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Protein

Adenylate cyclase type 7

Gene

ADCY7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi284 – 2841Magnesium 1PROSITE-ProRule annotation
Metal bindingi284 – 2841Magnesium 2PROSITE-ProRule annotation
Metal bindingi285 – 2851Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
Metal bindingi328 – 3281Magnesium 1PROSITE-ProRule annotation
Metal bindingi328 – 3281Magnesium 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. adenylate cyclase activity Source: UniProtKB
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. activation of phospholipase C activity Source: Reactome
  2. activation of protein kinase A activity Source: Reactome
  3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
  4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
  5. cellular response to ethanol Source: UniProtKB
  6. cellular response to glucagon stimulus Source: Reactome
  7. energy reserve metabolic process Source: Reactome
  8. epidermal growth factor receptor signaling pathway Source: Reactome
  9. fibroblast growth factor receptor signaling pathway Source: Reactome
  10. innate immune response Source: Reactome
  11. intracellular signal transduction Source: InterPro
  12. maternal process involved in female pregnancy Source: Ensembl
  13. neurotrophin TRK receptor signaling pathway Source: Reactome
  14. positive regulation of cAMP biosynthetic process Source: UniProtKB
  15. signal transduction Source: Reactome
  16. small molecule metabolic process Source: Reactome
  17. synaptic transmission Source: Reactome
  18. transmembrane transport Source: Reactome
  19. water transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

cAMP biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi4.6.1.1. 2681.
ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_267634. Hedgehog 'off' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate cyclase type 7 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase 7
Adenylate cyclase type VII
Adenylyl cyclase 7
Gene namesi
Name:ADCY7
Synonyms:KIAA0037
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:238. ADCY7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei34 – 5421HelicalSequence AnalysisAdd
BLAST
Transmembranei63 – 8321HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11723HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST
Transmembranei147 – 16721HelicalSequence AnalysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence AnalysisAdd
BLAST
Topological domaini197 – 594398CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei595 – 61521HelicalSequence AnalysisAdd
BLAST
Transmembranei620 – 64021HelicalSequence AnalysisAdd
BLAST
Transmembranei669 – 68820HelicalSequence AnalysisAdd
BLAST
Transmembranei718 – 73720HelicalSequence AnalysisAdd
BLAST
Transmembranei746 – 77328HelicalSequence AnalysisAdd
BLAST
Transmembranei794 – 81421HelicalSequence AnalysisAdd
BLAST
Topological domaini815 – 1080266CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10801080Adenylate cyclase type 7PRO_0000195703Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi781 – 7811N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP51828.
PaxDbiP51828.
PRIDEiP51828.

PTM databases

PhosphoSiteiP51828.

Expressioni

Gene expression databases

BgeeiP51828.
CleanExiHS_ADCY7.
ExpressionAtlasiP51828. baseline and differential.
GenevestigatoriP51828.

Organism-specific databases

HPAiHPA048241.
HPA048474.

Interactioni

Protein-protein interaction databases

BioGridi106626. 4 interactions.
IntActiP51828. 3 interactions.
STRINGi9606.ENSP00000254235.

Structurei

3D structure databases

ProteinModelPortaliP51828.
SMRiP51828. Positions 264-453, 871-1069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini279 – 406128Guanylate cyclase 1PROSITE-ProRule annotationAdd
BLAST
Domaini879 – 1023145Guanylate cyclase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiP51828.
KOiK08047.
OMAiMAAGYEC.
OrthoDBiEOG76X5ZC.
PhylomeDBiP51828.
TreeFamiTF313845.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51828-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI
60 70 80 90 100
IIAFSQGDPS RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT
110 120 130 140 150
WACLVALGYV LVFDAWTKAA CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV
160 170 180 190 200
GAVSTASHLL VLGSLMGGFT TPSVRVGLQL LANAVIFLCG NLTGAFHKHQ
210 220 230 240 250
MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH ISMGMKLAII
260 270 280 290 300
ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL
310 320 330 340 350
VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM
360 370 380 390 400
GLDMCQAIKQ VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS
410 420 430 440 450
LANRMEAAGV PGRVHITEAT LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY
460 470 480 490 500
LVIDPRSQQP PPPSQHLPRP KGDAALKMRA SVRMTRYLES WGAARPFAHL
510 520 530 540 550
NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS EDDSYDDEML
560 570 580 590 600
SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA
610 620 630 640 650
SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA
660 670 680 690 700
RGTLCTISER VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG
710 720 730 740 750
NETGLLAASS KTRALCEPLP YYTCSCVLGF IACSVFLRMS LEPKVVLLTV
760 770 780 790 800
ALVAYLVLFN LSPCWQWDCC GQGLGNLTKP NGTTSGTPSC SWKDLKTMTN
810 820 830 840 850
FYLVLFYITL LTLSRQIDYY CRLDCLWKKK FKKEHEEFET MENVNRLLLE
860 870 880 890 900
NVLPAHVAAH FIGDKLNEDW YHQSYDCVCV MFASVPDFKV FYTECDVNKE
910 920 930 940 950
GLECLRLLNE IIADFDELLL KPKFSGVEKI KTIGSTYMAA AGLSVASGHE
960 970 980 990 1000
NQELERQHAH IGVMVEFSIA LMSKLDGINR HSFNSFRLRV GINHGPVIAG
1010 1020 1030 1040 1050
VIGARKPQYD IWGNTVNVAS RMESTGELGK IQVTEETCTI LQGLGYSCEC
1060 1070 1080
RGLINVKGKG ELRTYFVCTD TAKFQGLGLN
Length:1,080
Mass (Da):120,308
Last modified:October 1, 1996 - v1
Checksum:iE33951621E281242
GO

Sequence cautioni

The sequence BAA05021.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25538 mRNA. Translation: BAA05021.2. Different initiation.
BC126271 mRNA. Translation: AAI26272.1.
CCDSiCCDS10741.1.
PIRiPN0453.
RefSeqiNP_001105.1. NM_001114.4.
XP_005255836.1. XM_005255779.2.
XP_005255837.1. XM_005255780.2.
XP_005255838.1. XM_005255781.2.
XP_005255839.1. XM_005255782.2.
XP_005255840.1. XM_005255783.2.
XP_005255841.1. XM_005255784.2.
UniGeneiHs.513578.

Genome annotation databases

EnsembliENST00000254235; ENSP00000254235; ENSG00000121281.
ENST00000394697; ENSP00000378187; ENSG00000121281.
GeneIDi113.
KEGGihsa:113.
UCSCiuc002egd.1. human.

Polymorphism databases

DMDMi1706218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D25538 mRNA. Translation: BAA05021.2. Different initiation.
BC126271 mRNA. Translation: AAI26272.1.
CCDSiCCDS10741.1.
PIRiPN0453.
RefSeqiNP_001105.1. NM_001114.4.
XP_005255836.1. XM_005255779.2.
XP_005255837.1. XM_005255780.2.
XP_005255838.1. XM_005255781.2.
XP_005255839.1. XM_005255782.2.
XP_005255840.1. XM_005255783.2.
XP_005255841.1. XM_005255784.2.
UniGeneiHs.513578.

3D structure databases

ProteinModelPortaliP51828.
SMRiP51828. Positions 264-453, 871-1069.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106626. 4 interactions.
IntActiP51828. 3 interactions.
STRINGi9606.ENSP00000254235.

Chemistry

ChEMBLiCHEMBL2097167.

PTM databases

PhosphoSiteiP51828.

Polymorphism databases

DMDMi1706218.

Proteomic databases

MaxQBiP51828.
PaxDbiP51828.
PRIDEiP51828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254235; ENSP00000254235; ENSG00000121281.
ENST00000394697; ENSP00000378187; ENSG00000121281.
GeneIDi113.
KEGGihsa:113.
UCSCiuc002egd.1. human.

Organism-specific databases

CTDi113.
GeneCardsiGC16P050280.
HGNCiHGNC:238. ADCY7.
HPAiHPA048241.
HPA048474.
MIMi600385. gene.
neXtProtiNX_P51828.
PharmGKBiPA28.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG2114.
GeneTreeiENSGT00760000119042.
HOGENOMiHOG000006941.
HOVERGENiHBG050458.
InParanoidiP51828.
KOiK08047.
OMAiMAAGYEC.
OrthoDBiEOG76X5ZC.
PhylomeDBiP51828.
TreeFamiTF313845.

Enzyme and pathway databases

BRENDAi4.6.1.1. 2681.
ReactomeiREACT_15312. Adenylate cyclase activating pathway.
REACT_15333. Adenylate cyclase inhibitory pathway.
REACT_15530. PKA activation.
REACT_1665. Glucagon signaling in metabolic regulation.
REACT_19231. G alpha (i) signalling events.
REACT_19327. G alpha (s) signalling events.
REACT_19333. G alpha (z) signalling events.
REACT_1946. PKA activation in glucagon signalling.
REACT_24023. Vasopressin regulates renal water homeostasis via Aquaporins.
REACT_267634. Hedgehog 'off' state.

Miscellaneous databases

GeneWikiiADCY7.
GenomeRNAii113.
NextBioi437.
PROiP51828.
SOURCEiSearch...

Gene expression databases

BgeeiP51828.
CleanExiHS_ADCY7.
ExpressionAtlasiP51828. baseline and differential.
GenevestigatoriP51828.

Family and domain databases

Gene3Di3.30.70.1230. 2 hits.
InterProiIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
IPR029787. Nucleotide_cyclase.
[Graphical view]
PfamiPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTiSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMiSSF55073. SSF55073. 2 hits.
PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiADCY7_HUMAN
AccessioniPrimary (citable) accession number: P51828
Secondary accession number(s): A0AVA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: January 7, 2015
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.