##gff-version 3 P51801 UniProtKB Chain 1 687 . . . ID=PRO_0000094459;Note=Chloride channel protein ClC-Kb P51801 UniProtKB Topological domain 1 50 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 51 82 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 91 111 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Intramembrane 116 127 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 141 160 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 161 180 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Intramembrane 203 224 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 236 255 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 282 310 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 325 342 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Intramembrane 349 360 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 400 420 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 421 440 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Intramembrane 464 496 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Transmembrane 500 520 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Topological domain 521 687 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P35523 P51801 UniProtKB Domain 551 609 . . . Note=CBS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703 P51801 UniProtKB Domain 626 684 . . . Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703 P51801 UniProtKB Binding site 121 121 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P37019 P51801 UniProtKB Binding site 259 259 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51801 UniProtKB Binding site 261 261 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51801 UniProtKB Binding site 278 278 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51801 UniProtKB Binding site 281 281 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51801 UniProtKB Binding site 426 426 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P37019 P51801 UniProtKB Glycosylation 193 193 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 P51801 UniProtKB Alternative sequence 1 49 . . . ID=VSP_045965;Note=In isoform 2. MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGED->MPCPPLLSVPVRAAGEQDRWVREEVTWGGGPTVTGGWGWRAHLRSVSPP;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P51801 UniProtKB Alternative sequence 50 218 . . . ID=VSP_045966;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P51801 UniProtKB Alternative sequence 616 616 . . . ID=VSP_045967;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P51801 UniProtKB Natural variant 4 4 . . . ID=VAR_033770;Note=F->L;Dbxref=dbSNP:rs34851419 P51801 UniProtKB Natural variant 27 27 . . . ID=VAR_046797;Note=R->L;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8041726,ECO:0000269|PubMed:8544406;Dbxref=dbSNP:rs2015352,PMID:8041726,PMID:8544406 P51801 UniProtKB Natural variant 88 88 . . . ID=VAR_014466;Note=S->R;Dbxref=dbSNP:rs5256 P51801 UniProtKB Natural variant 104 104 . . . ID=VAR_033771;Note=V->I;Dbxref=dbSNP:rs35530360 P51801 UniProtKB Natural variant 124 124 . . . ID=VAR_001624;Note=In BARTS3. P->L;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909131,PMID:9326936 P51801 UniProtKB Natural variant 143 143 . . . ID=VAR_014467;Note=N->H;Dbxref=dbSNP:rs5259 P51801 UniProtKB Natural variant 204 204 . . . ID=VAR_001625;Note=In BARTS3. A->T;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909132,PMID:9326936 P51801 UniProtKB Natural variant 214 214 . . . ID=VAR_033772;Note=A->G;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8041726,ECO:0000269|PubMed:8544406;Dbxref=dbSNP:rs1889789,PMID:8041726,PMID:8544406 P51801 UniProtKB Natural variant 287 287 . . . ID=VAR_069104;Note=A->V;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:8041726,ECO:0000269|PubMed:8544406;Dbxref=dbSNP:rs7367494,PMID:14702039,PMID:8041726,PMID:8544406 P51801 UniProtKB Natural variant 334 334 . . . ID=VAR_014468;Note=V->L;Dbxref=dbSNP:rs5251 P51801 UniProtKB Natural variant 349 349 . . . ID=VAR_001626;Note=In BARTS3. A->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909134,PMID:9326936 P51801 UniProtKB Natural variant 395 395 . . . ID=VAR_046799;Note=R->W;Dbxref=dbSNP:rs34255952 P51801 UniProtKB Natural variant 419 419 . . . ID=VAR_033773;Note=I->V;Dbxref=dbSNP:rs6650119 P51801 UniProtKB Natural variant 432 432 . . . ID=VAR_001627;Note=In BARTS3. Y->H;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909135,PMID:9326936 P51801 UniProtKB Natural variant 438 438 . . . ID=VAR_001628;Note=In BARTS3. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:9326936;Dbxref=dbSNP:rs121909133,PMID:9326936 P51801 UniProtKB Natural variant 481 481 . . . ID=VAR_046800;Note=T->S;Dbxref=dbSNP:rs12140311 P51801 UniProtKB Natural variant 562 562 . . . ID=VAR_014469;Note=M->T;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8041726,ECO:0000269|PubMed:8544406;Dbxref=dbSNP:rs5253,PMID:8041726,PMID:8544406 P51801 UniProtKB Natural variant 578 578 . . . ID=VAR_024409;Note=K->E;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:8041726,ECO:0000269|PubMed:8544406;Dbxref=dbSNP:rs2275166,PMID:8041726,PMID:8544406 P51801 UniProtKB Natural variant 660 660 . . . ID=VAR_046801;Note=S->L;Dbxref=dbSNP:rs5255 P51801 UniProtKB Sequence conflict 609 609 . . . Note=S->P;Ontology_term=ECO:0000305;evidence=ECO:0000305