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P51829

- ADCY7_MOUSE

UniProt

P51829 - ADCY7_MOUSE

Protein

Adenylate cyclase type 7

Gene

Adcy7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi286 – 2861Magnesium 1PROSITE-ProRule annotation
    Metal bindingi286 – 2861Magnesium 2PROSITE-ProRule annotation
    Metal bindingi287 – 2871Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi330 – 3301Magnesium 1PROSITE-ProRule annotation
    Metal bindingi330 – 3301Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: MGI
    2. cAMP biosynthetic process Source: MGI
    3. cellular response to ethanol Source: Ensembl
    4. intracellular signal transduction Source: InterPro
    5. maternal process involved in female pregnancy Source: Ensembl

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 7 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 7
    Adenylate cyclase type VII
    Adenylyl cyclase 7
    Gene namesi
    Name:Adcy7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:102891. Adcy7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10991099Adenylate cyclase type 7PRO_0000195704Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP51829.
    PRIDEiP51829.

    PTM databases

    PhosphoSiteiP51829.

    Expressioni

    Tissue specificityi

    Most abundant in heart, spleen and lung.

    Gene expression databases

    BgeeiP51829.
    CleanExiMM_ADCY7.
    GenevestigatoriP51829.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP51829.
    SMRiP51829. Positions 266-455, 890-1088.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini199 – 595397CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini834 – 1099266CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei178 – 19821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei596 – 61621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei621 – 64121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei670 – 68920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei719 – 73820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei747 – 76620HelicalSequence AnalysisAdd
    BLAST
    Transmembranei813 – 83321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    GeneTreeiENSGT00750000117304.
    HOVERGENiHBG050458.
    InParanoidiQ3U3P2.
    KOiK08047.
    OMAiESDDCRI.
    OrthoDBiEOG76X5ZC.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51829-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAKGRYFLN EGDEGPDQAA LYEKYRLTSL HGPLLLLLLL VAAATCIALI     50
    SIAFSHEDLR RHQVVLGTAF LMLTLFVALY VLVYVECLVQ RWLRALALLT 100
    WACLMVLGSV LMWDSLENEA HAWEQVPFFL FVVFVVYALL PLSRRAAIVA 150
    GVTSTVSHLL VFGAVTRAFQ TSMSSTQLGL QLLANAVILL GGNFTGAFHK 200
    HQLQDASRDL FIYTVKCIQI RRKLRVEKRQ QENLLLSVLP AHISMGMKLA 250
    IIERLKEGGD RHYMPDNNFH SLYVKRHQNV SILYADIVGF TRLASDCSPK 300
    ELVVVLNELF GKFDQIAKAN ECMRIKILGD CYYCVSGLPV SLPTHARNCV 350
    KMGLDICEAI KQVREATGVD ISMRVGIHSG NVLCGVIGLR KWQYDVWSHD 400
    VSLANRMEAA GVPGRVHITE ATLNHLDKAY EVEDGHGEQR DPYLKEMNIR 450
    TYLVIDPRSQ QPPPPSHHLS KPKGDATLKM RASVRVTRYL ESWGAARPFA 500
    HLNHRESVSS SETPISNGRR QKAIPLRRHR APDRSASPKG RLEDDCDDEM 550
    LSAIEGLSST RPCCSKSDDF HTFGPIFLEK GFEREYRLVP IPRARYDFAC 600
    ASLVFVCILL VHLLVMPRMA TLGVSFGLVA CLLGLVLSFC FATEFSRCFP 650
    SRSTLQAISE SVETQPLVRL VLVVLTVGSL LTVAIINMPL TLNPGPEQPG 700
    DNKTSPLAAQ NRVGTPCELL PYYTCSCILG FIACSVFLRM SLELKAMLLT 750
    VALVAYLLLF NLSPCWHVSG NSTETNGTQR TRLLLSDAQS MPSHTLAPGA 800
    RETAPSPSYL ERDLKIMVNF YLILFYATLI LLSRQIDYYC RLDCLWKKKF 850
    KKEHEEFETM ENVNRLLLEN VLPAHVAAHF IGDKAAEDWY HQSYDCVCVM 900
    FASVPDFKVF YTECDVNKEG LECLRLLNEI IADFDELLLK PKFSGVEKIK 950
    TIGSTYMAAA GLSAPSGHEN QDLERKHVHI GVLVEFSMAL MSKLDGINRH 1000
    SFNSFRLRVG INHGPVIAGV IGARKPQYDI WGNTVNVASR MESTGELGKI 1050
    QVTEETCTIL QGLGYSCECR GLINVKGKGE LRTYFVCTDT AKFQGLGLN 1099
    Length:1,099
    Mass (Da):122,708
    Last modified:July 27, 2011 - v2
    Checksum:i0EE189EA9070FF73
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501A → V in AAA57554. (PubMed:7961850)Curated
    Sequence conflicti717 – 7171C → Y in AAA57554. (PubMed:7961850)Curated
    Sequence conflicti801 – 8011R → Q in AAA57554. (PubMed:7961850)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12919 mRNA. Translation: AAA57554.1.
    AK154652 mRNA. Translation: BAE32743.1.
    CCDSiCCDS22509.1.
    PIRiA55405.
    RefSeqiNP_001032812.2. NM_001037723.3.
    NP_001032813.1. NM_001037724.4.
    NP_001103226.1. NM_001109756.1.
    NP_031432.2. NM_007406.2.
    UniGeneiMm.288206.

