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Reviewed, UniProtKB/Swiss-Prot P51793 (CLCN4_HUMAN)

Last modified November 25, 2008. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Chloride channel protein 4
      Short name=ClC-4
Gene names
Name: CLCN4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length760 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.

Subcellular location

Membrane; Multi-pass membrane protein.

Tissue specificity

Abundant in skeletal muscle and also detectable in brain and heart.

Sequence similarities

Belongs to the chloride channel (TC 2.A.49) family. [View classification]

Contains 2 CBS domains.

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Ontologies

Keywords

   Biological processIon transport
Transport
   Cellular componentMembrane
   DomainCBS domain
Repeat
Transmembrane
   LigandChloride
   Molecular functionChloride channel
Ionic channel
Voltage-gated channel

Gene Ontology (GO)

   Biological processchloride transport Ref.2

Inferred from direct assay. Source: MGI

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionchloride ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

voltage-gated chloride channel activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 760760Chloride channel protein 4
PRO_0000094443

Regions

Transmembrane68 – 8821 Potential
Transmembrane148 – 16821 Potential
Transmembrane202 – 22221 Potential
Transmembrane259 – 27921 Potential
Transmembrane330 – 35021 Potential
Transmembrane365 – 38521 Potential
Transmembrane442 – 46221 Potential
Transmembrane467 – 48721 Potential
Transmembrane508 – 52821 Potential
Transmembrane535 – 55521 Potential
Domain600 – 66667CBS 1
Domain697 – 75559CBS 2

Experimental info

Sequence conflict1781A → R in CAA54417. Ref.1
Sequence conflict498 – 4992II → YY in CAA54417. Ref.1
Sequence conflict6591K → N in CAA54417. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
P51793-1 [UniParc].

Last modified February 11, 2002. Version 2.
Checksum: 3A5A25D1FEF3F217

FASTA76084,917
        10         20         30         40         50         60 
MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT SKSKESIWEF 

        70         80         90        100        110        120 
IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE GVCLSAFWYS HEQCCWTSNE 

       130        140        150        160        170        180 
TTFEDRDKCP LWQKWSELLV NQSEGASAYI LNYLMYILWA LLFAFLAVSL VRVFAPYACG 

       190        200        210        220        230        240 
SGIPEIKTIL SGFIIRGYLG KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS 

       250        260        270        280        290        300 
LFSKYSKNEG KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV 

       310        320        330        340        350        360 
AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI RCNIAWCRRR 

       370        380        390        400        410        420 
KTTRLGKYPV LEVIVVTAIT AIIAYPNPYT RQSTSELISE LFNDCGALES SQLCDYINDP 

       430        440        450        460        470        480 
NMTRPVDDIP DRPAGVGVYT AMWQLALALI FKIVVTIFTF GMKIPSGLFI PSMAVGAIAG 

       490        500        510        520        530        540 
RMVGIGVEQL AYHHHDWIIF RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF 

       550        560        570        580        590        600 
ELTGGLEYIV PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM 

       610        620        630        640        650        660 
RPRRGEPPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSR DSERLIGFAQ RRELILAIKN 

       670        680        690        700        710        720 
ARQRQEGIVS NSIMYFTEEP PELPANSPHP LKLRRILNLS PFTVTDHTPM ETVVDIFRKL 

       730        740        750        760 
GLRQCLVTRS GRLLGIITKK DVLRHMAQMA NQDPESIMFN

« Hide

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References

[1]"A gene from the Xp22.3 region shares homology with voltage-gated chloride channels."
van Slegtenhorst M.A., Bassi M.T., Borsani G., Wapenaar M.C., Ferrero G.B., de Conciliis L., Rugarli E.I., Grillo A., Franco B., Zoghbi H.Y., Ballabio A.
Hum. Mol. Genet. 3:547-552(1994) [PubMed: 8069296] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Retina.
[2]"Identification of an acid-activated Cl- channel from human skeletal muscles."
Kawasaki M., Fukuma T., Yamauchi K., Sakamoto H., Marumo F., Sasaki S.
Am. J. Physiol. 277:C948-C954(1999) [PubMed: 10564087] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[3]"A chloride channel (ClC-4) in human lens epithelium."
Rae J.L.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lens epithelium.
+Additional computationally mapped references.

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Cross-references

Sequence databases

X77197 mRNA. Translation: CAA54417.1.
AB019432 mRNA. Translation: BAA77327.1.
AF170492 mRNA. Translation: AAD50981.1.
PIRI37242.
RefSeqNP_001821.2.
UniGeneHs.495674

3D structure databases

SMRP51793. Positions 592-753.
ModBaseSearch...

PTM databases

PhosphoSiteP51793.

Genome annotation databases

EnsemblENSG00000073464. Homo sapiens. [Contig view]
GeneID1183.
KEGGhsa:1183.

Organism-specific databases

HGNCHGNC:2022. CLCN4.
MIM302910. gene.
PharmGKBPA26549.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMP51793.
HOVERGENP51793.

Gene expression databases

ArrayExpressP51793.
CleanExHS_CLCN4.
GermOnlineENSG00000073464. Homo sapiens.

Family and domain databases

InterProIPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt.
IPR002246. Cl_channel4.
IPR000644. Cysta_beta_synth_core.
[Graphical view]
Gene3DG3DSA:1.10.3080.10. Cl-channel_core. 1 hit.
PANTHERPTHR11689. Cl-channel_volt. 1 hit.
PfamPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSPR00762. CLCHANNEL.
PR01115. CLCHANNEL4.
SMARTSM00116. CBS. 2 hits.
[Graphical view]
PROSITEPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio4890.
SOURCESearch...

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Entry information

Entry nameCLCN4_HUMAN
AccessionPrimary (citable) accession number: P51793
Secondary accession number(s): Q9UBU1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 11, 2002
Last modified: November 25, 2008
This is version 72 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents