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Protein

Dynein light chain Tctex-type 3

Gene

DYNLT3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity).By similarity

Caution

Was originally thought to be a candidate for RP3.1 Publication

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • motor activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain Tctex-type 3
Alternative name(s):
Protein 91/23
T-complex-associated testis-expressed 1-like
Gene namesi
Name:DYNLT3
Synonyms:TCTE1L, TCTE1XL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000165169.10
HGNCiHGNC:11694 DYNLT3
MIMi300302 gene
neXtProtiNX_P51808

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, Microtubule, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6990
OpenTargetsiENSG00000165169
PharmGKBiPA36414

Polymorphism and mutation databases

BioMutaiDYNLT3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951581 – 116Dynein light chain Tctex-type 3Add BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4Nitrated tyrosineBy similarity1

Keywords - PTMi

Nitration

Proteomic databases

EPDiP51808
PaxDbiP51808
PeptideAtlasiP51808
PRIDEiP51808

PTM databases

CarbonylDBiP51808
iPTMnetiP51808
PhosphoSitePlusiP51808

Expressioni

Gene expression databases

BgeeiENSG00000165169
CleanExiHS_DYNLT3
ExpressionAtlasiP51808 baseline and differential
GenevisibleiP51808 HS

Organism-specific databases

HPAiHPA003938

Interactioni

Subunit structurei

Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 (By similarity). Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.By similarity2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi112850, 21 interactors
CORUMiP51808
IntActiP51808, 17 interactors
STRINGi9606.ENSP00000367841

Structurei

3D structure databases

ProteinModelPortaliP51808
SMRiP51808
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4081 Eukaryota
ENOG4111NHR LUCA
GeneTreeiENSGT00390000013998
HOGENOMiHOG000255148
HOVERGENiHBG001217
InParanoidiP51808
KOiK10420
PhylomeDBiP51808
TreeFamiTF313904

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit

Sequencei

Sequence statusi: Complete.

P51808-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ
60 70 80 90 100
SLTHLVKLGK AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN
110
RTMNCIVNVF AIAIVL
Length:116
Mass (Da):13,062
Last modified:October 1, 1996 - v1
Checksum:i7DEB2A8B9D989632
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02556 mRNA Translation: AAA57444.1
AK311851 mRNA Translation: BAG34793.1
CR450320 mRNA Translation: CAG29316.1
CR542213 mRNA Translation: CAG47009.1
CH471141 Genomic DNA Translation: EAW59452.1
BC000968 mRNA Translation: AAH00968.1
CCDSiCCDS14243.1
PIRiI38410
RefSeqiNP_006511.1, NM_006520.2
UniGeneiHs.446392

Genome annotation databases

EnsembliENST00000378578; ENSP00000367841; ENSG00000165169
GeneIDi6990
KEGGihsa:6990
UCSCiuc004dds.4 human

Similar proteinsi

Entry informationi

Entry nameiDYLT3_HUMAN
AccessioniPrimary (citable) accession number: P51808
Secondary accession number(s): Q6ICS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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