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Protein

Cerebellar degeneration-related antigen 1

Gene

CDR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:G66-32753-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cerebellar degeneration-related antigen 1
Alternative name(s):
CDR34
Gene namesi
Name:CDR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:1798. CDR1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi1038.
OpenTargetsiENSG00000184258.
PharmGKBiPA26330.

Polymorphism and mutation databases

BioMutaiCDR1.
DMDMi160380504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894551 – 262Cerebellar degeneration-related antigen 1Add BLAST262

Proteomic databases

PaxDbiP51861.
PeptideAtlasiP51861.
PRIDEiP51861.

PTM databases

iPTMnetiP51861.
PhosphoSitePlusiP51861.

Expressioni

Tissue specificityi

Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.

Gene expression databases

BgeeiENSG00000184258.
CleanExiHS_CDR1.
GenevisibleiP51861. HS.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZMYND10O758003EBI-2836538,EBI-747061

Protein-protein interaction databases

BioGridi107469. 1 interactor.
IntActiP51861. 2 interactors.
STRINGi9606.ENSP00000359563.

Structurei

3D structure databases

ProteinModelPortaliP51861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati3 – 816
Repeati9 – 1426
Repeati15 – 2036
Repeati21 – 2646
Repeati27 – 3256
Repeati33 – 3866
Repeati39 – 4476
Repeati45 – 5086
Repeati51 – 5696
Repeati57 – 62106
Repeati63 – 68116
Repeati69 – 74126
Repeati75 – 80136
Repeati81 – 86146
Repeati87 – 92156
Repeati93 – 98166
Repeati99 – 104176
Repeati105 – 110186
Repeati111 – 116196
Repeati117 – 122206
Repeati123 – 128216
Repeati129 – 134226
Repeati135 – 140236
Repeati141 – 14616
Repeati147 – 15226
Repeati153 – 15836
Repeati159 – 16446
Repeati165 – 17056
Repeati171 – 17666
Repeati177 – 18216
Repeati183 – 18826
Repeati189 – 19436
Repeati195 – 20046
Repeati201 – 20656

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 14023 X 6 AA approximate repeatsAdd BLAST138
Regioni141 – 1766 X 6 AA approximate repeatsAdd BLAST36
Regioni177 – 2065 X 6 AA approximate repeatsAdd BLAST30

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J5UQ. Eukaryota.
ENOG410Y6AB. LUCA.
GeneTreeiENSGT00390000013647.
HOGENOMiHOG000111501.
InParanoidiP51861.
OMAiKTWISFW.
OrthoDBiEOG091G10IJ.
PhylomeDBiP51861.

Family and domain databases

InterProiIPR033233. CDR1.
[Graphical view]
PANTHERiPTHR15194:SF23. PTHR15194:SF23. 1 hit.

Sequencei

Sequence statusi: Complete.

P51861-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA
60 70 80 90 100
LLEDVDLLED TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL
110 120 130 140 150
EDTDFLEDPD FLEAIDLRED KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR
160 170 180 190 200
RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK TWIFWKTWIF WKTWIFRKTY
210 220 230 240 250
IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF WKTLIDWKTW
260
ISFWKTLIDW KI
Length:262
Mass (Da):31,279
Last modified:October 23, 2007 - v2
Checksum:i08EB318075AEE356
GO

Sequence cautioni

The sequence AAA51962 differs from that shown. Frameshifts in positions 134, 176.Curated
The sequence AAA52472 differs from that shown. Reason: Frameshift at positions 134 and 176.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31423 Genomic DNA. Translation: AAA51962.1. Sequence problems.
M16965 mRNA. Translation: AAA52472.1. Frameshift.
AL078639 Genomic DNA. Translation: CAI42370.1.
BC113472 mRNA. Translation: AAI13473.1.
BC113474 mRNA. Translation: AAI13475.1.
CCDSiCCDS14670.1.
PIRiA29770.
RefSeqiNP_004056.2. NM_004065.2.
UniGeneiHs.446675.

Genome annotation databases

EnsembliENST00000370532; ENSP00000359563; ENSG00000184258.
GeneIDi1038.
KEGGihsa:1038.
UCSCiuc004fbg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M31423 Genomic DNA. Translation: AAA51962.1. Sequence problems.
M16965 mRNA. Translation: AAA52472.1. Frameshift.
AL078639 Genomic DNA. Translation: CAI42370.1.
BC113472 mRNA. Translation: AAI13473.1.
BC113474 mRNA. Translation: AAI13475.1.
CCDSiCCDS14670.1.
PIRiA29770.
RefSeqiNP_004056.2. NM_004065.2.
UniGeneiHs.446675.

3D structure databases

ProteinModelPortaliP51861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107469. 1 interactor.
IntActiP51861. 2 interactors.
STRINGi9606.ENSP00000359563.

PTM databases

iPTMnetiP51861.
PhosphoSitePlusiP51861.

Polymorphism and mutation databases

BioMutaiCDR1.
DMDMi160380504.

Proteomic databases

PaxDbiP51861.
PeptideAtlasiP51861.
PRIDEiP51861.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370532; ENSP00000359563; ENSG00000184258.
GeneIDi1038.
KEGGihsa:1038.
UCSCiuc004fbg.2. human.

Organism-specific databases

CTDi1038.
DisGeNETi1038.
GeneCardsiCDR1.
HGNCiHGNC:1798. CDR1.
MIMi302650. gene.
neXtProtiNX_P51861.
OpenTargetsiENSG00000184258.
PharmGKBiPA26330.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J5UQ. Eukaryota.
ENOG410Y6AB. LUCA.
GeneTreeiENSGT00390000013647.
HOGENOMiHOG000111501.
InParanoidiP51861.
OMAiKTWISFW.
OrthoDBiEOG091G10IJ.
PhylomeDBiP51861.

Enzyme and pathway databases

BioCyciZFISH:G66-32753-MONOMER.

Miscellaneous databases

ChiTaRSiCDR1. human.
GeneWikiiCDR1_(gene).
GenomeRNAii1038.
PROiP51861.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184258.
CleanExiHS_CDR1.
GenevisibleiP51861. HS.

Family and domain databases

InterProiIPR033233. CDR1.
[Graphical view]
PANTHERiPTHR15194:SF23. PTHR15194:SF23. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCDR1_HUMAN
AccessioniPrimary (citable) accession number: P51861
Secondary accession number(s): Q5JXH6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 23, 2007
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.