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P51793

- CLCN4_HUMAN

UniProt

P51793 - CLCN4_HUMAN

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Protein

H(+)/Cl(-) exchange transporter 4

Gene

CLCN4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei181 – 1811ChlorideBy similarity
Sitei224 – 2241Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Sitei281 – 2811Mediates proton transfer from the protein to the inner aqueous phase
Binding sitei469 – 4691Chloride; via amide nitrogenBy similarity
Binding sitei572 – 5721ChlorideBy similarity
Binding sitei610 – 6101ATP; via amide nitrogen and carbonyl oxygenBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi631 – 6333ATPBy similarity
Nucleotide bindingi738 – 7414ATPBy similarity

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. ATP binding Source: UniProtKB-KW
  3. chloride channel activity Source: MGI
  4. voltage-gated chloride channel activity Source: ProtInc

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: MGI
  3. ion transmembrane transport Source: Reactome
  4. regulation of anion transport Source: GOC
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Chloride, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi2.A.49.2.8. the chloride carrier/channel (clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
H(+)/Cl(-) exchange transporter 4
Alternative name(s):
Chloride channel protein 4
Short name:
ClC-4
Chloride transporter ClC-4
Gene namesi
Name:CLCN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2022. CLCN4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767CytoplasmicBy similarityAdd
BLAST
Transmembranei68 – 10538HelicalBy similarityAdd
BLAST
Transmembranei151 – 17424HelicalBy similarityAdd
BLAST
Intramembranei183 – 1908HelicalBy similarity
Transmembranei200 – 21819HelicalBy similarityAdd
BLAST
Transmembranei224 – 24320HelicalBy similarityAdd
BLAST
Intramembranei255 – 26713HelicalBy similarityAdd
BLAST
Intramembranei271 – 2799HelicalBy similarity
Transmembranei291 – 30919HelicalBy similarityAdd
BLAST
Transmembranei333 – 35826HelicalBy similarityAdd
BLAST
Transmembranei365 – 38521HelicalBy similarityAdd
BLAST
Transmembranei442 – 46221HelicalBy similarityAdd
BLAST
Transmembranei467 – 48620HelicalBy similarityAdd
BLAST
Intramembranei514 – 52815HelicalBy similarityAdd
BLAST
Intramembranei532 – 54312HelicalBy similarityAdd
BLAST
Intramembranei544 – 5474Note=Loop between two helicesBy similarity
Transmembranei548 – 56619HelicalBy similarityAdd
BLAST
Topological domaini567 – 760194CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endosome membrane Source: Reactome
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi224 – 2241E → A: Restores chloride translocation, but not proton transport; when associated with A-281. 1 Publication
Mutagenesisi281 – 2811E → A: Abolishes translocation of protons and chloride ions. 1 Publication

Organism-specific databases

PharmGKBiPA26549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760H(+)/Cl(-) exchange transporter 4PRO_0000094443Add
BLAST

Proteomic databases

MaxQBiP51793.
PaxDbiP51793.
PRIDEiP51793.

PTM databases

PhosphoSiteiP51793.

Expressioni

Tissue specificityi

Abundant in skeletal muscle and also detectable in brain and heart.

Gene expression databases

BgeeiP51793.
CleanExiHS_CLCN4.
ExpressionAtlasiP51793. baseline and differential.
GenevestigatoriP51793.

Organism-specific databases

HPAiHPA031313.

Interactioni

Protein-protein interaction databases

MINTiMINT-3019161.
STRINGi9606.ENSP00000370213.

Structurei

3D structure databases

ProteinModelPortaliP51793.
SMRiP51793. Positions 139-572, 592-753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini600 – 66667CBS 1PROSITE-ProRule annotationAdd
BLAST
Domaini697 – 75559CBS 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi180 – 1845Selectivity filter part_1By similarity
Motifi222 – 2265Selectivity filter part_2By similarity
Motifi467 – 4715Selectivity filter part_3By similarity

Sequence similaritiesi

Contains 2 CBS domains.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0038.
GeneTreeiENSGT00760000119109.
HOGENOMiHOG000164493.
HOVERGENiHBG050984.
InParanoidiP51793.
KOiK05012.
OMAiQDGMTVE.
OrthoDBiEOG7MWGXT.
PhylomeDBiP51793.
TreeFamiTF313867.

