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P51830

- ADCY9_MOUSE

UniProt

P51830 - ADCY9_MOUSE

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Protein

Adenylate cyclase type 9

Gene
Adcy9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by magnesium, forskolin and mutationally activated G protein (GS)-alpha. Regulated by calcineurin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi399 – 3991Magnesium 1 By similarity
Metal bindingi399 – 3991Magnesium 2 By similarity
Metal bindingi400 – 4001Magnesium 2; via carbonyl oxygen By similarity
Metal bindingi443 – 4431Magnesium 1 By similarity
Metal bindingi443 – 4431Magnesium 2 By similarity

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 9 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 9
Adenylate cyclase type IX
Adenylyl cyclase 9
Adenylyl cyclase type 10
Short name:
ACTP10
Gene namesi
Name:Adcy9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:108450. Adcy9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei118 – 13821Helical; Reviewed predictionAdd
BLAST
Topological domaini139 – 1413Extracellular Reviewed prediction
Transmembranei142 – 16221Helical; Reviewed predictionAdd
BLAST
Topological domaini163 – 1719Cytoplasmic Reviewed prediction
Transmembranei172 – 19221Helical; Reviewed predictionAdd
BLAST
Topological domaini193 – 21523Extracellular Reviewed predictionAdd
BLAST
Transmembranei216 – 23520Helical; Reviewed predictionAdd
BLAST
Topological domaini236 – 2416Cytoplasmic Reviewed prediction
Transmembranei242 – 25918Helical; Reviewed predictionAdd
BLAST
Topological domaini260 – 28021Extracellular Reviewed predictionAdd
BLAST
Transmembranei281 – 30121Helical; Reviewed predictionAdd
BLAST
Topological domaini302 – 786485Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei787 – 80721Helical; Reviewed predictionAdd
BLAST
Topological domaini808 – 81811Extracellular Reviewed predictionAdd
BLAST
Transmembranei819 – 83921Helical; Reviewed predictionAdd
BLAST
Topological domaini840 – 86728Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei868 – 88821Helical; Reviewed predictionAdd
BLAST
Topological domaini889 – 8913Extracellular Reviewed prediction
Transmembranei892 – 91221Helical; Reviewed predictionAdd
BLAST
Topological domaini913 – 9208Cytoplasmic Reviewed prediction
Transmembranei921 – 94121Helical; Reviewed predictionAdd
BLAST
Topological domaini942 – 97534Extracellular Reviewed predictionAdd
BLAST
Transmembranei976 – 99621Helical; Reviewed predictionAdd
BLAST
Topological domaini997 – 1353357Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. dendrite Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Adenylate cyclase type 9PRO_0000195709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...) Reviewed prediction
Modified residuei613 – 6131Phosphoserine1 Publication
Glycosylationi955 – 9551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi964 – 9641N-linked (GlcNAc...) Reviewed prediction
Modified residuei1259 – 12591Phosphoserine By similarity
Modified residuei1307 – 13071Phosphoserine By similarity
Modified residuei1332 – 13321Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51830.
PRIDEiP51830.

PTM databases

PhosphoSiteiP51830.

Expressioni

Tissue specificityi

Found in decreasing order in skeletal muscle, heart, adrenal gland, ovary and brain; and to a lesser extent, in kidney, liver, testis, lung, thymus and spleen.

Gene expression databases

ArrayExpressiP51830.
BgeeiP51830.
CleanExiMM_ADCY9.
GenevestigatoriP51830.

Structurei

3D structure databases

ProteinModelPortaliP51830.
SMRiP51830. Positions 380-553, 1050-1241.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00750000117304.
HOGENOMiHOG000001574.
HOVERGENiHBG050459.
InParanoidiP51830.
KOiK08049.
OMAiIYFGVHM.
OrthoDBiEOG7TF78Q.
PhylomeDBiP51830.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51830-1 [UniParc]FASTAAdd to Basket

« Hide

MASSPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN THPKHCKYSI     50
SSSCSSSGDS GGLPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSMNL 100
EEACLERCFP QTQRRFRYAL FYVGFACLLW SIYFAVHMKS KVIVMVVPAL 150
CFLVVCVGFF LFTFTKLYAR HYAWTSLALT LLVFALTLAA QFQVWTPLSG 200
RVDSSNHTLT ATPADTCLSQ VGSFSICIEV LLLLYTVMQL PLYLSLFLGV 250
VYSVLFETFG YHFRNEDCYP SPGPGALHWE LLSRALLHVC IHAIGIHLFV 300
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG 350
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI 400
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EQTKCEKIST LGDCYYCVAG 450
CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL 500
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGRV 550
IERLGQSVVA DQLKGLKTYL ISGQRAKESH CSCAEALLSG FEVIDDSRES 600
SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGTV 650
QNGCQDEPKT STKASGGPNS KTQNGLLSPP AEEKLTNSQT SLCEILQEKG 700
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF 750
SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASATFSSLLD VFLSTTVFLI 800
LSITCFLKYG ATATPPPPAA LAVFGADLLL EVLSLIVSIR MVFFLEDVMT 850
CTKWLLEWIA GWLPRHCIGA ILVSLPALAV YSHITSEFET NIHVTMFTGS 900
AVLVAVVHYC NFCQLSSWMR SSLATIVGAG LLLLLHISLC QDSSIVMSPL 950
DSAQNFSAQR NPCNSSVLQD GRRPASLIGK ELILTFFLLL LLVWFLNREF 1000
EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY 1050
SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD 1100
YNSIEKIKTI GATYMAASGL NTAQCQEGGH PQEHLRILFE FAKEMMRVVD 1150
DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 1200
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDNGV 1250
VPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYSDK ASLGSDDSTQ 1300
AKEARLSSKR SWREPVKAEE RFPFGKAIEK DSCEDIGVEE ASELSKLNVS 1350
KSV 1353
Length:1,353
Mass (Da):150,954
Last modified:October 1, 1996 - v1
Checksum:iC65736A8304F689E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti893 – 8931H → Q in CAA90570. 1 Publication
Sequence conflicti1192 – 11921N → D no nucleotide entry 1 Publication
Sequence conflicti1305 – 13051R → H in CAA90570. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U30602 mRNA. Translation: AAC52603.1.
Z50190 mRNA. Translation: CAA90570.1.
CCDSiCCDS27917.1.
PIRiJC4279.
RefSeqiNP_033754.2. NM_009624.3.
XP_006521776.1. XM_006521713.1.
UniGeneiMm.439750.
Mm.482493.

Genome annotation databases

EnsembliENSMUST00000005719; ENSMUSP00000005719; ENSMUSG00000005580.
ENSMUST00000117801; ENSMUSP00000113498; ENSMUSG00000005580.
GeneIDi11515.
KEGGimmu:11515.
UCSCiuc007xzq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U30602 mRNA. Translation: AAC52603.1 .
Z50190 mRNA. Translation: CAA90570.1 .
CCDSi CCDS27917.1.
PIRi JC4279.
RefSeqi NP_033754.2. NM_009624.3.
XP_006521776.1. XM_006521713.1.
UniGenei Mm.439750.
Mm.482493.

3D structure databases

ProteinModelPortali P51830.
SMRi P51830. Positions 380-553, 1050-1241.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P51830.

Proteomic databases

PaxDbi P51830.
PRIDEi P51830.

Protocols and materials databases

DNASUi 11515.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000005719 ; ENSMUSP00000005719 ; ENSMUSG00000005580 .
ENSMUST00000117801 ; ENSMUSP00000113498 ; ENSMUSG00000005580 .
GeneIDi 11515.
KEGGi mmu:11515.
UCSCi uc007xzq.1. mouse.

Organism-specific databases

CTDi 115.
MGIi MGI:108450. Adcy9.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00750000117304.
HOGENOMi HOG000001574.
HOVERGENi HBG050459.
InParanoidi P51830.
KOi K08049.
OMAi IYFGVHM.
OrthoDBi EOG7TF78Q.
PhylomeDBi P51830.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

NextBioi 278930.
PROi P51830.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51830.
Bgeei P51830.
CleanExi MM_ADCY9.
Genevestigatori P51830.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view ]
Pfami PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a widely expressed form of adenylyl cyclase."
    Premont R.T., Matsuoka I., Mattei M.-G., Pouille Y., Defer N., Hanoune J.
    J. Biol. Chem. 271:13900-13907(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of adenylyl cyclases by amplification using degenerate primers."
    Premont R.T.
    Methods Enzymol. 238:116-127(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1193.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613 AND SER-1332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiADCY9_MOUSE
AccessioniPrimary (citable) accession number: P51830
Secondary accession number(s): Q61279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 3, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi