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Protein

V-type proton ATPase subunit d 1

Gene

Atp6v0d1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).By similarity1 Publication

Kineticsi

  1. KM=0.31 mM for ATP1 Publication

    GO - Molecular functioni

    GO - Biological processi

    Keywordsi

    Biological processCilium biogenesis/degradation, Hydrogen ion transport, Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiR-MMU-1222556 ROS, RNS production in phagocytes
    R-MMU-77387 Insulin receptor recycling
    R-MMU-917977 Transferrin endocytosis and recycling
    R-MMU-983712 Ion channel transport

    Protein family/group databases

    TCDBi3.A.2.2.6 the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-type proton ATPase subunit d 1
    Short name:
    V-ATPase subunit d 1
    Alternative name(s):
    P39
    Physophilin
    V-ATPase 40 kDa accessory protein
    V-ATPase AC39 subunit
    Vacuolar proton pump subunit d 1
    Gene namesi
    Name:Atp6v0d1
    Synonyms:Atp6d
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    Proteomesi
    • UP000000589 Componenti: Chromosome 8

    Organism-specific databases

    MGIiMGI:1201778 Atp6v0d1

    Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00001193511 – 351V-type proton ATPase subunit d 1Add BLAST351

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei270PhosphotyrosineCombined sources1
    Modified residuei283PhosphoserineCombined sources1

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    EPDiP51863
    MaxQBiP51863
    PaxDbiP51863
    PeptideAtlasiP51863
    PRIDEiP51863

    PTM databases

    iPTMnetiP51863
    PhosphoSitePlusiP51863

    Expressioni

    Tissue specificityi

    Ubiquitous.2 Publications

    Developmental stagei

    Expressed throughout early development.1 Publication

    Gene expression databases

    BgeeiENSMUSG00000013160
    CleanExiMM_ATP6V0D1
    GenevisibleiP51863 MM

    Interactioni

    Subunit structurei

    V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'' and d).

    Protein-protein interaction databases

    BioGridi1982646 interactors.
    IntActiP51863 9 interactors.
    MINTiP51863
    STRINGi10090.ENSMUSP00000013304

    Structurei

    3D structure databases

    ProteinModelPortaliP51863
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the V-ATPase V0D/AC39 subunit family.Curated

    Phylogenomic databases

    eggNOGiKOG2957 Eukaryota
    COG1527 LUCA
    GeneTreeiENSGT00390000002200
    HOGENOMiHOG000199065
    HOVERGENiHBG018065
    InParanoidiP51863
    KOiK02146
    OMAiFMDFITY
    OrthoDBiEOG091G09L5
    PhylomeDBiP51863
    TreeFamiTF300857

    Family and domain databases

    Gene3Di1.20.1690.102 hits
    InterProiView protein in InterPro
    IPR036079 ATPase_su_C-like
    IPR002843 ATPase_V0-cplx_csu/dsu
    IPR016727 ATPase_V0-cplx_dsu
    IPR035067 V-type_ATPase_suC
    PANTHERiPTHR11028 PTHR11028, 1 hit
    PfamiView protein in Pfam
    PF01992 vATP-synt_AC39, 1 hit
    PIRSFiPIRSF018497 V-ATP_synth_D, 1 hit
    SUPFAMiSSF103486 SSF103486, 1 hit

    Sequencei

    Sequence statusi: Complete.

    P51863-1 [UniParc]FASTAAdd to basket

    « Hide

            10         20         30         40         50
    MSFFPELYFN VDNGYLEGLV RGLKAGVLSQ ADYLNLVQCE TLEDLKLHLQ
    60 70 80 90 100
    STDYGNFLAN EASPLTVSVI DDKLKEKMVV EFRHMRNHAY EPLASFLDFI
    110 120 130 140 150
    TYSYMIDNVI LLITGTLHQR SIAELVPKCH PLGSFEQMEA VNIAQTPAEL
    160 170 180 190 200
    YNAILVDTPL AAFFQDCISE QDLDEMNIEI IRNTLYKAYL ESFYKFCTLL
    210 220 230 240 250
    GGTTADAMCP ILEFEADRRA FIITINSFGT ELSKEDRAKL FPHCGRLYPE
    260 270 280 290 300
    GLAQLARADD YEQVKNVADY YPEYKLLFEG AGSNPGDKTL EDRFFEHEVK
    310 320 330 340 350
    LNKLAFLNQF HFGVFYAFVK LKEQECRNIV WIAECIAQRH RAKIDNYIPI

    F
    Length:351
    Mass (Da):40,301
    Last modified:January 11, 2001 - v2
    Checksum:i62CDF67B982124C9
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Sequence conflicti23L → M in AAC83085 (Ref. 1) Curated1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U13840 mRNA Translation: AAC83085.1
    U21549 mRNA Translation: AAA92288.1
    AB088408 mRNA Translation: BAC57954.1
    AK083372 mRNA Translation: BAC38889.1
    AK171515 mRNA Translation: BAE42500.1
    CCDSiCCDS22604.1
    RefSeqiNP_038505.2, NM_013477.3
    UniGeneiMm.17708

    Genome annotation databases

    EnsembliENSMUST00000013304; ENSMUSP00000013304; ENSMUSG00000013160
    GeneIDi11972
    KEGGimmu:11972
    UCSCiuc009ndg.1 mouse

    Similar proteinsi

    Entry informationi

    Entry nameiVA0D1_MOUSE
    AccessioniPrimary (citable) accession number: P51863
    Secondary accession number(s): Q54A57, Q9QWJ2
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: January 11, 2001
    Last modified: April 25, 2018
    This is version 151 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome