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P51834

- SMC_BACSU

UniProt

P51834 - SMC_BACSU

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Protein

Chromosome partition protein Smc

Gene
smc, ylqA, BSU15940
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for chromosome condensation and partitioning.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi32 – 398ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: UniProtKB-HAMAP
  3. identical protein binding Source: IntAct
  4. protein binding Source: IntAct

GO - Biological processi

  1. chromosome condensation Source: InterPro
  2. DNA replication Source: UniProtKB-HAMAP
  3. sister chromatid cohesion Source: InterPro
Complete GO annotation...

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU15940-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome partition protein Smc
Gene namesi
Name:smc
Synonyms:ylqA
Ordered Locus Names:BSU15940
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU15940. [Micado]

Subcellular locationi

Cytoplasm
Note: Probably associated with the nucleoid.1 Publication

GO - Cellular componenti

  1. chromosome Source: InterPro
  2. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Mutants produce anucleate cells and show defects in nucleoid structure and in chromosome partitioning.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11861186Chromosome partition protein SmcUniRule annotationPRO_0000119028Add
BLAST

Proteomic databases

PaxDbiP51834.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-2121372,EBI-2121372
scpAP351546EBI-2121372,EBI-2121359
scpBP351552EBI-2121372,EBI-2121445

Protein-protein interaction databases

DIPiDIP-52199N.
IntActiP51834. 22 interactions.
STRINGi224308.BSU15940.

Structurei

Secondary structure

1
1186
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 149
Beta strandi24 – 307
Helixi39 – 4810
Beta strandi83 – 897
Beta strandi100 – 1078
Beta strandi112 – 1143
Helixi122 – 1254
Helixi126 – 1283
Beta strandi139 – 1424
Helixi143 – 1519
Helixi154 – 16411
Helixi168 – 19730
Helixi996 – 105257
Beta strandi1056 – 10594
Beta strandi1062 – 10665
Helixi1067 – 10693
Beta strandi1074 – 10774
Beta strandi1079 – 10813
Beta strandi1083 – 10897
Helixi1093 – 110816
Beta strandi1114 – 11185
Turni1119 – 11224
Helixi1126 – 113712
Beta strandi1139 – 11424
Beta strandi1144 – 11474
Helixi1151 – 11566
Beta strandi1160 – 11645
Beta strandi1171 – 11744

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZGXX-ray3.40A/B1-219[»]
A/B983-1186[»]
ProteinModelPortaliP51834.
SMRiP51834. Positions 1-197, 485-685, 1029-1186.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili167 – 20640 Reviewed predictionAdd
BLAST
Coiled coili259 – 481223 Reviewed predictionAdd
BLAST
Coiled coili672 – 864193 Reviewed predictionAdd
BLAST
Coiled coili893 – 94351 Reviewed predictionAdd
BLAST
Coiled coili990 – 102940 Reviewed predictionAdd
BLAST

Domaini

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures (By similarity).UniRule annotation

Sequence similaritiesi

Belongs to the SMC family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1196.
HOGENOMiHOG000036392.
KOiK03529.
OrthoDBiEOG6WQD34.
PhylomeDBiP51834.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01894. Smc_prok.
InterProiIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view]
PfamiPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFiPIRSF005719. SMC. 1 hit.
SMARTiSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsiTIGR02168. SMC_prok_B. 1 hit.

Sequencei

Sequence statusi: Complete.

P51834-1 [UniParc]FASTAAdd to Basket

« Hide

MFLKRLDVIG FKSFAERISV DFVKGVTAVV GPNGSGKSNI TDAIRWVLGE     50
QSARSLRGGK MEDIIFAGSD SRKRLNLAEV TLTLDNDDHF LPIDFHEVSV 100
TRRVYRSGES EFLINNQPCR LKDIIDLFMD SGLGKEAFSI ISQGKVEEIL 150
SSKAEDRRSI FEEAAGVLKY KTRKKKAENK LFETQDNLNR VEDILHELEG 200
QVEPLKIQAS IAKDYLEKKK ELEHVEIALT AYDIEELHGK WSTLKEKVQM 250
AKEEELAESS AISAKEAKIE DTRDKIQALD ESVDELQQVL LVTSEELEKL 300
EGRKEVLKER KKNAVQNQEQ LEEAIVQFQQ KETVLKEELS KQEAVFETLQ 350
AEVKQLRAQV KEKQQALSLH NENVEEKIEQ LKSDYFELLN SQASIRNELQ 400
LLDDQMSQSA VTLQRLADNN EKHLQERHDI SARKAACETE FARIEQEIHS 450
QVGAYRDMQT KYEQKKRQYE KNESALYQAY QYVQQARSKK DMLETMQGDF 500
SGFYQGVKEV LKAKERLGGI RGAVLELIST EQKYETAIEI ALGASAQHVV 550
TDDEQSARKA IQYLKQNSFG RATFLPLSVI RDRQLQSRDA ETAARHSSFL 600
GVASELVTFD PAYRSVIQNL LGTVLITEDL KGANELAKLL GHRYRIVTLE 650
GDVVNPGGSM TGGAVKKKNN SLLGRSRELE DVTKRLAEME EKTALLEQEV 700
KTLKHSIQDM EKKLADLRET GEGLRLKQQD VKGQLYELQV AEKNINTHLE 750
LYDQEKSALS ESDEERKVRK RKLEEELSAV SEKMKQLEED IDRLTKQKQT 800
QSSTKESLSN ELTELKIAAA KKEQACKGEE DNLARLKKEL TETELALKEA 850
KEDLSFLTSE MSSSTSGEEK LEEAAKHKLN DKTKTIELIA LRRDQRIKLQ 900
HGLDTYEREL KEMKRLYKQK TTLLKDEEVK LGRMEVELDN LLQYLREEYS 950
LSFEGAKEKY QLETDPEEAR KRVKLIKLAI EELGTVNLGS IDEFERVNER 1000
YKFLSEQKED LTEAKNTLFQ VIEEMDEEMT KRFNDTFVQI RSHFDQVFRS 1050
LFGGGRAELR LTDPNDLLHS GVEIIAQPPG KKLQNLNLLS GGERALTAIA 1100
LLFSILKVRP VPFCVLDEVE AALDEANVFR FAQYLKKYSS DTQFIVITHR 1150
KGTMEEADVL YGVTMQESGV SKVISVKLEE TKEFVQ 1186
Length:1,186
Mass (Da):135,513
Last modified:June 16, 2009 - v3
Checksum:iACC5D1A170453212
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti50 – 501E → G in BAA10977. 1 Publication
Sequence conflicti162 – 1621E → G in BAA10977. 1 Publication
Sequence conflicti175 – 1751K → E in BAA10977. 1 Publication
Sequence conflicti178 – 1781E → G in BAA10977. 1 Publication
Sequence conflicti192 – 1921E → G in BAA10977. 1 Publication
Sequence conflicti228 – 2281A → P in BAA10977. 1 Publication
Sequence conflicti264 – 2641A → P in BAA10977. 1 Publication
Sequence conflicti271 – 2711D → G in BAA10977. 1 Publication
Sequence conflicti309 – 3091E → D in BAA10977. 1 Publication
Sequence conflicti336 – 3427KEELSKQ → TRRAFEA in BAA10977. 1 Publication
Sequence conflicti365 – 3651Q → H in BAA10977. 1 Publication
Sequence conflicti438 – 4381E → K in BAA10977. 1 Publication
Sequence conflicti444 – 4441I → F in BAA10977. 1 Publication
Sequence conflicti475 – 4751A → P in BAA10977. 1 Publication
Sequence conflicti494 – 4941E → D in BAA10977. 1 Publication
Sequence conflicti515 – 5151E → D in BAA10977. 1 Publication
Sequence conflicti542 – 5421L → V in BAA10977. 1 Publication
Sequence conflicti546 – 5461A → P in BAA10977. 1 Publication
Sequence conflicti586 – 60015QSRDA…HSSFL → SKPLRGNSGPAFIISF in BAA10977. 1 PublicationAdd
BLAST
Sequence conflicti623 – 6319TVLITEDLK → NRSDYRGLKG in BAA10977. 1 Publication
Sequence conflicti664 – 6641A → S in BAA10977. 1 Publication
Sequence conflicti676 – 6761S → T in BAA10977. 1 Publication
Sequence conflicti680 – 6801E → G in BAA10977. 1 Publication
Sequence conflicti694 – 6941A → S in BAA10977. 1 Publication
Sequence conflicti701 – 7011K → Q in BAA10977. 1 Publication
Sequence conflicti726 – 7261L → V in BAA10977. 1 Publication
Sequence conflicti738 – 7403LQV → PQF in BAA10977. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64116 Genomic DNA. Translation: BAA10977.1.
AL009126 Genomic DNA. Translation: CAB13467.2.
D49781 Genomic DNA. Translation: BAA08615.1.
PIRiG69708.
RefSeqiNP_389476.2. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB13467; CAB13467; BSU15940.
GeneIDi938085.
KEGGibsu:BSU15940.
PATRICi18974993. VBIBacSub10457_1688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64116 Genomic DNA. Translation: BAA10977.1 .
AL009126 Genomic DNA. Translation: CAB13467.2 .
D49781 Genomic DNA. Translation: BAA08615.1 .
PIRi G69708.
RefSeqi NP_389476.2. NC_000964.3.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZGX X-ray 3.40 A/B 1-219 [» ]
A/B 983-1186 [» ]
ProteinModelPortali P51834.
SMRi P51834. Positions 1-197, 485-685, 1029-1186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-52199N.
IntActi P51834. 22 interactions.
STRINGi 224308.BSU15940.

