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P51842

- GUC2F_RAT

UniProt

P51842 - GUC2F_RAT

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Protein

Retinal guanylyl cyclase 2

Gene

Gucy2f

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. guanylate cyclase activity Source: RGD
  4. protein heterodimerization activity Source: RGD
  5. protein homodimerization activity Source: RGD
  6. protein kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis, Sensory transduction, Vision

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Retinal guanylyl cyclase 2 (EC:4.6.1.2)
Short name:
RETGC-2
Alternative name(s):
Guanylate cyclase 2F, retinal
Guanylate cyclase F
Short name:
GC-F
Rod outer segment membrane guanylate cyclase 2
Short name:
ROS-GC2
Gene namesi
Name:Gucy2f
Synonyms:Guc2f
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi620439. Gucy2f.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini51 – 465415ExtracellularSequence AnalysisAdd
BLAST
Transmembranei466 – 49025HelicalSequence AnalysisAdd
BLAST
Topological domaini491 – 1108618CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5050Sequence AnalysisAdd
BLAST
Chaini51 – 11081058Retinal guanylyl cyclase 2PRO_0000012387Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi104 ↔ 132By similarity
Disulfide bondi452 – 452InterchainBy similarity
Disulfide bondi460 – 460InterchainBy similarity

Post-translational modificationi

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51842.
PRIDEiP51842.

PTM databases

PhosphoSiteiP51842.

Expressioni

Tissue specificityi

Expressed only in the eye.

Gene expression databases

GenevestigatoriP51842.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049500.

Structurei

3D structure databases

ProteinModelPortaliP51842.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini532 – 812281Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini884 – 1014131Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118959.
HOGENOMiHOG000293307.
HOVERGENiHBG098487.
InParanoidiP51842.
KOiK12321.
OMAiNSIYFIA.
OrthoDBiEOG7QVM1V.
PhylomeDBiP51842.
TreeFamiTF106338.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51842-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLGPWPFSR LLSWFAISSR LSGQHGLTSS KFLRYLCLLA LLPLIWWGQA
60 70 80 90 100
LPYKIGVIGP WTCDPFFSKA LPEVAAALAI ERISRDMSFD RSYSFEYVIL
110 120 130 140 150
NEDCQTSKAL TSFISHQQMA SGFVGPANPG YCEAASLLGN SWDKGIFSWA
160 170 180 190 200
CVNHELDNKH SYPTFSRTLP SPIRVLVTVM KYFQWAHAGV ISSDEDIWVH
210 220 230 240 250
TANQVSSALR SHGLPVGVVL TSGQDSRSIQ KALQQIRQAD RIRIIIMCMH
260 270 280 290 300
SALIGGETQT HFLELAHDLK MTDGTYVFVP YDVLLYSLPY KHSPYQVLRN
310 320 330 340 350
NQKLREAYDA VLTITVESHE KTFYEAFTEA AAGGEIPEKL DSHQVSPLFG
360 370 380 390 400
TIYNSIYFIA QAMSNALKEN GQASAASLTR HSRNMQFYGF NQLIRTDSNG
410 420 430 440 450
NGISEYVILD TNGKEWELRG TYTVDMETEL LRFRGTPIHF PGGRPTSADA
460 470 480 490 500
KCWFAQGKIC QGGIDPALAM MVCFALLLAL LSINGFAYFI RRRINKIQLI
510 520 530 540 550
KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQIISEVQS GRSPRLSFSS
560 570 580 590 600
GSLTPATYEN SNIAIYQGDW VWLKKFPPGD FGDIKSIKSS ASDVFEMMKD
610 620 630 640 650
LRHENVNPLL GFFYDSGMFA IVSEFCSRRS LEDILTQDDV KLDWMFKSSL
660 670 680 690 700
LLDLIKGMKY LHHREFIHGR LKSRNCVVDG RFVLKVTDYG FNNILEMLRL
710 720 730 740 750
SEEEPSEEEL LWTAPELLRA PGGIRLGSFA GDVYSFAIIM QEVMVRGAPF
760 770 780 790 800
CMMDLSAKEV IDRLKMPPPV YRPVVSPEFA PPECLQLMKQ CWAEAAEQRP
810 820 830 840 850
TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR ERTEELEIEK
860 870 880 890 900
QKTEKLLTQM LPPSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS
910 920 930 940 950
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA
960 970 980 990 1000
AEIANMSLDI LSSVGTFKMR HMPEVPVRIR IGLHTGPVVA GVVGLTMPRY
1010 1020 1030 1040 1050
CLFGDTVNTA SRMESTGLPY RIHVSLSTVT ILRTLSEGYE VELRGRTELK
1060 1070 1080 1090 1100
GKGTEETFWL VGKKGFTKPL PVPPPVGKDG QVGHGLQPAE IAAFQRRKAE

RQLVRNKP
Length:1,108
Mass (Da):124,411
Last modified:October 1, 1996 - v1
Checksum:i2A9147AF2202E4E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36030 mRNA. Translation: AAA65511.1.
PIRiB55915.
RefSeqiNP_446283.1. NM_053831.1.
XP_008771608.1. XM_008773386.1.
UniGeneiRn.10061.

Genome annotation databases

EnsembliENSRNOT00000046804; ENSRNOP00000049500; ENSRNOG00000019086.
GeneIDi116556.
KEGGirno:116556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36030 mRNA. Translation: AAA65511.1 .
PIRi B55915.
RefSeqi NP_446283.1. NM_053831.1.
XP_008771608.1. XM_008773386.1.
UniGenei Rn.10061.

3D structure databases

ProteinModelPortali P51842.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000049500.

PTM databases

PhosphoSitei P51842.

Proteomic databases

PaxDbi P51842.
PRIDEi P51842.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000046804 ; ENSRNOP00000049500 ; ENSRNOG00000019086 .
GeneIDi 116556.
KEGGi rno:116556.

Organism-specific databases

CTDi 2986.
RGDi 620439. Gucy2f.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118959.
HOGENOMi HOG000293307.
HOVERGENi HBG098487.
InParanoidi P51842.
KOi K12321.
OMAi NSIYFIA.
OrthoDBi EOG7QVM1V.
PhylomeDBi P51842.
TreeFami TF106338.

Enzyme and pathway databases

Reactomei REACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi 619209.
PROi P51842.

Gene expression databases

Genevestigatori P51842.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Eye.

Entry informationi

Entry nameiGUC2F_RAT
AccessioniPrimary (citable) accession number: P51842
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 26, 2014
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3