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P51828

- ADCY7_HUMAN

UniProt

P51828 - ADCY7_HUMAN

Protein

Adenylate cyclase type 7

Gene

ADCY7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 1 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

    Catalytic activityi

    ATP = 3',5'-cyclic AMP + diphosphate.

    Cofactori

    Binds 2 magnesium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi284 – 2841Magnesium 1PROSITE-ProRule annotation
    Metal bindingi284 – 2841Magnesium 2PROSITE-ProRule annotation
    Metal bindingi285 – 2851Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation
    Metal bindingi328 – 3281Magnesium 1PROSITE-ProRule annotation
    Metal bindingi328 – 3281Magnesium 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. adenylate cyclase activity Source: UniProtKB
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. activation of phospholipase C activity Source: Reactome
    2. activation of protein kinase A activity Source: Reactome
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Reactome
    4. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    5. cellular response to ethanol Source: UniProtKB
    6. cellular response to glucagon stimulus Source: Reactome
    7. energy reserve metabolic process Source: Reactome
    8. epidermal growth factor receptor signaling pathway Source: Reactome
    9. fibroblast growth factor receptor signaling pathway Source: Reactome
    10. innate immune response Source: Reactome
    11. intracellular signal transduction Source: InterPro
    12. maternal process involved in female pregnancy Source: Ensembl
    13. neurotrophin TRK receptor signaling pathway Source: Reactome
    14. positive regulation of cAMP biosynthetic process Source: UniProtKB
    15. signal transduction Source: Reactome
    16. small molecule metabolic process Source: Reactome
    17. synaptic transmission Source: Reactome
    18. transmembrane transport Source: Reactome
    19. water transport Source: Reactome

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    cAMP biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi4.6.1.1. 2681.
    ReactomeiREACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Adenylate cyclase type 7 (EC:4.6.1.1)
    Alternative name(s):
    ATP pyrophosphate-lyase 7
    Adenylate cyclase type VII
    Adenylyl cyclase 7
    Gene namesi
    Name:ADCY7
    Synonyms:KIAA0037
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:238. ADCY7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10801080Adenylate cyclase type 7PRO_0000195703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi701 – 7011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi776 – 7761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi781 – 7811N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP51828.
    PaxDbiP51828.
    PRIDEiP51828.

    PTM databases

    PhosphoSiteiP51828.

    Expressioni

    Gene expression databases

    ArrayExpressiP51828.
    BgeeiP51828.
    CleanExiHS_ADCY7.
    GenevestigatoriP51828.

    Organism-specific databases

    HPAiHPA048241.
    HPA048474.

    Interactioni

    Protein-protein interaction databases

    BioGridi106626. 4 interactions.
    IntActiP51828. 3 interactions.
    STRINGi9606.ENSP00000254235.

    Structurei

    3D structure databases

    ProteinModelPortaliP51828.
    SMRiP51828. Positions 264-453, 871-1069.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini197 – 594398CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini815 – 1080266CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei63 – 8321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11723HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei176 – 19621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei595 – 61521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei620 – 64021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei669 – 68820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei718 – 73720HelicalSequence AnalysisAdd
    BLAST
    Transmembranei746 – 77328HelicalSequence AnalysisAdd
    BLAST
    Transmembranei794 – 81421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini279 – 406128Guanylate cyclase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini879 – 1023145Guanylate cyclase 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
    Contains 2 guanylate cyclase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2114.
    HOGENOMiHOG000006941.
    HOVERGENiHBG050458.
    InParanoidiP51828.
    KOiK08047.
    OMAiCTISERV.
    OrthoDBiEOG76X5ZC.
    PhylomeDBiP51828.
    TreeFamiTF313845.

    Family and domain databases

    Gene3Di3.30.70.1230. 2 hits.
    InterProiIPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view]
    PfamiPF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view]
    SMARTiSM00044. CYCc. 2 hits.
    [Graphical view]
    SUPFAMiSSF55073. SSF55073. 2 hits.
    PROSITEiPS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51828-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI     50
    IIAFSQGDPS RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT 100
    WACLVALGYV LVFDAWTKAA CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV 150
    GAVSTASHLL VLGSLMGGFT TPSVRVGLQL LANAVIFLCG NLTGAFHKHQ 200
    MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH ISMGMKLAII 250
    ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 300
    VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM 350
    GLDMCQAIKQ VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS 400
    LANRMEAAGV PGRVHITEAT LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY 450
    LVIDPRSQQP PPPSQHLPRP KGDAALKMRA SVRMTRYLES WGAARPFAHL 500
    NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS EDDSYDDEML 550
    SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA 600
    SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA 650
    RGTLCTISER VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG 700
    NETGLLAASS KTRALCEPLP YYTCSCVLGF IACSVFLRMS LEPKVVLLTV 750
    ALVAYLVLFN LSPCWQWDCC GQGLGNLTKP NGTTSGTPSC SWKDLKTMTN 800
    FYLVLFYITL LTLSRQIDYY CRLDCLWKKK FKKEHEEFET MENVNRLLLE 850
    NVLPAHVAAH FIGDKLNEDW YHQSYDCVCV MFASVPDFKV FYTECDVNKE 900
    GLECLRLLNE IIADFDELLL KPKFSGVEKI KTIGSTYMAA AGLSVASGHE 950
    NQELERQHAH IGVMVEFSIA LMSKLDGINR HSFNSFRLRV GINHGPVIAG 1000
    VIGARKPQYD IWGNTVNVAS RMESTGELGK IQVTEETCTI LQGLGYSCEC 1050
    RGLINVKGKG ELRTYFVCTD TAKFQGLGLN 1080
    Length:1,080
    Mass (Da):120,308
    Last modified:October 1, 1996 - v1
    Checksum:iE33951621E281242
    GO

    Sequence cautioni

    The sequence BAA05021.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25538 mRNA. Translation: BAA05021.2. Different initiation.
    BC126271 mRNA. Translation: AAI26272.1.
    CCDSiCCDS10741.1.
    PIRiPN0453.
    RefSeqiNP_001105.1. NM_001114.4.
    XP_005255836.1. XM_005255779.2.
    XP_005255837.1. XM_005255780.2.
    XP_005255838.1. XM_005255781.2.
    XP_005255839.1. XM_005255782.2.
    XP_005255840.1. XM_005255783.2.
    XP_005255841.1. XM_005255784.2.
    UniGeneiHs.513578.

    Genome annotation databases

    EnsembliENST00000254235; ENSP00000254235; ENSG00000121281.
    ENST00000394697; ENSP00000378187; ENSG00000121281.
    GeneIDi113.
    KEGGihsa:113.
    UCSCiuc002egd.1. human.

    Polymorphism databases

    DMDMi1706218.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D25538 mRNA. Translation: BAA05021.2 . Different initiation.
    BC126271 mRNA. Translation: AAI26272.1 .
    CCDSi CCDS10741.1.
    PIRi PN0453.
    RefSeqi NP_001105.1. NM_001114.4.
    XP_005255836.1. XM_005255779.2.
    XP_005255837.1. XM_005255780.2.
    XP_005255838.1. XM_005255781.2.
    XP_005255839.1. XM_005255782.2.
    XP_005255840.1. XM_005255783.2.
    XP_005255841.1. XM_005255784.2.
    UniGenei Hs.513578.

    3D structure databases

    ProteinModelPortali P51828.
    SMRi P51828. Positions 264-453, 871-1069.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106626. 4 interactions.
    IntActi P51828. 3 interactions.
    STRINGi 9606.ENSP00000254235.

    Chemistry

    BindingDBi P51828.
    ChEMBLi CHEMBL2097167.

    PTM databases

    PhosphoSitei P51828.

    Polymorphism databases

    DMDMi 1706218.

    Proteomic databases

    MaxQBi P51828.
    PaxDbi P51828.
    PRIDEi P51828.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000254235 ; ENSP00000254235 ; ENSG00000121281 .
    ENST00000394697 ; ENSP00000378187 ; ENSG00000121281 .
    GeneIDi 113.
    KEGGi hsa:113.
    UCSCi uc002egd.1. human.

    Organism-specific databases

    CTDi 113.
    GeneCardsi GC16P050347.
    HGNCi HGNC:238. ADCY7.
    HPAi HPA048241.
    HPA048474.
    MIMi 600385. gene.
    neXtProti NX_P51828.
    PharmGKBi PA28.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2114.
    HOGENOMi HOG000006941.
    HOVERGENi HBG050458.
    InParanoidi P51828.
    KOi K08047.
    OMAi CTISERV.
    OrthoDBi EOG76X5ZC.
    PhylomeDBi P51828.
    TreeFami TF313845.

    Enzyme and pathway databases

    BRENDAi 4.6.1.1. 2681.
    Reactomei REACT_15312. Adenylate cyclase activating pathway.
    REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15530. PKA activation.
    REACT_1665. Glucagon signaling in metabolic regulation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_1946. PKA activation in glucagon signalling.
    REACT_24023. Regulation of water balance by renal Aquaporins.

    Miscellaneous databases

    GeneWikii ADCY7.
    GenomeRNAii 113.
    NextBioi 437.
    PROi P51828.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51828.
    Bgeei P51828.
    CleanExi HS_ADCY7.
    Genevestigatori P51828.

    Family and domain databases

    Gene3Di 3.30.70.1230. 2 hits.
    InterProi IPR001054. A/G_cyclase.
    IPR018297. A/G_cyclase_CS.
    IPR009398. Adenylate_cyclase-like.
    [Graphical view ]
    Pfami PF06327. DUF1053. 1 hit.
    PF00211. Guanylate_cyc. 2 hits.
    [Graphical view ]
    SMARTi SM00044. CYCc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF55073. SSF55073. 2 hits.
    PROSITEi PS00452. GUANYLATE_CYCLASE_1. 1 hit.
    PS50125. GUANYLATE_CYCLASE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiADCY7_HUMAN
    AccessioniPrimary (citable) accession number: P51828
    Secondary accession number(s): A0AVA6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 127 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3