Reviewed, UniProtKB/Swiss-Prot P51817 (PRKX_HUMAN)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase PRKX
    EC=2.7.11.1
Alternative name(s):
    Protein kinase PKX1

Gene names

Name:	PRKX
Synonyms:	PKX1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	358 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Tissue specificity	High levels in adult and fetal brain, kidney and lung; low levels in adult placenta, heart, liver, skeletal muscle, pancreas and fetal liver.
Involvement in disease	A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Coding sequence diversity	Chromosomal rearrangement
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Ref.1 Traceable author statement. Source: ProtInc
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro cAMP-dependent protein kinase activity Ref.1 Traceable author statement. Source: ProtInc protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 358	358	Serine/threonine-protein kinase PRKX		PRO_0000086582
Regions
	Domain	49 – 303	255	Protein kinase
	Domain	304 – 358	55	AGC-kinase C-terminal
	Nucleotide binding	55 – 63	9	ATP By similarity
Sites
	Active site	172	1	Proton acceptor By similarity
	Binding site	78	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P51817-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: B603834E3541CB56	FASTA	358	40,896
	10 20 30 40 50 60 MEAPGLAQAA AAESDSRKVA EETPDGAPAL CPSPEALSPE PPVYSLQDFD TLATVGTGTF 70 80 90 100 110 120 GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER 130 140 150 160 170 180 FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 190 200 210 220 230 240 DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 250 260 270 280 290 300 FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKHH 310 320 330 340 350 RWFRSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability." Klink A., Schiebel K., Winkelmann M., Rao E., Horsthemke B., Luedecke H.-J., Claussen U., Scherer G., Rappold G. Hum. Mol. Genet. 4:869-878(1995) [PubMed: 7633447] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Blood.
[3]	"Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females." Schiebel K., Winkelmann M., Mertz A., Xu X., Page D.C., Weil D., Petit C., Rappold G.A. Hum. Mol. Genet. 6:1985-1989(1997) [PubMed: 9302280] [Abstract] Cited for: CHROMOSOMAL TRANSLOCATION WITH PRKY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X85545 mRNA. Translation: CAA59733.1. BC041073 mRNA. Translation: AAH41073.1.
PIR	I38121.
RefSeq	NP_005035.1.
UniGene	Hs.390788
3D structure databases
HSSP	HSSP built from PDB template 1J3H based on UniProtKB P05132.
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000183943. Homo sapiens. [Contig view]
GeneID	5613.
KEGG	hsa:5613.
Organism-specific databases
H-InvDB	HIX0021034. HIX0028453. HIX0077107. HIX0077167. HIX0077317.
HGNC	HGNC:9441. PRKX.
HPA	HPA015324.
MIM	300083. gene.
PharmGKB	PA33786.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	P51817.
HOVERGEN	P51817.
Gene expression databases
ArrayExpress	P51817.
CleanEx	HS_PRKX.
GermOnline	ENSG00000183943. Homo sapiens.
Family and domain databases
InterPro	IPR000961. Pkinase_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. IPR001245. Tyr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00109. TYRKINASE.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
LinkHub	P51817.
NextBio	21818.
SOURCE	Search...

Entry information

Entry name

PRKX_HUMAN

Accession

Primary (citable) accession number: P51817

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 25, 2008
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)