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P51841

- GUC2F_HUMAN

UniProt

P51841 - GUC2F_HUMAN

Protein

Retinal guanylyl cyclase 2

Gene

GUCY2F

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

    Catalytic activityi

    GTP = 3',5'-cyclic GMP + diphosphate.

    Enzyme regulationi

    Activated by GCAP-1; inhibited by calcium.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. guanylate cyclase activity Source: ProtInc
    4. protein kinase activity Source: InterPro
    5. receptor activity Source: ProtInc

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. phototransduction, visible light Source: Reactome
    3. receptor guanylyl cyclase signaling pathway Source: ProtInc
    4. regulation of rhodopsin mediated signaling pathway Source: Reactome
    5. rhodopsin mediated signaling pathway Source: Reactome
    6. visual perception Source: ProtInc

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cGMP biosynthesis, Sensory transduction, Vision

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Retinal guanylyl cyclase 2 (EC:4.6.1.2)
    Short name:
    RETGC-2
    Alternative name(s):
    Guanylate cyclase 2F, retinal
    Guanylate cyclase F
    Short name:
    GC-F
    Rod outer segment membrane guanylate cyclase 2
    Short name:
    ROS-GC2
    Gene namesi
    Name:GUCY2F
    Synonyms:GUC2F, RETGC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:4691. GUCY2F.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. nuclear outer membrane Source: ProtInc
    3. photoreceptor disc membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29071.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5050Sequence AnalysisAdd
    BLAST
    Chaini51 – 11081058Retinal guanylyl cyclase 2PRO_0000012386Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi104 ↔ 132By similarity
    Disulfide bondi452 – 452InterchainBy similarity
    Disulfide bondi460 – 460InterchainBy similarity

    Post-translational modificationi

    There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiP51841.
    PRIDEiP51841.

    PTM databases

    PhosphoSiteiP51841.

    Expressioni

    Tissue specificityi

    Retina. Localized exclusively in the outer nuclear layer and inner segments of the rod and cone photoreceptor cells.

    Gene expression databases

    BgeeiP51841.
    CleanExiHS_GUCY2F.
    GenevestigatoriP51841.

    Organism-specific databases

    HPAiHPA000734.
    HPA027473.

    Interactioni

    Protein-protein interaction databases

    BioGridi109241. 3 interactions.
    IntActiP51841. 2 interactions.
    MINTiMINT-7970335.
    STRINGi9606.ENSP00000218006.

    Structurei

    3D structure databases

    ProteinModelPortaliP51841.
    SMRiP51841. Positions 584-855, 883-1083.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini51 – 467417ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini491 – 1108618CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei468 – 49023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini532 – 812281Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini884 – 1014131Guanylate cyclasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000293307.
    HOVERGENiHBG098487.
    InParanoidiP51841.
    KOiK12321.
    OMAiNSIYFIA.
    OrthoDBiEOG7QVM1V.
    PhylomeDBiP51841.
    TreeFamiTF106338.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR001828. ANF_lig-bd_rcpt.
    IPR011645. Haem_no_assoc-bd.
    IPR011009. Kinase-like_dom.
    IPR028082. Peripla_BP_I.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00211. Guanylate_cyc. 1 hit.
    PF07701. HNOBA. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.
    SSF55073. SSF55073. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51841-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLGLGRFSR LVLWFAAFRK LLGHHGLASA KFLWCLCLLS VMSLPQQVWT     50
    LPYKIGVVGP WACDSLFSKA LPEVAARLAI ERINRDPSFD LSYSFEYVIL 100
    NEDCQTSRAL SSFISHHQMA SGFIGPTNPG YCEAASLLGN SWDKGIFSWA 150
    CVNYELDNKI SYPTFSRTLP SPIRVLVTVM KYFQWAHAGV ISSDEDIWVH 200
    TANRVASALR SHGLPVGVVL TTGQDSQSMR KALQRIHQAD RIRIIIMCMH 250
    SALIGGETQM HLLECAHDLK MTDGTYVFVP YDALLYSLPY KHTPYRVLRN 300
    NPKLREAYDA VLTITVESQE KTFYQAFTEA AARGEIPEKL EFDQVSPLFG 350
    TIYNSIYFIA QAMNNAMKEN GQAGAASLVQ HSRNMQFHGF NQLMRTDSNG 400
    NGISEYVILD TNLKEWELHS TYTVDMEMEL LRFGGTPIHF PGGRPPRADA 450
    KCWFAEGKIC HGGIDPAFAM MVCLTLLIAL LSINGFAYFI RRRINKIQLI 500
    KGPNRILLTL EDVTFINPHF GSKRGSRASV SFQITSEVQS GRSPRLSFSS 550
    GSLTPATYEN SNIAIYEGDW VWLKKFSLGD FGDLKSIKSR ASDVFEMMKD 600
    LRHENINPLL GFFYDSGMFA IVTEFCSRGS LEDILTNQDV KLDWMFKSSL 650
    LLDLIKGMKY LHHREFVHGR LKSRNCVVDG RFVLKVTDYG FNDILEMLRL 700
    SEEESSMEEL LWTAPELLRA PRGSRLGSFA GDVYSFAIIM QEVMVRGTPF 750
    CMMDLPAQEI INRLKKPPPV YRPVVPPEHA PPECLQLMKQ CWAEAAEQRP 800
    TFDEIFNQFK TFNKGKKTNI IDSMLRMLEQ YSSNLEDLIR ERTEELEIEK 850
    QKTEKLLTQM LPPSVAESLK KGCTVEPEGF DLVTLYFSDI VGFTTISAMS 900
    EPIEVVDLLN DLYTLFDAII GSHDVYKVET IGDAYMVASG LPKRNGSRHA 950
    AEIANMSLDI LSSVGTFKMR HMPEVPVRIR IGLHSGPVVA GVVGLTMPRY 1000
    CLFGDTVNTA SRMESTGLPY RIHVSLSTVT ILQNLSEGYE VELRGRTELK 1050
    GKGTEETFWL IGKKGFMKPL PVPPPVDKDG QVGHGLQPVE IAAFQRRKAE 1100
    RQLVRNKP 1108
    Length:1,108
    Mass (Da):124,850
    Last modified:November 2, 2010 - v2
    Checksum:iB047BBF1A3C009F9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti10 – 101R → P in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036419
    Natural varianti40 – 401S → C.1 Publication
    Corresponds to variant rs34228145 [ dbSNP | Ensembl ].
    VAR_042233
    Natural varianti160 – 1601I → N.1 Publication
    Corresponds to variant rs33971675 [ dbSNP | Ensembl ].
    VAR_042234
    Natural varianti230 – 2301R → W.1 Publication
    Corresponds to variant rs33973457 [ dbSNP | Ensembl ].
    VAR_042235
    Natural varianti284 – 2841L → P.1 Publication
    Corresponds to variant rs12008095 [ dbSNP | Ensembl ].
    VAR_009136
    Natural varianti296 – 2961R → Q.1 Publication
    Corresponds to variant rs502209 [ dbSNP | Ensembl ].
    VAR_009137
    Natural varianti305 – 3051R → Q.1 Publication
    Corresponds to variant rs55966326 [ dbSNP | Ensembl ].
    VAR_042236
    Natural varianti308 – 3081Y → C.1 Publication
    Corresponds to variant rs16985750 [ dbSNP | Ensembl ].
    VAR_030633
    Natural varianti380 – 3801Q → H.1 Publication
    Corresponds to variant rs2272925 [ dbSNP | Ensembl ].
    VAR_030634
    Natural varianti434 – 4341G → R.1 Publication
    Corresponds to variant rs56293008 [ dbSNP | Ensembl ].
    VAR_042237
    Natural varianti568 – 5681G → D in a glioblastoma multiforme sample; somatic mutation. 1 Publication
    VAR_042238
    Natural varianti628 – 6281R → Q.1 Publication
    Corresponds to variant rs7883913 [ dbSNP | Ensembl ].
    VAR_030635
    Natural varianti677 – 6771V → L.1 Publication
    Corresponds to variant rs35474112 [ dbSNP | Ensembl ].
    VAR_042239
    Natural varianti794 – 7941E → K.1 Publication
    Corresponds to variant rs35726803 [ dbSNP | Ensembl ].
    VAR_042240
    Natural varianti872 – 8721G → D.1 Publication
    VAR_069424
    Natural varianti1010 – 10101A → V.1 Publication
    Corresponds to variant rs55735218 [ dbSNP | Ensembl ].
    VAR_042241
    Natural varianti1052 – 10521K → R in a lung adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_042242
    Natural varianti1055 – 10551E → D in a lung squamous cell carcinoma sample; somatic mutation. 1 Publication
    VAR_042243

