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Protein

Putative teratocarcinoma-derived growth factor 3

Gene

TDGF1P3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. Activates the Nodal-dependent signaling pathway.1 Publication

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

GO - Biological processi

  • signal transduction Source: UniProtKB

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-HSA-1181150. Signaling by NODAL.
R-HSA-1433617. Regulation of signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative teratocarcinoma-derived growth factor 3
Alternative name(s):
Cripto-3 growth factor
Epidermal growth factor-like cripto protein CR3
Teratocarcinoma-derived growth factor 1 pseudogene 3
Gene namesi
Name:TDGF1P3
Synonyms:CRIPTO3, TDGF2, TDGF3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:11703. TDGF1P3.

Subcellular locationi

GO - Cellular componenti

  • cell outer membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6998.
MIMi187395. gene+phenotype.

Polymorphism and mutation databases

DMDMi1706127.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000556271 – 188Putative teratocarcinoma-derived growth factor 3Add BLAST188

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi82 ↔ 89By similarity
Disulfide bondi83 ↔ 95By similarity
Disulfide bondi97 ↔ 106By similarity
Disulfide bondi115 ↔ 133By similarity
Disulfide bondi128 ↔ 149By similarity
Disulfide bondi131 ↔ 140By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51864.
PeptideAtlasiP51864.
PRIDEiP51864.

Expressioni

Tissue specificityi

Expressed weakly in lung, colon and breast. Expressed also strongly in primary cancer tissues; lung and colon cancers.1 Publication

Interactioni

GO - Molecular functioni

  • growth factor activity Source: UniProtKB

Structurei

3D structure databases

ProteinModelPortaliP51864.
SMRiP51864.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 107EGF-likeAdd BLAST30

Keywords - Domaini

EGF-like domain

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
HOVERGENiHBG054705.
InParanoidiP51864.

Family and domain databases

InterProiView protein in InterPro
IPR017047. Cripto_growth_factor.
IPR019011. Cryptic/Cripto_CFC-dom.
IPR013032. EGF-like_CS.
PANTHERiPTHR14949:SF28. PTHR14949:SF28. 1 hit.
PfamiView protein in Pfam
PF09443. CFC. 1 hit.
PIRSFiPIRSF036301. Cripto_growth_factor. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P51864-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDCRKMVRFS YSVIWIMAIS KAFELGLVAG LGHQEFARPS RGDLAFRDDS
60 70 80 90 100
IWPQEEPAIR PRSSQRVLPM GIQHSKELNR TCCLNGGTCM LESFCACPPS
110 120 130 140 150
FYGRNCEHDV RKENCGSVPH DTWLPKKCSL CKCWHGQLRC FPQAFLPGCD
160 170 180
GLVMDEHLVA SRTPELPPSA RTTTFMLAGI CLSIQSYY
Length:188
Mass (Da):21,181
Last modified:October 1, 1996 - v1
Checksum:iC07AC973E4D82B32
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96956 mRNA. Translation: AAA61135.1.
AF251549 Genomic DNA. Translation: AAG49538.1.
AF251550 Genomic DNA. Translation: AAG49539.1.
AC000113 Genomic DNA. Translation: AAB46353.1.
UniGeneiHs.592361.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTDGF3_HUMAN
AccessioniPrimary (citable) accession number: P51864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 5, 2017
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot