P51861 (CDR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cerebellar degeneration-related antigen 1

Alternative name(s):
CDR34

Gene names

Name:

CDR1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	262 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.
Miscellaneous	Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.
Sequence caution	The sequence AAA51962.1 differs from that shown. Reason: Frameshifts in positions 134, 176. The sequence AAA52472.1 differs from that shown. Reason: Frameshift at positions 134 and 176.

Ontologies

Keywords
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 262	262	Cerebellar degeneration-related antigen 1		PRO_0000089455
Regions
	Repeat	3 – 8	6	1
	Repeat	9 – 14	6	2
	Repeat	15 – 20	6	3
	Repeat	21 – 26	6	4
	Repeat	27 – 32	6	5
	Repeat	33 – 38	6	6
	Repeat	39 – 44	6	7
	Repeat	45 – 50	6	8
	Repeat	51 – 56	6	9
	Repeat	57 – 62	6	10
	Repeat	63 – 68	6	11
	Repeat	69 – 74	6	12
	Repeat	75 – 80	6	13
	Repeat	81 – 86	6	14
	Repeat	87 – 92	6	15
	Repeat	93 – 98	6	16
	Repeat	99 – 104	6	17
	Repeat	105 – 110	6	18
	Repeat	111 – 116	6	19
	Repeat	117 – 122	6	20
	Repeat	123 – 128	6	21
	Repeat	129 – 134	6	22
	Repeat	135 – 140	6	23
	Repeat	141 – 146	6	1
	Repeat	147 – 152	6	2
	Repeat	153 – 158	6	3
	Repeat	159 – 164	6	4
	Repeat	165 – 170	6	5
	Repeat	171 – 176	6	6
	Repeat	177 – 182	6	1
	Repeat	183 – 188	6	2
	Repeat	189 – 194	6	3
	Repeat	195 – 200	6	4
	Repeat	201 – 206	6	5
	Region	3 – 140	138	23 X 6 AA approximate repeats
	Region	141 – 176	36	6 X 6 AA approximate repeats
	Region	177 – 206	30	5 X 6 AA approximate repeats

Sequences

	Sequence		Length	Mass (Da)
	P51861 [UniParc]. Last modified October 23, 2007. Version 2. Checksum: 08EB318075AEE356	FASTA	262	31,279
	10 20 30 40 50 60 MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA LLEDVDLLED 70 80 90 100 110 120 TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL EDTDFLEDPD FLEAIDLRED 130 140 150 160 170 180 KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK 190 200 210 220 230 240 TWIFWKTWIF WKTWIFRKTY IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF 250 260 WKTLIDWKTW ISFWKTLIDW KI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse." Chen Y.-T., Rettig W.J., Yenamandra A.K., Kozak C.A., Chaganti R.S., Posner J.B., Old L.J. Proc. Natl. Acad. Sci. U.S.A. 87:3077-3081(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration." Dropcho E.J., Chen Y.-T., Posner J.B., Old L.J. Proc. Natl. Acad. Sci. U.S.A. 84:4552-4556(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M31423 Genomic DNA. Translation: AAA51962.1. Sequence problems. M16965 mRNA. Translation: AAA52472.1. Frameshift. AL078639 Genomic DNA. Translation: CAI42370.1. BC113472 mRNA. Translation: AAI13473.1. BC113474 mRNA. Translation: AAI13475.1.
IPI	IPI00020963.
PIR	A29770.
RefSeq	NP_004056.2. NM_004065.2.
UniGene	Hs.446675.
3D structure databases
ProteinModelPortal	P51861.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51861. 1 interaction.
STRING	9606.ENSP00000359563.
PTM databases
PhosphoSite	P51861.
Polymorphism databases
DMDM	160380504.
Proteomic databases
PRIDE	P51861.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000370532; ENSP00000359563; ENSG00000184258.
GeneID	1038.
KEGG	hsa:1038.
UCSC	uc004fbg.1. human.
Organism-specific databases
CTD	1038.
GeneCards	GC0XM139865.
HGNC	HGNC:1798. CDR1.
MIM	302650. gene.
neXtProt	NX_P51861.
PharmGKB	PA26330.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG84128.
HOGENOM	HOG000111501.
InParanoid	P51861.
OMA	KTWISFW.
OrthoDB	EOG4M0F31.
Gene expression databases
Bgee	P51861.
CleanEx	HS_CDR1.
Genevestigator	P51861.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	CDR1. human.
GenomeRNAi	1038.
NextBio	4357.
SOURCE	Search...

Entry information

Entry name

CDR1_HUMAN

Accession

Primary (citable) accession number: P51861
Secondary accession number(s): Q5JXH6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 23, 2007
Last modified:	April 3, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.