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37378 mRNA. Translation: AAA74451.1.
    AL031387 Genomic DNA. Translation: CAB41303.1.
    CCDSiCCDS14545.1.
    PIRiI59385.
    RefSeqiNP_001513.2. NM_001522.2.
    UniGeneiHs.123074.

    Genome annotation databases

    EnsembliENST00000218006; ENSP00000218006; ENSG00000101890.
    GeneIDi2986.
    KEGGihsa:2986.
    UCSCiuc004eod.4. human.

    Polymorphism databases

    DMDMi311033391.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Mutations of the GUCY2F gene

    Retina International's Scientific Newsletter

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L37378 mRNA. Translation: AAA74451.1 .
    AL031387 Genomic DNA. Translation: CAB41303.1 .
    CCDSi CCDS14545.1.
    PIRi I59385.
    RefSeqi NP_001513.2. NM_001522.2.
    UniGenei Hs.123074.

    3D structure databases

    ProteinModelPortali P51841.
    SMRi P51841. Positions 584-855, 883-1083.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109241. 3 interactions.
    IntActi P51841. 2 interactions.
    MINTi MINT-7970335.
    STRINGi 9606.ENSP00000218006.

    PTM databases

    PhosphoSitei P51841.

    Polymorphism databases

    DMDMi 311033391.

    Proteomic databases

    PaxDbi P51841.
    PRIDEi P51841.

    Protocols and materials databases

    DNASUi 2986.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000218006 ; ENSP00000218006 ; ENSG00000101890 .
    GeneIDi 2986.
    KEGGi hsa:2986.
    UCSCi uc004eod.4. human.

    Organism-specific databases

    CTDi 2986.
    GeneCardsi GC0XM108616.
    H-InvDB HIX0056276.
    HGNCi HGNC:4691. GUCY2F.
    HPAi HPA000734.
    HPA027473.
    MIMi 300041. gene.
    neXtProti NX_P51841.
    PharmGKBi PA29071.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000293307.
    HOVERGENi HBG098487.
    InParanoidi P51841.
    KOi K12321.
    OMAi NSIYFIA.
    OrthoDBi EOG7QVM1V.
    PhylomeDBi P51841.
    TreeFami TF106338.

    Enzyme and pathway databases

    Reactomei REACT_163919. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    GenomeRNAii 2986.
    NextBioi 11840.
    PROi P51841.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51841.
    CleanExi HS_GUCY2F.
    Genevestigatori P51841.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR001828. ANF_lig-bd_rcpt.
    IPR011645. Haem_no_assoc-bd.
    IPR011009. Kinase-like_dom.
    IPR028082. Peripla_BP_I.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00211. Guanylate_cyc. 1 hit.
    PF07701. HNOBA. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    SSF55073. SSF55073. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2."
      Lowe D.G., Dizhoor A.M., Liu K., Gu Q., Spencer M., Laura R., Lu L., Hurley J.B.
      Proc. Natl. Acad. Sci. U.S.A. 92:5535-5539(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLN-296.
      Tissue: Retina.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-10.
    4. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] CYS-40; ASN-160; TRP-230; PRO-284; GLN-305; CYS-308; HIS-380; ARG-434; ASP-568; GLN-628; LEU-677; LYS-794; VAL-1010; ARG-1052 AND ASP-1055.
    5. Cited for: VARIANT ASP-872.

    Entry informationi

    Entry nameiGUC2F_HUMAN
    AccessioniPrimary (citable) accession number: P51841
    Secondary accession number(s): Q9UJF1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3