Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Adenylate cyclase type 9

Gene

Adcy9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+Note: Binds 2 magnesium ions per subunit.

Enzyme regulationi

Insensitive to calcium/calmodulin. Stimulated by magnesium, forskolin and mutationally activated G protein (GS)-alpha. Regulated by calcineurin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi399 – 3991Magnesium 1PROSITE-ProRule annotation
Metal bindingi399 – 3991Magnesium 2PROSITE-ProRule annotation
Metal bindingi400 – 4001Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi443 – 4431Magnesium 1PROSITE-ProRule annotation
Metal bindingi443 – 4431Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. intracellular signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.1. 3474.
ReactomeiREACT_278699. Hedgehog 'off' state.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_295338. PKA activation in glucagon signalling.
REACT_296380. G alpha (z) signalling events.
REACT_297425. Adenylate cyclase activating pathway.
REACT_309686. Adenylate cyclase inhibitory pathway.
REACT_310977. PKA activation.
REACT_313192. G alpha (s) signalling events.
REACT_331048. G alpha (i) signalling events.
REACT_345203. Glucagon signaling in metabolic regulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 9 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 9
Adenylate cyclase type IX
Adenylyl cyclase 9
Adenylyl cyclase type 10
Short name:
ACTP10
Gene namesi
Name:Adcy9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:108450. Adcy9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 117117CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei118 – 13821HelicalSequence AnalysisAdd
BLAST
Topological domaini139 – 1413ExtracellularSequence Analysis
Transmembranei142 – 16221HelicalSequence AnalysisAdd
BLAST
Topological domaini163 – 1719CytoplasmicSequence Analysis
Transmembranei172 – 19221HelicalSequence AnalysisAdd
BLAST
Topological domaini193 – 21523ExtracellularSequence AnalysisAdd
BLAST
Transmembranei216 – 23520HelicalSequence AnalysisAdd
BLAST
Topological domaini236 – 2416CytoplasmicSequence Analysis
Transmembranei242 – 25918HelicalSequence AnalysisAdd
BLAST
Topological domaini260 – 28021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Topological domaini302 – 786485CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei787 – 80721HelicalSequence AnalysisAdd
BLAST
Topological domaini808 – 81811ExtracellularSequence AnalysisAdd
BLAST
Transmembranei819 – 83921HelicalSequence AnalysisAdd
BLAST
Topological domaini840 – 86728CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei868 – 88821HelicalSequence AnalysisAdd
BLAST
Topological domaini889 – 8913ExtracellularSequence Analysis
Transmembranei892 – 91221HelicalSequence AnalysisAdd
BLAST
Topological domaini913 – 9208CytoplasmicSequence Analysis
Transmembranei921 – 94121HelicalSequence AnalysisAdd
BLAST
Topological domaini942 – 97534ExtracellularSequence AnalysisAdd
BLAST
Transmembranei976 – 99621HelicalSequence AnalysisAdd
BLAST
Topological domaini997 – 1353357CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13531353Adenylate cyclase type 9PRO_0000195709Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
Modified residuei613 – 6131Phosphoserine1 Publication
Modified residuei706 – 7061PhosphoserineBy similarity
Glycosylationi955 – 9551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi964 – 9641N-linked (GlcNAc...)Sequence Analysis
Modified residuei1259 – 12591PhosphoserineBy similarity
Modified residuei1307 – 13071PhosphoserineBy similarity
Modified residuei1332 – 13321Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP51830.
PaxDbiP51830.
PRIDEiP51830.

PTM databases

PhosphoSiteiP51830.

Expressioni

Tissue specificityi

Found in decreasing order in skeletal muscle, heart, adrenal gland, ovary and brain; and to a lesser extent, in kidney, liver, testis, lung, thymus and spleen.

Gene expression databases

BgeeiP51830.
CleanExiMM_ADCY9.
ExpressionAtlasiP51830. baseline and differential.
GenevestigatoriP51830.

Structurei

3D structure databases

ProteinModelPortaliP51830.
SMRiP51830. Positions 380-553, 1050-1241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000001574.
HOVERGENiHBG050459.
InParanoidiP51830.
KOiK08049.
OMAiQNMKNQA.
OrthoDBiEOG7TF78Q.
PhylomeDBiP51830.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSPHQQLL HHHSTEVSCD SSGDSNSVRV KINPKQLSSN THPKHCKYSI
60 70 80 90 100
SSSCSSSGDS GGLPRRVGGG GRLRRQKKLP QLFERASSRW WDPKFDSMNL
110 120 130 140 150
EEACLERCFP QTQRRFRYAL FYVGFACLLW SIYFAVHMKS KVIVMVVPAL
160 170 180 190 200
CFLVVCVGFF LFTFTKLYAR HYAWTSLALT LLVFALTLAA QFQVWTPLSG
210 220 230 240 250
RVDSSNHTLT ATPADTCLSQ VGSFSICIEV LLLLYTVMQL PLYLSLFLGV
260 270 280 290 300
VYSVLFETFG YHFRNEDCYP SPGPGALHWE LLSRALLHVC IHAIGIHLFV
310 320 330 340 350
MSQVRSRSTF LKVGQSIMHG KDLEVEKALK ERMIHSVMPR IIADDLMKQG
360 370 380 390 400
DEESENSVKR HATSSPKNRK KKSSIQKAPI AFRPFKMQQI EEVSILFADI
410 420 430 440 450
VGFTKMSANK SAHALVGLLN DLFGRFDRLC EQTKCEKIST LGDCYYCVAG
460 470 480 490 500
CPEPRADHAY CCIEMGLGMI KAIEQFCQEK KEMVNMRVGV HTGTVLCGIL
510 520 530 540 550
GMRRFKFDVW SNDVNLANLM EQLGVAGKVH ISEATAKYLD DRYEMEDGRV
560 570 580 590 600
IERLGQSVVA DQLKGLKTYL ISGQRAKESH CSCAEALLSG FEVIDDSRES
610 620 630 640 650
SGPRGQGTAS PGSVSDLAQT VKTFDNLKTC PSCGITFAPK SEAGAEGGTV
660 670 680 690 700
QNGCQDEPKT STKASGGPNS KTQNGLLSPP AEEKLTNSQT SLCEILQEKG
710 720 730 740 750
RWAGVSLDQS ALLPLRFKNI REKTDAHFVD VIKEDSLMKD YFFKPPINQF
760 770 780 790 800
SLNFLDQELE RSYRTSYQEE VIKNSPVKTF ASATFSSLLD VFLSTTVFLI
810 820 830 840 850
LSITCFLKYG ATATPPPPAA LAVFGADLLL EVLSLIVSIR MVFFLEDVMT
860 870 880 890 900
CTKWLLEWIA GWLPRHCIGA ILVSLPALAV YSHITSEFET NIHVTMFTGS
910 920 930 940 950
AVLVAVVHYC NFCQLSSWMR SSLATIVGAG LLLLLHISLC QDSSIVMSPL
960 970 980 990 1000
DSAQNFSAQR NPCNSSVLQD GRRPASLIGK ELILTFFLLL LLVWFLNREF
1010 1020 1030 1040 1050
EVSYRLHYHG DVEADLHRTK IQSMRDQADW LLRNIIPYHV AEQLKVSQTY
1060 1070 1080 1090 1100
SKNHDSGGVI FASIVNFSEF YEENYEGGKE CYRVLNELIG DFDELLSKPD
1110 1120 1130 1140 1150
YNSIEKIKTI GATYMAASGL NTAQCQEGGH PQEHLRILFE FAKEMMRVVD
1160 1170 1180 1190 1200
DFNNNMLWFN FKLRVGFNHG PLTAGVIGTT KLLYDIWGDT VNIASRMDTT
1210 1220 1230 1240 1250
GVECRIQVSE ESYRVLSKMG YDFDYRGTVN VKGKGQMKTY LYPKCTDNGV
1260 1270 1280 1290 1300
VPQHQLSISP DIRVQVDGSI GRSPTDEIAN LVPSVQYSDK ASLGSDDSTQ
1310 1320 1330 1340 1350
AKEARLSSKR SWREPVKAEE RFPFGKAIEK DSCEDIGVEE ASELSKLNVS

