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P51840

- GUC2E_RAT

UniProt

P51840 - GUC2E_RAT

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Protein
Guanylyl cyclase GC-E
Gene
Gucy2e, Guc2e
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. guanylate cyclase activity Source: RGD
  4. identical protein binding Source: RGD
  5. protein binding Source: RGD
  6. protein kinase activity Source: InterPro

GO - Biological processi

  1. cGMP biosynthetic process Source: RGD
  2. intracellular signal transduction Source: InterPro
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis, Sensory transduction, Vision

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase GC-E (EC:4.6.1.2)
Alternative name(s):
Guanylate cyclase 2E
Gene namesi
Name:Gucy2e
Synonyms:Guc2e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620438. Gucy2e.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 465411Extracellular Reviewed prediction
Add
BLAST
Transmembranei466 – 49025Helical; Reviewed prediction
Add
BLAST
Topological domaini491 – 1108618Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5454 Reviewed prediction
Add
BLAST
Chaini55 – 11081054Guanylyl cyclase GC-E
PRO_0000012384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 136 By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi452 – 452Interchain By similarity
Disulfide bondi460 – 460Interchain By similarity

Post-translational modificationi

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51840.
PRIDEiP51840.

PTM databases

PhosphoSiteiP51840.

Expressioni

Tissue specificityi

Expressed in the eye and the pineal gland.

Gene expression databases

GenevestigatoriP51840.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010790.

Structurei

3D structure databases

ProteinModelPortaliP51840.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini520 – 811292Protein kinase
Add
BLAST
Domaini883 – 1013131Guanylate cyclase
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000293307.
HOVERGENiHBG098487.
InParanoidiP51840.
KOiK12321.
OrthoDBiEOG7QVM1V.
PhylomeDBiP51840.
TreeFamiTF106338.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51840-1 [UniParc]FASTAAdd to Basket

« Hide

MSAWLLPAGG FPGAGFCIPA WQSRSSLSRV LRWPGPGLPG LLLLLLLPSP     50
SAFSAVFKVG VLGPWACDPI FARARPDLAA RLATDRLNRD LALDGGPWFE 100
VTLLPEPCLT PGSLGAVSSA LTRVSGLVGP VNPAACRPAE LLAQEAGVAL 150
VPWGCPGTRA AGTTAPAVTP AADALYVLLK AFRWARVALI TAPQDLWVEA 200
GRALSTALRA RGLPVALVTS MVPSDLSGAR EALRRIRDGP RVRVVIMVMH 250
SVLLGGEEQR YLLEAAEELG LTDGSLVFLP FDTLHYALSP GPEALAAFVN 300
SSKLRRAHDA VLTLTRRCPP GGSVQDSLRR AQEHQELPLD LDLKQVSPLF 350
GTIYDAVFLL AGGVTRARAA VGGGWVSGAS VARQMREAQV FGFCGILGRT 400
EEPSFVLLDT DAAGERLFTT HLLDPVLGSL RSAGTPVHFP RGAPAPGPDP 450
SCWFDPDVIC NGGVEPGLVF VGFLLVIVVG LTGAFLAHYL RHRLLHMQMV 500
SGPNKIILTL EDVTFLHPQG GSSRKVAQGS RSSLATRSTS DIRSVPSQPQ 550
ESTNIGLYEG DWVWLKKFPG EHHMAIRPAT KMAFSKLREL RHENVALYLG 600
LFLAGTADSP ATPGEGILAV VSEHCARGSL HDLLAQRDIK LDWMFKSSLL 650
LDLIKGMRYL HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL 700
PEPPSAEDQL WTAPELLRDP ALERRGTLAG DVFSLGIIMQ EVVCRSTPYA 750
MLELTPEEVI QRVRSPPPLC RPLVSMDQAP MECIQLMAQC WAEHPELRPS 800
MDLTFDLFKG INKGRKTNII DSMLRMLEQY SSNLEDLIRE RTEELEQEKQ 850
KTDRLLTQML PPSVAEALKM GTSVEPEYFE EVTLYFSDIV GFTTISAMSE 900
PIEVVDLLND LYTLFDAIIG SHDVYKVETI GDAYMVASGL PQRNGQRHAA 950
EIANMSLDIL SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC 1000
LFGDTVNTAS RMESTGLPYR IHVNMSTVRI LRALDQGFQM ECRGRTELKG 1050
KGVEDTYWLV GRVGFNKPIP KPPDLQPGAS NHGISLQEIP PERRKKLEKA 1100
RPGQFTGK 1108
Length:1,108
Mass (Da):120,801
Last modified:October 1, 1996 - v1
Checksum:i4FA1BE9325A2A979
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36029 mRNA. Translation: AAA65510.1.
PIRiA55915.
RefSeqiNP_077356.1. NM_024380.1.
UniGeneiRn.10060.

Genome annotation databases

GeneIDi79222.
KEGGirno:79222.
UCSCiRGD:620438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36029 mRNA. Translation: AAA65510.1 .
PIRi A55915.
RefSeqi NP_077356.1. NM_024380.1.
UniGenei Rn.10060.

3D structure databases

ProteinModelPortali P51840.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010790.

PTM databases

PhosphoSitei P51840.

Proteomic databases

PaxDbi P51840.
PRIDEi P51840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 79222.
KEGGi rno:79222.
UCSCi RGD:620438. rat.

Organism-specific databases

CTDi 14919.
RGDi 620438. Gucy2e.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000293307.
HOVERGENi HBG098487.
InParanoidi P51840.
KOi K12321.
OrthoDBi EOG7QVM1V.
PhylomeDBi P51840.
TreeFami TF106338.

Enzyme and pathway databases

Reactomei REACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi 614644.
PROi P51840.

Gene expression databases

Genevestigatori P51840.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Eye.
  2. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 203-209, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGUC2E_RAT
AccessioniPrimary (citable) accession number: P51840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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