Reviewed, UniProtKB/Swiss-Prot P51829 (ADCY7_MOUSE)

Names and origin

Protein names

Recommended name:
    Adenylate cyclase type 7
    EC=4.6.1.1
Alternative name(s):
    Adenylate cyclase type VII
    ATP pyrophosphate-lyase 7
    Adenylyl cyclase 7

Gene names

Name:

Adcy7

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	1099 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Most abundant in heart, spleen and lung.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	activation of adenylate cyclase activity Ref.1 Traceable author statement. Source: MGI cAMP biosynthetic process Ref.1 Traceable author statement. Source: MGI intracellular signaling cascade Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Ref.1 Traceable author statement. Source: MGI
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Ref.1 Traceable author statement. Source: MGI magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1099	1099	Adenylate cyclase type 7		PRO_0000195704
Regions
	Topological domain	1 – 33	33	Cytoplasmic Potential
	Transmembrane	34 – 54	21	Potential
	Transmembrane	63 – 83	21	Potential
	Transmembrane	95 – 117	23	Potential
	Transmembrane	122 – 142	21	Potential
	Transmembrane	147 – 167	21	Potential
	Transmembrane	178 – 198	21	Potential
	Topological domain	199 – 595	397	Cytoplasmic Potential
	Transmembrane	596 – 616	21	Potential
	Transmembrane	621 – 641	21	Potential
	Transmembrane	670 – 689	20	Potential
	Transmembrane	719 – 738	20	Potential
	Transmembrane	747 – 766	20	Potential
	Transmembrane	813 – 833	21	Potential
	Topological domain	834 – 1099	266	Cytoplasmic Potential
Sites
	Metal binding	286	1	Magnesium 1 By similarity
	Metal binding	286	1	Magnesium 2 By similarity
	Metal binding	287	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	330	1	Magnesium 1 By similarity
	Metal binding	330	1	Magnesium 2 By similarity
Amino acid modifications
	Glycosylation	702	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P51829-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: ADF3B3559CD11B96	FASTA	1,099	122,768
	10 20 30 40 50 60 MPAKGRYFLN EGDEGPDQAA LYEKYRLTSL HGPLLLLLLL VAAATCIALI SIAFSHEDLR 70 80 90 100 110 120 RHQVVLGTAF LMLTLFVALY VLVYVECLVQ RWLRALALLT WACLMVLGSV LMWDSLENEA 130 140 150 160 170 180 HAWEQVPFFL FVVFVVYALL PLSRRAAIVV GVTSTVSHLL VFGAVTRAFQ TSMSSTQLGL 190 200 210 220 230 240 QLLANAVILL GGNFTGAFHK HQLQDASRDL FIYTVKCIQI RRKLRVEKRQ QENLLLSVLP 250 260 270 280 290 300 AHISMGMKLA IIERLKEGGD RHYMPDNNFH SLYVKRHQNV SILYADIVGF TRLASDCSPK 310 320 330 340 350 360 ELVVVLNELF GKFDQIAKAN ECMRIKILGD CYYCVSGLPV SLPTHARNCV KMGLDICEAI 370 380 390 400 410 420 KQVREATGVD ISMRVGIHSG NVLCGVIGLR KWQYDVWSHD VSLANRMEAA GVPGRVHITE 430 440 450 460 470 480 ATLNHLDKAY EVEDGHGEQR DPYLKEMNIR TYLVIDPRSQ QPPPPSHHLS KPKGDATLKM 490 500 510 520 530 540 RASVRVTRYL ESWGAARPFA HLNHRESVSS SETPISNGRR QKAIPLRRHR APDRSASPKG 550 560 570 580 590 600 RLEDDCDDEM LSAIEGLSST RPCCSKSDDF HTFGPIFLEK GFEREYRLVP IPRARYDFAC 610 620 630 640 650 660 ASLVFVCILL VHLLVMPRMA TLGVSFGLVA CLLGLVLSFC FATEFSRCFP SRSTLQAISE 670 680 690 700 710 720 SVETQPLVRL VLVVLTVGSL LTVAIINMPL TLNPGPEQPG DNKTSPLAAQ NRVGTPYELL 730 740 750 760 770 780 PYYTCSCILG FIACSVFLRM SLELKAMLLT VALVAYLLLF NLSPCWHVSG NSTETNGTQR 790 800 810 820 830 840 TRLLLSDAQS MPSHTLAPGA QETAPSPSYL ERDLKIMVNF YLILFYATLI LLSRQIDYYC 850 860 870 880 890 900 RLDCLWKKKF KKEHEEFETM ENVNRLLLEN VLPAHVAAHF IGDKAAEDWY HQSYDCVCVM 910 920 930 940 950 960 FASVPDFKVF YTECDVNKEG LECLRLLNEI IADFDELLLK PKFSGVEKIK TIGSTYMAAA 970 980 990 1000 1010 1020 GLSAPSGHEN QDLERKHVHI GVLVEFSMAL MSKLDGINRH SFNSFRLRVG INHGPVIAGV 1030 1040 1050 1060 1070 1080 IGARKPQYDI WGNTVNVASR MESTGELGKI QVTEETCTIL QGLGYSCECR GLINVKGKGE 1090 LRTYFVCTDT AKFQGLGLN

References

[1]	"Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells." Watson P.A., Krupinski J., Kempinski A.M., Frankenfield C.D. J. Biol. Chem. 269:28893-28898(1994) [PubMed: 7961850] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lymphoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U12919 mRNA. Translation: AAA57554.1.
IPI	IPI00127551.
PIR	A55405.
RefSeq	NP_031432.2.
UniGene	Mm.288206
3D structure databases
HSSP	HSSP built from PDB template 1CUL based on UniProtKB P26769.
SMR	P51829. Positions 890-1088.
ModBase	Search...
Protein-protein interaction databases
STRING	P51829.
Proteomic databases
PRIDE	P51829.
Genome annotation databases
Ensembl	ENSMUST00000098521; ENSMUSP00000096122; ENSMUSG00000031659; Mus musculus. [Genome view]
GeneID	11513.
UCSC	uc009mrh.1. mouse.
Organism-specific databases
CTD	11513.
MGI	MGI:102891. Adcy7.
Phylogenomic databases
HOVERGEN	P51829.
Enzyme and pathway databases
BRENDA	4.6.1.1. 244.
Gene expression databases
ArrayExpress	P51829.
Bgee	P51829.
CleanEx	MM_ADCY7.
Genevestigator	P51829.
GermOnline	ENSMUSG00000031659. Mus musculus.
Family and domain databases
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Aden_cycl-like. [Graphical view]
Gene3D	G3DSA:3.30.70.1230. A/G_cyclase. 2 hits.
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 1 hit. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	278918.
SOURCE	Search...

Entry information

Entry name

ADCY7_MOUSE

Accession

Primary (citable) accession number: P51829

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	October 13, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)