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Protein

Teratocarcinoma-derived growth factor

Gene

Tdgf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.

GO - Molecular functioni

  • coreceptor activity Source: UniProtKB
  • growth factor activity Source: MGI
  • nodal binding Source: UniProtKB
  • receptor binding Source: MGI
  • type I activin receptor binding Source: UniProtKB
  • Wnt-protein binding Source: UniProtKB

GO - Biological processi

  • activation of MAPK activity Source: MGI
  • anterior/posterior axis specification Source: MGI
  • anterior/posterior axis specification, embryo Source: MGI
  • BMP signaling pathway Source: MGI
  • canonical Wnt signaling pathway Source: MGI
  • cardiac muscle cell differentiation Source: MGI
  • cell differentiation Source: UniProtKB
  • cell migration involved in sprouting angiogenesis Source: MGI
  • cellular response to epidermal growth factor stimulus Source: MGI
  • cellular response to fibroblast growth factor stimulus Source: MGI
  • cellular response to hepatocyte growth factor stimulus Source: MGI
  • cellular response to interferon-gamma Source: MGI
  • cellular response to interleukin-6 Source: MGI
  • cellular response to tumor necrosis factor Source: MGI
  • gastrulation Source: MGI
  • heart development Source: UniProtKB
  • in utero embryonic development Source: MGI
  • morphogenesis of a branching structure Source: UniProtKB
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • nodal signaling pathway Source: UniProtKB
  • peptidyl-serine phosphorylation Source: MGI
  • positive regulation of cell-matrix adhesion Source: MGI
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of endothelial cell migration Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of cell migration Source: MGI
  • regulation of signal transduction Source: MGI
  • vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-1181150. Signaling by NODAL.
R-MMU-1433617. Regulation of signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Teratocarcinoma-derived growth factor
Alternative name(s):
Cripto growth factor
Epidermal growth factor-like Cripto protein
Gene namesi
Name:Tdgf1
Synonyms:Cripto
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:98658. Tdgf1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • apical plasma membrane Source: MGI
  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • extracellular region Source: UniProtKB
  • extracellular space Source: MGI
  • extrinsic component of plasma membrane Source: MGI
  • Golgi apparatus Source: MGI
  • membrane raft Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi107W → A: Unable to bind Cripto receptor. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000750418 – 134Teratocarcinoma-derived growth factorAdd BLAST117
PropeptideiPRO_0000395411135 – 171Removed in mature formBy similarityAdd BLAST37

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi63N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi66 ↔ 73PROSITE-ProRule annotation
Disulfide bondi67 ↔ 79PROSITE-ProRule annotation
Disulfide bondi81 ↔ 90PROSITE-ProRule annotation
Disulfide bondi99 ↔ 117PROSITE-ProRule annotation1 Publication
Disulfide bondi112 ↔ 133PROSITE-ProRule annotation1 Publication
Disulfide bondi115 ↔ 124PROSITE-ProRule annotation1 Publication
Lipidationi134GPI-anchor amidated aspartateBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP51865.
PRIDEiP51865.

Expressioni

Tissue specificityi

Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus.

Developmental stagei

First expressed prior to the onset of gastrulation (early streak stage), then continues throughout embryonic development.

Gene expression databases

CleanExiMM_TDGF1.

Interactioni

Subunit structurei

Interacts with the activin type-1 receptor ACVR1B.By similarity

GO - Molecular functioni

  • growth factor activity Source: MGI
  • nodal binding Source: UniProtKB
  • receptor binding Source: MGI
  • type I activin receptor binding Source: UniProtKB
  • Wnt-protein binding Source: UniProtKB

Protein-protein interaction databases

DIPiDIP-46063N.
STRINGi10090.ENSMUSP00000035075.

Structurei

Secondary structure

1171
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi119 – 121Combined sources3
Beta strandi127 – 130Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J5HNMR-A96-134[»]
ProteinModelPortaliP51865.
SMRiP51865.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51865.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 91EGF-likePROSITE-ProRule annotationAdd BLAST30

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000145523.
HOVERGENiHBG054705.
InParanoidiP51865.
PhylomeDBiP51865.

Family and domain databases

InterProiIPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PANTHERiPTHR14949:SF26. PTHR14949:SF26. 1 hit.
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51865-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYFSSSVVL LVAISSAFEF GPVAGRDLAI RDNSIWDQKE PAVRDRSFQF
60 70 80 90 100
VPSVGIQNSK SLNKTCCLNG GTCILGSFCA CPPSFYGRNC EHDVRKEHCG
110 120 130 140 150
SILHGTWLPK KCSLCRCWHG QLHCLPQTFL PGCDGHVMDQ DLKASRTPCQ
160 170
TPSVTTTFML AGACLFLDMK V
Length:171
Mass (Da):18,754
Last modified:October 1, 1996 - v1
Checksum:iC52051AEACDB5380
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87321 mRNA. Translation: AAA37459.1.
X94083 Genomic DNA. Translation: CAA63827.1.
CCDSiCCDS40783.1.
PIRiI49612.
UniGeneiMm.5090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M87321 mRNA. Translation: AAA37459.1.
X94083 Genomic DNA. Translation: CAA63827.1.
CCDSiCCDS40783.1.
PIRiI49612.
UniGeneiMm.5090.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J5HNMR-A96-134[»]
ProteinModelPortaliP51865.
SMRiP51865.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46063N.
STRINGi10090.ENSMUSP00000035075.

Proteomic databases

PaxDbiP51865.
PRIDEiP51865.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98658. Tdgf1.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOGENOMiHOG000145523.
HOVERGENiHBG054705.
InParanoidiP51865.
PhylomeDBiP51865.

Enzyme and pathway databases

ReactomeiR-MMU-1181150. Signaling by NODAL.
R-MMU-1433617. Regulation of signaling by NODAL.

Miscellaneous databases

EvolutionaryTraceiP51865.
PROiP51865.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TDGF1.

Family and domain databases

InterProiIPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
[Graphical view]
PANTHERiPTHR14949:SF26. PTHR14949:SF26. 1 hit.
PfamiPF09443. CFC. 1 hit.
[Graphical view]
PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTDGF1_MOUSE
AccessioniPrimary (citable) accession number: P51865
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.