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Protein

Olfactory guanylyl cyclase GC-D

Gene

Gucy2d

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.

Catalytic activityi

GTP = 3',5'-cyclic GMP + diphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cGMP biosynthesis, Olfaction, Sensory transduction

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory guanylyl cyclase GC-D (EC:4.6.1.2)
Alternative name(s):
Guanylate cyclase, olfactory
Gene namesi
Name:Gucy2d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69322. Gucy2d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini67 – 475409ExtracellularSequence analysisAdd
BLAST
Transmembranei476 – 50025HelicalSequence analysisAdd
BLAST
Topological domaini501 – 1110610CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 6666Sequence analysisAdd
BLAST
Chaini67 – 11101044Olfactory guanylyl cyclase GC-DPRO_0000012382Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi121 ↔ 149By similarity
Glycosylationi304 – 3041N-linked (GlcNAc...)Sequence analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi462 – 462InterchainBy similarity
Disulfide bondi470 – 470InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51839.
PRIDEiP51839.

Expressioni

Tissue specificityi

Specifically expressed in a subpopulation of olfactory sensory neurons.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020513.

Structurei

3D structure databases

ProteinModelPortaliP51839.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini541 – 818278Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini893 – 1023131Guanylate cyclasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 1 guanylate cyclase domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
HOVERGENiHBG098487.
InParanoidiP51839.
KOiK12321.
PhylomeDBiP51839.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLQQGCHP EGQDWTAPHW KTCRALPGPR GLTVRHLRTV SSISVFSVVF
60 70 80 90 100
WGVLLWADSL SLPAWARETF TLGVLGPWDC DPIFAQALPS MATQLAVDRV
110 120 130 140 150
NQDASLLLGS QLDFKILPTG CDTPHALATF VAHRNTVAAF IGPVNPGYCP
160 170 180 190 200
AAALLAQGWG KSLFSWACGA PEGGGALVPT LPSMADVLLS VMRHFGWARL
210 220 230 240 250
AIVSSHQDIW VTTAQQLATA FRAHGLPIGL ITSLGPGEKG ATEVCKQLHS
260 270 280 290 300
VHGLKIVVLC MHSALLGGLE QTVLLRCARE EGLTDGRLVF LPYDTLLFAL
310 320 330 340 350
PYRNRSYLVL DDDGPLQEAY DAVLTISLDT SPESHAFTAT KMRGGAAANL
360 370 380 390 400
GPEQVSPLFG TIYDAVILLA HALNHSETHG TGLSGAHLGN HIRALDVAGF
410 420 430 440 450
SQRIRIDGKG RRLPQYVILD TNGEGSQLVP THILDVSTQQ VQPLGTAVHF
460 470 480 490 500
PGGSPPAHDA SCWFDPNTLC IRGVQPLGSL LTLTITCVLA LVGGFLAYFI
510 520 530 540 550
RLGLQQLRLL RGPHRILLTP QELTFLQRTP SRRRPHVDSG SESRSVVDGG
560 570 580 590 600
SPQSVIQGST RSVPAFLEHT NVALYQGEWV WLKKFEAGTA PDLRPSSLSL
610 620 630 640 650
LRKMREMRHE NVTAFLGLFV GPEVSAMVLE HCARGSLEDL LRNEDLRLDW
660 670 680 690 700
TFKASLLLDL IRGLRYLHHR HFPHGRLKSR NCVVDTRFVL KITDHGYAEF
710 720 730 740 750
LESHCSFRPQ PAPEELLWTA PELLRGPRGP WGPGKATFKG DVFSLGIILQ
760 770 780 790 800
EVLTRDPPYC SWGLSAEEII RKVASPPPLC RPLVSPDQGP LECIQLMQLC
810 820 830 840 850
WEEAPDDRPS LDQIYTQFKS INQGKKTSVA DSMLRMLEKY SQSLEGLVQE
860 870 880 890 900
RTEELELERR KTERLLSQML PPSVAHALKM GTTVEPEYFD QVTIYFSDIV
910 920 930 940 950
GFTTISALSE PIEVVGFLND LYTMFDAVLD SHDVYKVETI GDAYMVASGL
960 970 980 990 1000
PRRNGNRHAA EIANMALEIL SYAGNFRMRH APDVPIRVRA GLHSGPCVAG
1010 1020 1030 1040 1050
VVGLTMPRYC LFGDTVNTAS RMESTGLPYR IHVSRNTVQA LLSLDEGYKI
1060 1070 1080 1090 1100
DVRGQTELKG KGLEETYWLT GKTGFCRSLP TPLSIQPGDP WQDHINQEIR
1110
TGFAKLARVC
Length:1,110
Mass (Da):121,975
Last modified:October 1, 1996 - v1
Checksum:iEDA1E3A0B5BB462E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37203 mRNA. Translation: AAC42057.1.
PIRiI59370.
RefSeqiNP_570093.1. NM_130737.4.
UniGeneiRn.10067.

Genome annotation databases

GeneIDi113911.
KEGGirno:113911.
UCSCiRGD:69322. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37203 mRNA. Translation: AAC42057.1.
PIRiI59370.
RefSeqiNP_570093.1. NM_130737.4.
UniGeneiRn.10067.

3D structure databases

ProteinModelPortaliP51839.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020513.

Proteomic databases

PaxDbiP51839.
PRIDEiP51839.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113911.
KEGGirno:113911.
UCSCiRGD:69322. rat.

Organism-specific databases

CTDi3000.
RGDi69322. Gucy2d.

Phylogenomic databases

eggNOGiKOG1023. Eukaryota.
COG2114. LUCA.
HOVERGENiHBG098487.
InParanoidiP51839.
KOiK12321.
PhylomeDBiP51839.

Miscellaneous databases

PROiP51839.

Family and domain databases

Gene3Di3.30.70.1230. 1 hit.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR001828. ANF_lig-bd_rcpt.
IPR011009. Kinase-like_dom.
IPR029787. Nucleotide_cyclase.
IPR028082. Peripla_BP_I.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF01094. ANF_receptor. 1 hit.
PF00211. Guanylate_cyc. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
SMARTiSM00044. CYCc. 1 hit.
[Graphical view]
SUPFAMiSSF53822. SSF53822. 1 hit.
SSF55073. SSF55073. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons."
    Fuelle H.-J., Vassar R., Foster D.C., Yang R.-B., Axel R., Garbers D.L.
    Proc. Natl. Acad. Sci. U.S.A. 92:3571-3575(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Olfactory neuron.

Entry informationi

Entry nameiGUC2D_RAT
AccessioniPrimary (citable) accession number: P51839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 6, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.