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P51840 (GUC2E_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Guanylyl cyclase GC-E

EC=4.6.1.2
Alternative name(s):
Guanylate cyclase 2E
Gene names
Name:Gucy2e
Synonyms:Guc2e
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length1108 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

GTP = 3',5'-cyclic GMP + diphosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

Expressed in the eye and the pineal gland.

Post-translational modification

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 1 guanylate cyclase domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5454 Potential
Chain55 – 11081054Guanylyl cyclase GC-E
PRO_0000012384

Regions

Topological domain55 – 465411Extracellular Potential
Transmembrane466 – 49025Helical; Potential
Topological domain491 – 1108618Cytoplasmic Potential
Domain520 – 811292Protein kinase
Domain883 – 1013131Guanylate cyclase

Amino acid modifications

Glycosylation3001N-linked (GlcNAc...) Potential
Disulfide bond108 ↔ 136 By similarity
Disulfide bond452Interchain By similarity
Disulfide bond460Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P51840 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 4FA1BE9325A2A979

FASTA1,108120,801
        10         20         30         40         50         60 
MSAWLLPAGG FPGAGFCIPA WQSRSSLSRV LRWPGPGLPG LLLLLLLPSP SAFSAVFKVG 

        70         80         90        100        110        120 
VLGPWACDPI FARARPDLAA RLATDRLNRD LALDGGPWFE VTLLPEPCLT PGSLGAVSSA 

       130        140        150        160        170        180 
LTRVSGLVGP VNPAACRPAE LLAQEAGVAL VPWGCPGTRA AGTTAPAVTP AADALYVLLK 

       190        200        210        220        230        240 
AFRWARVALI TAPQDLWVEA GRALSTALRA RGLPVALVTS MVPSDLSGAR EALRRIRDGP 

       250        260        270        280        290        300 
RVRVVIMVMH SVLLGGEEQR YLLEAAEELG LTDGSLVFLP FDTLHYALSP GPEALAAFVN 

       310        320        330        340        350        360 
SSKLRRAHDA VLTLTRRCPP GGSVQDSLRR AQEHQELPLD LDLKQVSPLF GTIYDAVFLL 

       370        380        390        400        410        420 
AGGVTRARAA VGGGWVSGAS VARQMREAQV FGFCGILGRT EEPSFVLLDT DAAGERLFTT 

       430        440        450        460        470        480 
HLLDPVLGSL RSAGTPVHFP RGAPAPGPDP SCWFDPDVIC NGGVEPGLVF VGFLLVIVVG 

       490        500        510        520        530        540 
LTGAFLAHYL RHRLLHMQMV SGPNKIILTL EDVTFLHPQG GSSRKVAQGS RSSLATRSTS 

       550        560        570        580        590        600 
DIRSVPSQPQ ESTNIGLYEG DWVWLKKFPG EHHMAIRPAT KMAFSKLREL RHENVALYLG 

       610        620        630        640        650        660 
LFLAGTADSP ATPGEGILAV VSEHCARGSL HDLLAQRDIK LDWMFKSSLL LDLIKGMRYL 

       670        680        690        700        710        720 
HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL PEPPSAEDQL WTAPELLRDP 

       730        740        750        760        770        780 
ALERRGTLAG DVFSLGIIMQ EVVCRSTPYA MLELTPEEVI QRVRSPPPLC RPLVSMDQAP 

       790        800        810        820        830        840 
MECIQLMAQC WAEHPELRPS MDLTFDLFKG INKGRKTNII DSMLRMLEQY SSNLEDLIRE 

       850        860        870        880        890        900 
RTEELEQEKQ KTDRLLTQML PPSVAEALKM GTSVEPEYFE EVTLYFSDIV GFTTISAMSE 

       910        920        930        940        950        960 
PIEVVDLLND LYTLFDAIIG SHDVYKVETI GDAYMVASGL PQRNGQRHAA EIANMSLDIL 

       970        980        990       1000       1010       1020 
SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC LFGDTVNTAS RMESTGLPYR 

      1030       1040       1050       1060       1070       1080 
IHVNMSTVRI LRALDQGFQM ECRGRTELKG KGVEDTYWLV GRVGFNKPIP KPPDLQPGAS 

      1090       1100 
NHGISLQEIP PERRKKLEKA RPGQFTGK 

« Hide

References

[1]"Two membrane forms of guanylyl cyclase found in the eye."
Yang R.-B., Foster D.C., Garbers D.L., Fuelle H.-J.
Proc. Natl. Acad. Sci. U.S.A. 92:602-606(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Eye.
[2]Lubec G., Kang S.U.
Submitted (JUL-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 203-209, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L36029 mRNA. Translation: AAA65510.1.
PIRA55915.
RefSeqNP_077356.1. NM_024380.1.
UniGeneRn.10060.

3D structure databases

ProteinModelPortalP51840.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000010790.

PTM databases

PhosphoSiteP51840.

Proteomic databases

PaxDbP51840.
PRIDEP51840.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID79222.
KEGGrno:79222.
UCSCRGD:620438. rat.

Organism-specific databases

CTD14919.
RGD620438. Gucy2e.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000293307.
HOVERGENHBG098487.
InParanoidP51840.
KOK12321.
OrthoDBEOG7QVM1V.
PhylomeDBP51840.
TreeFamTF106338.

Gene expression databases

GenevestigatorP51840.

Family and domain databases

Gene3D3.30.70.1230. 1 hit.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614644.
PROP51840.

Entry information

Entry nameGUC2E_RAT
AccessionPrimary (citable) accession number: P51840
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 11, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families