KSV
Length:1,353
Mass (Da):150,954
Last modified:October 1, 1996 - v1
Checksum:iC65736A8304F689E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti893 – 8931H → Q in CAA90570 (PubMed:7575502).Curated
Sequence conflicti1192 – 11921N → D no nucleotide entry (PubMed:7528319).Curated
Sequence conflicti1305 – 13051R → H in CAA90570 (PubMed:7575502).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30602 mRNA. Translation: AAC52603.1.
Z50190 mRNA. Translation: CAA90570.1.
CCDSiCCDS27917.1.
PIRiJC4279.
RefSeqiNP_033754.2. NM_009624.3.
UniGeneiMm.439750.
Mm.482493.

Genome annotation databases

EnsembliENSMUST00000005719; ENSMUSP00000005719; ENSMUSG00000005580.
ENSMUST00000117801; ENSMUSP00000113498; ENSMUSG00000005580.
GeneIDi11515.
KEGGimmu:11515.
UCSCiuc007xzq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30602 mRNA. Translation: AAC52603.1.
Z50190 mRNA. Translation: CAA90570.1.
CCDSiCCDS27917.1.
PIRiJC4279.
RefSeqiNP_033754.2. NM_009624.3.
UniGeneiMm.439750.
Mm.482493.

3D structure databases

ProteinModelPortaliP51830.
SMRiP51830. Positions 380-553, 1050-1241.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP51830.

Proteomic databases

MaxQBiP51830.
PaxDbiP51830.
PRIDEiP51830.

Protocols and materials databases

DNASUi11515.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005719; ENSMUSP00000005719; ENSMUSG00000005580.
ENSMUST00000117801; ENSMUSP00000113498; ENSMUSG00000005580.
GeneIDi11515.
KEGGimmu:11515.
UCSCiuc007xzq.1. mouse.

Organism-specific databases

CTDi115.
MGIiMGI:108450. Adcy9.

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000001574.
HOVERGENiHBG050459.
InParanoidiP51830.
KOiK08049.
OMAiQNMKNQA.
OrthoDBiEOG7TF78Q.
PhylomeDBiP51830.
TreeFamiTF313845.

Enzyme and pathway databases

BRENDAi4.6.1.1. 3474.
ReactomeiREACT_278699. Hedgehog 'off' state.
REACT_286837. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_295338. PKA activation in glucagon signalling.
REACT_296380. G alpha (z) signalling events.
REACT_297425. Adenylate cyclase activating pathway.
REACT_309686. Adenylate cyclase inhibitory pathway.
REACT_310977. PKA activation.
REACT_313192. G alpha (s) signalling events.
REACT_331048. G alpha (i) signalling events.
REACT_345203. Glucagon signaling in metabolic regulation.

Miscellaneous databases

NextBioi278930.
PROiP51830.
SOURCEiSearch...

Gene expression databases

BgeeiP51830.
CleanExiMM_ADCY9.
ExpressionAtlasiP51830. baseline and differential.
GenevestigatoriP51830.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 2 hits.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of a widely expressed form of adenylyl cyclase."
    Premont R.T., Matsuoka I., Mattei M.-G., Pouille Y., Defer N., Hanoune J.
    J. Biol. Chem. 271:13900-13907(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Identification of adenylyl cyclases by amplification using degenerate primers."
    Premont R.T.
    Methods Enzymol. 238:116-127(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1106-1193.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-613 AND SER-1332, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiADCY9_MOUSE
AccessioniPrimary (citable) accession number: P51830
Secondary accession number(s): Q61279
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 1, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.