P51808 (DYLT3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynein light chain Tctex-type 3

Alternative name(s):
Protein 91/23
T-complex-associated testis-expressed 1-like

Gene names

Name:	DYNLT3
Synonyms:	TCTE1L, TCTE1XL

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	116 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis By similarity.
Subunit structure	Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 By similarity. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA. Ref.3 Ref.4
Subcellular location	Nucleus. Cytoplasm › cytoskeleton. Chromosome › centromere › kinetochore. Note: Colocalizes with BUB3 at kinetochores specifically during prometaphase. Ref.3 Ref.4
Sequence similarities	Belongs to the dynein light chain Tctex-type family.
Caution	Was originally (Ref.1) thought to be a candidate for RP3.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Transport
Cellular component	Centromere Chromosome Cytoplasm Cytoskeleton Dynein Kinetochore Microtubule Nucleus
Molecular function	Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW regulation of mitotic cell cycle Inferred from sequence or structural similarity. Source: UniProtKB transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic dynein complex Inferred from direct assay PubMed 11425878. Source: UniProtKB microtubule Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from direct assay. Source: HPA
Molecular_function	motor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 116	116	Dynein light chain Tctex-type 3		PRO_0000195158

Sequences

	Sequence		Length	Mass (Da)
	P51808 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: 7DEB2A8B9D989632	FASTA	116	13,062
	10 20 30 40 50 60 MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ SLTHLVKLGK 70 80 90 100 110 AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN RTMNCIVNVF AIAIVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex." Roux A.-F., Rommens J., McDowell C., Anson-Cartwright L., Bell S., Schappert K.T., Fishman G.A., Musarella M. Hum. Mol. Genet. 3:257-263(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway." Yeh T.-Y., Chuang J.-Z., Sung C.-H. J. Cell Sci. 118:3431-3443(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH SATB1, SUBCELLULAR LOCATION.
[4]	"The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3." Lo K.W., Kogoy J.M., Pfister K.K. J. Biol. Chem. 282:11205-11212(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH BUB3, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U02556 mRNA. Translation: AAA57444.1. BC000968 mRNA. Translation: AAH00968.1.
IPI	IPI00020885.
PIR	I38410.
RefSeq	NP_006511.1. NM_006520.2.
UniGene	Hs.446392.
3D structure databases
ProteinModelPortal	P51808.
ModBase	Search...
Protein-protein interaction databases
IntAct	P51808. 6 interactions.
MINT	MINT-1452735.
STRING	9606.ENSP00000367841.
Polymorphism databases
DMDM	1729884.
Proteomic databases
PaxDb	P51808.
PRIDE	P51808.
Protocols and materials databases
DNASU	6990.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000378578; ENSP00000367841; ENSG00000165169.
GeneID	6990.
KEGG	hsa:6990.
UCSC	uc004dds.3. human.
Organism-specific databases
CTD	6990.
GeneCards	GC0XM037696.
HGNC	HGNC:11694. DYNLT3.
HPA	HPA003938.
MIM	300302. gene.
neXtProt	NX_P51808.
PharmGKB	PA36414.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278055.
HOGENOM	HOG000255148.
HOVERGEN	HBG001217.
KO	K10420.
OrthoDB	EOG466VND.
PhylomeDB	P51808.
Gene expression databases
ArrayExpress	P51808.
Bgee	P51808.
CleanEx	HS_DYNLT3.
Genevestigator	P51808.
GermOnline	ENSG00000165169. Homo sapiens.
Family and domain databases
InterPro	IPR005334. Tctex. [Graphical view]
PANTHER	PTHR21255. PTHR21255. 1 hit.
Pfam	PF03645. Tctex-1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	6990.
NextBio	27309.
SOURCE	Search...

Entry information

Entry name

DYLT3_HUMAN

Accession

Primary (citable) accession number: P51808

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	May 1, 2013
This is version 96 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.