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Protein

Zinc finger protein 75D

Gene

ZNF75D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri365 – 387C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147280-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 75D
Alternative name(s):
Zinc finger protein 75
Zinc finger protein 82
Gene namesi
Name:ZNF75D
Synonyms:ZNF75, ZNF82
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:13145. ZNF75D.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186376.
PharmGKBiPA37719.

Polymorphism and mutation databases

BioMutaiZNF75D.
DMDMi212276486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473841 – 510Zinc finger protein 75DAdd BLAST510

Proteomic databases

PaxDbiP51815.
PeptideAtlasiP51815.
PRIDEiP51815.

PTM databases

iPTMnetiP51815.
PhosphoSitePlusiP51815.

Expressioni

Gene expression databases

BgeeiENSG00000186376.
CleanExiHS_ZNF75D.
GenevisibleiP51815. HS.

Organism-specific databases

HPAiHPA004705.

Interactioni

Protein-protein interaction databases

IntActiP51815. 2 interactors.
STRINGi9606.ENSP00000359802.

Structurei

3D structure databases

ProteinModelPortaliP51815.
SMRiP51815.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 131SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini235 – 318KRABPROSITE-ProRule annotationAdd BLAST84

Sequence similaritiesi

Contains 5 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri365 – 387C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri393 – 415C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri449 – 471C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri477 – 499C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128328.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP51815.
KOiK09229.
OMAiQKEYWNT.
OrthoDBiEOG091G06EQ.
PhylomeDBiP51815.
TreeFamiTF341729.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P51815-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAMRELNADS CSSPQMGAMW ETSGSVKENS SQSKKYSTKI ENLGPESACR
60 70 80 90 100
HFWSFRYHEA TGPLETISQL QKLCHQWLRP EIHSKEQILE MLVLEQFLSI
110 120 130 140 150
LPKETQNWVQ KHHPQNVKQA LVLVEFLQRE PDGTKNEVTA HELGKEAVLL
160 170 180 190 200
GGTAVAPGFK WKPAEPQPMG VFQKEYWNTY RVLQEQLGWN THKETQPVYE
210 220 230 240 250
RAVHDQQMLA LSEQKRIKHW KMASKLILPE SLSLLTFEDV AVYFSEEEWQ
260 270 280 290 300
LLNPLEKTLY NDVMQDIYET VISLGLKLKN DTGNDHPISV STSEIQTSGC
310 320 330 340 350
EVSKKTRMKI AQKTMGRENP GDTHSVQKWH RAFPRKKRKK PATCKQELPK
360 370 380 390 400
LMDLHGKGPT GEKPFKCQEC GKSFRVSSDL IKHHRIHTGE KPYKCQQCDR
410 420 430 440 450
RFRWSSDLNK HFMTHQGIKP YRCSWCGKSF SHNTNLHTHQ RIHTGEKPFK
460 470 480 490 500
CDECGKRFIQ NSHLIKHQRT HTGEQPYTCS LCKRNFSRRS SLLRHQKLHR
510
RREACLVSPN
Length:510
Mass (Da):59,298
Last modified:November 4, 2008 - v2
Checksum:i37D405F102965A24
GO
Isoform 2 (identifier: P51815-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     138-232: Missing.

Show »
Length:415
Mass (Da):48,362
Checksum:iE62E74F35BCB7C71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti409N → S in BAG52399 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_044460138 – 232Missing in isoform 2. 1 PublicationAdd BLAST95

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091687 mRNA. Translation: BAG52399.1.
AK290215 mRNA. Translation: BAF82904.1.
AL832801 mRNA. Translation: CAI46130.1.
AL450472 Genomic DNA. No translation available.
AL590282 Genomic DNA. Translation: CAQ08421.1.
AL590282 Genomic DNA. Translation: CAQ08422.1.
BC109100 mRNA. Translation: AAI09101.1.
S67970 mRNA. Translation: AAB29696.1.
S43109 Genomic DNA. Translation: AAB22971.1.
X68010 Genomic DNA. Translation: CAA48147.1.
CCDSiCCDS14648.1. [P51815-1]
CCDS55503.1. [P51815-2]
PIRiA48913.
RefSeqiNP_001171992.1. NM_001185063.2. [P51815-2]
NP_009062.2. NM_007131.4. [P51815-1]
XP_005262526.1. XM_005262469.1. [P51815-1]
XP_011529693.1. XM_011531391.1. [P51815-1]
UniGeneiHs.371717.
Hs.533540.
Hs.637362.
Hs.639976.
Hs.667773.
Hs.736951.

Genome annotation databases

EnsembliENST00000370764; ENSP00000359800; ENSG00000186376. [P51815-2]
ENST00000370766; ENSP00000359802; ENSG00000186376. [P51815-1]
GeneIDi7626.
KEGGihsa:7626.
UCSCiuc004eyo.5. human. [P51815-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091687 mRNA. Translation: BAG52399.1.
AK290215 mRNA. Translation: BAF82904.1.
AL832801 mRNA. Translation: CAI46130.1.
AL450472 Genomic DNA. No translation available.
AL590282 Genomic DNA. Translation: CAQ08421.1.
AL590282 Genomic DNA. Translation: CAQ08422.1.
BC109100 mRNA. Translation: AAI09101.1.
S67970 mRNA. Translation: AAB29696.1.
S43109 Genomic DNA. Translation: AAB22971.1.
X68010 Genomic DNA. Translation: CAA48147.1.
CCDSiCCDS14648.1. [P51815-1]
CCDS55503.1. [P51815-2]
PIRiA48913.
RefSeqiNP_001171992.1. NM_001185063.2. [P51815-2]
NP_009062.2. NM_007131.4. [P51815-1]
XP_005262526.1. XM_005262469.1. [P51815-1]
XP_011529693.1. XM_011531391.1. [P51815-1]
UniGeneiHs.371717.
Hs.533540.
Hs.637362.
Hs.639976.
Hs.667773.
Hs.736951.

3D structure databases

ProteinModelPortaliP51815.
SMRiP51815.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51815. 2 interactors.
STRINGi9606.ENSP00000359802.

PTM databases

iPTMnetiP51815.
PhosphoSitePlusiP51815.

Polymorphism and mutation databases

BioMutaiZNF75D.
DMDMi212276486.

Proteomic databases

PaxDbiP51815.
PeptideAtlasiP51815.
PRIDEiP51815.

Protocols and materials databases

DNASUi7626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370764; ENSP00000359800; ENSG00000186376. [P51815-2]
ENST00000370766; ENSP00000359802; ENSG00000186376. [P51815-1]
GeneIDi7626.
KEGGihsa:7626.
UCSCiuc004eyo.5. human. [P51815-1]

Organism-specific databases

CTDi7626.
GeneCardsiZNF75D.
HGNCiHGNC:13145. ZNF75D.
HPAiHPA004705.
MIMi314997. gene.
neXtProtiNX_P51815.
OpenTargetsiENSG00000186376.
PharmGKBiPA37719.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128328.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiP51815.
KOiK09229.
OMAiQKEYWNT.
OrthoDBiEOG091G06EQ.
PhylomeDBiP51815.
TreeFamiTF341729.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147280-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7626.
PROiP51815.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000186376.
CleanExiHS_ZNF75D.
GenevisibleiP51815. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 5 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 5 hits.
PS50157. ZINC_FINGER_C2H2_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN75D_HUMAN
AccessioniPrimary (citable) accession number: P51815
Secondary accession number(s): A6NK62
, B3KRI7, Q5JPG0, Q6LDE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 4, 2008
Last modified: November 2, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.