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P51828 (ADCY7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 125. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenylate cyclase type 7

EC=4.6.1.1
Alternative name(s):
ATP pyrophosphate-lyase 7
Adenylate cyclase type VII
Adenylyl cyclase 7
Gene names
Name:ADCY7
Synonyms:KIAA0037
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1080 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a membrane-bound, calcium-inhibitable adenylyl cyclase.

Catalytic activity

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactor

Binds 2 magnesium ions per subunit By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.

Contains 2 guanylate cyclase domains.

Sequence caution

The sequence BAA05021.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processcAMP biosynthesis
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionLyase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processactivation of phospholipase C activity

Traceable author statement. Source: Reactome

activation of protein kinase A activity

Traceable author statement. Source: Reactome

adenylate cyclase-activating G-protein coupled receptor signaling pathway

Traceable author statement. Source: Reactome

adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway

Traceable author statement. Source: Reactome

cellular response to ethanol

Inferred from direct assay PubMed 17760784. Source: UniProtKB

cellular response to glucagon stimulus

Traceable author statement. Source: Reactome

energy reserve metabolic process

Traceable author statement. Source: Reactome

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

innate immune response

Traceable author statement. Source: Reactome

intracellular signal transduction

Inferred from electronic annotation. Source: InterPro

maternal process involved in female pregnancy

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

positive regulation of cAMP biosynthetic process

Inferred from direct assay PubMed 11113152PubMed 17760784. Source: UniProtKB

signal transduction

Traceable author statement. Source: Reactome

small molecule metabolic process

Traceable author statement. Source: Reactome

synaptic transmission

Traceable author statement. Source: Reactome

transmembrane transport

Traceable author statement. Source: Reactome

water transport

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from direct assay PubMed 11113152. Source: UniProtKB

plasma membrane

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

adenylate cyclase activity

Inferred from direct assay PubMed 11113152PubMed 17760784. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10801080Adenylate cyclase type 7
PRO_0000195703

Regions

Topological domain1 – 3333Cytoplasmic Potential
Transmembrane34 – 5421Helical; Potential
Transmembrane63 – 8321Helical; Potential
Transmembrane95 – 11723Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane176 – 19621Helical; Potential
Topological domain197 – 594398Cytoplasmic Potential
Transmembrane595 – 61521Helical; Potential
Transmembrane620 – 64021Helical; Potential
Transmembrane669 – 68820Helical; Potential
Transmembrane718 – 73720Helical; Potential
Transmembrane746 – 77328Helical; Potential
Transmembrane794 – 81421Helical; Potential
Topological domain815 – 1080266Cytoplasmic Potential
Domain279 – 406128Guanylate cyclase 1
Domain879 – 1023145Guanylate cyclase 2

Sites

Metal binding2841Magnesium 1 By similarity
Metal binding2841Magnesium 2 By similarity
Metal binding2851Magnesium 2; via carbonyl oxygen By similarity
Metal binding3281Magnesium 1 By similarity
Metal binding3281Magnesium 2 By similarity

Amino acid modifications

Glycosylation7011N-linked (GlcNAc...) Potential
Glycosylation7761N-linked (GlcNAc...) Potential
Glycosylation7811N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P51828 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: E33951621E281242

FASTA1,080120,308
        10         20         30         40         50         60 
MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI IIAFSQGDPS 

        70         80         90        100        110        120 
RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT WACLVALGYV LVFDAWTKAA 

       130        140        150        160        170        180 
CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV GAVSTASHLL VLGSLMGGFT TPSVRVGLQL 

       190        200        210        220        230        240 
LANAVIFLCG NLTGAFHKHQ MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH 

       250        260        270        280        290        300 
ISMGMKLAII ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL 

       310        320        330        340        350        360 
VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM GLDMCQAIKQ 

       370        380        390        400        410        420 
VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS LANRMEAAGV PGRVHITEAT 

       430        440        450        460        470        480 
LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY LVIDPRSQQP PPPSQHLPRP KGDAALKMRA 

       490        500        510        520        530        540 
SVRMTRYLES WGAARPFAHL NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS 

       550        560        570        580        590        600 
EDDSYDDEML SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA 

       610        620        630        640        650        660 
SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA RGTLCTISER 

       670        680        690        700        710        720 
VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG NETGLLAASS KTRALCEPLP 

       730        740        750        760        770        780 
YYTCSCVLGF IACSVFLRMS LEPKVVLLTV ALVAYLVLFN LSPCWQWDCC GQGLGNLTKP 

       790        800        810        820        830        840 
NGTTSGTPSC SWKDLKTMTN FYLVLFYITL LTLSRQIDYY CRLDCLWKKK FKKEHEEFET 

       850        860        870        880        890        900 
MENVNRLLLE NVLPAHVAAH FIGDKLNEDW YHQSYDCVCV MFASVPDFKV FYTECDVNKE 

       910        920        930        940        950        960 
GLECLRLLNE IIADFDELLL KPKFSGVEKI KTIGSTYMAA AGLSVASGHE NQELERQHAH 

       970        980        990       1000       1010       1020 
IGVMVEFSIA LMSKLDGINR HSFNSFRLRV GINHGPVIAG VIGARKPQYD IWGNTVNVAS 

      1030       1040       1050       1060       1070       1080 
RMESTGELGK IQVTEETCTI LQGLGYSCEC RGLINVKGKG ELRTYFVCTD TAKFQGLGLN 

« Hide

References

[1]"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D25538 mRNA. Translation: BAA05021.2. Different initiation.
BC126271 mRNA. Translation: AAI26272.1.
CCDSCCDS10741.1.
PIRPN0453.
RefSeqNP_001105.1. NM_001114.4.
XP_005255836.1. XM_005255779.2.
XP_005255837.1. XM_005255780.2.
XP_005255838.1. XM_005255781.2.
XP_005255839.1. XM_005255782.2.
XP_005255840.1. XM_005255783.2.
XP_005255841.1. XM_005255784.2.
UniGeneHs.513578.

3D structure databases

ProteinModelPortalP51828.
SMRP51828. Positions 264-453, 871-1069.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid106626. 4 interactions.
IntActP51828. 3 interactions.
STRING9606.ENSP00000254235.

Chemistry

BindingDBP51828.
ChEMBLCHEMBL2097167.
DrugBankDB01200. Bromocriptine.

PTM databases

PhosphoSiteP51828.

Polymorphism databases

DMDM1706218.

Proteomic databases

MaxQBP51828.
PaxDbP51828.
PRIDEP51828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000254235; ENSP00000254235; ENSG00000121281.
ENST00000394697; ENSP00000378187; ENSG00000121281.
GeneID113.
KEGGhsa:113.
UCSCuc002egd.1. human.

Organism-specific databases

CTD113.
GeneCardsGC16P050347.
HGNCHGNC:238. ADCY7.
HPAHPA048241.
HPA048474.
MIM600385. gene.
neXtProtNX_P51828.
PharmGKBPA28.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2114.
HOGENOMHOG000006941.
HOVERGENHBG050458.
InParanoidP51828.
KOK08047.
OMACTISERV.
OrthoDBEOG76X5ZC.
PhylomeDBP51828.
TreeFamTF313845.

Enzyme and pathway databases

BRENDA4.6.1.1. 2681.
ReactomeREACT_111102. Signal Transduction.
REACT_111217. Metabolism.
REACT_116125. Disease.
REACT_13685. Neuronal System.
REACT_15518. Transmembrane transport of small molecules.
REACT_6900. Immune System.

Gene expression databases

ArrayExpressP51828.
BgeeP51828.
CleanExHS_ADCY7.
GenevestigatorP51828.

Family and domain databases

Gene3D3.30.70.1230. 2 hits.
InterProIPR001054. A/G_cyclase.
IPR018297. A/G_cyclase_CS.
IPR009398. Adenylate_cyclase-like.
[Graphical view]
PfamPF06327. DUF1053. 1 hit.
PF00211. Guanylate_cyc. 2 hits.
[Graphical view]
SMARTSM00044. CYCc. 2 hits.
[Graphical view]
SUPFAMSSF55073. SSF55073. 2 hits.
PROSITEPS00452. GUANYLATE_CYCLASE_1. 1 hit.
PS50125. GUANYLATE_CYCLASE_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiADCY7.
GenomeRNAi113.
NextBio437.
PROP51828.
SOURCESearch...

Entry information

Entry nameADCY7_HUMAN
AccessionPrimary (citable) accession number: P51828
Secondary accession number(s): A0AVA6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 16

Human chromosome 16: entries, gene names and cross-references to MIM