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Protein

Dynein light chain Tctex-type 3

Gene

DYNLT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).By similarity

GO - Molecular functioni

  1. motor activity Source: UniProtKB-KW

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. regulation of mitotic cell cycle Source: UniProtKB
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain Tctex-type 3
Alternative name(s):
Protein 91/23
T-complex-associated testis-expressed 1-like
Gene namesi
Name:DYNLT3
Synonyms:TCTE1L, TCTE1XL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:11694. DYNLT3.

Subcellular locationi

Nucleus. Cytoplasmcytoskeleton. Chromosomecentromerekinetochore
Note: Colocalizes with BUB3 at kinetochores specifically during prometaphase.

GO - Cellular componenti

  1. condensed chromosome kinetochore Source: UniProtKB-SubCell
  2. cytoplasmic dynein complex Source: UniProtKB
  3. microtubule Source: UniProtKB-KW
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Dynein light chain Tctex-type 3PRO_0000195158Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41Nitrated tyrosineBy similarity

Keywords - PTMi

Nitration

Proteomic databases

MaxQBiP51808.
PaxDbiP51808.
PRIDEiP51808.

Expressioni

Gene expression databases

BgeeiP51808.
CleanExiHS_DYNLT3.
ExpressionAtlasiP51808. baseline and differential.
GenevestigatoriP51808.

Organism-specific databases

HPAiHPA003938.

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.By similarity2 Publications

Protein-protein interaction databases

BioGridi112850. 17 interactions.
IntActiP51808. 6 interactions.
MINTiMINT-1452735.
STRINGi9606.ENSP00000367841.

Structurei

3D structure databases

ProteinModelPortaliP51808.
SMRiP51808. Positions 13-114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG278055.
GeneTreeiENSGT00390000013998.
HOGENOMiHOG000255148.
HOVERGENiHBG001217.
InParanoidiP51808.
KOiK10420.
PhylomeDBiP51808.
TreeFamiTF313904.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PANTHERiPTHR21255. PTHR21255. 1 hit.
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ
60 70 80 90 100
SLTHLVKLGK AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN
110
RTMNCIVNVF AIAIVL
Length:116
Mass (Da):13,062
Last modified:October 1, 1996 - v1
Checksum:i7DEB2A8B9D989632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02556 mRNA. Translation: AAA57444.1.
AK311851 mRNA. Translation: BAG34793.1.
CR450320 mRNA. Translation: CAG29316.1.
CR542213 mRNA. Translation: CAG47009.1.
CH471141 Genomic DNA. Translation: EAW59452.1.
BC000968 mRNA. Translation: AAH00968.1.
CCDSiCCDS14243.1.
PIRiI38410.
RefSeqiNP_006511.1. NM_006520.2.
UniGeneiHs.446392.

Genome annotation databases

EnsembliENST00000378578; ENSP00000367841; ENSG00000165169.
GeneIDi6990.
KEGGihsa:6990.
UCSCiuc004dds.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02556 mRNA. Translation: AAA57444.1.
AK311851 mRNA. Translation: BAG34793.1.
CR450320 mRNA. Translation: CAG29316.1.
CR542213 mRNA. Translation: CAG47009.1.
CH471141 Genomic DNA. Translation: EAW59452.1.
BC000968 mRNA. Translation: AAH00968.1.
CCDSiCCDS14243.1.
PIRiI38410.
RefSeqiNP_006511.1. NM_006520.2.
UniGeneiHs.446392.

3D structure databases

ProteinModelPortaliP51808.
SMRiP51808. Positions 13-114.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112850. 17 interactions.
IntActiP51808. 6 interactions.
MINTiMINT-1452735.
STRINGi9606.ENSP00000367841.

Proteomic databases

MaxQBiP51808.
PaxDbiP51808.
PRIDEiP51808.

Protocols and materials databases

DNASUi6990.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378578; ENSP00000367841; ENSG00000165169.
GeneIDi6990.
KEGGihsa:6990.
UCSCiuc004dds.3. human.

Organism-specific databases

CTDi6990.
GeneCardsiGC0XM037696.
HGNCiHGNC:11694. DYNLT3.
HPAiHPA003938.
MIMi300302. gene.
neXtProtiNX_P51808.
PharmGKBiPA36414.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278055.
GeneTreeiENSGT00390000013998.
HOGENOMiHOG000255148.
HOVERGENiHBG001217.
InParanoidiP51808.
KOiK10420.
PhylomeDBiP51808.
TreeFamiTF313904.

Miscellaneous databases

GeneWikiiDYNLT3.
GenomeRNAii6990.
NextBioi27309.
PROiP51808.
SOURCEiSearch...

Gene expression databases

BgeeiP51808.
CleanExiHS_DYNLT3.
ExpressionAtlasiP51808. baseline and differential.
GenevestigatoriP51808.

Family and domain databases

InterProiIPR005334. Tctex.
[Graphical view]
PANTHERiPTHR21255. PTHR21255. 1 hit.
PfamiPF03645. Tctex-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex."
    Roux A.-F., Rommens J., McDowell C., Anson-Cartwright L., Bell S., Schappert K.T., Fishman G.A., Musarella M.
    Hum. Mol. Genet. 3:257-263(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  6. "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway."
    Yeh T.-Y., Chuang J.-Z., Sung C.-H.
    J. Cell Sci. 118:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SATB1, SUBCELLULAR LOCATION.
  7. "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3."
    Lo K.W., Kogoy J.M., Pfister K.K.
    J. Biol. Chem. 282:11205-11212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH BUB3, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDYLT3_HUMAN
AccessioniPrimary (citable) accession number: P51808
Secondary accession number(s): Q6ICS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 4, 2015
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was originally thought to be a candidate for RP3.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.