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P51805 (PLXA3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 129. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Plexin-A3
Alternative name(s):
Plexin-4
Semaphorin receptor SEX
Gene names
Name:PLXNA3
Synonyms:PLXN4, SEX
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1871 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Subunit structure

Interacts with CBFA2T3/MTG16. Ref.3

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the plexin family.

Contains 4 IPT/TIG domains.

Contains 1 Sema domain.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainRepeat
Signal
Transmembrane
Transmembrane helix
   Molecular functionReceptor
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaxon guidance

Traceable author statement. Source: Reactome

hippocampus development

Inferred from electronic annotation. Source: Ensembl

multicellular organismal development

Traceable author statement Ref.1. Source: UniProtKB

negative chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of axon extension involved in axon guidance

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

pyramidal neuron development

Inferred from electronic annotation. Source: Ensembl

semaphorin-plexin signaling pathway

Non-traceable author statement PubMed 19909241. Source: BHF-UCL

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular

Inferred from electronic annotation. Source: InterPro

membrane

Traceable author statement Ref.1. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

semaphorin receptor complex

Traceable author statement PubMed 19909241. Source: BHF-UCL

   Molecular_functionprotein binding

Inferred from physical interaction Ref.3. Source: IntAct

semaphorin receptor activity

Inferred from electronic annotation. Source: Ensembl

transmembrane signaling receptor activity

Non-traceable author statement Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CBFA2T3O750812EBI-7135904,EBI-1190217

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 18711852Plexin-A3
PRO_0000024670

Regions

Topological domain20 – 12201201Extracellular Potential
Transmembrane1221 – 124121Helical; Potential
Topological domain1242 – 1871630Cytoplasmic Potential
Domain20 – 488469Sema
Domain840 – 93394IPT/TIG 1
Domain935 – 102086IPT/TIG 2
Domain1023 – 1122100IPT/TIG 3
Domain1125 – 121187IPT/TIG 4

Amino acid modifications

Glycosylation591N-linked (GlcNAc...) Potential
Glycosylation5481N-linked (GlcNAc...) Potential
Glycosylation6371N-linked (GlcNAc...) Potential
Glycosylation7381N-linked (GlcNAc...) Potential
Glycosylation7461N-linked (GlcNAc...) Potential
Glycosylation10091N-linked (GlcNAc...) Potential
Glycosylation10361N-linked (GlcNAc...) Potential
Glycosylation10731N-linked (GlcNAc...) Potential
Glycosylation11151N-linked (GlcNAc...) Potential
Glycosylation11621N-linked (GlcNAc...) Potential
Disulfide bond77 ↔ 86 By similarity
Disulfide bond112 ↔ 120 By similarity
Disulfide bond266 ↔ 387 By similarity
Disulfide bond282 ↔ 338 By similarity
Disulfide bond356 ↔ 375 By similarity
Disulfide bond491 ↔ 508 By similarity
Disulfide bond497 ↔ 539 By similarity
Disulfide bond500 ↔ 517 By similarity
Disulfide bond511 ↔ 523 By similarity
Disulfide bond574 ↔ 594 By similarity

Natural variations

Natural variant3841G → S.
Corresponds to variant rs34585333 [ dbSNP | Ensembl ].
VAR_050595
Natural variant4131G → S.
Corresponds to variant rs36115591 [ dbSNP | Ensembl ].
VAR_050596
Natural variant8631D → E. Ref.1
Corresponds to variant rs5945430 [ dbSNP | Ensembl ].
VAR_050597

Experimental info

Sequence conflict2221F → L in CAA61132. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P51805 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: F0D21C3FD4CE9FBA

FASTA1,871207,703
        10         20         30         40         50         60 
MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV NRVFKLAPNL 

        70         80         90        100        110        120 
TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL LIDYAARRLV ACGSIWQGIC 

       130        140        150        160        170        180 
QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT 

       190        200        210        220        230        240 
LSSRKLISDE DSADMFSLVY QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT 

       250        260        270        280        290        300 
LQLDTQQTLL DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP 

       310        320        330        340        350        360 
GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR RRIQSCYRGE 

       370        380        390        400        410        420 
GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV IEGLPLLADS TDGMASVAAY 

       430        440        450        460        470        480 
TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL YETVPVVDGS PILRDLLFSP DHRHIYLLSE 

       490        500        510        520        530        540 
KQVSQLPVET CEQYQSCAAC LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV 

       550        560        570        580        590        600 
QVRVRPNNVS VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ 

       610        620        630        640        650        660 
ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS PYPCHWCKYR 

       670        680        690        700        710        720 
HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ PLTLRAKNLP QPQSGQKNYE 

       730        740        750        760        770        780 
CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR 

       790        800        810        820        830        840 
ALLYKCWAQR PSCGLCLKAD PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP 

       850        860        870        880        890        900 
RITQIHPLVG PKEGGTRVTI VGDNLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE 

       910        920        930        940        950        960 
SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG TRLTISGSSL 

       970        980        990       1000       1010       1020 
DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP ITLAIDRANI SSPGLIYTYT 

      1030       1040       1050       1060       1070       1080 
QDPTVTRLEP TWSIINGSTA ITVSGTHLLT VQEPRVRAKY RGIETTNTCQ VINDTAMLCK 

      1090       1100       1110       1120       1130       1140 
APGIFLGRPQ PRAQGEHPDE FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP 

      1150       1160       1170       1180       1190       1200 
GSHVVLKGKN LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG 

      1210       1220       1230       1240       1250       1260 
LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD RTLKRLQLQM 

      1270       1280       1290       1300       1310       1320 
DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR TYAVRVLFPG IEAHPVLKEL 

      1330       1340       1350       1360       1370       1380 
DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL EAQSSFSMRD RGTVASLTMV ALQSRLDYAT 

      1390       1400       1410       1420       1430       1440 
GLLKQLLADL IEKNLESKNH PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY 

      1450       1460       1470       1480       1490       1500 
CAIKQQMEKG PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC 

      1510       1520       1530       1540       1550       1560 
DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT KIECDWKRLN 

      1570       1580       1590       1600       1610       1620 
SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES LLRTASSPDS LRSRAPMITP 

      1630       1640       1650       1660       1670       1680 
DQETGTKLWH LVKNHDHADH REGDRGSKMV SEIYLTRLLA TKGTLQKFVD DLFETVFSTA 

      1690       1700       1710       1720       1730       1740 
HRGSALPLAI KYMFDFLDEQ ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK 

      1750       1760       1770       1780       1790       1800 
NSITDACLSV VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS 

      1810       1820       1830       1840       1850       1860 
ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS CRKHKLRQKL 

      1870 
EQIISLVSSD S 

« Hide

References

« Hide 'large scale' references
[1]"A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor."
Maestrini E., Tamagnone L., Longati P., Cremona O., Gulisano M., Bione S., Tamanini F., Neel B.G., Toniolo D., Comoglio P.M.
Proc. Natl. Acad. Sci. U.S.A. 93:674-678(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLU-863.
Tissue: Embryo, Fetal brain and Skeletal muscle.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"Myeloid translocation gene 16b is a dual A-kinase anchoring protein that interacts selectively with plexins in a phospho-regulated manner."
Fiedler S.E., Schillace R.V., Daniels C.J., Andrews S.F., Carr D.W.
FEBS Lett. 584:873-877(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH CBFA2T3/MTG16.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X87852 mRNA. Translation: CAA61132.1.
BX936365 Genomic DNA. Translation: CAI43194.1.
CCDSCCDS14752.1.
RefSeqNP_059984.3. NM_017514.4.
UniGeneHs.632839.

3D structure databases

ProteinModelPortalP51805.
SMRP51805. Positions 30-684, 1246-1869.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120717. 5 interactions.
DIPDIP-57386N.
IntActP51805. 6 interactions.
MINTMINT-7556947.
STRING9606.ENSP00000358696.

PTM databases

PhosphoSiteP51805.

Polymorphism databases

DMDM118572690.

Proteomic databases

MaxQBP51805.
PaxDbP51805.
PRIDEP51805.

Protocols and materials databases

DNASU55558.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369682; ENSP00000358696; ENSG00000130827.
GeneID55558.
KEGGhsa:55558.
UCSCuc004flm.3. human.

Organism-specific databases

CTD55558.
GeneCardsGC0XP153686.
H-InvDBHIX0203329.
HGNCHGNC:9101. PLXNA3.
MIM300022. gene.
neXtProtNX_P51805.
PharmGKBPA33427.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG254546.
HOGENOMHOG000231377.
HOVERGENHBG105711.
InParanoidP51805.
KOK06820.
OMANTEGMAS.
OrthoDBEOG7Q8CM9.
PhylomeDBP51805.
TreeFamTF312962.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

BgeeP51805.
CleanExHS_PLXNA3.
GenevestigatorP51805.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPLXNA3.
GenomeRNAi55558.
NextBio60030.
PROP51805.
SOURCESearch...

Entry information

Entry namePLXA3_HUMAN
AccessionPrimary (citable) accession number: P51805
Secondary accession number(s): Q5HY36
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 28, 2006
Last modified: July 9, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM