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Protein

Zinc finger protein 75D

Gene

ZNF75D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri365 – 387C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 75D
Alternative name(s):
Zinc finger protein 75
Zinc finger protein 82
Gene namesi
Name:ZNF75D
Synonyms:ZNF75, ZNF82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000186376.14
HGNCiHGNC:13145 ZNF75D
MIMi314997 gene
neXtProtiNX_P51815

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186376
PharmGKBiPA37719

Polymorphism and mutation databases

BioMutaiZNF75D
DMDMi212276486

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473841 – 510Zinc finger protein 75DAdd BLAST510

Proteomic databases

PaxDbiP51815
PeptideAtlasiP51815
PRIDEiP51815

PTM databases

iPTMnetiP51815
PhosphoSitePlusiP51815

Expressioni

Gene expression databases

BgeeiENSG00000186376
CleanExiHS_ZNF75D
GenevisibleiP51815 HS

Organism-specific databases

HPAiHPA004705

Interactioni

Protein-protein interaction databases

IntActiP51815, 2 interactors
STRINGi9606.ENSP00000359802

Structurei

3D structure databases

ProteinModelPortaliP51815
SMRiP51815
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 131SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini235 – 318KRABPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri365 – 387C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00830000128328
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiP51815
KOiK09229
OMAiQPVYERA
OrthoDBiEOG091G06EQ
PhylomeDBiP51815
TreeFamiTF341729

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
cd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 5 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51815-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR
60 70 80 90 100
HFWSFRYHEA TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI
110 120 130 140 150
LPKETQNWVQ KHHPQNVKQA LVLVEFLQRE PDGTKNEVTA HELGKEAVLL
160 170 180 190 200
GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY RVLQEQLGWN THKETQPVYE
210 220 230 240 250
RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV AVYFSEEEWQ
260 270 280 290 300
LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC
310 320 330 340 350
EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK
360 370 380 390 400
LMDLHGKGPT GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR
410 420 430 440 450
RFRWSSDLNK HFMTHQGIKP YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK
460 470 480 490 500
CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS LCKRNFSRRS SLLRHQKLHR
510
RREACLVSPN
Length:510
Mass (Da):59,298
Last modified:November 4, 2008 - v2
Checksum:i37D405F102965A24
GO
Isoform 2 (identifier: P51815-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-232: Missing.

Show »
Length:415
Mass (Da):48,362
Checksum:iE62E74F35BCB7C71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409N → S in BAG52399 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044460138 – 232Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091687 mRNA Translation: BAG52399.1
AK290215 mRNA Translation: BAF82904.1
AL832801 mRNA Translation: CAI46130.1
AL450472 Genomic DNA No translation available.
AL590282 Genomic DNA No translation available.
BC109100 mRNA Translation: AAI09101.1
S67970 mRNA Translation: AAB29696.1
S43109 Genomic DNA Translation: AAB22971.1
X68010 Genomic DNA Translation: CAA48147.1
CCDSiCCDS14648.1 [P51815-1]
CCDS55503.1 [P51815-2]
PIRiA48913
RefSeqiNP_001171992.1, NM_001185063.2 [P51815-2]
NP_009062.2, NM_007131.4 [P51815-1]
XP_005262526.1, XM_005262469.1 [P51815-1]
XP_011529693.1, XM_011531391.1 [P51815-1]
UniGeneiHs.371717
Hs.533540
Hs.637362
Hs.639976
Hs.667773
Hs.736951

Genome annotation databases

EnsembliENST00000370764; ENSP00000359800; ENSG00000186376 [P51815-2]
ENST00000370766; ENSP00000359802; ENSG00000186376 [P51815-1]
GeneIDi7626
KEGGihsa:7626
UCSCiuc004eyo.5 human [P51815-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN75D_HUMAN
AccessioniPrimary (citable) accession number: P51815
Secondary accession number(s): A6NK62
, B3KRI7, Q5JPG0, Q6LDE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: May 23, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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