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P51805

- PLXA3_HUMAN

UniProt

P51805 - PLXA3_HUMAN

Protein

Plexin-A3

Gene

PLXNA3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. semaphorin receptor activity Source: Ensembl
    3. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: Reactome
    2. hippocampus development Source: Ensembl
    3. multicellular organismal development Source: UniProtKB
    4. negative chemotaxis Source: Ensembl
    5. negative regulation of axon extension involved in axon guidance Source: Ensembl
    6. positive regulation of cytoskeleton organization Source: Ensembl
    7. pyramidal neuron development Source: Ensembl
    8. semaphorin-plexin signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    ReactomeiREACT_19199. CRMPs in Sema3A signaling.
    REACT_19236. Sema3A PAK dependent Axon repulsion.
    REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plexin-A3
    Alternative name(s):
    Plexin-4
    Semaphorin receptor SEX
    Gene namesi
    Name:PLXNA3
    Synonyms:PLXN4, SEX
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:9101. PLXNA3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: InterPro
    3. membrane Source: UniProtKB
    4. plasma membrane Source: Reactome
    5. semaphorin receptor complex Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33427.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 18711852Plexin-A3PRO_0000024670Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
    Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
    Disulfide bondi266 ↔ 387PROSITE-ProRule annotation
    Disulfide bondi282 ↔ 338PROSITE-ProRule annotation
    Disulfide bondi356 ↔ 375PROSITE-ProRule annotation
    Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
    Disulfide bondi497 ↔ 539PROSITE-ProRule annotation
    Disulfide bondi500 ↔ 517PROSITE-ProRule annotation
    Disulfide bondi511 ↔ 523PROSITE-ProRule annotation
    Glycosylationi548 – 5481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi574 ↔ 594PROSITE-ProRule annotation
    Glycosylationi637 – 6371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi738 – 7381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi746 – 7461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1036 – 10361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1073 – 10731N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1115 – 11151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1162 – 11621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP51805.
    PaxDbiP51805.
    PRIDEiP51805.

    PTM databases

    PhosphoSiteiP51805.

    Expressioni

    Gene expression databases

    BgeeiP51805.
    CleanExiHS_PLXNA3.
    GenevestigatoriP51805.

    Interactioni

    Subunit structurei

    Interacts with CBFA2T3/MTG16.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CBFA2T3O750812EBI-7135904,EBI-1190217

    Protein-protein interaction databases

    BioGridi120717. 5 interactions.
    DIPiDIP-57386N.
    IntActiP51805. 6 interactions.
    MINTiMINT-7556947.
    STRINGi9606.ENSP00000358696.

    Structurei

    3D structure databases

    ProteinModelPortaliP51805.
    SMRiP51805. Positions 30-684, 1246-1869.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 12201201ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1242 – 1871630CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1221 – 124121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 488469SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini840 – 93394IPT/TIG 1Add
    BLAST
    Domaini935 – 102086IPT/TIG 2Add
    BLAST
    Domaini1023 – 1122100IPT/TIG 3Add
    BLAST
    Domaini1125 – 121187IPT/TIG 4Add
    BLAST

    Sequence similaritiesi

    Belongs to the plexin family.Curated
    Contains 4 IPT/TIG domains.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254546.
    HOGENOMiHOG000231377.
    HOVERGENiHBG105711.
    InParanoidiP51805.
    KOiK06820.
    OMAiNTEGMAS.
    OrthoDBiEOG7Q8CM9.
    PhylomeDBiP51805.
    TreeFamiTF312962.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 3 hits.
    PF01403. Sema. 1 hit.
    PF01833. TIG. 4 hits.
    [Graphical view]
    SMARTiSM00429. IPT. 4 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 4 hits.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P51805-1 [UniParc]FASTAAdd to Basket

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    MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV     50
    NRVFKLAPNL TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL 100
    LIDYAARRLV ACGSIWQGIC QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS 150
    MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT LSSRKLISDE DSADMFSLVY 200
    QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT LQLDTQQTLL 250
    DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP 300
    GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR 350
    RRIQSCYRGE GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV 400
    IEGLPLLADS TDGMASVAAY TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL 450
    YETVPVVDGS PILRDLLFSP DHRHIYLLSE KQVSQLPVET CEQYQSCAAC 500
    LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV QVRVRPNNVS 550
    VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ 600
    ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS 650
    PYPCHWCKYR HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ 700
    PLTLRAKNLP QPQSGQKNYE CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS 750
    YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR ALLYKCWAQR PSCGLCLKAD 800
    PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP RITQIHPLVG 850
    PKEGGTRVTI VGDNLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE 900
    SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG 950
    TRLTISGSSL DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP 1000
    ITLAIDRANI SSPGLIYTYT QDPTVTRLEP TWSIINGSTA ITVSGTHLLT 1050
    VQEPRVRAKY RGIETTNTCQ VINDTAMLCK APGIFLGRPQ PRAQGEHPDE 1100
    FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP GSHVVLKGKN 1150
    LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG 1200
    LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD 1250
    RTLKRLQLQM DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR 1300
    TYAVRVLFPG IEAHPVLKEL DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL 1350
    EAQSSFSMRD RGTVASLTMV ALQSRLDYAT GLLKQLLADL IEKNLESKNH 1400
    PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY CAIKQQMEKG 1450
    PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC 1500
    DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT 1550
    KIECDWKRLN SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES 1600
    LLRTASSPDS LRSRAPMITP DQETGTKLWH LVKNHDHADH REGDRGSKMV 1650
    SEIYLTRLLA TKGTLQKFVD DLFETVFSTA HRGSALPLAI KYMFDFLDEQ 1700
    ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK NSITDACLSV 1750
    VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS 1800
    ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS 1850
    CRKHKLRQKL EQIISLVSSD S 1871
    Length:1,871
    Mass (Da):207,703
    Last modified:November 28, 2006 - v2
    Checksum:iF0D21C3FD4CE9FBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti222 – 2221F → L in CAA61132. (PubMed:8570614)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti384 – 3841G → S.
    Corresponds to variant rs34585333 [ dbSNP | Ensembl ].
    VAR_050595
    Natural varianti413 – 4131G → S.
    Corresponds to variant rs36115591 [ dbSNP | Ensembl ].
    VAR_050596
    Natural varianti863 – 8631D → E.1 Publication
    Corresponds to variant rs5945430 [ dbSNP | Ensembl ].
    VAR_050597

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87852 mRNA. Translation: CAA61132.1.
    BX936365 Genomic DNA. Translation: CAI43194.1.
    CCDSiCCDS14752.1.
    RefSeqiNP_059984.3. NM_017514.4.
    UniGeneiHs.632839.

    Genome annotation databases

    EnsembliENST00000369682; ENSP00000358696; ENSG00000130827.
    GeneIDi55558.
    KEGGihsa:55558.
    UCSCiuc004flm.3. human.

    Polymorphism databases

    DMDMi118572690.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X87852 mRNA. Translation: CAA61132.1 .
    BX936365 Genomic DNA. Translation: CAI43194.1 .
    CCDSi CCDS14752.1.
    RefSeqi NP_059984.3. NM_017514.4.
    UniGenei Hs.632839.

    3D structure databases

    ProteinModelPortali P51805.
    SMRi P51805. Positions 30-684, 1246-1869.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120717. 5 interactions.
    DIPi DIP-57386N.
    IntActi P51805. 6 interactions.
    MINTi MINT-7556947.
    STRINGi 9606.ENSP00000358696.

    PTM databases

    PhosphoSitei P51805.

    Polymorphism databases

    DMDMi 118572690.

    Proteomic databases

    MaxQBi P51805.
    PaxDbi P51805.
    PRIDEi P51805.

    Protocols and materials databases

    DNASUi 55558.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369682 ; ENSP00000358696 ; ENSG00000130827 .
    GeneIDi 55558.
    KEGGi hsa:55558.
    UCSCi uc004flm.3. human.

    Organism-specific databases

    CTDi 55558.
    GeneCardsi GC0XP153686.
    H-InvDB HIX0203329.
    HGNCi HGNC:9101. PLXNA3.
    MIMi 300022. gene.
    neXtProti NX_P51805.
    PharmGKBi PA33427.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG254546.
    HOGENOMi HOG000231377.
    HOVERGENi HBG105711.
    InParanoidi P51805.
    KOi K06820.
    OMAi NTEGMAS.
    OrthoDBi EOG7Q8CM9.
    PhylomeDBi P51805.
    TreeFami TF312962.

    Enzyme and pathway databases

    Reactomei REACT_19199. CRMPs in Sema3A signaling.
    REACT_19236. Sema3A PAK dependent Axon repulsion.
    REACT_19279. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.

    Miscellaneous databases

    GeneWikii PLXNA3.
    GenomeRNAii 55558.
    NextBioi 60030.
    PROi P51805.
    SOURCEi Search...

    Gene expression databases

    Bgeei P51805.
    CleanExi HS_PLXNA3.
    Genevestigatori P51805.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 3 hits.
    PF01403. Sema. 1 hit.
    PF01833. TIG. 4 hits.
    [Graphical view ]
    SMARTi SM00429. IPT. 4 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 4 hits.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor."
      Maestrini E., Tamagnone L., Longati P., Cremona O., Gulisano M., Bione S., Tamanini F., Neel B.G., Toniolo D., Comoglio P.M.
      Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-863.
      Tissue: Embryo, Fetal brain and Skeletal muscle.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner."
      Fiedler S.E., Schillace R.V., Daniels C.J., Andrews S.F., Carr D.W.
      FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBFA2T3/MTG16.

    Entry informationi

    Entry nameiPLXA3_HUMAN
    AccessioniPrimary (citable) accession number: P51805
    Secondary accession number(s): Q5HY36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3