Ensembl
  25. response to toxic substance Source: Ensembl
  26. spleen development Source: Ensembl
  27. transformed cell apoptotic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiREACT_295557. Regulation by c-FLIP.
REACT_300777. Caspase-8 activation by cleavage.
REACT_333623. FasL/ CD95L signaling.
REACT_334572. Dimerization of procaspase-8.

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 6
Alternative name(s):
Apo-1 antigen
Apoptosis-mediating surface antigen FAS
FASLG receptor
CD_antigen: CD95
Gene namesi
Name:FAS
Synonyms:APT1, TNFRSF6
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136 Componenti: Chromosome 26

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 170148ExtracellularSequence AnalysisAdd
BLAST
Transmembranei171 – 18818HelicalSequence AnalysisAdd
BLAST
Topological domaini189 – 323135CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. CD95 death-inducing signaling complex Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular vesicular exosome Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. membrane raft Source: Ensembl
  7. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 323301Tumor necrosis factor receptor superfamily member 6PRO_0000034561Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi45 ↔ 56PROSITE-ProRule annotation
Disulfide bondi57 ↔ 70PROSITE-ProRule annotation
Disulfide bondi60 ↔ 79PROSITE-ProRule annotation
Disulfide bondi82 ↔ 98PROSITE-ProRule annotation
Disulfide bondi101 ↔ 116PROSITE-ProRule annotation
Disulfide bondi104 ↔ 124PROSITE-ProRule annotation
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi126 ↔ 140PROSITE-ProRule annotation
Disulfide bondi143 ↔ 154PROSITE-ProRule annotation
Disulfide bondi146 ↔ 162PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP51867.

Interactioni

Subunit structurei

Binds DAXX and RIPK1. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD. Interacts with BRE and FEM1B (By similarity). Interacts with FADD (By similarity). Interacts directly (via DED domain) with NOL3 (via CARD domain); inhibits death-inducing signaling complex (DISC) assembly by inhibiting the increase in FAS-FADD binding induced by FAS activation (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP51867.
SMRiP51867. Positions 214-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati45 – 8036TNFR-Cys 1Add
BLAST
Repeati81 – 12444TNFR-Cys 2Add
BLAST
Repeati125 – 16339TNFR-Cys 3Add
BLAST
Domaini238 – 30669DeathPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni204 – 305102Interaction with HIPK3By similarityAdd
BLAST

Domaini

Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins.

Sequence similaritiesi

Contains 1 death domain.PROSITE-ProRule annotation
Contains 3 TNFR-Cys repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45364.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiP51867.
KOiK04390.
OMAiCDPCTKC.
OrthoDBiEOG7DVDC8.
TreeFamiTF333916.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51867-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGIWVHLSL IFISVSGPLS KGENAHMAGI NSEGLKLNIT EANSCQEGLY
60 70 80 90 100
REHQFCCQPC PPGKRKNGDC KRDGDTPECV LCSEGNEYTD KSHHSDKCIR
110 120 130 140 150
CSICDEEHGL EVEQNCTRTR NTKCRCKSNF FCNSSPCEHC NPCTTCEHGI
160 170 180 190 200
IEKCTPTSNT KCKGSRSHAN SLWALLILLI PIVLIIYKVV KSRERNKKND
210 220 230 240 250
YCNSAASNDE GRQLNLTDVD LGKYIPSIAE QMRITEVKEF VRKNGMEEAK
260 270 280 290 300
IDDIMHDNVH ETAEQKVQLL RNWYQSHGKK NAYCTLTKSL PKALAEKICD
310 320
IVMKDITNER ENANLQNENE NLV
Length:323
Mass (Da):36,445
Last modified:October 1, 1996 - v1
Checksum:i4D88A90E9E1F4892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34794 mRNA. Translation: AAC48546.1.
RefSeqiNP_777087.1. NM_174662.2.
UniGeneiBt.4345.

Genome annotation databases

EnsembliENSBTAT00000014282; ENSBTAP00000014282; ENSBTAG00000010785.
GeneIDi282488.
KEGGibta:282488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34794 mRNA. Translation: AAC48546.1.
RefSeqiNP_777087.1. NM_174662.2.
UniGeneiBt.4345.

3D structure databases

ProteinModelPortaliP51867.
SMRiP51867. Positions 214-323.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP51867.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000014282; ENSBTAP00000014282; ENSBTAG00000010785.
GeneIDi282488.
KEGGibta:282488.

Organism-specific databases

CTDi355.

Phylogenomic databases

eggNOGiNOG45364.
GeneTreeiENSGT00730000111280.
HOGENOMiHOG000139681.
HOVERGENiHBG004091.
InParanoidiP51867.
KOiK04390.
OMAiCDPCTKC.
OrthoDBiEOG7DVDC8.
TreeFamiTF333916.

Enzyme and pathway databases

ReactomeiREACT_295557. Regulation by c-FLIP.
REACT_300777. Caspase-8 activation by cleavage.
REACT_333623. FasL/ CD95L signaling.
REACT_334572. Dimerization of procaspase-8.

Miscellaneous databases

NextBioi20806250.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR008063. Fas_rcpt.
IPR001368. TNFR/NGFR_Cys_rich_reg.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 2 hits.
[Graphical view]
PRINTSiPR01680. TNFACTORR6.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 3 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of the bovine Fas."
    Yoo J., Stone R.T., Beattie C.W.
    DNA Cell Biol. 15:227-234(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiTNR6_BOVIN
AccessioniPrimary (citable) accession number: P51867
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.