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P51861

- CDR1_HUMAN

UniProt

P51861 - CDR1_HUMAN

Protein

Cerebellar degeneration-related antigen 1

Gene

CDR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 2 (23 Oct 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cerebellar degeneration-related antigen 1
    Alternative name(s):
    CDR34
    Gene namesi
    Name:CDR1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:1798. CDR1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26330.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Cerebellar degeneration-related antigen 1PRO_0000089455Add
    BLAST

    Proteomic databases

    PRIDEiP51861.

    PTM databases

    PhosphoSiteiP51861.

    Expressioni

    Tissue specificityi

    Brain; predominantly expressed in normal neuroectodermal tissues and in certain malignant tumors.

    Gene expression databases

    BgeeiP51861.
    CleanExiHS_CDR1.
    GenevestigatoriP51861.

    Interactioni

    Protein-protein interaction databases

    IntActiP51861. 1 interaction.
    STRINGi9606.ENSP00000359563.

    Structurei

    3D structure databases

    ProteinModelPortaliP51861.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati3 – 861
    Repeati9 – 1462
    Repeati15 – 2063
    Repeati21 – 2664
    Repeati27 – 3265
    Repeati33 – 3866
    Repeati39 – 4467
    Repeati45 – 5068
    Repeati51 – 5669
    Repeati57 – 62610
    Repeati63 – 68611
    Repeati69 – 74612
    Repeati75 – 80613
    Repeati81 – 86614
    Repeati87 – 92615
    Repeati93 – 98616
    Repeati99 – 104617
    Repeati105 – 110618
    Repeati111 – 116619
    Repeati117 – 122620
    Repeati123 – 128621
    Repeati129 – 134622
    Repeati135 – 140623
    Repeati141 – 14661
    Repeati147 – 15262
    Repeati153 – 15863
    Repeati159 – 16464
    Repeati165 – 17065
    Repeati171 – 17666
    Repeati177 – 18261
    Repeati183 – 18862
    Repeati189 – 19463
    Repeati195 – 20064
    Repeati201 – 20665

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni3 – 14013823 X 6 AA approximate repeatsAdd
    BLAST
    Regioni141 – 176366 X 6 AA approximate repeatsAdd
    BLAST
    Regioni177 – 206305 X 6 AA approximate repeatsAdd
    BLAST

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG84128.
    HOGENOMiHOG000111501.
    InParanoidiP51861.
    OMAiKTWISFW.
    OrthoDBiEOG7RFTK0.
    PhylomeDBiP51861.

    Sequencei

    Sequence statusi: Complete.

    P51861-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAWLEDVDFL EDVPLLEDIP LLEDVPLLED VPLLEDTSRL EDINLMEDMA    50
    LLEDVDLLED TDFLEDLDFS EAMDLREDKD FLEDMDSLED MALLEDVDLL 100
    EDTDFLEDPD FLEAIDLRED KDFLEDMDSL EDLEAIGRCG FSGRHGFFGR 150
    RRFSGRPKLS GRLGLLGRRG FSGRLGGYWK TWIFWKTWIF WKTWIFRKTY 200
    IGWKTWIFSG RCGLTGRPGF GGRRRFFWKT LTDWKTWISF WKTLIDWKTW 250
    ISFWKTLIDW KI 262
    Length:262
    Mass (Da):31,279
    Last modified:October 23, 2007 - v2
    Checksum:i08EB318075AEE356
    GO

    Sequence cautioni

    The sequence AAA51962.1 differs from that shown. Reason: Frameshifts in positions 134, 176.
    The sequence AAA52472.1 differs from that shown. Reason: Frameshift at positions 134 and 176.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31423 Genomic DNA. Translation: AAA51962.1. Sequence problems.
    M16965 mRNA. Translation: AAA52472.1. Frameshift.
    AL078639 Genomic DNA. Translation: CAI42370.1.
    BC113472 mRNA. Translation: AAI13473.1.
    BC113474 mRNA. Translation: AAI13475.1.
    CCDSiCCDS14670.1.
    PIRiA29770.
    RefSeqiNP_004056.2. NM_004065.2.
    UniGeneiHs.446675.

    Genome annotation databases

    EnsembliENST00000370532; ENSP00000359563; ENSG00000184258.
    GeneIDi1038.
    KEGGihsa:1038.
    UCSCiuc004fbg.1. human.

    Polymorphism databases

    DMDMi160380504.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M31423 Genomic DNA. Translation: AAA51962.1 . Sequence problems.
    M16965 mRNA. Translation: AAA52472.1 . Frameshift.
    AL078639 Genomic DNA. Translation: CAI42370.1 .
    BC113472 mRNA. Translation: AAI13473.1 .
    BC113474 mRNA. Translation: AAI13475.1 .
    CCDSi CCDS14670.1.
    PIRi A29770.
    RefSeqi NP_004056.2. NM_004065.2.
    UniGenei Hs.446675.

    3D structure databases

    ProteinModelPortali P51861.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P51861. 1 interaction.
    STRINGi 9606.ENSP00000359563.

    PTM databases

    PhosphoSitei P51861.

    Polymorphism databases

    DMDMi 160380504.

    Proteomic databases

    PRIDEi P51861.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370532 ; ENSP00000359563 ; ENSG00000184258 .
    GeneIDi 1038.
    KEGGi hsa:1038.
    UCSCi uc004fbg.1. human.

    Organism-specific databases

    CTDi 1038.
    GeneCardsi GC0XM139865.
    HGNCi HGNC:1798. CDR1.
    MIMi 302650. gene.
    neXtProti NX_P51861.
    PharmGKBi PA26330.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG84128.
    HOGENOMi HOG000111501.
    InParanoidi P51861.
    OMAi KTWISFW.
    OrthoDBi EOG7RFTK0.
    PhylomeDBi P51861.

    Miscellaneous databases

    ChiTaRSi CDR1. human.
    GeneWikii CDR1_(gene).
    GenomeRNAii 1038.
    NextBioi 4357.
    PROi P51861.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51861.
    CleanExi HS_CDR1.
    Genevestigatori P51861.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cerebellar degeneration-related antigen: a highly conserved neuroectodermal marker mapped to chromosomes X in human and mouse."
      Chen Y.-T., Rettig W.J., Yenamandra A.K., Kozak C.A., Chaganti R.S., Posner J.B., Old L.J.
      Proc. Natl. Acad. Sci. U.S.A. 87:3077-3081(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration."
      Dropcho E.J., Chen Y.-T., Posner J.B., Old L.J.
      Proc. Natl. Acad. Sci. U.S.A. 84:4552-4556(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCDR1_HUMAN
    AccessioniPrimary (citable) accession number: P51861
    Secondary accession number(s): Q5JXH6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 23, 2007
    Last modified: October 1, 2014
    This is version 87 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Autoantibodies against CDR1 are found in patients with paraneoplastic cerebellar degeneration.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3