Reviewed, UniProtKB/Swiss-Prot P51797 (CLCN6_HUMAN)

Names and origin

Protein names

Recommended name:
    Chloride transport protein 6
      Short name=ClC-6

Gene names

Name:	CLCN6
Synonyms:	KIAA0046

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	869 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Chloride transport protein, initially identified as voltage-gated chloride channel. The presence of the conserved gating glutamate residues suggests that is functions as antiporter.
Subcellular location	Endosome membrane; Multi-pass membrane protein. Note: Detected in detergent-resistant lipid rafts.
Tissue specificity	Testis, ovary, small intestine, brain and skeletal muscle. Low level expression in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Isoform C is only detected in kidney. Ref.1 Ref.2 Ref.8
Post-translational modification	N-glycosylated on several asparagine residues.
Miscellaneous	The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters By similarity.
Sequence similarities	Belongs to the chloride channel (TC 2.A.49) family. [View classification] Contains 2 CBS domains.

Ontologies

Keywords
Biological process	Antiport Ion transport Transport
Cellular component	Endosome Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	CBS domain Repeat Transmembrane
Ligand	ATP-binding Chloride Nucleotide-binding
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	cell volume homeostasis Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB chloride transport Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB signal transduction Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB
Cellular component	integral to membrane Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB
Molecular function	chloride ion binding Inferred from electronic annotation. Source: UniProtKB-KW voltage-gated chloride channel activity Ref.1 Ref.2 Non-traceable author statement. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P51797-1)

Also known as: Clc-6a;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P51797-2)

Also known as: ClC-6b; D2-A1;

The sequence of this isoform differs from the canonical sequence as follows:
     237-320: DKRDFVSAGA...LLNFGEFKCS → YGKRQERLCI...APWIAELWRV
     321-869: Missing.

Isoform C (identifier: P51797-3)

Also known as: ClC-6c; D1-A1;

The sequence of this isoform differs from the canonical sequence as follows:
     319-353: CSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNC → SLREPPCVSGNHRGGVCGLDGVRRMPTDVLFESNR
     354-869: Missing.

Isoform D (identifier: P51797-4)

Also known as: ClC-6d; D1-A2;

The sequence of this isoform differs from the canonical sequence as follows:
     237-308: DKRDFVSAGA...QFGSWGSFQL → SGCWSCCSFR...APWIAELWRV
     309-869: Missing.

Isoform E (identifier: P51797-5)

The sequence of this isoform differs from the canonical sequence as follows:
     844-869: IVGIITRHNLTYEFLQARLRQHYQTI → VSEAPALPPP...LHLRRDLRIR

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 869	869	Chloride transport protein 6		PRO_0000094449
Regions
	Topological domain	1 – 80	80	Cytoplasmic By similarity
	Transmembrane	81 – 113	33	By similarity
	Transmembrane	128 – 150	23	By similarity
	Transmembrane	176 – 194	19	By similarity
	Transmembrane	200 – 217	18	By similarity
	Transmembrane	277 – 294	18	By similarity
	Transmembrane	335 – 364	30	By similarity
	Transmembrane	371 – 392	22	By similarity
	Transmembrane	462 – 481	20	By similarity
	Transmembrane	487 – 511	25	By similarity
	Transmembrane	553 – 571	19	By similarity
	Topological domain	572 – 869	298	Cytoplasmic By similarity
	Domain	605 – 662	58	CBS 1
	Domain	807 – 868	62	CBS 2
	Nucleotide binding	630 – 632	3	ATP By similarity
	Nucleotide binding	849 – 852	4	ATP By similarity
	Region	159 – 166	8	In-membrane helix By similarity
	Region	241 – 253	13	In-membrane helix By similarity
	Region	257 – 265	9	In-membrane helix By similarity
	Region	519 – 533	15	In-membrane helix By similarity
	Region	534 – 536	3	In-membrane loop between two helices By similarity
	Region	537 – 548	12	In-membrane helix By similarity
	Region	549 – 552	4	In-membrane loop between two helices By similarity
	Motif	156 – 160	5	Selectivity filter part_1 By similarity
	Motif	198 – 202	5	Selectivity filter part_2 By similarity
	Motif	487 – 491	5	Selectivity filter part_3 By similarity
	Compositional bias	4 – 18	15	Cys-rich
Sites
	Binding site	157	1	Chloride By similarity
	Binding site	489	1	Chloride; via amide nitrogen By similarity
	Binding site	576	1	Chloride By similarity
	Site	200	1	Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport By similarity
	Site	267	1	Mediates proton transfer from the protein to the inner aqueous phase By similarity
Amino acid modifications
	Glycosylation	410	1	N-linked (GlcNAc...)
	Glycosylation	422	1	N-linked (GlcNAc...)
	Glycosylation	432	1	N-linked (GlcNAc...)
Natural variations
	Alternative sequence	237 – 320	84	DKRDF…EFKCS → YGKRQERLCISRSGCWSCCS FRGANRGYLVQSRGGFVLLE PRAHVESALLFHVCHLHPQL LPFWDSVWKLGFLPAPWIAE LWRV in isoform B.		VSP_001043
	Alternative sequence	237 – 308	72	DKRDF…GSFQL → SGCWSCCSFRGANRGYLVQS RGGFVLLEPRAHVESALLFH VCHLHPQLLPFWDSVWKLGF LPAPWIAELWRV in isoform D.		VSP_001047
	Alternative sequence	309 – 869	561	Missing in isoform D.		VSP_001048
	Alternative sequence	319 – 353	35	CSDSD…ATFNC → SLREPPCVSGNHRGGVCGLD GVRRMPTDVLFESNR in isoform C.		VSP_001045
	Alternative sequence	321 – 869	549	Missing in isoform B.		VSP_001044
	Alternative sequence	354 – 869	516	Missing in isoform C.		VSP_001046
	Alternative sequence	844 – 869	26	IVGII…HYQTI → VSEAPALPPPLREDPLARCC LCTQASHQKRRHPTRRGECG PTLALNPARLPCTRDPFPCL PADGTSVPLAVLSSQSRAST RLCLPPEMLLFTPYHWCSLV LHLRRDLRIR in isoform E.		VSP_017188
	Natural variant	198	1	G → E: dbSNP rs198400. Ref.6		VAR_023051
Experimental info
	Mutagenesis	410	1	N → A: Abolishes N-glycosylation; when associated with A-422 and A-432.
	Mutagenesis	422	1	N → A: Abolishes N-glycosylation; when associated with A-410 and A-432.
	Mutagenesis	432	1	N → A: Abolishes N-glycosylation; when associated with A-410 and A-422.

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (Clc-6a) [UniParc]. Last modified October 1, 1996. Version 1. Checksum: E4273777D9FF4328	FASTA	869	97,217
	10 20 30 40 50 60 MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP 70 80 90 100 110 120 YLEVLETMDN KKGRRYEAVK WMVVFAIGVC TGLVGLFVDF FVRLFTQLKF GVVQTSVEEC 130 140 150 160 170 180 SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EVKCYLNGVK VPGIVRLRTL 190 200 210 220 230 240 LCKVLGVLFS VAGGLFVGKE GPMIHSGSVV GAGLPQFQSI SLRKIQFNFP YFRSDRDKRD 250 260 270 280 290 300 FVSAGAAAGV AAAFGAPIGG TLFSLEEGSS FWNQGLTWKV LFCSMSATFT LNFFRSGIQF 310 320 330 340 350 360 GSWGSFQLPG LLNFGEFKCS DSDKKCHLWT AMDLGFFVVM GVIGGLLGAT FNCLNKRLAK 370 380 390 400 410 420 YRMRNVHPKP KLVRVLESLL VSLVTTVVVF VASMVLGECR QMSSSSQIGN DSFQLQVTED 430 440 450 460 470 480 VNSSIKTFFC PNDTYNDMAT LFFNPQESAI LQLFHQDGTF SPVTLALFFV LYFLLACWTY 490 500 510 520 530 540 GISVPSGLFV PSLLCGAAFG RLVANVLKSY IGLGHIYSGT FALIGAAAFL GGVVRMTISL 550 560 570 580 590 600 TVILIESTNE ITYGLPIMVT LMVAKWTGDF FNKGIYDIHV GLRGVPLLEW ETEVEMDKLR 610 620 630 640 650 660 ASDIMEPNLT YVYPHTRIQS LVSILRTTVH HAFPVVTENR GNEKEFMKGN QLISNNIKFK 670 680 690 700 710 720 KSSILTRAGE QRKRSQSMKS YPSSELRNMC DEHIASEEPA EKEDLLQQML ERRYTPYPNL 730 740 750 760 770 780 YPDQSPSEDW TMEERFRPLT FHGLILRSQL VTLLVRGVCY SESQSSASQP RLSYAEMAED 790 800 810 820 830 840 YPRYPDIHDL DLTLLNPRMI VDVTPYMNPS PFTVSPNTHV SQVFNLFRTM GLRHLPVVNA 850 860 VGEIVGIITR HNLTYEFLQA RLRQHYQTI
	Isoform B (ClC-6b) (D2-A1). Checksum: 6B004FDB1915E8CA	FASTA	320	35,934
	10 20 30 40 50 60 MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP 70 80 90 100 110 120 YLEVLETMDN KKGRRYEAVK WMVVFAIGVC TGLVGLFVDF FVRLFTQLKF GVVQTSVEEC 130 140 150 160 170 180 SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EVKCYLNGVK VPGIVRLRTL 190 200 210 220 230 240 LCKVLGVLFS VAGGLFVGKE GPMIHSGSVV GAGLPQFQSI SLRKIQFNFP YFRSDRYGKR 250 260 270 280 290 300 QERLCISRSG CWSCCSFRGA NRGYLVQSRG GFVLLEPRAH VESALLFHVC HLHPQLLPFW 310 320 DSVWKLGFLP APWIAELWRV
	Isoform C (ClC-6c) (D1-A1). Checksum: 078E68BE3A147EB6	FASTA	353	38,742
	10 20 30 40 50 60 MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP 70 80 90 100 110 120 YLEVLETMDN KKGRRYEAVK WMVVFAIGVC TGLVGLFVDF FVRLFTQLKF GVVQTSVEEC 130 140 150 160 170 180 SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EVKCYLNGVK VPGIVRLRTL 190 200 210 220 230 240 LCKVLGVLFS VAGGLFVGKE GPMIHSGSVV GAGLPQFQSI SLRKIQFNFP YFRSDRDKRD 250 260 270 280 290 300 FVSAGAAAGV AAAFGAPIGG TLFSLEEGSS FWNQGLTWKV LFCSMSATFT LNFFRSGIQF 310 320 330 340 350 GSWGSFQLPG LLNFGEFKSL REPPCVSGNH RGGVCGLDGV RRMPTDVLFE SNR
	Isoform D (ClC-6d) (D1-A2). Checksum: 5BAE9FE7C2AD341E	FASTA	308	34,443
	10 20 30 40 50 60 MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP 70 80 90 100 110 120 YLEVLETMDN KKGRRYEAVK WMVVFAIGVC TGLVGLFVDF FVRLFTQLKF GVVQTSVEEC 130 140 150 160 170 180 SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EVKCYLNGVK VPGIVRLRTL 190 200 210 220 230 240 LCKVLGVLFS VAGGLFVGKE GPMIHSGSVV GAGLPQFQSI SLRKIQFNFP YFRSDRSGCW 250 260 270 280 290 300 SCCSFRGANR GYLVQSRGGF VLLEPRAHVE SALLFHVCHL HPQLLPFWDS VWKLGFLPAP WIAELWRV