Proteomic databases

PaxDbi P51834.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB13467 ; CAB13467 ; BSU15940 .
GeneIDi 938085.
KEGGi bsu:BSU15940.
PATRICi 18974993. VBIBacSub10457_1688.

Organism-specific databases

GenoListi BSU15940. [Micado ]

Phylogenomic databases

eggNOGi COG1196.
HOGENOMi HOG000036392.
KOi K03529.
OrthoDBi EOG6WQD34.
PhylomeDBi P51834.

Enzyme and pathway databases

BioCyci BSUB:BSU15940-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01894. Smc_prok.
InterProi IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view ]
Pfami PF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF005719. SMC. 1 hit.
SMARTi SM00968. SMC_hinge. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsi TIGR02168. SMC_prok_B. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The effect of Srb, a homologue of the mammalian SRP receptor alpha-subunit, on Bacillus subtilis growth and protein translocation."
    Oguro A., Kakeshita H., Takamatsu H., Nakamura K., Yamane K.
    Gene 172:17-24(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  3. "From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
    Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
    Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 236 AND 284.
  4. "srb: a Bacillus subtilis gene encoding a homologue of the alpha-subunit of the mammalian signal recognition particle receptor."
    Oguro A., Kakeshita H., Honda K., Takamatsu H., Nakamura K., Yamane K.
    DNA Res. 2:95-100(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1171-1186.
    Strain: 168.
  5. "Characterization of a prokaryotic SMC protein involved in chromosome partitioning."
    Britton R.A., Lin D.C., Grossman A.D.
    Genes Dev. 12:1254-1259(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    Strain: 168 / JH642.
  6. "A Bacillus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partition."
    Moriya S., Tsujikawa E., Hassan A.K., Asai K., Kodama T., Ogasawara N.
    Mol. Microbiol. 29:179-187(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    Strain: 168.

Entry informationi

Entry nameiSMC_BACSU
AccessioniPrimary (citable) accession number: P51834
Secondary accession number(s): O31735
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 16, 2009
Last modified: September 3, 2014
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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