##gff-version 3 P51797 UniProtKB Chain 1 869 . . . ID=PRO_0000094449;Note=H(+)/Cl(-) exchange transporter 6 P51797 UniProtKB Topological domain 1 80 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 81 113 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 128 150 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 159 166 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 176 194 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 200 217 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 241 253 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 257 265 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 277 294 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 335 364 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 371 392 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 462 481 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 487 511 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 519 533 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 534 536 . . . Note=Note%3DLoop between two helices;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 537 548 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Intramembrane 549 552 . . . Note=Note%3DLoop between two helices;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Transmembrane 553 571 . . . Note=Helical;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Topological domain 572 869 . . . Note=Cytoplasmic;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Domain 605 662 . . . Note=CBS 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703 P51797 UniProtKB Domain 807 868 . . . Note=CBS 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00703 P51797 UniProtKB Motif 156 160 . . . Note=Selectivity filter part_1;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Motif 198 202 . . . Note=Selectivity filter part_2;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Motif 487 491 . . . Note=Selectivity filter part_3;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Binding site 157 157 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Binding site 489 489 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Binding site 576 576 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Binding site 630 632 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Binding site 849 852 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Site 200 200 . . . Note=Mediates proton transfer from the outer aqueous phase to the interior of the protein%3B involved in linking H(+) and Cl(-) transport;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Site 267 267 . . . Note=Mediates proton transfer from the protein to the inner aqueous phase;Ontology_term=ECO:0000250;evidence=ECO:0000250 P51797 UniProtKB Modified residue 773 773 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O35454 P51797 UniProtKB Glycosylation 410 410 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17534424;Dbxref=PMID:17534424 P51797 UniProtKB Glycosylation 422 422 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17534424;Dbxref=PMID:17534424 P51797 UniProtKB Glycosylation 432 432 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17534424;Dbxref=PMID:17534424 P51797 UniProtKB Alternative sequence 50 71 . . . ID=VSP_047169;Note=In isoform 6. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 P51797 UniProtKB Alternative sequence 237 320 . . . ID=VSP_001043;Note=In isoform 2. DKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCS->YGKRQERLCISRSGCWSCCSFRGANRGYLVQSRGGFVLLEPRAHVESALLFHVCHLHPQLLPFWDSVWKLGFLPAPWIAELWRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224655;Dbxref=PMID:9224655 P51797 UniProtKB Alternative sequence 237 308 . . . ID=VSP_001047;Note=In isoform 4. DKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQL->SGCWSCCSFRGANRGYLVQSRGGFVLLEPRAHVESALLFHVCHLHPQLLPFWDSVWKLGFLPAPWIAELWRV;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224655;Dbxref=PMID:9224655 P51797 UniProtKB Alternative sequence 309 869 . . . ID=VSP_001048;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224655;Dbxref=PMID:9224655 P51797 UniProtKB Alternative sequence 319 353 . . . ID=VSP_001045;Note=In isoform 3. CSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNC->SLREPPCVSGNHRGGVCGLDGVRRMPTDVLFESNR;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224655;Dbxref=PMID:9224655 P51797 UniProtKB Alternative sequence 321 869 . . . ID=VSP_001044;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224655;Dbxref=PMID:9224655 P51797 UniProtKB Alternative sequence 354 869 . . . ID=VSP_001046;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9224655;Dbxref=PMID:9224655 P51797 UniProtKB Alternative sequence 844 869 . . . ID=VSP_017188;Note=In isoform 5. IVGIITRHNLTYEFLQARLRQHYQTI->VSEAPALPPPLREDPLARCCLCTQASHQKRRHPTRRGECGPTLALNPARLPCTRDPFPCLPADGTSVPLAVLSSQSRASTRLCLPPEMLLFTPYHWCSLVLHLRRDLRIR;Ontology_term=ECO:0000305;evidence=ECO:0000305 P51797 UniProtKB Natural variant 198 198 . . . ID=VAR_023051;Note=E->G;Ontology_term=ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:10500249,ECO:0000269|PubMed:14702039,ECO:0000269|PubMed:15489334,ECO:0000269|PubMed:7584044,ECO:0000269|PubMed:8543009,ECO:0000269|PubMed:9224655,ECO:0000269|Ref.8;Dbxref=dbSNP:rs198400,PMID:10500249,PMID:14702039,PMID:15489334,PMID:7584044,PMID:8543009,PMID:9224655 P51797 UniProtKB Natural variant 553 553 . . . ID=VAR_085384;Note=In CONRIBA%3B strongly slowed gating and increased current amplitudes. Y->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:33217309;Dbxref=dbSNP:rs1644918844,PMID:33217309 P51797 UniProtKB Mutagenesis 157 157 . . . Note=Increases the nitrate/chloride conductance ratio. S->P;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20466723;Dbxref=PMID:20466723 P51797 UniProtKB Mutagenesis 200 200 . . . Note=Abolishes proton transport%2C but not chloride transport. Strongly increases anion current%3B when associated with S-576. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20466723;Dbxref=PMID:20466723 P51797 UniProtKB Mutagenesis 267 267 . . . Note=Loss of proton and chloride transport. E->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20466723;Dbxref=PMID:20466723 P51797 UniProtKB Mutagenesis 410 410 . . . Note=Abolishes N-glycosylation%3B when associated with A-422 and A-432. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17534424;Dbxref=PMID:17534424 P51797 UniProtKB Mutagenesis 422 422 . . . Note=Abolishes N-glycosylation%3B when associated with A-410 and A-432. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17534424;Dbxref=PMID:17534424 P51797 UniProtKB Mutagenesis 432 432 . . . Note=Abolishes N-glycosylation%3B when associated with A-410 and A-422. N->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:17534424;Dbxref=PMID:17534424 P51797 UniProtKB Mutagenesis 576 576 . . . Note=Strongly increases anion current%3B when associated with A-200. Y->S;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:20466723;Dbxref=PMID:20466723 P51797 UniProtKB Sequence conflict 19 19 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 P51797 UniProtKB Sequence conflict 92 92 . . . Note=G->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 P51797 UniProtKB Sequence conflict 442 442 . . . Note=F->S;Ontology_term=ECO:0000305;evidence=ECO:0000305