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P51842 (GUC2F_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Retinal guanylyl cyclase 2

Short name=RETGC-2
EC=4.6.1.2
Alternative name(s):
Guanylate cyclase 2F, retinal
Guanylate cyclase F
Short name=GC-F
Rod outer segment membrane guanylate cyclase 2
Short name=ROS-GC2
Gene names
Name:Gucy2f
Synonyms:Guc2f
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1108 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed only in the eye.

Domain

The protein kinase domain is predicted to be catalytically inactive.

Post-translational modification

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 1 guanylate cyclase domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5050 Potential
Chain51 – 11081058Retinal guanylyl cyclase 2
PRO_0000012387

Regions

Topological domain51 – 465415Extracellular Potential
Transmembrane466 – 49025Helical; Potential
Topological domain491 – 1108618Cytoplasmic Potential
Domain532 – 812281Protein kinase
Domain884 – 1014131Guanylate cyclase

Amino acid modifications

Disulfide bond104 ↔ 132 By similarity
Disulfide bond452Interchain By similarity
Disulfide bond460Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P51842 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 2A9147AF2202E4E3

FASTA1,108124,411
        10         20         30         40         50         60 
MFLGPWPFSR LLSWFAISSR LSGQHGLTSS KFLRYLCLLA LLPLIWWGQA LPYKIGVIGP 

        70         80         90        100        110        120 
WTCDPFFSKA LPEVAAALAI ERISRDMSFD RSYSFEYVIL NEDCQTSKAL TSFISHQQMA 

       130        140        150        160        170        180 
SGFVGPANPG YCEAASLLGN SWDKGIFSWA CVNHELDNKH SYPTFSRTLP SPIRVLVTVM 

       190        200        210        220        230        240 
KYFQWAHAGV ISSDEDIWVH TANQVSSALR SHGLPVGVVL TSGQDSRSIQ KALQQIRQAD 

       250        260        270        280        290        300 
RIRIIIMCMH SALIGGETQT HFLELAHDLK MTDGTYVFVP YDVLLYSLPY KHSPYQVLRN 

       310        320        330        340        350        360 
NQKLREAYDA VLTITVESHE KTFYEAFTEA AAGGEIPEKL DSHQVSPLFG TIYNSIYFIA 

       370        380        390        400        410        420 
QAMSNALKEN GQASAASLTR HSRNMQFYGF NQLIRTDSNG NGISEYVILD TNGKEWELRG 

       430        440        450        460        470        480 
TYTVDMETEL LRFRGTPIHF PGGRPTSADA KCWFAQGKIC QGGIDPALAM MVCFALLLAL 

       490        500        510        520        530        540 
LSINGFAYFI RRRINKIQLI KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQIISEVQS 

       550        560        570        580        590        600 
GRSPRLSFSS GSLTPATYEN SNIAIYQGDW VWLKKFPPGD FGDIKSIKSS ASDVFEMMKD 

       610        620        630        640        650        660 
LRHENVNPLL GFFYDSGMFA IVSEFCSRRS LEDILTQDDV KLDWMFKSSL LLDLIKGMKY 

       670        680        690        700        710        720 
LHHREFIHGR LKSRNCVVDG RFVLKVTDYG FNNILEMLRL SEEEPSEEEL LWTAPELLRA 

       730        740        750        760        770        780 
PGGIRLGSFA GDVYSFAIIM QEVMVRGAPF CMMDLSAKEV IDRLKMPPPV YRPVVSPEFA 

       790        800        810        820        830        840 
PPECLQLMKQ CWAEAAEQRP TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR 

       850        860        870        880        890        900 
ERTEELEIEK QKTEKLLTQM LPPSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS 

       910        920        930        940        950        960 
EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA AEIANMSLDI 

       970        980        990       1000       1010       1020 
LSSVGTFKMR HMPEVPVRIR IGLHTGPVVA GVVGLTMPRY CLFGDTVNTA SRMESTGLPY 

      1030       1040       1050       1060       1070       1080 
RIHVSLSTVT ILRTLSEGYE VELRGRTELK GKGTEETFWL VGKKGFTKPL PVPPPVGKDG 

      1090       1100 
QVGHGLQPAE IAAFQRRKAE RQLVRNKP 

« Hide

References

[1]"Two membrane forms of guanylyl cyclase found in the eye."
Yang R.-B., Foster D.C., Garbers D.L., Fuelle H.-J.
Proc. Natl. Acad. Sci. U.S.A. 92:602-606(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L36030 mRNA. Translation: AAA65511.1.
PIRB55915.
RefSeqNP_446283.1. NM_053831.1.
UniGeneRn.10061.

3D structure databases

ProteinModelPortalP51842.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000049500.

PTM databases

PhosphoSiteP51842.

Proteomic databases

PaxDbP51842.
PRIDEP51842.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000046804; ENSRNOP00000049500; ENSRNOG00000019086.
GeneID116556.
KEGGrno:116556.

Organism-specific databases

CTD2986.
RGD620439. Gucy2f.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00730000110520.
HOGENOMHOG000293307.
HOVERGENHBG098487.
InParanoidP51842.
KOK12321.
OMANSIYFIA.
OrthoDBEOG7QVM1V.
PhylomeDBP51842.
TreeFamTF106338.

Gene expression databases

GenevestigatorP51842.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio619209.
PROP51842.

Entry information

Entry nameGUC2F_RAT
AccessionPrimary (citable) accession number: P51842
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families