Reviewed,
UniProtKB/Swiss-Prot P51817 (PRKX_HUMAN)
Last modified
November 25, 2008.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Serine/threonine-protein kinase PRKX EC=2.7.11.1 Alternative name(s): Protein kinase PKX1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 358 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Tissue specificity | High levels in adult and fetal brain, kidney and lung; low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver. |
| Involvement in disease | A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Coding sequence diversity | Chromosomal rearrangement |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Ref.1 Traceable author statement. Source: ProtInc |
| Molecular function | ATP binding Inferred from electronic annotation. Source: InterPro cAMP-dependent protein kinase activity Ref.1Traceable author statement. Source: ProtInc protein tyrosine kinase activityInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 358 | 358 | Serine/threonine-protein kinase PRKX | PRO_0000086582 | |||||
Regions | |||||||||
| Domain | 49 – 303 | 255 | Protein kinase | ||||||
| Domain | 304 – 358 | 55 | AGC-kinase C-terminal | ||||||
| Nucleotide binding | 55 – 63 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 172 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 78 | 1 | ATP By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability." Klink A., Schiebel K., Winkelmann M., Rao E., Horsthemke B., Luedecke H.-J., Claussen U., Scherer G., Rappold G. Hum. Mol. Genet. 4:869-878(1995) [PubMed: 7633447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood. |
| [3] | "Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females." Schiebel K., Winkelmann M., Mertz A., Xu X., Page D.C., Weil D., Petit C., Rappold G.A. Hum. Mol. Genet. 6:1985-1989(1997) [PubMed: 9302280] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PRKY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| X85545 mRNA. Translation: CAA59733.1. BC041073 mRNA. Translation: AAH41073.1. | |
| PIR | I38121. |
| RefSeq | NP_005035.1. |
| UniGene | Hs.390788 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1J3H based on UniProtKB P05132. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSG00000183943. Homo sapiens. [Contig view] |
| GeneID | 5613. |
| KEGG | hsa:5613. |
Organism-specific databases | |
| H-InvDB | HIX0021034. HIX0028453. HIX0077107. HIX0077167. HIX0077317. |
| HGNC | HGNC:9441. PRKX. |
| HPA | HPA015324. |
| MIM | 300083. gene. |
| PharmGKB | PA33786. |
| GenAtlas | Search... |
| GeneCards | Search... |
Phylogenomic databases | |
| HOGENOM | P51817. |
| HOVERGEN | P51817. |
Gene expression databases | |
| ArrayExpress | P51817. |
| CleanEx | HS_PRKX. |
| GermOnline | ENSG00000183943. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000961. Pkinase_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. IPR001245. Tyr_pkinase. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| PRINTS | PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | P51817. |
| NextBio | 21818. |
| SOURCE | Search... |
Entry information
| Entry name | PRKX_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P51817 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


