P51828 (ADCY7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate cyclase type 7
EC=4.6.1.1

Alternative name(s):
ATP pyrophosphate-lyase 7
Adenylate cyclase type VII
Adenylyl cyclase 7

Gene names

Name:	ADCY7
Synonyms:	KIAA0037

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1080 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is a membrane-bound, calcium-inhibitable adenylyl cyclase.
Catalytic activity	ATP = 3',5'-cyclic AMP + diphosphate.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Contains 2 guanylate cyclase domains.
Sequence caution	The sequence BAA05021.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	cAMP biosynthesis
Cellular component	Membrane
Domain	Repeat Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Lyase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	activation of phospholipase C activity Traceable author statement. Source: Reactome activation of protein kinase A activity Traceable author statement. Source: Reactome adenylate cyclase-activating G-protein coupled receptor signaling pathway Traceable author statement. Source: Reactome adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Traceable author statement. Source: Reactome cellular response to ethanol Inferred from direct assay PubMed 17760784. Source: UniProtKB cellular response to glucagon stimulus Traceable author statement. Source: Reactome energy reserve metabolic process Traceable author statement. Source: Reactome epidermal growth factor receptor signaling pathway Traceable author statement. Source: Reactome fibroblast growth factor receptor signaling pathway Traceable author statement. Source: Reactome intracellular signal transduction Inferred from electronic annotation. Source: InterPro nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome positive regulation of cAMP biosynthetic process Inferred from direct assay PubMed 11113152PubMed 17760784. Source: UniProtKB synaptic transmission Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome water transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from direct assay PubMed 11113152. Source: UniProtKB plasma membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate cyclase activity Inferred from direct assay PubMed 11113152PubMed 17760784. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1080	1080	Adenylate cyclase type 7		PRO_0000195703
Regions
	Topological domain	1 – 33	33	Cytoplasmic Potential
	Transmembrane	34 – 54	21	Helical; Potential
	Transmembrane	63 – 83	21	Helical; Potential
	Transmembrane	95 – 117	23	Helical; Potential
	Transmembrane	122 – 142	21	Helical; Potential
	Transmembrane	147 – 167	21	Helical; Potential
	Transmembrane	176 – 196	21	Helical; Potential
	Topological domain	197 – 594	398	Cytoplasmic Potential
	Transmembrane	595 – 615	21	Helical; Potential
	Transmembrane	620 – 640	21	Helical; Potential
	Transmembrane	669 – 688	20	Helical; Potential
	Transmembrane	718 – 737	20	Helical; Potential
	Transmembrane	746 – 773	28	Helical; Potential
	Transmembrane	794 – 814	21	Helical; Potential
	Topological domain	815 – 1080	266	Cytoplasmic Potential
	Domain	279 – 406	128	Guanylate cyclase 1
	Domain	879 – 1023	145	Guanylate cyclase 2
Sites
	Metal binding	284	1	Magnesium 1 By similarity
	Metal binding	284	1	Magnesium 2 By similarity
	Metal binding	285	1	Magnesium 2; via carbonyl oxygen By similarity
	Metal binding	328	1	Magnesium 1 By similarity
	Metal binding	328	1	Magnesium 2 By similarity
Amino acid modifications
	Glycosylation	701	1	N-linked (GlcNAc...) Potential
	Glycosylation	776	1	N-linked (GlcNAc...) Potential
	Glycosylation	781	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P51828 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E33951621E281242	FASTA	1,080	120,308
	10 20 30 40 50 60 MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS 70 80 90 100 110 120 RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA 130 140 150 160 170 180 CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL 190 200 210 220 230 240 LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH 250 260 270 280 290 300 ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 310 320 330 340 350 360 VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ 370 380 390 400 410 420 VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT 430 440 450 460 470 480 LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY LVIDPRSQQP PPPSQHLPRP KGDAALKMRA 490 500 510 520 530 540 SVRMTRYLES WGAARPFAHL NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS 550 560 570 580 590 600 EDDSYDDEML SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA 610 620 630 640 650 660 SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA RGTLCTISER 670 680 690 700 710 720 VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG NETGLLAASS KTRALCEPLP 730 740 750 760 770 780 YYTCSCVLGF IACSVFLRMS LEPKVVLLTV ALVAYLVLFN LSPCWQWDCC GQGLGNLTKP 790 800 810 820 830 840 NGTTSGTPSC SWKDLKTMTN FYLVLFYITL LTLSRQIDYY CRLDCLWKKK FKKEHEEFET 850 860 870 880 890 900 MENVNRLLLE NVLPAHVAAH FIGDKLNEDW YHQSYDCVCV MFASVPDFKV FYTECDVNKE 910 920 930 940 950 960 GLECLRLLNE IIADFDELLL KPKFSGVEKI KTIGSTYMAA AGLSVASGHE NQELERQHAH 970 980 990 1000 1010 1020 IGVMVEFSIA LMSKLDGINR HSFNSFRLRV GINHGPVIAG VIGARKPQYD IWGNTVNVAS 1030 1040 1050 1060 1070 1080 RMESTGELGK IQVTEETCTI LQGLGYSCEC RGLINVKGKG ELRTYFVCTD TAKFQGLGLN

