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P51840

- GUC2E_RAT

UniProt

P51840 - GUC2E_RAT

Protein

Guanylyl cyclase GC-E

Gene

Gucy2e

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    GTP = 3',5'-cyclic GMP + diphosphate.

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. guanylate cyclase activity Source: RGD
    4. identical protein binding Source: RGD
    5. protein binding Source: RGD
    6. protein kinase activity Source: InterPro

    GO - Biological processi

    1. cGMP biosynthetic process Source: RGD
    2. intracellular signal transduction Source: InterPro
    3. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cGMP biosynthesis, Sensory transduction, Vision

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanylyl cyclase GC-E (EC:4.6.1.2)
    Alternative name(s):
    Guanylate cyclase 2E
    Gene namesi
    Name:Gucy2e
    Synonyms:Guc2e
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620438. Gucy2e.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: RGD
    2. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5454Sequence AnalysisAdd
    BLAST
    Chaini55 – 11081054Guanylyl cyclase GC-EPRO_0000012384Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi108 ↔ 136By similarity
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi452 – 452InterchainBy similarity
    Disulfide bondi460 – 460InterchainBy similarity

    Post-translational modificationi

    There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP51840.
    PRIDEiP51840.

    PTM databases

    PhosphoSiteiP51840.

    Expressioni

    Tissue specificityi

    Expressed in the eye and the pineal gland.

    Gene expression databases

    GenevestigatoriP51840.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000010790.

    Structurei

    3D structure databases

    ProteinModelPortaliP51840.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini55 – 465411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini491 – 1108618CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei466 – 49025HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini520 – 811292Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini883 – 1013131Guanylate cyclasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000293307.
    HOVERGENiHBG098487.
    InParanoidiP51840.
    KOiK12321.
    OrthoDBiEOG7QVM1V.
    PhylomeDBiP51840.
    TreeFamiTF106338.

    Family and domain databases

    Gene3Di3.30.70.1230. 1 hit.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR001828. ANF_lig-bd_rcpt.
    IPR011645. Haem_no_assoc-bd.
    IPR011009. Kinase-like_dom.
    IPR028082. Peripla_BP_I.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view]
    PfamiPF01094. ANF_receptor. 1 hit.
    PF00211. Guanylate_cyc. 1 hit.
    PF07701. HNOBA. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    SMARTiSM00044. CYCc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53822. SSF53822. 1 hit.
    SSF55073. SSF55073. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51840-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAWLLPAGG FPGAGFCIPA WQSRSSLSRV LRWPGPGLPG LLLLLLLPSP     50
    SAFSAVFKVG VLGPWACDPI FARARPDLAA RLATDRLNRD LALDGGPWFE 100
    VTLLPEPCLT PGSLGAVSSA LTRVSGLVGP VNPAACRPAE LLAQEAGVAL 150
    VPWGCPGTRA AGTTAPAVTP AADALYVLLK AFRWARVALI TAPQDLWVEA 200
    GRALSTALRA RGLPVALVTS MVPSDLSGAR EALRRIRDGP RVRVVIMVMH 250
    SVLLGGEEQR YLLEAAEELG LTDGSLVFLP FDTLHYALSP GPEALAAFVN 300
    SSKLRRAHDA VLTLTRRCPP GGSVQDSLRR AQEHQELPLD LDLKQVSPLF 350
    GTIYDAVFLL AGGVTRARAA VGGGWVSGAS VARQMREAQV FGFCGILGRT 400
    EEPSFVLLDT DAAGERLFTT HLLDPVLGSL RSAGTPVHFP RGAPAPGPDP 450
    SCWFDPDVIC NGGVEPGLVF VGFLLVIVVG LTGAFLAHYL RHRLLHMQMV 500
    SGPNKIILTL EDVTFLHPQG GSSRKVAQGS RSSLATRSTS DIRSVPSQPQ 550
    ESTNIGLYEG DWVWLKKFPG EHHMAIRPAT KMAFSKLREL RHENVALYLG 600
    LFLAGTADSP ATPGEGILAV VSEHCARGSL HDLLAQRDIK LDWMFKSSLL 650
    LDLIKGMRYL HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL 700
    PEPPSAEDQL WTAPELLRDP ALERRGTLAG DVFSLGIIMQ EVVCRSTPYA 750
    MLELTPEEVI QRVRSPPPLC RPLVSMDQAP MECIQLMAQC WAEHPELRPS 800
    MDLTFDLFKG INKGRKTNII DSMLRMLEQY SSNLEDLIRE RTEELEQEKQ 850
    KTDRLLTQML PPSVAEALKM GTSVEPEYFE EVTLYFSDIV GFTTISAMSE 900
    PIEVVDLLND LYTLFDAIIG SHDVYKVETI GDAYMVASGL PQRNGQRHAA 950
    EIANMSLDIL SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC 1000
    LFGDTVNTAS RMESTGLPYR IHVNMSTVRI LRALDQGFQM ECRGRTELKG 1050
    KGVEDTYWLV GRVGFNKPIP KPPDLQPGAS NHGISLQEIP PERRKKLEKA 1100
    RPGQFTGK 1108
    Length:1,108
    Mass (Da):120,801
    Last modified:October 1, 1996 - v1
    Checksum:i4FA1BE9325A2A979
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36029 mRNA. Translation: AAA65510.1.
    PIRiA55915.
    RefSeqiNP_077356.1. NM_024380.1.
    UniGeneiRn.10060.

    Genome annotation databases

    GeneIDi79222.
    KEGGirno:79222.
    UCSCiRGD:620438. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L36029 mRNA. Translation: AAA65510.1 .
    PIRi A55915.
    RefSeqi NP_077356.1. NM_024380.1.
    UniGenei Rn.10060.

    3D structure databases

    ProteinModelPortali P51840.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000010790.

    PTM databases

    PhosphoSitei P51840.

    Proteomic databases

    PaxDbi P51840.
    PRIDEi P51840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 79222.
    KEGGi rno:79222.
    UCSCi RGD:620438. rat.

    Organism-specific databases

    CTDi 14919.
    RGDi 620438. Gucy2e.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000293307.
    HOVERGENi HBG098487.
    InParanoidi P51840.
    KOi K12321.
    OrthoDBi EOG7QVM1V.
    PhylomeDBi P51840.
    TreeFami TF106338.

    Enzyme and pathway databases

    Reactomei REACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

    Miscellaneous databases

    NextBioi 614644.
    PROi P51840.

    Gene expression databases

    Genevestigatori P51840.

    Family and domain databases

    Gene3Di 3.30.70.1230. 1 hit.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR001828. ANF_lig-bd_rcpt.
    IPR011645. Haem_no_assoc-bd.
    IPR011009. Kinase-like_dom.
    IPR028082. Peripla_BP_I.
    IPR000719. Prot_kinase_dom.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    [Graphical view ]
    Pfami PF01094. ANF_receptor. 1 hit.
    PF00211. Guanylate_cyc. 1 hit.
    PF07701. HNOBA. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    SMARTi SM00044. CYCc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53822. SSF53822. 1 hit.
    SSF55073. SSF55073. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Eye.
    2. Lubec G., Kang S.U.
      Submitted (JUL-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 203-209, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiGUC2E_RAT
    AccessioniPrimary (citable) accession number: P51840
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3