Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P51834 (SMC_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosome partition protein Smc
Gene names
Name:smc
Synonyms:ylqA
Ordered Locus Names:BSU15940
OrganismBacillus subtilis (strain 168) [Reference proteome] [HAMAP]
Taxonomic identifier224308 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Protein attributes

Sequence length1186 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for chromosome condensation and partitioning. Ref.5 Ref.6

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01894

Subcellular location

Cytoplasm. Note: Probably associated with the nucleoid. Ref.5

Domain

Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures By similarity. HAMAP-Rule MF_01894

Disruption phenotype

Mutants produce anucleate cells and show defects in nucleoid structure and in chromosome partitioning. Ref.5 Ref.6

Sequence similarities

Belongs to the SMC family.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11861186Chromosome partition protein Smc HAMAP-Rule MF_01894
PRO_0000119028

Regions

Nucleotide binding32 – 398ATP By similarity
Coiled coil167 – 20640 Potential
Coiled coil259 – 481223 Potential
Coiled coil672 – 864193 Potential
Coiled coil893 – 94351 Potential
Coiled coil990 – 102940 Potential

Experimental info

Sequence conflict501E → G in BAA10977. Ref.1
Sequence conflict1621E → G in BAA10977. Ref.1
Sequence conflict1751K → E in BAA10977. Ref.1
Sequence conflict1781E → G in BAA10977. Ref.1
Sequence conflict1921E → G in BAA10977. Ref.1
Sequence conflict2281A → P in BAA10977. Ref.1
Sequence conflict2641A → P in BAA10977. Ref.1
Sequence conflict2711D → G in BAA10977. Ref.1
Sequence conflict3091E → D in BAA10977. Ref.1
Sequence conflict336 – 3427KEELSKQ → TRRAFEA in BAA10977. Ref.1
Sequence conflict3651Q → H in BAA10977. Ref.1
Sequence conflict4381E → K in BAA10977. Ref.1
Sequence conflict4441I → F in BAA10977. Ref.1
Sequence conflict4751A → P in BAA10977. Ref.1
Sequence conflict4941E → D in BAA10977. Ref.1
Sequence conflict5151E → D in BAA10977. Ref.1
Sequence conflict5421L → V in BAA10977. Ref.1
Sequence conflict5461A → P in BAA10977. Ref.1
Sequence conflict586 – 60015QSRDA…HSSFL → SKPLRGNSGPAFIISF in BAA10977. Ref.1
Sequence conflict623 – 6319TVLITEDLK → NRSDYRGLKG in BAA10977. Ref.1
Sequence conflict6641A → S in BAA10977. Ref.1
Sequence conflict6761S → T in BAA10977. Ref.1
Sequence conflict6801E → G in BAA10977. Ref.1
Sequence conflict6941A → S in BAA10977. Ref.1
Sequence conflict7011K → Q in BAA10977. Ref.1
Sequence conflict7261L → V in BAA10977. Ref.1
Sequence conflict738 – 7403LQV → PQF in BAA10977. Ref.1

Secondary structure

..................................................... 1186
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P51834 [UniParc].

Last modified June 16, 2009. Version 3.
Checksum: ACC5D1A170453212

FASTA1,186135,513
        10         20         30         40         50         60 
MFLKRLDVIG FKSFAERISV DFVKGVTAVV GPNGSGKSNI TDAIRWVLGE QSARSLRGGK 

        70         80         90        100        110        120 
MEDIIFAGSD SRKRLNLAEV TLTLDNDDHF LPIDFHEVSV TRRVYRSGES EFLINNQPCR 

       130        140        150        160        170        180 
LKDIIDLFMD SGLGKEAFSI ISQGKVEEIL SSKAEDRRSI FEEAAGVLKY KTRKKKAENK 

       190        200        210        220        230        240 
LFETQDNLNR VEDILHELEG QVEPLKIQAS IAKDYLEKKK ELEHVEIALT AYDIEELHGK 

       250        260        270        280        290        300 
WSTLKEKVQM AKEEELAESS AISAKEAKIE DTRDKIQALD ESVDELQQVL LVTSEELEKL 

       310        320        330        340        350        360 
EGRKEVLKER KKNAVQNQEQ LEEAIVQFQQ KETVLKEELS KQEAVFETLQ AEVKQLRAQV 

       370        380        390        400        410        420 
KEKQQALSLH NENVEEKIEQ LKSDYFELLN SQASIRNELQ LLDDQMSQSA VTLQRLADNN 

       430        440        450        460        470        480 
EKHLQERHDI SARKAACETE FARIEQEIHS QVGAYRDMQT KYEQKKRQYE KNESALYQAY 

       490        500        510        520        530        540 
QYVQQARSKK DMLETMQGDF SGFYQGVKEV LKAKERLGGI RGAVLELIST EQKYETAIEI 

       550        560        570        580        590        600 
ALGASAQHVV TDDEQSARKA IQYLKQNSFG RATFLPLSVI RDRQLQSRDA ETAARHSSFL 

