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Protein

Hepatoma-derived growth factor

Gene

Hdgf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei19HeparinBy similarity1
Binding sitei21HeparinBy similarity1
Binding sitei72HeparinBy similarity1
Binding sitei75HeparinBy similarity1
Binding sitei79HeparinBy similarity1
Binding sitei80HeparinBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Heparin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatoma-derived growth factor
Short name:
HDGF
Gene namesi
Name:Hdgf
Synonyms:Tdrm1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1194494. Hdgf.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular space Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • transcriptional repressor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001917011 – 237Hepatoma-derived growth factorAdd BLAST237

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44N6-acetyllysineBy similarity1
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternateBy similarity
Cross-linki80Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei128PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei199PhosphoserineBy similarity1
Modified residuei200PhosphothreonineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei236PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated with SUMO1. Sumoylation prevents binding to chromatin (By similarity).By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP51859.
MaxQBiP51859.
PaxDbiP51859.
PeptideAtlasiP51859.
PRIDEiP51859.
TopDownProteomicsiP51859.

PTM databases

iPTMnetiP51859.
PhosphoSitePlusiP51859.
SwissPalmiP51859.

Miscellaneous databases

PMAP-CutDBP51859.

Expressioni

Tissue specificityi

Expressed predominantly in testis and skeletal muscle, to intermediate extents in heart, brain, lung, liver, and kidney, and to a minimal extent in spleen.

Gene expression databases

BgeeiENSMUSG00000004897.
CleanExiMM_HDGF.
ExpressionAtlasiP51859. baseline and differential.
GenevisibleiP51859. MM.

Interactioni

Subunit structurei

Monomer, and domain-swapped homodimer.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Q3UMU9-14EBI-2943087,EBI-7627862
Q3UMU9-34EBI-2943087,EBI-7627932
Hdgfrp2Q3UMU94EBI-2943087,EBI-7627961

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200265. 2 interactors.
IntActiP51859. 8 interactors.
MINTiMINT-4097326.
STRINGi10090.ENSMUSP00000005017.

Structurei

3D structure databases

ProteinModelPortaliP51859.
SMRiP51859.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 69PWWPPROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi75 – 80Nuclear localization signalBy similarity6
Motifi155 – 170Bipartite nuclear localization signalBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi111 – 227Glu-richAdd BLAST117

Domaini

The PWWP domain harbors the heparin-binding sites and is responsible for DNA-binding, while the C-terminal region is essentially unstructured.By similarity

Sequence similaritiesi

Belongs to the HDGF family.Curated
Contains 1 PWWP domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IMJ5. Eukaryota.
ENOG4111IFT. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiP51859.
KOiK16641.
OMAiGEKKGNT.
OrthoDBiEOG091G045X.
PhylomeDBiP51859.
TreeFamiTF105385.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51859-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSNRQKEY KCGDLVFAKM KGYPHWPARI DEMPEAAVKS TANKYQVFFF
60 70 80 90 100
GTHETAFLGP KDLFPYEESK EKFGKPNKRK GFSEGLWEIE NNPTVKASGY
110 120 130 140 150
QSSQKKSCAA EPEVEPEAHE GDGDKKGSAE GSSDEEGKLV IDEPAKEKNE
160 170 180 190 200
KGTLKRRAGD VLEDSPKRPK ESGDHEEEDK EIAALEGERP LPVEVEKNST
210 220 230
PSEPDSGQGP PAEEEEGEEE AAKEEAEAQG VRDHESL
Length:237
Mass (Da):26,269
Last modified:August 13, 2002 - v2
Checksum:iAAE4CF574DA4733F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118A → D in BAB30979 (PubMed:16141072).Curated1
Sequence conflicti190P → H in BAA09838 (PubMed:9299445).Curated1
Sequence conflicti229Q → E in BAC36126 (PubMed:16141072).Curated1
Sequence conflicti229Q → P in BAA09838 (PubMed:9299445).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63707 mRNA. Translation: BAA09838.1.
AF251787 mRNA. Translation: AAF65469.1.
AK017863 mRNA. Translation: BAB30979.1.
AK029475 mRNA. Translation: BAC26466.1.
AK076021 mRNA. Translation: BAC36126.1.
BC005713 mRNA. Translation: AAH05713.1.
BC021654 mRNA. Translation: AAH21654.1.
CCDSiCCDS17457.1.
PIRiJC5660.
RefSeqiNP_032257.3. NM_008231.4.
UniGeneiMm.292208.

Genome annotation databases

EnsembliENSMUST00000005017; ENSMUSP00000005017; ENSMUSG00000004897.
GeneIDi15191.
KEGGimmu:15191.
UCSCiuc008ptc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63707 mRNA. Translation: BAA09838.1.
AF251787 mRNA. Translation: AAF65469.1.
AK017863 mRNA. Translation: BAB30979.1.
AK029475 mRNA. Translation: BAC26466.1.
AK076021 mRNA. Translation: BAC36126.1.
BC005713 mRNA. Translation: AAH05713.1.
BC021654 mRNA. Translation: AAH21654.1.
CCDSiCCDS17457.1.
PIRiJC5660.
RefSeqiNP_032257.3. NM_008231.4.
UniGeneiMm.292208.

3D structure databases

ProteinModelPortaliP51859.
SMRiP51859.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200265. 2 interactors.
IntActiP51859. 8 interactors.
MINTiMINT-4097326.
STRINGi10090.ENSMUSP00000005017.

PTM databases

iPTMnetiP51859.
PhosphoSitePlusiP51859.
SwissPalmiP51859.

Proteomic databases

EPDiP51859.
MaxQBiP51859.
PaxDbiP51859.
PeptideAtlasiP51859.
PRIDEiP51859.
TopDownProteomicsiP51859.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005017; ENSMUSP00000005017; ENSMUSG00000004897.
GeneIDi15191.
KEGGimmu:15191.
UCSCiuc008ptc.2. mouse.

Organism-specific databases

CTDi3068.
MGIiMGI:1194494. Hdgf.

Phylogenomic databases

eggNOGiENOG410IMJ5. Eukaryota.
ENOG4111IFT. LUCA.
GeneTreeiENSGT00530000063013.
HOGENOMiHOG000112874.
HOVERGENiHBG010574.
InParanoidiP51859.
KOiK16641.
OMAiGEKKGNT.
OrthoDBiEOG091G045X.
PhylomeDBiP51859.
TreeFamiTF105385.

Miscellaneous databases

ChiTaRSiHdgf. mouse.
PMAP-CutDBP51859.
PROiP51859.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004897.
CleanExiMM_HDGF.
ExpressionAtlasiP51859. baseline and differential.
GenevisibleiP51859. MM.

Family and domain databases

InterProiIPR000313. PWWP_dom.
[Graphical view]
PfamiPF00855. PWWP. 1 hit.
[Graphical view]
SMARTiSM00293. PWWP. 1 hit.
[Graphical view]
PROSITEiPS50812. PWWP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHDGF_MOUSE
AccessioniPrimary (citable) accession number: P51859
Secondary accession number(s): Q8BPG7, Q9CYA4, Q9JK87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 13, 2002
Last modified: November 2, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.