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P51808

- DYLT3_HUMAN

UniProt

P51808 - DYLT3_HUMAN

Protein

Dynein light chain Tctex-type 3

Gene

DYNLT3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis By similarity.By similarity

    GO - Molecular functioni

    1. motor activity Source: UniProtKB-KW

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. regulation of mitotic cell cycle Source: UniProtKB
    3. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Motor protein

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dynein light chain Tctex-type 3
    Alternative name(s):
    Protein 91/23
    T-complex-associated testis-expressed 1-like
    Gene namesi
    Name:DYNLT3
    Synonyms:TCTE1L, TCTE1XL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:11694. DYNLT3.

    Subcellular locationi

    Nucleus. Cytoplasmcytoskeleton. Chromosomecentromerekinetochore
    Note: Colocalizes with BUB3 at kinetochores specifically during prometaphase.

    GO - Cellular componenti

    1. condensed chromosome kinetochore Source: UniProtKB-SubCell
    2. cytoplasmic dynein complex Source: UniProtKB
    3. microtubule Source: UniProtKB-KW
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Centromere, Chromosome, Cytoplasm, Cytoskeleton, Dynein, Kinetochore, Microtubule, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36414.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 116116Dynein light chain Tctex-type 3PRO_0000195158Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei4 – 41Nitrated tyrosineBy similarity

    Keywords - PTMi

    Nitration

    Proteomic databases

    MaxQBiP51808.
    PaxDbiP51808.
    PRIDEiP51808.

    Expressioni

    Gene expression databases

    ArrayExpressiP51808.
    BgeeiP51808.
    CleanExiHS_DYNLT3.
    GenevestigatoriP51808.

    Organism-specific databases

    HPAiHPA003938.

    Interactioni

    Subunit structurei

    Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with DYNC1I1 and DYNC1I2 By similarity. Interacts with BUB3. Interacts with SATB1 in nucleus to form complex with matrix attachment regions (MARs) of DNA.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi112850. 16 interactions.
    IntActiP51808. 6 interactions.
    MINTiMINT-1452735.
    STRINGi9606.ENSP00000367841.

    Structurei

    3D structure databases

    ProteinModelPortaliP51808.
    SMRiP51808. Positions 13-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG278055.
    HOGENOMiHOG000255148.
    HOVERGENiHBG001217.
    KOiK10420.
    PhylomeDBiP51808.
    TreeFamiTF313904.

    Family and domain databases

    InterProiIPR005334. Tctex.
    [Graphical view]
    PANTHERiPTHR21255. PTHR21255. 1 hit.
    PfamiPF03645. Tctex-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P51808-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEYHRHCDE VGFNAEEAHN IVKECVDGVL GGEDYNHNNI NQWTASIVEQ    50
    SLTHLVKLGK AYKYIVTCAV VQKSAYGFHT ASSCFWDTTS DGTCTVRWEN 100
    RTMNCIVNVF AIAIVL 116
    Length:116
    Mass (Da):13,062
    Last modified:October 1, 1996 - v1
    Checksum:i7DEB2A8B9D989632
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02556 mRNA. Translation: AAA57444.1.
    AK311851 mRNA. Translation: BAG34793.1.
    CR450320 mRNA. Translation: CAG29316.1.
    CR542213 mRNA. Translation: CAG47009.1.
    CH471141 Genomic DNA. Translation: EAW59452.1.
    BC000968 mRNA. Translation: AAH00968.1.
    CCDSiCCDS14243.1.
    PIRiI38410.
    RefSeqiNP_006511.1. NM_006520.2.
    UniGeneiHs.446392.

    Genome annotation databases

    EnsembliENST00000378578; ENSP00000367841; ENSG00000165169.
    GeneIDi6990.
    KEGGihsa:6990.
    UCSCiuc004dds.3. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U02556 mRNA. Translation: AAA57444.1 .
    AK311851 mRNA. Translation: BAG34793.1 .
    CR450320 mRNA. Translation: CAG29316.1 .
    CR542213 mRNA. Translation: CAG47009.1 .
    CH471141 Genomic DNA. Translation: EAW59452.1 .
    BC000968 mRNA. Translation: AAH00968.1 .
    CCDSi CCDS14243.1.
    PIRi I38410.
    RefSeqi NP_006511.1. NM_006520.2.
    UniGenei Hs.446392.

    3D structure databases

    ProteinModelPortali P51808.
    SMRi P51808. Positions 13-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112850. 16 interactions.
    IntActi P51808. 6 interactions.
    MINTi MINT-1452735.
    STRINGi 9606.ENSP00000367841.

    Proteomic databases

    MaxQBi P51808.
    PaxDbi P51808.
    PRIDEi P51808.

    Protocols and materials databases

    DNASUi 6990.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000378578 ; ENSP00000367841 ; ENSG00000165169 .
    GeneIDi 6990.
    KEGGi hsa:6990.
    UCSCi uc004dds.3. human.

    Organism-specific databases

    CTDi 6990.
    GeneCardsi GC0XM037696.
    HGNCi HGNC:11694. DYNLT3.
    HPAi HPA003938.
    MIMi 300302. gene.
    neXtProti NX_P51808.
    PharmGKBi PA36414.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278055.
    HOGENOMi HOG000255148.
    HOVERGENi HBG001217.
    KOi K10420.
    PhylomeDBi P51808.
    TreeFami TF313904.

    Miscellaneous databases

    GeneWikii DYNLT3.
    GenomeRNAii 6990.
    NextBioi 27309.
    PROi P51808.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51808.
    Bgeei P51808.
    CleanExi HS_DYNLT3.
    Genevestigatori P51808.

    Family and domain databases

    InterProi IPR005334. Tctex.
    [Graphical view ]
    PANTHERi PTHR21255. PTHR21255. 1 hit.
    Pfami PF03645. Tctex-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a gene from Xp21 with similarity to the tctex-1 gene of the murine t complex."
      Roux A.-F., Rommens J., McDowell C., Anson-Cartwright L., Bell S., Schappert K.T., Fishman G.A., Musarella M.
      Hum. Mol. Genet. 3:257-263(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Subthalamic nucleus.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    6. "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway."
      Yeh T.-Y., Chuang J.-Z., Sung C.-H.
      J. Cell Sci. 118:3431-3443(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SATB1, SUBCELLULAR LOCATION.
    7. "The DYNLT3 light chain directly links cytoplasmic dynein to a spindle checkpoint protein, Bub3."
      Lo K.W., Kogoy J.M., Pfister K.K.
      J. Biol. Chem. 282:11205-11212(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH BUB3, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDYLT3_HUMAN
    AccessioniPrimary (citable) accession number: P51808
    Secondary accession number(s): Q6ICS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was originally thought to be a candidate for RP3.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3