       610        620        630        640        650        660 
GVASELVTFD PAYRSVIQNL LGTVLITEDL KGANELAKLL GHRYRIVTLE GDVVNPGGSM 

       670        680        690        700        710        720 
TGGAVKKKNN SLLGRSRELE DVTKRLAEME EKTALLEQEV KTLKHSIQDM EKKLADLRET 

       730        740        750        760        770        780 
GEGLRLKQQD VKGQLYELQV AEKNINTHLE LYDQEKSALS ESDEERKVRK RKLEEELSAV 

       790        800        810        820        830        840 
SEKMKQLEED IDRLTKQKQT QSSTKESLSN ELTELKIAAA KKEQACKGEE DNLARLKKEL 

       850        860        870        880        890        900 
TETELALKEA KEDLSFLTSE MSSSTSGEEK LEEAAKHKLN DKTKTIELIA LRRDQRIKLQ 

       910        920        930        940        950        960 
HGLDTYEREL KEMKRLYKQK TTLLKDEEVK LGRMEVELDN LLQYLREEYS LSFEGAKEKY 

       970        980        990       1000       1010       1020 
QLETDPEEAR KRVKLIKLAI EELGTVNLGS IDEFERVNER YKFLSEQKED LTEAKNTLFQ 

      1030       1040       1050       1060       1070       1080 
VIEEMDEEMT KRFNDTFVQI RSHFDQVFRS LFGGGRAELR LTDPNDLLHS GVEIIAQPPG 

      1090       1100       1110       1120       1130       1140 
KKLQNLNLLS GGERALTAIA LLFSILKVRP VPFCVLDEVE AALDEANVFR FAQYLKKYSS 

      1150       1160       1170       1180 
DTQFIVITHR KGTMEEADVL YGVTMQESGV SKVISVKLEE TKEFVQ 

« Hide

References

« Hide 'large scale' references
[1]"The effect of Srb, a homologue of the mammalian SRP receptor alpha-subunit, on Bacillus subtilis growth and protein translocation."
Oguro A., Kakeshita H., Takamatsu H., Nakamura K., Yamane K.
Gene 172:17-24(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 168.
[2]"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. expand/collapse author list , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 168.
[3]"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later."
Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.
Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SEQUENCE REVISION TO 236 AND 284.
[4]"srb: a Bacillus subtilis gene encoding a homologue of the alpha-subunit of the mammalian signal recognition particle receptor."
Oguro A., Kakeshita H., Honda K., Takamatsu H., Nakamura K., Yamane K.
DNA Res. 2:95-100(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1171-1186.
Strain: 168.
[5]"Characterization of a prokaryotic SMC protein involved in chromosome partitioning."
Britton R.A., Lin D.C., Grossman A.D.
Genes Dev. 12:1254-1259(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
Strain: 168 / JH642.
[6]"A Bacillus subtilis gene-encoding protein homologous to eukaryotic SMC motor protein is necessary for chromosome partition."
Moriya S., Tsujikawa E., Hassan A.K., Asai K., Kodama T., Ogasawara N.
Mol. Microbiol. 29:179-187(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DISRUPTION PHENOTYPE.
Strain: 168.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D64116 Genomic DNA. Translation: BAA10977.1.
AL009126 Genomic DNA. Translation: CAB13467.2.
D49781 Genomic DNA. Translation: BAA08615.1.
PIRG69708.
RefSeqNP_389476.2. NC_000964.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZGXX-ray3.40A/B1-1186[»]
ProteinModelPortalP51834.
SMRP51834. Positions 1-197, 485-685, 1029-1186.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-52199N.
IntActP51834. 22 interactions.
STRING224308.BSU15940.

Proteomic databases

PaxDbP51834.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB13467; CAB13467; BSU15940.
GeneID938085.
KEGGbsu:BSU15940.
PATRIC18974993. VBIBacSub10457_1688.

Organism-specific databases

GenoListBSU15940. [Micado]

Phylogenomic databases

eggNOGCOG1196.
HOGENOMHOG000036392.
KOK03529.
OrthoDBEOG6WQD34.
ProtClustDBCLSK2765274.

Enzyme and pathway databases

BioCycBSUB:BSU15940-MONOMER.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01894. Smc_prok.
InterProIPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
IPR024704. SMC.
IPR010935. SMC_hinge.
IPR011890. SMC_prok.
[Graphical view]
PfamPF06470. SMC_hinge. 1 hit.
PF02463. SMC_N. 1 hit.
[Graphical view]
PIRSFPIRSF005719. SMC. 1 hit.
SMARTSM00968. SMC_hinge. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF75553. SSF75553. 1 hit.
TIGRFAMsTIGR02168. SMC_prok_B. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSMC_BACSU
AccessionPrimary (citable) accession number: P51834
Secondary accession number(s): O31735
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 16, 2009
Last modified: April 16, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList