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P51861 (CDR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cerebellar degeneration-related antigen 1
Alternative name(s):
CDR34
Gene names
Name:CDR1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length262 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.

Miscellaneous

Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.

Sequence caution

The sequence AAA51962.1 differs from that shown. Reason: Frameshifts in positions 134, 176.

The sequence AAA52472.1 differs from that shown. Reason: Frameshift at positions 134 and 176.

Ontologies

Keywords
   DomainRepeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 262262Cerebellar degeneration-related antigen 1
PRO_0000089455

Regions

Repeat3 – 861
Repeat9 – 1462
Repeat15 – 2063
Repeat21 – 2664
Repeat27 – 3265
Repeat33 – 3866
Repeat39 – 4467
Repeat45 – 5068
Repeat51 – 5669
Repeat57 – 62610
Repeat63 – 68611
Repeat69 – 74612
Repeat75 – 80613
Repeat81 – 86614
Repeat87 – 92615
Repeat93 – 98616
Repeat99 – 104617
Repeat105 – 110618
Repeat111 – 116619
Repeat117 – 122620
Repeat123 – 128621
Repeat129 – 134622
Repeat135 – 140623
Repeat141 – 14661
Repeat147 – 15262
Repeat153 – 15863
Repeat159 – 16464
Repeat165 – 17065
Repeat171 – 17666
Repeat177 – 18261
Repeat183 – 18862
Repeat189 – 19463
Repeat195 – 20064
Repeat201 – 20665
Region3 – 14013823 X 6 AA approximate repeats
Region141 – 176366 X 6 AA approximate repeats
Region177 – 206305 X 6 AA approximate repeats

Sequences

Sequence LengthMass (Da)Tools
P51861 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 08EB318075AEE356

FASTA26231,279
        10         20         30         40         50         60 
MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA LLEDVDLLED 

        70         80         90        100        110        120 
TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL EDTDFLEDPD FLEAIDLRED 

       130        140        150        160        170        180 
KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK 

       190        200        210        220        230        240 
TWIFWKTWIF WKTWIFRKTY IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF 

       250        260 
WKTLIDWKTW ISFWKTLIDW KI 

« Hide

References

« Hide 'large scale' references
[1]"Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse."
Chen Y.-T., Rettig W.J., Yenamandra A.K., Kozak C.A., Chaganti R.S., Posner J.B., Old L.J.
Proc. Natl. Acad. Sci. U.S.A. 87:3077-3081(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration."
Dropcho E.J., Chen Y.-T., Posner J.B., Old L.J.
Proc. Natl. Acad. Sci. U.S.A. 84:4552-4556(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M31423 Genomic DNA. Translation: AAA51962.1. Sequence problems.
M16965 mRNA. Translation: AAA52472.1. Frameshift.
AL078639 Genomic DNA. Translation: CAI42370.1.
BC113472 mRNA. Translation: AAI13473.1.
BC113474 mRNA. Translation: AAI13475.1.
PIRA29770.
RefSeqNP_004056.2. NM_004065.2.
UniGeneHs.446675.

3D structure databases

ProteinModelPortalP51861.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP51861. 1 interaction.
STRING9606.ENSP00000359563.

PTM databases

PhosphoSiteP51861.

Polymorphism databases

DMDM160380504.

Proteomic databases

PRIDEP51861.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000370532; ENSP00000359563; ENSG00000184258.
GeneID1038.
KEGGhsa:1038.
UCSCuc004fbg.1. human.

Organism-specific databases

CTD1038.
GeneCardsGC0XM139865.
HGNCHGNC:1798. CDR1.
MIM302650. gene.
neXtProtNX_P51861.
PharmGKBPA26330.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG84128.
HOGENOMHOG000111501.
InParanoidP51861.
OMAKTWISFW.
OrthoDBEOG7RFTK0.
PhylomeDBP51861.

Gene expression databases

BgeeP51861.
CleanExHS_CDR1.
GenevestigatorP51861.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSCDR1. human.
GeneWikiCDR1_(gene).
GenomeRNAi1038.
NextBio4357.
PROP51861.
SOURCESearch...

Entry information

Entry nameCDR1_HUMAN
AccessionPrimary (citable) accession number: P51861
Secondary accession number(s): Q5JXH6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 23, 2007
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM