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P51852 (DCIP_AZOBR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Indole-3-pyruvate decarboxylase
Short name=Indolepyruvate decarboxylase
EC=4.1.1.74
Gene names
Name:ipdC
OrganismAzospirillum brasilense
Taxonomic identifier192 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Rhodospirillaceae › Azospirillum

Protein attributes

Sequence length545 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO2.

Cofactor

Binds 1 metal ion per subunit.

Binds 1 thiamine pyrophosphate per subunit.

Pathway

Plant hormone metabolism; auxin biosynthesis.

Sequence similarities

Belongs to the TPP enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 545545Indole-3-pyruvate decarboxylase
PRO_0000090821

Regions

Region382 – 46079Thiamine pyrophosphate binding

Sites

Metal binding4291Magnesium By similarity
Metal binding4561Magnesium By similarity
Binding site481Thiamine pyrophosphate By similarity

Secondary structure

1 ........................................................................................................ 545
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P51852 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C636A081729B8CD3

FASTA54557,981
        10         20         30         40         50         60 
MKLAEALLRA LKDRGAQAMF GIPGDFALPF FKVAEETQIL PLHTLSHEPA VGFAADAAAR 

        70         80         90        100        110        120 
YSSTLGVAAV TYGAGAFNMV NAVAGAYAEK SPVVVISGAP GTTEGNAGLL LHHQGRTLDT 

       130        140        150        160        170        180 
QFQVFKEITV AQARLDDPAK APAEIARVLG AARALSRPVY LEIPRNMVNA EVEPVGDDPA 

       190        200        210        220        230        240 
WPVDRDALAA CADEVLAAMR SATSPVLMVC VEVRRYGLEA KVAELAQRLG VPVVTTFMGR 

       250        260        270        280        290        300 
GLLADAPTPP LGTYIGVAGD AEITRLVEES DGLFLLGAIL SDTNFAVSQR KIDLRKTIHA 

       310        320        330        340        350        360 
FDRAVTLGYH TYADIPLAGL VDALLEGLPP SDRTTRGKEP HAYPTGLQAD GEPIAPMDIA 

       370        380        390        400        410        420 
RAVNDRVRAG QEPLLIAADM GDCLFTAMDM IDAGLMAPGY YAGMGFGVPA GIGAQCVSGG 

       430        440        450        460        470        480 
KRILTVVGDG AFQMTGWELG NCRRLGIDPI VILFNNASWE MLRTFQPESA FNDLDDWRFA 

       490        500        510        520        530        540 
DMAAGMGGDG VRVRTRAELK AALDKAFATR GRFQLIEAMI PRGVLSDTLA RFVQGQKRLH 


AAPRE

« Hide

References

[1]"Molecular cloning and sequence analysis of an Azospirillum brasilense indole-3-pyruvate decarboxylase gene."
Costacurta A., Keijers V., Vanderleyden J.
Mol. Gen. Genet. 243:463-472(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Sp245.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L26240 Unassigned DNA. Translation: AAC36886.1.
PIRS44486.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXWX-ray1.50A/B1-545[»]
2Q5JX-ray3.20A/B1-545[»]
2Q5LX-ray1.85A/B1-545[»]
2Q5OX-ray2.15A/B1-545[»]
2Q5QX-ray1.90A/B1-545[»]
ProteinModelPortalP51852.
SMRP51852. Positions 1-535.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00151.

Family and domain databases

InterProIPR017765. IPDC.
IPR012000. Thiamin_PyroP_enz_cen_dom.
IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
IPR012110. TPP_enzyme.
IPR011766. TPP_enzyme-bd_C.
[Graphical view]
PfamPF02775. TPP_enzyme_C. 1 hit.
PF00205. TPP_enzyme_M. 1 hit.
PF02776. TPP_enzyme_N. 1 hit.
[Graphical view]
PIRSFPIRSF036565. Pyruvt_ip_decrb. 1 hit.
TIGRFAMsTIGR03394. indol_phenyl_DC. 1 hit.
PROSITEPS00187. TPP_ENZYMES. False negative.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP51852.

Entry information

Entry nameDCIP_AZOBR
AccessionPrimary (citable) accession number: P51852
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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