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P51830

- ADCY9_MOUSE

UniProt

P51830 - ADCY9_MOUSE

Protein

Adenylate cyclase type 9

Gene

Adcy9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.

    Enzyme regulationi

    Insensitive to calcium/calmodulin. Stimulated by magnesium, forskolin and mutationally activated G protein (GS)-alpha. Regulated by calcineurin.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi399 – 3991Magnesium 1PROSITE-ProRule annotation
    Metal bindingi399 – 3991Magnesium 2PROSITE-ProRule annotation
    Metal bindingi400 – 4001Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi443 – 4431Magnesium 1PROSITE-ProRule annotation
    Metal bindingi443 – 4431Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. cAMP biosynthetic process Source: MGI
    3. intracellular signal transduction Source: InterPro

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 9 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 9
    Adenylate cyclase type IX
    Adenylyl cyclase 9
    Adenylyl cyclase type 10
    Short name:
    ACTP10
    Gene namesi
    Name:Adcy9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:108450. Adcy9.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. dendrite Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13531353Adenylate cyclase type 9PRO_0000195709Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Modified residuei613 – 6131Phosphoserine1 Publication
    Glycosylationi955 – 9551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi964 – 9641N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1259 – 12591PhosphoserineBy similarity
    Modified residuei1307 – 13071PhosphoserineBy similarity
    Modified residuei1332 – 13321Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiP51830.
    PRIDEiP51830.

    PTM databases

    PhosphoSiteiP51830.

    Expressioni

    Tissue specificityi

    Found in decreasing order in skeletal muscle, heart, adrenal gland, ovary and brain; and to a lesser extent, in kidney, liver, testis, lung, thymus and spleen.

    Gene expression databases

    ArrayExpressiP51830.
    BgeeiP51830.
    CleanExiMM_ADCY9.
    GenevestigatoriP51830.

    Structurei

    3D structure databases

    ProteinModelPortaliP51830.
    SMRiP51830. Positions 380-553, 1050-1241.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini139 – 1413ExtracellularSequence Analysis
    Topological domaini163 – 1719CytoplasmicSequence Analysis
    Topological domaini193 – 21523ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini236 – 2416CytoplasmicSequence Analysis
    Topological domaini260 – 28021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini302 – 786485CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini808 – 81811ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini840 – 86728CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini889 – 8913ExtracellularSequence Analysis
    Topological domaini913 – 9208CytoplasmicSequence Analysis
    Topological domaini942 – 97534ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini997 – 1353357CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei118 – 13821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23520HelicalSequence AnalysisAdd
    BLAST
    Transmembranei242 – 25918HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei787 – 80721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei819 – 83921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei868 – 88821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei892 – 91221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei921 – 94121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei976 – 99621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00750000117304.
    HOGENOMiHOG000001574.
    HOVERGENiHBG050459.
    InParanoidiP51830.
    KOiK08049.
    OMAiIYFGVHM.
    OrthoDBiEOG7TF78Q.
    PhylomeDBiP51830.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view]
    PfamiPF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51830-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN THPKHCKYSI     50
    SSSCSSSGDS GGLPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSMNL 100
    EEACLERCFP QTQRRFRYAL FYVGFACLLW SIYFAVHMKS KVIVMVVPAL 150
    CFLVVCVGFF LFTFTKLYAR HYAWTSLALT LLVFALTLAA QFQVWTPLSG 200
    RVDSSNHTLT ATPADTCLSQ VGSFSICIEV LLLLYTVMQL PLYLSLFLGV 250
    VYSVLFETFG YHFRNEDCYP SPGPGALHWE LLSRALLHVC IHAIGIHLFV 300
    MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG 350
    DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI 400
    VGFTKMSANK SAHALVGLLN DLFGRFDRLC EQTKCEKIST LGDCYYCVAG 450
    CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL 500
    GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGRV 550
    IERLGQSVVA DQLKGLKTYL ISGQRAKESH CSCAEALLSG FEVIDDSRES 600
    SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGTV 650
    QNGCQDEPKT STKASGGPNS KTQNGLLSPP AEEKLTNSQT SLCEILQEKG 700
    RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF 750
    SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASATFSSLLD VFLSTTVFLI 800
    LSITCFLKYG ATATPPPPAA LAVFGADLLL EVLSLIVSIR MVFFLEDVMT 850
    CTKWLLEWIA GWLPRHCIGA ILVSLPALAV YSHITSEFET NIHVTMFTGS 900
    AVLVAVVHYC NFCQLSSWMR SSLATIVGAG LLLLLHISLC QDSSIVMSPL 950
    DSAQNFSAQR NPCNSSVLQD GRRPASLIGK ELILTFFLLL LLVWFLNREF 1000
    EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY 1050
    SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD 1100
    YNSIEKIKTI GATYMAASGL NTAQCQEGGH PQEHLRILFE FAKEMMRVVD 1150
    DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT 1200
    GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDNGV 1250
    VPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYSDK ASLGSDDSTQ 1300
    AKEARLSSKR SWREPVKAEE RFPFGKAIEK DSCEDIGVEE ASELSKLNVS 1350
    KSV 1353
    Length:1,353
    Mass (Da):150,954
    Last modified:October 1, 1996 - v1
    Checksum:iC65736A8304F689E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti893 – 8931H → Q in CAA90570. (PubMed:7575502)Curated
    Sequence conflicti1192 – 11921N → D no nucleotide entry (PubMed:7528319)Curated
    Sequence conflicti1305 – 13051R → H in CAA90570. (PubMed:7575502)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30602 mRNA. Translation: AAC52603.1.
    Z50190 mRNA. Translation: CAA90570.1.
    CCDSiCCDS27917.1.
    PIRiJC4279.
    RefSeqiNP_033754.2. NM_009624.3.
    XP_006521776.1. XM_006521713.1.
    UniGeneiMm.439750.
    Mm.482493.

    Genome annotation databases

    EnsembliENSMUST00000005719; ENSMUSP00000005719; ENSMUSG00000005580.
    ENSMUST00000117801; ENSMUSP00000113498; ENSMUSG00000005580.
    GeneIDi11515.
    KEGGimmu:11515.
    UCSCiuc007xzq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U30602 mRNA. Translation: AAC52603.1 .
    Z50190 mRNA. Translation: CAA90570.1 .
    CCDSi CCDS27917.1.
    PIRi JC4279.
    RefSeqi NP_033754.2. NM_009624.3.
    XP_006521776.1. XM_006521713.1.
    UniGenei Mm.439750.
    Mm.482493.

    3D structure databases

    ProteinModelPortali P51830.
    SMRi P51830. Positions 380-553, 1050-1241.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P51830.

    Proteomic databases

    PaxDbi P51830.
    PRIDEi P51830.

    Protocols and materials databases

    DNASUi 11515.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000005719 ; ENSMUSP00000005719 ; ENSMUSG00000005580 .
    ENSMUST00000117801 ; ENSMUSP00000113498 ; ENSMUSG00000005580 .
    GeneIDi 11515.
    KEGGi mmu:11515.
    UCSCi uc007xzq.1. mouse.

    Organism-specific databases

    CTDi 115.
    MGIi MGI:108450. Adcy9.

    Phylogenomic databases

    eggNOGi COG2114.
    GeneTreei ENSGT00750000117304.
    HOGENOMi HOG000001574.
    HOVERGENi HBG050459.
    InParanoidi P51830.
    KOi K08049.
    OMAi IYFGVHM.
    OrthoDBi EOG7TF78Q.
    PhylomeDBi P51830.
    TreeFami TF313845.

    Enzyme and pathway databases

    Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Miscellaneous databases

    NextBioi 278930.
    PROi P51830.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51830.
    Bgeei P51830.
    CleanExi MM_ADCY9.
    Genevestigatori P51830.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    [Graphical view ]
    Pfami PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 2 hits.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a widely expressed form of adenylyl cyclase."
      Premont R.T., Matsuoka I., Mattei M.-G., Pouille Y., Defer N., Hanoune J.
      J. Biol. Chem. 271:13900-13907(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Identification of adenylyl cyclases by amplification using degenerate primers."
      Premont R.T.
      Methods Enzymol. 238:116-127(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1193.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613 AND SER-1332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiADCY9_MOUSE
    AccessioniPrimary (citable) accession number: P51830
    Secondary accession number(s): Q61279
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3