Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P51830 (ADCY9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase type 9

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 9
Adenylate cyclase type IX
Adenylyl cyclase 9
Adenylyl cyclase type 10
Short name=ACTP10
Gene names
Name:Adcy9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1353 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit.

Enzyme regulation

Insensitive to calcium/calmodulin. Stimulated by magnesium, forskolin and mutationally activated G protein (GS)-alpha. Regulated by calcineurin.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Found in decreasing order in skeletal muscle, heart, adrenal gland, ovary and brain; and to a lesser extent, in kidney, liver, testis, lung, thymus and spleen.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13531353Adenylate cyclase type 9
PRO_0000195709

Regions

Topological domain1 – 117117Cytoplasmic Potential
Transmembrane118 – 13821Helical; Potential
Topological domain139 – 1413Extracellular Potential
Transmembrane142 – 16221Helical; Potential
Topological domain163 – 1719Cytoplasmic Potential
Transmembrane172 – 19221Helical; Potential
Topological domain193 – 21523Extracellular Potential
Transmembrane216 – 23520Helical; Potential
Topological domain236 – 2416Cytoplasmic Potential
Transmembrane242 – 25918Helical; Potential
Topological domain260 – 28021Extracellular Potential
Transmembrane281 – 30121Helical; Potential
Topological domain302 – 786485Cytoplasmic Potential
Transmembrane787 – 80721Helical; Potential
Topological domain808 – 81811Extracellular Potential
Transmembrane819 – 83921Helical; Potential
Topological domain840 – 86728Cytoplasmic Potential
Transmembrane868 – 88821Helical; Potential
Topological domain889 – 8913Extracellular Potential
Transmembrane892 – 91221Helical; Potential
Topological domain913 – 9208Cytoplasmic Potential
Transmembrane921 – 94121Helical; Potential
Topological domain942 – 97534Extracellular Potential
Transmembrane976 – 99621Helical; Potential
Topological domain997 – 1353357Cytoplasmic Potential

Sites

Metal binding3991Magnesium 1 By similarity
Metal binding3991Magnesium 2 By similarity
Metal binding4001Magnesium 2; via carbonyl oxygen By similarity
Metal binding4431Magnesium 1 By similarity
Metal binding4431Magnesium 2 By similarity

Amino acid modifications

Modified residue6131Phosphoserine Ref.4
Modified residue12591Phosphoserine By similarity
Modified residue13071Phosphoserine By similarity
Modified residue13321Phosphoserine Ref.4
Glycosylation2061N-linked (GlcNAc...) Potential
Glycosylation9551N-linked (GlcNAc...) Potential
Glycosylation9641N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict8931H → Q in CAA90570. Ref.2
Sequence conflict11921N → D no nucleotide entry Ref.3
Sequence conflict13051R → H in CAA90570. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P51830 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: C65736A8304F689E

FASTA1,353150,954
        10         20         30         40         50         60 
MASSPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN THPKHCKYSI SSSCSSSGDS 

        70         80         90        100        110        120 
GGLPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSMNL EEACLERCFP QTQRRFRYAL 

       130        140        150        160        170        180 
FYVGFACLLW SIYFAVHMKS KVIVMVVPAL CFLVVCVGFF LFTFTKLYAR HYAWTSLALT 

       190        200        210        220        230        240 
LLVFALTLAA QFQVWTPLSG RVDSSNHTLT ATPADTCLSQ VGSFSICIEV LLLLYTVMQL 

       250        260        270        280        290        300 
PLYLSLFLGV VYSVLFETFG YHFRNEDCYP SPGPGALHWE LLSRALLHVC IHAIGIHLFV 

       310        320        330        340        350        360 
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG DEESENSVKR 

       370        380        390        400        410        420 
HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI VGFTKMSANK SAHALVGLLN 

       430        440        450        460        470        480 
DLFGRFDRLC EQTKCEKIST LGDCYYCVAG CPEPRADHAY CCIEMGLGMI KAIEQFCQEK 

       490        500        510        520        530        540 
KEMVNMRVGV HTGTVLCGIL GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD 

       550        560        570        580        590        600 
DRYEMEDGRV IERLGQSVVA DQLKGLKTYL ISGQRAKESH CSCAEALLSG FEVIDDSRES 

       610        620        630        640        650        660 
SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGTV QNGCQDEPKT 

       670        680        690        700        710        720 
STKASGGPNS KTQNGLLSPP AEEKLTNSQT SLCEILQEKG RWAGVSLDQS ALLPLRFKNI 

       730        740        750        760        770        780 
REKTDAHFVD VIKEDSLMKD YFFKPPINQF SLNFLDQELE RSYRTSYQEE VIKNSPVKTF 

       790        800        810        820        830        840 
ASATFSSLLD VFLSTTVFLI LSITCFLKYG ATATPPPPAA LAVFGADLLL EVLSLIVSIR 

       850        860        870        880        890        900 
MVFFLEDVMT CTKWLLEWIA GWLPRHCIGA ILVSLPALAV YSHITSEFET NIHVTMFTGS 

       910        920        930        940        950        960 
AVLVAVVHYC NFCQLSSWMR SSLATIVGAG LLLLLHISLC QDSSIVMSPL DSAQNFSAQR 

       970        980        990       1000       1010       1020 
NPCNSSVLQD GRRPASLIGK ELILTFFLLL LLVWFLNREF EVSYRLHYHG DVEADLHRTK 

      1030       1040       1050       1060       1070       1080 
IQSMRDQADW LLRNIIPYHV AEQLKVSQTY SKNHDSGGVI FASIVNFSEF YEENYEGGKE 

      1090       1100       1110       1120       1130       1140 
CYRVLNELIG DFDELLSKPD YNSIEKIKTI GATYMAASGL NTAQCQEGGH PQEHLRILFE 

      1150       1160       1170       1180       1190       1200 
FAKEMMRVVD DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 

      1210       1220       1230       1240       1250       1260 
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDNGV VPQHQLSISP 

      1270       1280       1290       1300       1310       1320 
DIRVQVDGSI GRSPTDEIAN LVPSVQYSDK ASLGSDDSTQ AKEARLSSKR SWREPVKAEE 

      1330       1340       1350 
RFPFGKAIEK DSCEDIGVEE ASELSKLNVS KSV 

« Hide

References

« Hide 'large scale' references
[1]"Identification and characterization of a widely expressed form of adenylyl cyclase."
Premont R.T., Matsuoka I., Mattei M.-G., Pouille Y., Defer N., Hanoune J.
J. Biol. Chem. 271:13900-13907(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Control of a novel adenylyl cyclase by calcineurin."
Paterson J.M., Smith S.M., Harmar A.J., Antoni F.A.
Biochem. Biophys. Res. Commun. 214:1000-1008(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Identification of adenylyl cyclases by amplification using degenerate primers."
Premont R.T.
Methods Enzymol. 238:116-127(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1193.
[4]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613 AND SER-1332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U30602 mRNA. Translation: AAC52603.1.
Z50190 mRNA. Translation: CAA90570.1.
CCDSCCDS27917.1.
PIRJC4279.
RefSeqNP_033754.2. NM_009624.3.
XP_006521776.1. XM_006521713.1.
UniGeneMm.439750.
Mm.482493.

3D structure databases

ProteinModelPortalP51830.
SMRP51830. Positions 380-553, 1050-1241.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP51830.

Proteomic databases

PaxDbP51830.
PRIDEP51830.

Protocols and materials databases

DNASU11515.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000005719; ENSMUSP00000005719; ENSMUSG00000005580.
ENSMUST00000117801; ENSMUSP00000113498; ENSMUSG00000005580.
GeneID11515.
KEGGmmu:11515.
UCSCuc007xzq.1. mouse.

Organism-specific databases

CTD115.
MGIMGI:108450. Adcy9.

Phylogenomic databases

eggNOGCOG2114.
GeneTreeENSGT00750000117304.
HOGENOMHOG000001574.
HOVERGENHBG050459.
InParanoidP51830.
KOK08049.
OMAIYFGVHM.
OrthoDBEOG7TF78Q.
PhylomeDBP51830.
TreeFamTF313845.

Gene expression databases

ArrayExpressP51830.
BgeeP51830.
CleanExMM_ADCY9.
GenevestigatorP51830.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
[Graphical view]
PfamPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio278930.
PROP51830.
SOURCESearch...

Entry information

Entry nameADCY9_MOUSE
AccessionPrimary (citable) accession number: P51830
Secondary accession number(s): Q61279
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot