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P51793

- CLCN4_HUMAN

UniProt

P51793 - CLCN4_HUMAN

Protein

H(+)/Cl(-) exchange transporter 4

Gene

CLCN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (11 Feb 2002)
      Previous versions | rss
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    Functioni

    Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei181 – 1811ChlorideBy similarity
    Sitei224 – 2241Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
    Sitei281 – 2811Mediates proton transfer from the protein to the inner aqueous phase
    Binding sitei469 – 4691Chloride; via amide nitrogenBy similarity
    Binding sitei572 – 5721ChlorideBy similarity
    Binding sitei610 – 6101ATP; via amide nitrogen and carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi631 – 6333ATPBy similarity
    Nucleotide bindingi738 – 7414ATPBy similarity

    GO - Molecular functioni

    1. antiporter activity Source: UniProtKB-KW
    2. ATP binding Source: UniProtKB-KW
    3. chloride channel activity Source: MGI
    4. voltage-gated chloride channel activity Source: ProtInc

    GO - Biological processi

    1. chloride transmembrane transport Source: GOC
    2. chloride transport Source: MGI
    3. ion transmembrane transport Source: Reactome
    4. regulation of anion transport Source: GOC
    5. transmembrane transport Source: Reactome
    6. transport Source: ProtInc

    Keywords - Biological processi

    Antiport, Ion transport, Transport

    Keywords - Ligandi

    ATP-binding, Chloride, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.

    Protein family/group databases

    TCDBi2.A.49.2.8. the chloride carrier/channel (clc) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    H(+)/Cl(-) exchange transporter 4
    Alternative name(s):
    Chloride channel protein 4
    Short name:
    ClC-4
    Chloride transporter ClC-4
    Gene namesi
    Name:CLCN4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:2022. CLCN4.

    Subcellular locationi

    GO - Cellular componenti

    1. early endosome membrane Source: UniProtKB-SubCell
    2. endosome membrane Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. late endosome membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi224 – 2241E → A: Restores chloride translocation, but not proton transport; when associated with A-281. 1 Publication
    Mutagenesisi281 – 2811E → A: Abolishes translocation of protons and chloride ions. 1 Publication

    Organism-specific databases

    PharmGKBiPA26549.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 760760H(+)/Cl(-) exchange transporter 4PRO_0000094443Add
    BLAST

    Proteomic databases

    MaxQBiP51793.
    PaxDbiP51793.
    PRIDEiP51793.

    PTM databases

    PhosphoSiteiP51793.

    Expressioni

    Tissue specificityi

    Abundant in skeletal muscle and also detectable in brain and heart.

    Gene expression databases

    ArrayExpressiP51793.
    BgeeiP51793.
    CleanExiHS_CLCN4.
    GenevestigatoriP51793.

    Organism-specific databases

    HPAiHPA031313.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-3019161.
    STRINGi9606.ENSP00000370213.

    Structurei

    3D structure databases

    ProteinModelPortaliP51793.
    SMRiP51793. Positions 148-572, 592-753.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 6767CytoplasmicBy similarityAdd
    BLAST
    Topological domaini567 – 760194CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei183 – 1908HelicalBy similarity
    Intramembranei255 – 26713HelicalBy similarityAdd
    BLAST
    Intramembranei271 – 2799HelicalBy similarity
    Intramembranei514 – 52815HelicalBy similarityAdd
    BLAST
    Intramembranei532 – 54312HelicalBy similarityAdd
    BLAST
    Intramembranei544 – 5474Note=Loop between two helicesBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei68 – 10538HelicalBy similarityAdd
    BLAST
    Transmembranei151 – 17424HelicalBy similarityAdd
    BLAST
    Transmembranei200 – 21819HelicalBy similarityAdd
    BLAST
    Transmembranei224 – 24320HelicalBy similarityAdd
    BLAST
    Transmembranei291 – 30919HelicalBy similarityAdd
    BLAST
    Transmembranei333 – 35826HelicalBy similarityAdd
    BLAST
    Transmembranei365 – 38521HelicalBy similarityAdd
    BLAST
    Transmembranei442 – 46221HelicalBy similarityAdd
    BLAST
    Transmembranei467 – 48620HelicalBy similarityAdd
    BLAST
    Transmembranei548 – 56619HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini600 – 66667CBS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini697 – 75559CBS 2PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi180 – 1845Selectivity filter part_1By similarity
    Motifi222 – 2265Selectivity filter part_2By similarity
    Motifi467 – 4715Selectivity filter part_3By similarity

    Sequence similaritiesi

    Contains 2 CBS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    CBS domain, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0038.
    HOGENOMiHOG000164493.
    HOVERGENiHBG050984.
    InParanoidiP51793.
    KOiK05012.
    OMAiQDGMTVE.
    OrthoDBiEOG7MWGXT.
    PhylomeDBiP51793.
    TreeFamiTF313867.

    Family and domain databases

    Gene3Di1.10.3080.10. 3 hits.
    InterProiIPR000644. CBS_dom.
    IPR014743. Cl-channel_core.
    IPR001807. Cl-channel_volt-gated.
    IPR002246. Cl_channel-4.
    [Graphical view]
    PfamiPF00571. CBS. 2 hits.
    PF00654. Voltage_CLC. 1 hit.
    [Graphical view]
    PRINTSiPR00762. CLCHANNEL.
    PR01115. CLCHANNEL4.
    SMARTiSM00116. CBS. 2 hits.
    [Graphical view]
    SUPFAMiSSF81340. SSF81340. 3 hits.
    PROSITEiPS51371. CBS. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P51793-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT    50
    SKSKESIWEF IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE 100
    GVCLSAFWYS HEQCCWTSNE TTFEDRDKCP LWQKWSELLV NQSEGASAYI 150
    LNYLMYILWA LLFAFLAVSL VRVFAPYACG SGIPEIKTIL SGFIIRGYLG 200
    KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS LFSKYSKNEG 250
    KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV 300
    AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI 350
    RCNIAWCRRR KTTRLGKYPV LEVIVVTAIT AIIAYPNPYT RQSTSELISE 400
    LFNDCGALES SQLCDYINDP NMTRPVDDIP DRPAGVGVYT AMWQLALALI 450
    FKIVVTIFTF GMKIPSGLFI PSMAVGAIAG RMVGIGVEQL AYHHHDWIIF 500
    RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF ELTGGLEYIV 550
    PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM 600
    RPRRGEPPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSR DSERLIGFAQ 650
    RRELILAIKN ARQRQEGIVS NSIMYFTEEP PELPANSPHP LKLRRILNLS 700
    PFTVTDHTPM ETVVDIFRKL GLRQCLVTRS GRLLGIITKK DVLRHMAQMA 750
    NQDPESIMFN 760
    Length:760
    Mass (Da):84,917
    Last modified:February 11, 2002 - v2
    Checksum:i3A5A25D1FEF3F217
    GO
    Isoform 2 (identifier: P51793-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-94: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:666
    Mass (Da):74,347
    Checksum:i4A8ACB4F7865A5C8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti178 – 1781A → R in CAA54417. (PubMed:8069296)Curated
    Sequence conflicti498 – 4992II → YY in CAA54417. (PubMed:8069296)Curated
    Sequence conflicti659 – 6591K → N in CAA54417. (PubMed:8069296)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_054658Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77197 mRNA. Translation: CAA54417.1.
    AB019432 mRNA. Translation: BAA77327.1.
    AF170492 mRNA. Translation: AAD50981.1.
    AK289564 mRNA. Translation: BAF82253.1.
    AK299611 mRNA. Translation: BAH13080.1.
    AC003666 Genomic DNA. No translation available.
    AC121345 Genomic DNA. No translation available.
    CH471074 Genomic DNA. Translation: EAW98778.1.
    BC130278 mRNA. Translation: AAI30279.1.
    CCDSiCCDS14137.1. [P51793-1]
    CCDS59159.1. [P51793-2]
    PIRiI37242.
    RefSeqiNP_001243873.1. NM_001256944.1. [P51793-2]
    NP_001821.2. NM_001830.3. [P51793-1]
    UniGeneiHs.495674.

    Genome annotation databases

    EnsembliENST00000380833; ENSP00000370213; ENSG00000073464. [P51793-1]
    ENST00000421085; ENSP00000405754; ENSG00000073464. [P51793-2]
    GeneIDi1183.
    KEGGihsa:1183.
    UCSCiuc004csy.4. human. [P51793-1]

    Polymorphism databases

    DMDMi20141247.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77197 mRNA. Translation: CAA54417.1 .
    AB019432 mRNA. Translation: BAA77327.1 .
    AF170492 mRNA. Translation: AAD50981.1 .
    AK289564 mRNA. Translation: BAF82253.1 .
    AK299611 mRNA. Translation: BAH13080.1 .
    AC003666 Genomic DNA. No translation available.
    AC121345 Genomic DNA. No translation available.
    CH471074 Genomic DNA. Translation: EAW98778.1 .
    BC130278 mRNA. Translation: AAI30279.1 .
    CCDSi CCDS14137.1. [P51793-1 ]
    CCDS59159.1. [P51793-2 ]
    PIRi I37242.
    RefSeqi NP_001243873.1. NM_001256944.1. [P51793-2 ]
    NP_001821.2. NM_001830.3. [P51793-1 ]
    UniGenei Hs.495674.

    3D structure databases

    ProteinModelPortali P51793.
    SMRi P51793. Positions 148-572, 592-753.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-3019161.
    STRINGi 9606.ENSP00000370213.

    Chemistry

    GuidetoPHARMACOLOGYi 703.

    Protein family/group databases

    TCDBi 2.A.49.2.8. the chloride carrier/channel (clc) family.

    PTM databases

    PhosphoSitei P51793.

    Polymorphism databases

    DMDMi 20141247.

    Proteomic databases

    MaxQBi P51793.
    PaxDbi P51793.
    PRIDEi P51793.

    Protocols and materials databases

    DNASUi 1183.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000380833 ; ENSP00000370213 ; ENSG00000073464 . [P51793-1 ]
    ENST00000421085 ; ENSP00000405754 ; ENSG00000073464 . [P51793-2 ]
    GeneIDi 1183.
    KEGGi hsa:1183.
    UCSCi uc004csy.4. human. [P51793-1 ]

    Organism-specific databases

    CTDi 1183.
    GeneCardsi GC0XP010085.
    H-InvDB HIX0056096.
    HGNCi HGNC:2022. CLCN4.
    HPAi HPA031313.
    MIMi 302910. gene.
    neXtProti NX_P51793.
    PharmGKBi PA26549.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0038.
    HOGENOMi HOG000164493.
    HOVERGENi HBG050984.
    InParanoidi P51793.
    KOi K05012.
    OMAi QDGMTVE.
    OrthoDBi EOG7MWGXT.
    PhylomeDBi P51793.
    TreeFami TF313867.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.

    Miscellaneous databases

    ChiTaRSi CLCN4. human.
    GeneWikii CLCN4.
    GenomeRNAii 1183.
    NextBioi 4890.
    PROi P51793.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P51793.
    Bgeei P51793.
    CleanExi HS_CLCN4.
    Genevestigatori P51793.

    Family and domain databases

    Gene3Di 1.10.3080.10. 3 hits.
    InterProi IPR000644. CBS_dom.
    IPR014743. Cl-channel_core.
    IPR001807. Cl-channel_volt-gated.
    IPR002246. Cl_channel-4.
    [Graphical view ]
    Pfami PF00571. CBS. 2 hits.
    PF00654. Voltage_CLC. 1 hit.
    [Graphical view ]
    PRINTSi PR00762. CLCHANNEL.
    PR01115. CLCHANNEL4.
    SMARTi SM00116. CBS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF81340. SSF81340. 3 hits.
    PROSITEi PS51371. CBS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. "Identification of an acid-activated Cl- channel from human skeletal muscles."
      Kawasaki M., Fukuma T., Yamauchi K., Sakamoto H., Marumo F., Sasaki S.
      Am. J. Physiol. 277:C948-C954(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Skeletal muscle.
    3. "A chloride channel (ClC-4) in human lens epithelium."
      Rae J.L.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Lens epithelium.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Cerebellum.
    5. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    8. "Determinants of anion-proton coupling in mammalian endosomal CLC proteins."
      Zdebik A.A., Zifarelli G., Bergsdorf E.-Y., Soliani P., Scheel O., Jentsch T.J., Pusch M.
      J. Biol. Chem. 283:4219-4227(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLU-224 AND GLU-281.

    Entry informationi

    Entry nameiCLCN4_HUMAN
    AccessioniPrimary (citable) accession number: P51793
    Secondary accession number(s): A1L3U1, B7Z5Z4, Q9UBU1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1996
    Last sequence update: February 11, 2002
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3