    Genome annotation databases

    EnsembliENSMUST00000098521; ENSMUSP00000096122; ENSMUSG00000031659.
    ENSMUST00000168545; ENSMUSP00000129252; ENSMUSG00000031659.
    ENSMUST00000169037; ENSMUSP00000130594; ENSMUSG00000031659.
    ENSMUST00000171456; ENSMUSP00000132528; ENSMUSG00000031659.
    GeneIDi11513.
    KEGGimmu:11513.
    UCSCiuc009mrh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U12919 mRNA. Translation: AAA57554.1 .
    AK154652 mRNA. Translation: BAE32743.1 .
    CCDSi CCDS22509.1.
    PIRi A55405.
    RefSeqi NP_001032812.2. NM_001037723.3.
    NP_001032813.1. NM_001037724.4.
    NP_001103226.1. NM_001109756.1.
    NP_031432.2. NM_007406.2.
    UniGenei Mm.288206.

    3D structure databases

    ProteinModelPortali P51829.
    SMRi P51829. Positions 266-455, 890-1088.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P51829.

    PTM databases

    PhosphoSitei P51829.

    Proteomic databases

    PaxDbi P51829.
    PRIDEi P51829.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000098521 ; ENSMUSP00000096122 ; ENSMUSG00000031659 .
    ENSMUST00000168545 ; ENSMUSP00000129252 ; ENSMUSG00000031659 .
    ENSMUST00000169037 ; ENSMUSP00000130594 ; ENSMUSG00000031659 .
    ENSMUST00000171456 ; ENSMUSP00000132528 ; ENSMUSG00000031659 .
    GeneIDi 11513.
    KEGGi mmu:11513.
    UCSCi uc009mrh.2. mouse.

    Organism-specific databases

    CTDi 113.
    MGIi MGI:102891. Adcy7.

    Phylogenomic databases

    eggNOGi COG2114.
    GeneTreei ENSGT00750000117304.
    HOVERGENi HBG050458.
    InParanoidi Q3U3P2.
    KOi K08047.
    OMAi ESDDCRI.
    OrthoDBi EOG76X5ZC.
    TreeFami TF313845.

    Enzyme and pathway databases

    Reactomei REACT_210399. Glucagon signaling in metabolic regulation.
    REACT_213947. Regulation of water balance by renal Aquaporins.
    REACT_220108. PKA activation.
    REACT_220758. PKA activation in glucagon signalling.
    REACT_222824. Adenylate cyclase inhibitory pathway.
    REACT_224974. Adenylate cyclase activating pathway.

    Miscellaneous databases

    ChiTaRSi ADCY7. mouse.
    NextBioi 278918.
    PROi P51829.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51829.
    CleanExi MM_ADCY7.
    Genevestigatori P51829.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of the type VII isoform of mammalian adenylyl cyclase expressed widely in mouse tissues and in S49 mouse lymphoma cells."
      Watson P.A., Krupinski J., Kempinski A.M., Frankenfield C.D.
      J. Biol. Chem. 269:28893-28898(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lymphoma.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.

    Entry informationi

    Entry nameiADCY7_MOUSE
    AccessioniPrimary (citable) accession number: P51829
    Secondary accession number(s): Q3U3P2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3