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P51829

- ADCY7_MOUSE

UniProt

P51829 - ADCY7_MOUSE

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Protein

Adenylate cyclase type 7

Gene

Adcy7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi286 – 2861Magnesium 1PROSITE-ProRule annotation
Metal bindingi286 – 2861Magnesium 2PROSITE-ProRule annotation
Metal bindingi287 – 2871Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi330 – 3301Magnesium 1PROSITE-ProRule annotation
Metal bindingi330 – 3301Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of adenylate cyclase activity Source: MGI
  2. cAMP biosynthetic process Source: MGI
  3. cellular response to ethanol Source: Ensembl
  4. intracellular signal transduction Source: InterPro
  5. maternal process involved in female pregnancy Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 7 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 7
Adenylate cyclase type VII
Adenylyl cyclase 7
Gene namesi
Name:Adcy7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:102891. Adcy7.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10991099Adenylate cyclase type 7PRO_0000195704Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP51829.
PRIDEiP51829.

PTM databases

PhosphoSiteiP51829.

Expressioni

Tissue specificityi

Most abundant in heart, spleen and lung.

Gene expression databases

BgeeiP51829.
CleanExiMM_ADCY7.
GenevestigatoriP51829.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP51829.
SMRiP51829. Positions 266-455, 890-1088.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini199 – 595397CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini834 – 1099266CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11723HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence AnalysisAdd
BLAST
Transmembranei596 – 61621HelicalSequence AnalysisAdd
BLAST
Transmembranei621 – 64121HelicalSequence AnalysisAdd
BLAST
Transmembranei670 – 68920HelicalSequence AnalysisAdd
BLAST
Transmembranei719 – 73820HelicalSequence AnalysisAdd
BLAST
Transmembranei747 – 76620HelicalSequence AnalysisAdd
BLAST
Transmembranei813 – 83321HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOVERGENiHBG050458.
InParanoidiP51829.
KOiK08047.
OMAiESDDCRI.
OrthoDBiEOG76X5ZC.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51829 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAKGRYFLN EGDEGPDQAA LYEKYRLTSL HGPLLLLLLL VAAATCIALI
60 70 80 90 100
SIAFSHEDLR RHQVVLGTAF LMLTLFVALY VLVYVECLVQ RWLRALALLT
110 120 130 140 150
WACLMVLGSV LMWDSLENEA HAWEQVPFFL FVVFVVYALL PLSRRAAIVA
160 170 180 190 200
GVTSTVSHLL VFGAVTRAFQ TSMSSTQLGL QLLANAVILL GGNFTGAFHK
210 220 230 240 250
HQLQDASRDL FIYTVKCIQI RRKLRVEKRQ QENLLLSVLP AHISMGMKLA
260 270 280 290 300
IIERLKEGGD RHYMPDNNFH SLYVKRHQNV SILYADIVGF TRLASDCSPK
310 320 330 340 350
ELVVVLNELF GKFDQIAKAN ECMRIKILGD CYYCVSGLPV SLPTHARNCV
360 370 380 390 400
KMGLDICEAI KQVREATGVD ISMRVGIHSG NVLCGVIGLR KWQYDVWSHD
410 420 430 440 450
VSLANRMEAA GVPGRVHITE ATLNHLDKAY EVEDGHGEQR DPYLKEMNIR
460 470 480 490 500
TYLVIDPRSQ QPPPPSHHLS KPKGDATLKM RASVRVTRYL ESWGAARPFA
510 520 530 540 550
HLNHRESVSS SETPISNGRR QKAIPLRRHR APDRSASPKG RLEDDCDDEM
560 570 580 590 600
LSAIEGLSST RPCCSKSDDF HTFGPIFLEK GFEREYRLVP IPRARYDFAC
610 620 630 640 650
ASLVFVCILL VHLLVMPRMA TLGVSFGLVA CLLGLVLSFC FATEFSRCFP
660 670 680 690 700
SRSTLQAISE SVETQPLVRL VLVVLTVGSL LTVAIINMPL TLNPGPEQPG
710 720 730 740 750
DNKTSPLAAQ NRVGTPCELL PYYTCSCILG FIACSVFLRM SLELKAMLLT
760 770 780 790 800
VALVAYLLLF NLSPCWHVSG NSTETNGTQR TRLLLSDAQS MPSHTLAPGA
810 820 830 840 850
RETAPSPSYL ERDLKIMVNF YLILFYATLI LLSRQIDYYC RLDCLWKKKF
860 870 880 890 900
KKEHEEFETM ENVNRLLLEN VLPAHVAAHF IGDKAAEDWY HQSYDCVCVM
910 920 930 940 950
FASVPDFKVF YTECDVNKEG LECLRLLNEI IADFDELLLK PKFSGVEKIK
960 970 980 990 1000
TIGSTYMAAA GLSAPSGHEN QDLERKHVHI GVLVEFSMAL MSKLDGINRH
1010 1020 1030 1040 1050
SFNSFRLRVG INHGPVIAGV IGARKPQYDI WGNTVNVASR MESTGELGKI
1060 1070 1080 1090
QVTEETCTIL QGLGYSCECR GLINVKGKGE LRTYFVCTDT AKFQGLGLN
Length:1,099
Mass (Da):122,708
Last modified:July 27, 2011 - v2
Checksum:i0EE189EA9070FF73
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501A → V in AAA57554. (PubMed:7961850)Curated
Sequence conflicti717 – 7171C → Y in AAA57554. (PubMed:7961850)Curated
Sequence conflicti801 – 8011R → Q in AAA57554. (PubMed:7961850)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12919 mRNA. Translation: AAA57554.1.
AK154652 mRNA. Translation: BAE32743.1.
CCDSiCCDS22509.1.
PIRiA55405.
RefSeqiNP_001032812.2. NM_001037723.3.
NP_001032813.1. NM_001037724.4.
NP_001103226.1. NM_001109756.1.
NP_031432.2. NM_007406.2.
UniGeneiMm.288206.

Genome annotation databases

EnsembliENSMUST00000098521; ENSMUSP00000096122; ENSMUSG00000031659.
ENSMUST00000168545; ENSMUSP00000129252; ENSMUSG00000031659.
ENSMUST00000169037; ENSMUSP00000130594; ENSMUSG00000031659.
ENSMUST00000171456; ENSMUSP00000132528; ENSMUSG00000031659.
GeneIDi11513.
KEGGimmu:11513.
UCSCiuc009mrh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U12919 mRNA. Translation: AAA57554.1 .
AK154652 mRNA. Translation: BAE32743.1 .
CCDSi CCDS22509.1.
PIRi A55405.
RefSeqi NP_001032812.2. NM_001037723.3.
NP_001032813.1. NM_001037724.4.
NP_001103226.1. NM_001109756.1.
NP_031432.2. NM_007406.2.
UniGenei Mm.288206.

3D structure databases

ProteinModelPortali P51829.
SMRi P51829. Positions 266-455, 890-1088.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P51829.

PTM databases

PhosphoSitei P51829.

Proteomic databases

PaxDbi P51829.
PRIDEi P51829.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000098521 ; ENSMUSP00000096122 ; ENSMUSG00000031659 .
ENSMUST00000168545 ; ENSMUSP00000129252 ; ENSMUSG00000031659 .
ENSMUST00000169037 ; ENSMUSP00000130594 ; ENSMUSG00000031659 .
ENSMUST00000171456 ; ENSMUSP00000132528 ; ENSMUSG00000031659 .
GeneIDi 11513.
KEGGi mmu:11513.
UCSCi uc009mrh.2. mouse.

Organism-specific databases

CTDi 113.
MGIi MGI:102891. Adcy7.

Phylogenomic databases

eggNOGi COG2114.
GeneTreei ENSGT00760000119042.
HOVERGENi HBG050458.
InParanoidi P51829.
KOi K08047.
OMAi ESDDCRI.
OrthoDBi EOG76X5ZC.
TreeFami TF313845.

Enzyme and pathway databases

Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
REACT_213947. Regulation of water balance by renal Aquaporins.
REACT_220108. PKA activation.
REACT_220758. PKA activation in glucagon signalling.
REACT_222824. Adenylate cyclase inhibitory pathway.
REACT_224974. Adenylate cyclase activating pathway.

Miscellaneous databases

ChiTaRSi ADCY7. mouse.
NextBioi 278918.
PROi P51829.
SOURCEi Search...

Gene expression databases

Bgeei P51829.
CleanExi MM_ADCY7.
Genevestigatori P51829.

Family and domain databases

Gene3Di 3.30.70.1230. 2 hits.
InterProi IPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view ]
Pfami PF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view ]
SMARTi SM00044. CYCc. 2 hits.
[Graphical view ]
SUPFAMi SSF55073. SSF55073. 2 hits.
PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells."
    Watson P.A., Krupinski J., Kempinski A.M., Frankenfield C.D.
    J. Biol. Chem. 269:28893-28898(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lymphoma.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.

Entry informationi

Entry nameiADCY7_MOUSE
AccessioniPrimary (citable) accession number: P51829
Secondary accession number(s): Q3U3P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3