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P51840

- GUC2E_RAT

UniProt

P51840 - GUC2E_RAT

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Protein

Guanylyl cyclase GC-E

Gene

Gucy2e

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. GTP binding Source: UniProtKB-KW
  3. guanylate cyclase activity Source: RGD
  4. identical protein binding Source: RGD
  5. protein kinase activity Source: InterPro

GO - Biological processi

  1. cGMP biosynthetic process Source: RGD
  2. intracellular signal transduction Source: InterPro
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis, Sensory transduction, Vision

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylyl cyclase GC-E (EC:4.6.1.2)
Alternative name(s):
Guanylate cyclase 2E
Gene namesi
Name:Gucy2e
Synonyms:Guc2e
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620438. Gucy2e.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: RGD
  2. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 5454Sequence AnalysisAdd
BLAST
Chaini55 – 11081054Guanylyl cyclase GC-EPRO_0000012384Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 136By similarity
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi452 – 452InterchainBy similarity
Disulfide bondi460 – 460InterchainBy similarity

Post-translational modificationi

There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51840.
PRIDEiP51840.

PTM databases

PhosphoSiteiP51840.

Expressioni

Tissue specificityi

Expressed in the eye and the pineal gland.

Gene expression databases

GenevestigatoriP51840.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010790.

Structurei

3D structure databases

ProteinModelPortaliP51840.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini55 – 465411ExtracellularSequence AnalysisAdd
BLAST
Topological domaini491 – 1108618CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei466 – 49025HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini520 – 811292Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini883 – 1013131Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000293307.
HOVERGENiHBG098487.
InParanoidiP51840.
KOiK12321.
OrthoDBiEOG7QVM1V.
PhylomeDBiP51840.
TreeFamiTF106338.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51840-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAWLLPAGG FPGAGFCIPA WQSRSSLSRV LRWPGPGLPG LLLLLLLPSP
60 70 80 90 100
SAFSAVFKVG VLGPWACDPI FARARPDLAA RLATDRLNRD LALDGGPWFE
110 120 130 140 150
VTLLPEPCLT PGSLGAVSSA LTRVSGLVGP VNPAACRPAE LLAQEAGVAL
160 170 180 190 200
VPWGCPGTRA AGTTAPAVTP AADALYVLLK AFRWARVALI TAPQDLWVEA
210 220 230 240 250
GRALSTALRA RGLPVALVTS MVPSDLSGAR EALRRIRDGP RVRVVIMVMH
260 270 280 290 300
SVLLGGEEQR YLLEAAEELG LTDGSLVFLP FDTLHYALSP GPEALAAFVN
310 320 330 340 350
SSKLRRAHDA VLTLTRRCPP GGSVQDSLRR AQEHQELPLD LDLKQVSPLF
360 370 380 390 400
GTIYDAVFLL AGGVTRARAA VGGGWVSGAS VARQMREAQV FGFCGILGRT
410 420 430 440 450
EEPSFVLLDT DAAGERLFTT HLLDPVLGSL RSAGTPVHFP RGAPAPGPDP
460 470 480 490 500
SCWFDPDVIC NGGVEPGLVF VGFLLVIVVG LTGAFLAHYL RHRLLHMQMV
510 520 530 540 550
SGPNKIILTL EDVTFLHPQG GSSRKVAQGS RSSLATRSTS DIRSVPSQPQ
560 570 580 590 600
ESTNIGLYEG DWVWLKKFPG EHHMAIRPAT KMAFSKLREL RHENVALYLG
610 620 630 640 650
LFLAGTADSP ATPGEGILAV VSEHCARGSL HDLLAQRDIK LDWMFKSSLL
660 670 680 690 700
LDLIKGMRYL HHRGVAHGRL KSRNCVVDGR FVLKVTDHGH GRLLEAQRVL
710 720 730 740 750
PEPPSAEDQL WTAPELLRDP ALERRGTLAG DVFSLGIIMQ EVVCRSTPYA
760 770 780 790 800
MLELTPEEVI QRVRSPPPLC RPLVSMDQAP MECIQLMAQC WAEHPELRPS
810 820 830 840 850
MDLTFDLFKG INKGRKTNII DSMLRMLEQY SSNLEDLIRE RTEELEQEKQ
860 870 880 890 900
KTDRLLTQML PPSVAEALKM GTSVEPEYFE EVTLYFSDIV GFTTISAMSE
910 920 930 940 950
PIEVVDLLND LYTLFDAIIG SHDVYKVETI GDAYMVASGL PQRNGQRHAA
960 970 980 990 1000
EIANMSLDIL SAVGSFRMRH MPEVPVRIRI GLHSGPCVAG VVGLTMPRYC
1010 1020 1030 1040 1050
LFGDTVNTAS RMESTGLPYR IHVNMSTVRI LRALDQGFQM ECRGRTELKG
1060 1070 1080 1090 1100
KGVEDTYWLV GRVGFNKPIP KPPDLQPGAS NHGISLQEIP PERRKKLEKA

RPGQFTGK
Length:1,108
Mass (Da):120,801
Last modified:October 1, 1996 - v1
Checksum:i4FA1BE9325A2A979
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36029 mRNA. Translation: AAA65510.1.
PIRiA55915.
RefSeqiNP_077356.1. NM_024380.1.
UniGeneiRn.10060.

Genome annotation databases

GeneIDi79222.
KEGGirno:79222.
UCSCiRGD:620438. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L36029 mRNA. Translation: AAA65510.1 .
PIRi A55915.
RefSeqi NP_077356.1. NM_024380.1.
UniGenei Rn.10060.

3D structure databases

ProteinModelPortali P51840.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000010790.

PTM databases

PhosphoSitei P51840.

Proteomic databases

PaxDbi P51840.
PRIDEi P51840.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 79222.
KEGGi rno:79222.
UCSCi RGD:620438. rat.

Organism-specific databases

CTDi 14919.
RGDi 620438. Gucy2e.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000293307.
HOVERGENi HBG098487.
InParanoidi P51840.
KOi K12321.
OrthoDBi EOG7QVM1V.
PhylomeDBi P51840.
TreeFami TF106338.

Enzyme and pathway databases

Reactomei REACT_227662. Inactivation, recovery and regulation of the phototransduction cascade.

Miscellaneous databases

NextBioi 614644.
PROi P51840.

Gene expression databases

Genevestigatori P51840.

Family and domain databases

Gene3Di 3.30.70.1230. 1 hit.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011645. Haem_no_assoc-bd.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view ]
Pfami PF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07701. HNOBA. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
SMARTi SM00044. CYCc. 1 hit.
[Graphical view ]
SUPFAMi SSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Eye.
  2. Lubec G., Kang S.U.
    Submitted (JUL-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 203-209, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGUC2E_RAT
AccessioniPrimary (citable) accession number: P51840
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3