P51805 (PLXA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plexin-A3

Alternative name(s):
Plexin-4
Semaphorin receptor SEX

Gene names

Name:	PLXNA3
Synonyms:	PLXN4, SEX

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1871 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.
Subunit structure	Interacts with CBFA2T3/MTG16. Ref.3
Subcellular location	Cell membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Traceable author statement. Source: Reactome hippocampus development Inferred from electronic annotation. Source: Compara negative chemotaxis Inferred from electronic annotation. Source: Compara negative regulation of axon extension involved in axon guidance Inferred from electronic annotation. Source: Compara positive regulation of cytoskeleton organization Inferred from electronic annotation. Source: Compara pyramidal neuron development Inferred from electronic annotation. Source: Compara semaphorin-plexin signaling pathway Non-traceable author statement PubMed 19909241. Source: BHF-UCL
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Traceable author statement. Source: Reactome semaphorin receptor complex Traceable author statement PubMed 19909241. Source: BHF-UCL
Molecular_function	semaphorin receptor activity Inferred from electronic annotation. Source: Compara transmembrane signaling receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 1871	1852	Plexin-A3		PRO_0000024670
Regions
	Topological domain	20 – 1220	1201	Extracellular Potential
	Transmembrane	1221 – 1241	21	Helical; Potential
	Topological domain	1242 – 1871	630	Cytoplasmic Potential
	Domain	20 – 488	469	Sema
	Domain	840 – 933	94	IPT/TIG 1
	Domain	935 – 1020	86	IPT/TIG 2
	Domain	1023 – 1122	100	IPT/TIG 3
	Domain	1125 – 1211	87	IPT/TIG 4
Amino acid modifications
	Glycosylation	59	1	N-linked (GlcNAc...) Potential
	Glycosylation	548	1	N-linked (GlcNAc...) Potential
	Glycosylation	637	1	N-linked (GlcNAc...) Potential
	Glycosylation	738	1	N-linked (GlcNAc...) Potential
	Glycosylation	746	1	N-linked (GlcNAc...) Potential
	Glycosylation	1009	1	N-linked (GlcNAc...) Potential
	Glycosylation	1036	1	N-linked (GlcNAc...) Potential
	Glycosylation	1073	1	N-linked (GlcNAc...) Potential
	Glycosylation	1115	1	N-linked (GlcNAc...) Potential
	Glycosylation	1162	1	N-linked (GlcNAc...) Potential
	Disulfide bond	77 ↔ 86		By similarity
	Disulfide bond	112 ↔ 120		By similarity
	Disulfide bond	266 ↔ 387		By similarity
	Disulfide bond	282 ↔ 338		By similarity
	Disulfide bond	356 ↔ 375		By similarity
	Disulfide bond	491 ↔ 508		By similarity
	Disulfide bond	497 ↔ 539		By similarity
	Disulfide bond	500 ↔ 517		By similarity
	Disulfide bond	511 ↔ 523		By similarity
	Disulfide bond	574 ↔ 594		By similarity
Natural variations
	Natural variant	384	1	G → S. Corresponds to variant rs34585333 [ dbSNP | Ensembl ].		VAR_050595
	Natural variant	413	1	G → S. Corresponds to variant rs36115591 [ dbSNP | Ensembl ].		VAR_050596
	Natural variant	863	1	D → E. Ref.1 Corresponds to variant rs5945430 [ dbSNP | Ensembl ].		VAR_050597
Experimental info
	Sequence conflict	222	1	F → L in CAA61132. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P51805 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: F0D21C3FD4CE9FBA	FASTA	1,871	207,703
	10 20 30 40 50 60 MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL 70 80 90 100 110 120 TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL LIDYAARRLV ACGSIWQGIC 130 140 150 160 170 180 QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT 190 200 210 220 230 240 LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT 250 260 270 280 290 300 LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP 310 320 330 340 350 360 GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE 370 380 390 400 410 420 GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLLADS TDGMASVAAY 430 440 450 460 470 480 TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL YETVPVVDGS PILRDLLFSP DHRHIYLLSE 490 500 510 520 530 540 KQVSQLPVET CEQYQSCAAC LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV 550 560 570 580 590 600 QVRVRPNNVS VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ 610 620 630 640 650 660 ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS PYPCHWCKYR 670 680 690 700 710 720 HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ PLTLRAKNLP QPQSGQKNYE 730 740 750 760 770 780 CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR 790 800 810 820 830 840 ALLYKCWAQR PSCGLCLKAD PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP 850 860 870 880 890 900 RITQIHPLVG PKEGGTRVTI VGDNLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE 910 920 930 940 950 960 SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG TRLTISGSSL 970 980 990 1000 1010 1020 DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP ITLAIDRANI SSPGLIYTYT 1030 1040 1050 1060 1070 1080 QDPTVTRLEP TWSIINGSTA ITVSGTHLLT VQEPRVRAKY RGIETTNTCQ VINDTAMLCK 1090 1100 1110 1120 1130 1140 APGIFLGRPQ PRAQGEHPDE FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP 1150 1160 1170 1180 1190 1200 GSHVVLKGKN LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG 1210 1220 1230 1240 1250 1260 LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD RTLKRLQLQM 1270 1280 1290 1300 1310 1320 DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR TYAVRVLFPG IEAHPVLKEL 1330 1340 1350 1360 1370 1380 DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL EAQSSFSMRD RGTVASLTMV ALQSRLDYAT 1390 1400 1410 1420 1430 1440 GLLKQLLADL IEKNLESKNH PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY 1450 1460 1470 1480 1490 1500 CAIKQQMEKG PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC 1510 1520 1530 1540 1550 1560 DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT KIECDWKRLN 1570 1580 1590 1600 1610 1620 SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES LLRTASSPDS LRSRAPMITP 1630 1640 1650 1660 1670 1680 DQETGTKLWH LVKNHDHADH REGDRGSKMV SEIYLTRLLA TKGTLQKFVD DLFETVFSTA 1690 1700 1710 1720 1730 1740 HRGSALPLAI KYMFDFLDEQ ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK 1750 1760 1770 1780 1790 1800 NSITDACLSV VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS 1810 1820 1830 1840 1850 1860 ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS CRKHKLRQKL 1870 EQIISLVSSD S

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor." Maestrini E., Tamagnone L., Longati P., Cremona O., Gulisano M., Bione S., Tamanini F., Neel B.G., Toniolo D., Comoglio P.M. Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-863. Tissue: Embryo, Fetal brain and Skeletal muscle.
[2]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner." Fiedler S.E., Schillace R.V., Daniels C.J., Andrews S.F., Carr D.W. FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH CBFA2T3/MTG16.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X87852 mRNA. Translation: CAA61132.1. BX936365 Genomic DNA. Translation: CAI43194.1.
IPI	IPI00020884.
RefSeq	NP_059984.2. NM_017514.3.
UniGene	Hs.632839.
3D structure databases
ProteinModelPortal	P51805.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-57386N.
STRING	9606.ENSP00000358696.
PTM databases
PhosphoSite	P51805.
Polymorphism databases
DMDM	118572690.
Proteomic databases
PaxDb	P51805.
PRIDE	P51805.
Protocols and materials databases
DNASU	55558.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369682; ENSP00000358696; ENSG00000130827.
GeneID	55558.
KEGG	hsa:55558.
UCSC	uc004flm.3. human.
Organism-specific databases
CTD	55558.
GeneCards	GC0XP153686.
H-InvDB	HIX0203329.
HGNC	HGNC:9101. PLXNA3.
MIM	300022. gene.
neXtProt	NX_P51805.
PharmGKB	PA33427.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG254546.
HOGENOM	HOG000231377.
HOVERGEN	HBG105711.
InParanoid	P51805.
KO	K06820.
OMA	GVMQPLT.
OrthoDB	EOG49W2DH.
PhylomeDB	P51805.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology.
Gene expression databases
Bgee	P51805.
CleanEx	HS_PLXNA3.
Genevestigator	P51805.
GermOnline	ENSG00000130827. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit. 2.60.40.10. 4 hits.
InterPro	IPR013783. Ig-like_fold. IPR014756. Ig_E-set. IPR002909. IPT_TIG_rcpt. IPR003659. Plexin-like. IPR016201. Plexin-like_fold. IPR013548. Plexin_cytoplasmic_RasGAP_dom. IPR002165. Plexin_repeat. IPR008936. Rho_GTPase_activation_prot. IPR001627. Semaphorin/CD100_Ag. IPR015943. WD40/YVTN_repeat-like_dom. [Graphical view]
Pfam	PF08337. Plexin_cytopl. 1 hit. PF01437. PSI. 3 hits. PF01403. Sema. 1 hit. PF01833. TIG. 4 hits. [Graphical view]
SMART	SM00429. IPT. 4 hits. SM00423. PSI. 3 hits. SM00630. Sema. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 4 hits. SSF103575. Plexin-like_fold. 2 hits. SSF48350. Rho_GAP. 1 hit. SSF101912. Sema. 1 hit.
PROSITE	PS51004. SEMA. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55558.
NextBio	60030.
SOURCE	Search...

Entry information

Entry name

PLXA3_HUMAN

Accession

Primary (citable) accession number: P51805
Secondary accession number(s): Q5HY36

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.