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P51863

- VA0D1_MOUSE

UniProt

P51863 - VA0D1_MOUSE

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Protein

V-type proton ATPase subunit d 1

Gene

Atp6v0d1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity).By similarity

Kineticsi

  1. KM=0.31 mM for ATP1 Publication

GO - Molecular functioni

  1. hydrogen-exporting ATPase activity, phosphorylative mechanism Source: MGI

GO - Biological processi

  1. ATP hydrolysis coupled proton transport Source: InterPro
  2. brain development Source: Ensembl
  3. cilium assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_106572. XBP1(S) activates chaperone genes.
REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Protein family/group databases

TCDBi3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase subunit d 1
Short name:
V-ATPase subunit d 1
Alternative name(s):
P39
Physophilin
V-ATPase 40 kDa accessory protein
V-ATPase AC39 subunit
Vacuolar proton pump subunit d 1
Gene namesi
Name:Atp6v0d1
Synonyms:Atp6d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1201778. Atp6v0d1.

Subcellular locationi

Membrane Curated; Peripheral membrane protein Curated; Cytoplasmic side Curated
Note: Localizes to centrosome and the base of the cilium.By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. axon terminus Source: Ensembl
  3. centrosome Source: Ensembl
  4. early endosome Source: MGI
  5. extracellular vesicular exosome Source: Ensembl
  6. lysosomal membrane Source: Ensembl
  7. proton-transporting V-type ATPase, V0 domain Source: InterPro
  8. synaptic vesicle Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 351351V-type proton ATPase subunit d 1PRO_0000119351Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei270 – 2701Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP51863.
PaxDbiP51863.
PRIDEiP51863.

PTM databases

PhosphoSiteiP51863.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Developmental stagei

Expressed throughout early development.1 Publication

Gene expression databases

BgeeiP51863.
CleanExiMM_ATP6V0D1.
GenevestigatoriP51863.

Interactioni

Subunit structurei

V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

Protein-protein interaction databases

BioGridi198264. 2 interactions.
IntActiP51863. 8 interactions.
MINTiMINT-1858223.

Structurei

3D structure databases

ProteinModelPortaliP51863.
SMRiP51863. Positions 28-54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the V-ATPase V0D/AC39 subunit family.Curated

Phylogenomic databases

eggNOGiCOG1527.
GeneTreeiENSGT00390000002200.
HOGENOMiHOG000199065.
HOVERGENiHBG018065.
InParanoidiP51863.
KOiK02146.
OMAiQMEAIHV.
OrthoDBiEOG7KH9JT.
PhylomeDBiP51863.
TreeFamiTF300857.

Family and domain databases

InterProiIPR002843. ATPase_V0-cplx_csu/dsu.
IPR016727. ATPase_V0-cplx_dsu.
[Graphical view]
PANTHERiPTHR11028. PTHR11028. 1 hit.
PfamiPF01992. vATP-synt_AC39. 1 hit.
[Graphical view]
PIRSFiPIRSF018497. V-ATP_synth_D. 1 hit.
SUPFAMiSSF103486. SSF103486. 1 hit.

Sequencei

Sequence statusi: Complete.

P51863-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ
60 70 80 90 100
STDYGNFLAN EASPLTVSVI DDKLKEKMVV EFRHMRNHAY EPLASFLDFI
110 120 130 140 150
TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL
160 170 180 190 200
YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL
210 220 230 240 250
GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE
260 270 280 290 300
GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
310 320 330 340 350
LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI

F
Length:351
Mass (Da):40,301
Last modified:January 11, 2001 - v2
Checksum:i62CDF67B982124C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231L → M in AAC83085. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13840 mRNA. Translation: AAC83085.1.
U21549 mRNA. Translation: AAA92288.1.
AB088408 mRNA. Translation: BAC57954.1.
AK083372 mRNA. Translation: BAC38889.1.
AK171515 mRNA. Translation: BAE42500.1.
CCDSiCCDS22604.1.
RefSeqiNP_038505.2. NM_013477.3.
UniGeneiMm.17708.

Genome annotation databases

EnsembliENSMUST00000013304; ENSMUSP00000013304; ENSMUSG00000013160.
GeneIDi11972.
KEGGimmu:11972.
UCSCiuc009ndg.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13840 mRNA. Translation: AAC83085.1 .
U21549 mRNA. Translation: AAA92288.1 .
AB088408 mRNA. Translation: BAC57954.1 .
AK083372 mRNA. Translation: BAC38889.1 .
AK171515 mRNA. Translation: BAE42500.1 .
CCDSi CCDS22604.1.
RefSeqi NP_038505.2. NM_013477.3.
UniGenei Mm.17708.

3D structure databases

ProteinModelPortali P51863.
SMRi P51863. Positions 28-54.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198264. 2 interactions.
IntActi P51863. 8 interactions.
MINTi MINT-1858223.

Protein family/group databases

TCDBi 3.A.2.2.6. the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily.

PTM databases

PhosphoSitei P51863.

Proteomic databases

MaxQBi P51863.
PaxDbi P51863.
PRIDEi P51863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000013304 ; ENSMUSP00000013304 ; ENSMUSG00000013160 .
GeneIDi 11972.
KEGGi mmu:11972.
UCSCi uc009ndg.1. mouse.

Organism-specific databases

CTDi 9114.
MGIi MGI:1201778. Atp6v0d1.

Phylogenomic databases

eggNOGi COG1527.
GeneTreei ENSGT00390000002200.
HOGENOMi HOG000199065.
HOVERGENi HBG018065.
InParanoidi P51863.
KOi K02146.
OMAi QMEAIHV.
OrthoDBi EOG7KH9JT.
PhylomeDBi P51863.
TreeFami TF300857.

Enzyme and pathway databases

Reactomei REACT_106572. XBP1(S) activates chaperone genes.
REACT_198345. Phagosomal maturation (early endosomal stage).
REACT_198515. Transferrin endocytosis and recycling.

Miscellaneous databases

ChiTaRSi ATP6V0D1. mouse.
NextBioi 280095.
PROi P51863.
SOURCEi Search...

Gene expression databases

Bgeei P51863.
CleanExi MM_ATP6V0D1.
Genevestigatori P51863.

Family and domain databases

InterProi IPR002843. ATPase_V0-cplx_csu/dsu.
IPR016727. ATPase_V0-cplx_dsu.
[Graphical view ]
PANTHERi PTHR11028. PTHR11028. 1 hit.
Pfami PF01992. vATP-synt_AC39. 1 hit.
[Graphical view ]
PIRSFi PIRSF018497. V-ATP_synth_D. 1 hit.
SUPFAMi SSF103486. SSF103486. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequences for mouse vacuolar ATPase subunits."
    Howell M.L., Dean G.E.
    Submitted (AUG-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Brain Ac39/physophilin: cloning, coexpression and colocalization with synaptophysin."
    Carrion-Vazquez M., Fernandez A.M., Chowen J., Nieto-Sampedro M.
    Eur. J. Neurosci. 10:1153-1166(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  3. "Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits."
    Sun-Wada G.-H., Yoshimizu T., Imai-Senga Y., Wada Y., Futai M.
    Gene 302:147-153(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  5. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 25-73; 87-128; 188-237; 240-288; 294-300; 304-320; 328-339 AND 344-351, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Expression and function of the mouse V-ATPase d subunit isoforms."
    Nishi T., Kawasaki-Nishi S., Forgac M.
    J. Biol. Chem. 278:46396-46402(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  7. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-270, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiVA0D1_MOUSE
AccessioniPrimary (citable) accession number: P51863
Secondary accession number(s): Q54A57, Q9QWJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3