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Protein

GTPase Era

Gene

era

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTP8
Nucleotide bindingi60 – 64GTP5
Nucleotide bindingi121 – 124GTP4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase Era
Gene namesi
Name:era
Ordered Locus Names:CBU_1502
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm
  • Cell inner membrane ; Peripheral membrane protein

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001800101 – 295GTPase EraAdd BLAST295

Proteomic databases

PRIDEiP51836.

Expressioni

Developmental stagei

More than twofold more abundant in the small cell variant (SCV) stage than in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi227377.CBU_1502.

Structurei

3D structure databases

ProteinModelPortaliP51836.
SMRiP51836.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 172Era-type GAdd BLAST168
Domaini203 – 279KH type-2Add BLAST77

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.

Phylogenomic databases

eggNOGiENOG4105CWT. Bacteria.
COG1159. LUCA.
HOGENOMiHOG000245596.
KOiK03595.
OMAiKVAKDWQ.

Family and domain databases

CDDicd04163. Era. 1 hit.
Gene3Di3.30.300.20. 1 hit.
HAMAPiMF_00367. GTPase_Era. 1 hit.
InterProiView protein in InterPro
IPR030388. G_ERA_dom.
IPR005662. GTP-bd_Era.
IPR006073. GTP_binding_domain.
IPR015946. KH_dom-like_a/b.
IPR004044. KH_dom_type_2.
IPR009019. KH_sf_prok-type.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
PfamiView protein in Pfam
PF07650. KH_2. 1 hit.
PF01926. MMR_HSR1. 1 hit.
PRINTSiPR00326. GTP1OBG.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54814. SSF54814. 1 hit.
TIGRFAMsiTIGR00436. era. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51713. G_ERA. 1 hit.
PS50823. KH_TYPE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P51836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTYCGYAA IIGRPNVGKS TLLNQLLEQK ISITSRKPQT TRYQILGVKT
60 70 80 90 100
FKDIQVIYVD TPGLHAGTER TINRYMNRTA RGALRDVDAI VFVIEPHWES
110 120 130 140 150
QDAWVLDNLK EIETPVFLVI NKVDKIKNRA ELLPLIEKVS SLYAFQKITP
160 170 180 190 200
LSAKTGDQVG TLEQAVHQLM PESPFYFPPE QVTDRSDQFM ASEIIREKLM
210 220 230 240 250
RLLGQEIPYS LAVTLIEFRK EEKIIRISAV IWVEKKSQKG IVIGKGGERL
260 270 280 290
KRVGTNARLD MEKWFGKRVF LQLWVKVKSG WADNERLLRE LGFEE
Length:295
Mass (Da):33,873
Last modified:October 1, 1996 - v1
Checksum:i559AB52D2922119E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27436 Genomic DNA. Translation: AAA69691.1.
AE016828 Genomic DNA. Translation: AAO90999.1.
PIRiS60768.
RefSeqiNP_820485.1. NC_002971.3.
WP_010958267.1. NC_002971.4.

Genome annotation databases

EnsemblBacteriaiAAO90999; AAO90999; CBU_1502.
GeneIDi1209412.
KEGGicbu:CBU_1502.
PATRICifig|227377.7.peg.1504.

Similar proteinsi

Entry informationi

Entry nameiERA_COXBU
AccessioniPrimary (citable) accession number: P51836
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 22, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families