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P51808 (DYLT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dynein light chain Tctex-type 3
Alternative name(s):
Protein 91/23
T-complex-associated testis-expressed 1-like
Gene names
Name:DYNLT3
Synonyms:TCTE1L, TCTE1XL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length116 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis By similarity.

Subunit structure

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 By similarity. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA. Ref.6 Ref.7

Subcellular location

Nucleus. Cytoplasmcytoskeleton. Chromosomecentromerekinetochore. Note: Colocalizes with BUB3 at kinetochores specifically during prometaphase. Ref.6 Ref.7

Sequence similarities

Belongs to the dynein light chain Tctex-type family.

Caution

Was originally (Ref.1) thought to be a candidate for RP3.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 116116Dynein light chain Tctex-type 3
PRO_0000195158

Amino acid modifications

Modified residue41Nitrated tyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P51808 [UniParc].

Last modified October 1, 1996. Version 1.
Checksum: 7DEB2A8B9D989632

FASTA11613,062
        10         20         30         40         50         60 
MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ SLTHLVKLGK 

        70         80         90        100        110 
AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN RTMNCIVNVF AIAIVL 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex."
Roux A.-F., Rommens J., McDowell C., Anson-Cartwright L., Bell S., Schappert K.T., Fishman G.A., Musarella M.
Hum. Mol. Genet. 3:257-263(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Subthalamic nucleus.
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[6]"Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway."
Yeh T.-Y., Chuang J.-Z., Sung C.-H.
J. Cell Sci. 118:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH SATB1, SUBCELLULAR LOCATION.
[7]"The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3."
Lo K.W., Kogoy J.M., Pfister K.K.
J. Biol. Chem. 282:11205-11212(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH BUB3, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U02556 mRNA. Translation: AAA57444.1.
AK311851 mRNA. Translation: BAG34793.1.
CR450320 mRNA. Translation: CAG29316.1.
CR542213 mRNA. Translation: CAG47009.1.
CH471141 Genomic DNA. Translation: EAW59452.1.
BC000968 mRNA. Translation: AAH00968.1.
CCDSCCDS14243.1.
PIRI38410.
RefSeqNP_006511.1. NM_006520.2.
UniGeneHs.446392.

3D structure databases

ProteinModelPortalP51808.
SMRP51808. Positions 13-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112850. 16 interactions.
IntActP51808. 6 interactions.
MINTMINT-1452735.
STRING9606.ENSP00000367841.

Proteomic databases

MaxQBP51808.
PaxDbP51808.
PRIDEP51808.

Protocols and materials databases

DNASU6990.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000378578; ENSP00000367841; ENSG00000165169.
GeneID6990.
KEGGhsa:6990.
UCSCuc004dds.3. human.

Organism-specific databases

CTD6990.
GeneCardsGC0XM037696.
HGNCHGNC:11694. DYNLT3.
HPAHPA003938.
MIM300302. gene.
neXtProtNX_P51808.
PharmGKBPA36414.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278055.
HOGENOMHOG000255148.
HOVERGENHBG001217.
KOK10420.
PhylomeDBP51808.
TreeFamTF313904.

Gene expression databases

ArrayExpressP51808.
BgeeP51808.
CleanExHS_DYNLT3.
GenevestigatorP51808.

Family and domain databases

InterProIPR005334. Tctex.
[Graphical view]
PANTHERPTHR21255. PTHR21255. 1 hit.
PfamPF03645. Tctex-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDYNLT3.
GenomeRNAi6990.
NextBio27309.
PROP51808.
SOURCESearch...

Entry information

Entry nameDYLT3_HUMAN
AccessionPrimary (citable) accession number: P51808
Secondary accession number(s): Q6ICS3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM