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P51861

- CDR1_HUMAN

UniProt

P51861 - CDR1_HUMAN

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Protein

Cerebellar degeneration-related antigen 1

Gene

CDR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellar degeneration-related antigen 1
Alternative name(s):
CDR34
Gene namesi
Name:CDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:1798. CDR1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Cerebellar degeneration-related antigen 1PRO_0000089455Add
BLAST

Proteomic databases

PRIDEiP51861.

PTM databases

PhosphoSiteiP51861.

Expressioni

Tissue specificityi

Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.

Gene expression databases

BgeeiP51861.
CleanExiHS_CDR1.
GenevestigatoriP51861.

Interactioni

Protein-protein interaction databases

IntActiP51861. 1 interaction.
STRINGi9606.ENSP00000359563.

Structurei

3D structure databases

ProteinModelPortaliP51861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati3 – 861
Repeati9 – 1462
Repeati15 – 2063
Repeati21 – 2664
Repeati27 – 3265
Repeati33 – 3866
Repeati39 – 4467
Repeati45 – 5068
Repeati51 – 5669
Repeati57 – 62610
Repeati63 – 68611
Repeati69 – 74612
Repeati75 – 80613
Repeati81 – 86614
Repeati87 – 92615
Repeati93 – 98616
Repeati99 – 104617
Repeati105 – 110618
Repeati111 – 116619
Repeati117 – 122620
Repeati123 – 128621
Repeati129 – 134622
Repeati135 – 140623
Repeati141 – 14661
Repeati147 – 15262
Repeati153 – 15863
Repeati159 – 16464
Repeati165 – 17065
Repeati171 – 17666
Repeati177 – 18261
Repeati183 – 18862
Repeati189 – 19463
Repeati195 – 20064
Repeati201 – 20665

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni3 – 14013823 X 6 AA approximate repeatsAdd
BLAST
Regioni141 – 176366 X 6 AA approximate repeatsAdd
BLAST
Regioni177 – 206305 X 6 AA approximate repeatsAdd
BLAST

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG84128.
GeneTreeiENSGT00390000013647.
HOGENOMiHOG000111501.
InParanoidiP51861.
OMAiKTWISFW.
OrthoDBiEOG7RFTK0.
PhylomeDBiP51861.

Sequencei

Sequence statusi: Complete.

P51861-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA
60 70 80 90 100
LLEDVDLLED TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL
110 120 130 140 150
EDTDFLEDPD FLEAIDLRED KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR
160 170 180 190 200
RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK TWIFWKTWIF WKTWIFRKTY
210 220 230 240 250
IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF WKTLIDWKTW
260
ISFWKTLIDW KI
Length:262
Mass (Da):31,279
Last modified:October 23, 2007 - v2
Checksum:i08EB318075AEE356
GO

Sequence cautioni

The sequence AAA51962.1 differs from that shown. Reason: Frameshifts in positions 134, 176.Curated
The sequence AAA52472.1 differs from that shown. Reason: Frameshift at positions 134 and 176. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31423 Genomic DNA. Translation: AAA51962.1. Sequence problems.
M16965 mRNA. Translation: AAA52472.1. Frameshift.
AL078639 Genomic DNA. Translation: CAI42370.1.
BC113472 mRNA. Translation: AAI13473.1.
BC113474 mRNA. Translation: AAI13475.1.
CCDSiCCDS14670.1.
PIRiA29770.
RefSeqiNP_004056.2. NM_004065.2.
UniGeneiHs.446675.

Genome annotation databases

EnsembliENST00000370532; ENSP00000359563; ENSG00000184258.
GeneIDi1038.
KEGGihsa:1038.
UCSCiuc004fbg.1. human.

Polymorphism databases

DMDMi160380504.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31423 Genomic DNA. Translation: AAA51962.1 . Sequence problems.
M16965 mRNA. Translation: AAA52472.1 . Frameshift.
AL078639 Genomic DNA. Translation: CAI42370.1 .
BC113472 mRNA. Translation: AAI13473.1 .
BC113474 mRNA. Translation: AAI13475.1 .
CCDSi CCDS14670.1.
PIRi A29770.
RefSeqi NP_004056.2. NM_004065.2.
UniGenei Hs.446675.

3D structure databases

ProteinModelPortali P51861.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P51861. 1 interaction.
STRINGi 9606.ENSP00000359563.

PTM databases

PhosphoSitei P51861.

Polymorphism databases

DMDMi 160380504.

Proteomic databases

PRIDEi P51861.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370532 ; ENSP00000359563 ; ENSG00000184258 .
GeneIDi 1038.
KEGGi hsa:1038.
UCSCi uc004fbg.1. human.

Organism-specific databases

CTDi 1038.
GeneCardsi GC0XM139865.
HGNCi HGNC:1798. CDR1.
MIMi 302650. gene.
neXtProti NX_P51861.
PharmGKBi PA26330.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG84128.
GeneTreei ENSGT00390000013647.
HOGENOMi HOG000111501.
InParanoidi P51861.
OMAi KTWISFW.
OrthoDBi EOG7RFTK0.
PhylomeDBi P51861.

Miscellaneous databases

ChiTaRSi CDR1. human.
GeneWikii CDR1_(gene).
GenomeRNAii 1038.
NextBioi 4357.
PROi P51861.
SOURCEi Search...

Gene expression databases

Bgeei P51861.
CleanExi HS_CDR1.
Genevestigatori P51861.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse."
    Chen Y.-T., Rettig W.J., Yenamandra A.K., Kozak C.A., Chaganti R.S., Posner J.B., Old L.J.
    Proc. Natl. Acad. Sci. U.S.A. 87:3077-3081(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration."
    Dropcho E.J., Chen Y.-T., Posner J.B., Old L.J.
    Proc. Natl. Acad. Sci. U.S.A. 84:4552-4556(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCDR1_HUMAN
AccessioniPrimary (citable) accession number: P51861
Secondary accession number(s): Q5JXH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 23, 2007
Last modified: October 29, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3