References

[1]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D25538 mRNA. Translation: BAA05021.2. Different initiation. BC126271 mRNA. Translation: AAI26272.1.
IPI	IPI00020920.
PIR	PN0453.
RefSeq	NP_001105.1. NM_001114.3.
UniGene	Hs.513578.
3D structure databases
ProteinModelPortal	P51828.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51828. 3 interactions.
STRING	9606.ENSP00000254235.
PTM databases
PhosphoSite	P51828.
Polymorphism databases
DMDM	1706218.
Proteomic databases
PaxDb	P51828.
PRIDE	P51828.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000254235; ENSP00000254235; ENSG00000121281. ENST00000394697; ENSP00000378187; ENSG00000121281.
GeneID	113.
KEGG	hsa:113.
UCSC	uc002egd.1. human.
Organism-specific databases
CTD	113.
GeneCards	GC16P050347.
HGNC	HGNC:238. ADCY7.
HPA	HPA048241.
MIM	600385. gene.
neXtProt	NX_P51828.
PharmGKB	PA28.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2114.
HOGENOM	HOG000006941.
HOVERGEN	HBG050458.
InParanoid	P51828.
KO	K08047.
OMA	PRARYDF.
OrthoDB	EOG40P461.
PhylomeDB	P51828.
Enzyme and pathway databases
BRENDA	4.6.1.1. 2681.
Pathway_Interaction_DB	endothelinpathway. Endothelins. lysophospholipid_pathway. LPA receptor mediated events. lpa4_pathway. LPA4-mediated signaling events.
Reactome	REACT_111102. Signal Transduction. REACT_111217. Metabolism. REACT_116125. Disease. REACT_13685. Neuronal System. REACT_15518. Transmembrane transport of small molecules. REACT_6900. Immune System.
Gene expression databases
ArrayExpress	P51828.
Bgee	P51828.
CleanEx	HS_ADCY7.
Genevestigator	P51828.
GermOnline	ENSG00000121281. Homo sapiens.
Family and domain databases
Gene3D	3.30.70.1230. 2 hits.
InterPro	IPR001054. A/G_cyclase. IPR018297. A/G_cyclase_CS. IPR009398. Adenylate_cyclase-like. [Graphical view]
Pfam	PF06327. DUF1053. 1 hit. PF00211. Guanylate_cyc. 2 hits. [Graphical view]
SMART	SM00044. CYCc. 2 hits. [Graphical view]
SUPFAM	SSF55073. A/G_cyclase. 2 hits.
PROSITE	PS00452. GUANYLATE_CYCLASE_1. 1 hit. PS50125. GUANYLATE_CYCLASE_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P51828.
ChEMBL	CHEMBL4922.
DrugBank	DB01200. Bromocriptine.
GenomeRNAi	113.
NextBio	437.
SOURCE	Search...

Entry information

Entry name

ADCY7_HUMAN

Accession

Primary (citable) accession number: P51828
Secondary accession number(s): A0AVA6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 114 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.