	Isoform E. Checksum: 1FD666515C9CA2BF	FASTA	953	106,304
	10 20 30 40 50 60 MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP 70 80 90 100 110 120 YLEVLETMDN KKGRRYEAVK WMVVFAIGVC TGLVGLFVDF FVRLFTQLKF GVVQTSVEEC 130 140 150 160 170 180 SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EVKCYLNGVK VPGIVRLRTL 190 200 210 220 230 240 LCKVLGVLFS VAGGLFVGKE GPMIHSGSVV GAGLPQFQSI SLRKIQFNFP YFRSDRDKRD 250 260 270 280 290 300 FVSAGAAAGV AAAFGAPIGG TLFSLEEGSS FWNQGLTWKV LFCSMSATFT LNFFRSGIQF 310 320 330 340 350 360 GSWGSFQLPG LLNFGEFKCS DSDKKCHLWT AMDLGFFVVM GVIGGLLGAT FNCLNKRLAK 370 380 390 400 410 420 YRMRNVHPKP KLVRVLESLL VSLVTTVVVF VASMVLGECR QMSSSSQIGN DSFQLQVTED 430 440 450 460 470 480 VNSSIKTFFC PNDTYNDMAT LFFNPQESAI LQLFHQDGTF SPVTLALFFV LYFLLACWTY 490 500 510 520 530 540 GISVPSGLFV PSLLCGAAFG RLVANVLKSY IGLGHIYSGT FALIGAAAFL GGVVRMTISL 550 560 570 580 590 600 TVILIESTNE ITYGLPIMVT LMVAKWTGDF FNKGIYDIHV GLRGVPLLEW ETEVEMDKLR 610 620 630 640 650 660 ASDIMEPNLT YVYPHTRIQS LVSILRTTVH HAFPVVTENR GNEKEFMKGN QLISNNIKFK 670 680 690 700 710 720 KSSILTRAGE QRKRSQSMKS YPSSELRNMC DEHIASEEPA EKEDLLQQML ERRYTPYPNL 730 740 750 760 770 780 YPDQSPSEDW TMEERFRPLT FHGLILRSQL VTLLVRGVCY SESQSSASQP RLSYAEMAED 790 800 810 820 830 840 YPRYPDIHDL DLTLLNPRMI VDVTPYMNPS PFTVSPNTHV SQVFNLFRTM GLRHLPVVNA 850 860 870 880 890 900 VGEVSEAPAL PPPLREDPLA RCCLCTQASH QKRRHPTRRG ECGPTLALNP ARLPCTRDPF 910 920 930 940 950 PCLPADGTSV PLAVLSSQSR ASTRLCLPPE MLLFTPYHWC SLVLHLRRDL RIR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ClC-6 and ClC-7 are two novel broadly expressed members of the CLC chloride channel family." Brandt S., Jentsch T.J. FEBS Lett. 377:15-20(1995) [PubMed: 8543009] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Alternative splicing of ClC-6 (a member of the ClC chloride-channel family) transcripts generates three truncated isoforms one of which, ClC-6c, is kidney-specific." Eggermont J., Buyse G., Voets T., Tytgat J., De Smedt H., Droogmans G., Nilius B. Biochem. J. 325:269-276(1997) [PubMed: 9224655] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS B; C AND D), NUCLEOTIDE SEQUENCE [MRNA] OF 1-409 (ISOFORM A), TISSUE SPECIFICITY. Tissue: Chronic myeloid leukemia cell.
[3]	"Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes." Kornak U., Boesl M.R., Kubisch C. Biochim. Biophys. Acta 1447:100-106(1999) [PubMed: 10500249] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
[4]	"Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1." Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S. DNA Res. 1:223-229(1994) [PubMed: 7584044] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Bone marrow.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT GLU-198.
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A). Tissue: Brain.
[8]	"Expression of CLCN voltage-gated chloride channel genes in human blood vessels." Lamb F.S., Clayton G.H., Liu B.-X., Smith R.L., Barna T.J., Schutte B.C. J. Mol. Cell. Cardiol. 31:657-666(1999) [PubMed: 10198195] [Abstract] Cited for: TISSUE SPECIFICITY. Tissue: Aortic endothelium and Vascular smooth muscle.
[9]	"Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains." Ignoul S., Simaels J., Hermans D., Annaert W., Eggermont J. PLoS ONE 2:E474-E474(2007) [PubMed: 17534424] [Abstract] Cited for: SUBCELLULAR LOCATION, GLYCOSYLATION, MUTAGENESIS OF ASN-410; ASN-422 AND ASN-432.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X83378 mRNA. Translation: CAA58292.1. X96391 mRNA. Translation: CAA65255.1. X99472 Genomic DNA. Translation: CAA67835.1. X99473 mRNA. Translation: CAA67836.1. X99474 mRNA. Translation: CAA67837.1. X99475 mRNA. Translation: CAA67838.1. AF009257 , AF009247, AF009248, AF009249, AF009250, AF009251, AF009252, AF009253, AF009254, AF009255, AF009256 Genomic DNA. Translation: AAB69287.1. D28475 mRNA. Translation: BAA05836.4. AL953897, AL021155 Genomic DNA. Translation: CAI15891.1. AL953897, AL021155 Genomic DNA. Translation: CAI15892.1. AL953897, AL021155 Genomic DNA. Translation: CAI15893.1. AL953897, AL021155 Genomic DNA. Translation: CAI15894.1. AL953897, AL021155 Genomic DNA. Translation: CAI15895.1. AL021155, AL953897 Genomic DNA. Translation: CAI23402.1. AL021155, AL953897 Genomic DNA. Translation: CAI23403.1. AL021155, AL953897 Genomic DNA. Translation: CAI23404.1. AL021155, AL953897 Genomic DNA. Translation: CAI23405.1. AL021155, AL953897 Genomic DNA. Translation: CAI23406.1. BC117420 mRNA. Translation: AAI17421.1. BC117424 mRNA. Translation: AAI17425.1.
IPI	IPI00180121. IPI00305252. IPI00395741. IPI00414669. IPI00642888.
PIR	S68428.
RefSeq	NP_001277.1. NP_068503.1. NP_068504.1. NP_068505.1.
UniGene	Hs.193043
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	P51797.
Genome annotation databases
Ensembl	ENSG00000011021. Homo sapiens. [Contig view]
GeneID	1185.
KEGG	hsa:1185.
Organism-specific databases
GeneCards	GC01P011800.
H-InvDB	HIX0000129.
HGNC	HGNC:2024. CLCN6.
MIM	602726. gene.
PharmGKB	PA26551.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	P51797.
Gene expression databases
ArrayExpress	P51797.
Bgee	P51797.
Family and domain databases
InterPro	IPR014743. Cl-channel_core. IPR001807. Cl-channel_volt. IPR002248. Cl_channel6. IPR000644. Cysta_beta_synth_core. [Graphical view]
Gene3D	G3DSA:1.10.3080.10. Cl-channel_core. 1 hit.
PANTHER	PTHR11689. Cl-channel_volt. 1 hit.
Pfam	PF00571. CBS. 1 hit. PF00654. Voltage_CLC. 1 hit. [Graphical view]
PRINTS	PR00762. CLCHANNEL. PR01117. CLCHANNEL6.
SMART	SM00116. CBS. 2 hits. [Graphical view]
PROSITE	PS51371. CBS. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	4898.
SOURCE	Search...

Entry information

Entry name

CLCN6_HUMAN

Accession

Primary (citable) accession number: P51797
Secondary accession number(s): O60818 , O60819, O60820, O60821, P78520, P78521, Q17R81, Q5SNW2, Q5SNW3, Q5SNX1, Q5SNX2, Q5SNX3, Q99427, Q99428, Q99429

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	June 16, 2009
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)