Family and domain databases

Gene3Di1.10.3080.10. 3 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002246. Cl_channel-4.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01115. CLCHANNEL4.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 3 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51793-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT
60 70 80 90 100
SKSKESIWEF IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE
110 120 130 140 150
GVCLSAFWYS HEQCCWTSNE TTFEDRDKCP LWQKWSELLV NQSEGASAYI
160 170 180 190 200
LNYLMYILWA LLFAFLAVSL VRVFAPYACG SGIPEIKTIL SGFIIRGYLG
210 220 230 240 250
KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS LFSKYSKNEG
260 270 280 290 300
KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV
310 320 330 340 350
AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI
360 370 380 390 400
RCNIAWCRRR KTTRLGKYPV LEVIVVTAIT AIIAYPNPYT RQSTSELISE
410 420 430 440 450
LFNDCGALES SQLCDYINDP NMTRPVDDIP DRPAGVGVYT AMWQLALALI
460 470 480 490 500
FKIVVTIFTF GMKIPSGLFI PSMAVGAIAG RMVGIGVEQL AYHHHDWIIF
510 520 530 540 550
RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF ELTGGLEYIV
560 570 580 590 600
PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM
610 620 630 640 650
RPRRGEPPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSR DSERLIGFAQ
660 670 680 690 700
RRELILAIKN ARQRQEGIVS NSIMYFTEEP PELPANSPHP LKLRRILNLS
710 720 730 740 750
PFTVTDHTPM ETVVDIFRKL GLRQCLVTRS GRLLGIITKK DVLRHMAQMA
760
NQDPESIMFN
Length:760
Mass (Da):84,917
Last modified:February 11, 2002 - v2
Checksum:i3A5A25D1FEF3F217
GO
Isoform 2 (identifier: P51793-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Note: No experimental confirmation available.

Show »
Length:666
Mass (Da):74,347
Checksum:i4A8ACB4F7865A5C8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781A → R in CAA54417. (PubMed:8069296)Curated
Sequence conflicti498 – 4992II → YY in CAA54417. (PubMed:8069296)Curated
Sequence conflicti659 – 6591K → N in CAA54417. (PubMed:8069296)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2. 1 PublicationVSP_054658Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77197 mRNA. Translation: CAA54417.1.
AB019432 mRNA. Translation: BAA77327.1.
AF170492 mRNA. Translation: AAD50981.1.
AK289564 mRNA. Translation: BAF82253.1.
AK299611 mRNA. Translation: BAH13080.1.
AC003666 Genomic DNA. No translation available.
AC121345 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98778.1.
BC130278 mRNA. Translation: AAI30279.1.
CCDSiCCDS14137.1. [P51793-1]
CCDS59159.1. [P51793-2]
PIRiI37242.
RefSeqiNP_001243873.1. NM_001256944.1. [P51793-2]
NP_001821.2. NM_001830.3. [P51793-1]
UniGeneiHs.495674.

Genome annotation databases

EnsembliENST00000380833; ENSP00000370213; ENSG00000073464. [P51793-1]
ENST00000421085; ENSP00000405754; ENSG00000073464. [P51793-2]
GeneIDi1183.
KEGGihsa:1183.
UCSCiuc004csy.4. human. [P51793-1]

Polymorphism databases

DMDMi20141247.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77197 mRNA. Translation: CAA54417.1 .
AB019432 mRNA. Translation: BAA77327.1 .
AF170492 mRNA. Translation: AAD50981.1 .
AK289564 mRNA. Translation: BAF82253.1 .
AK299611 mRNA. Translation: BAH13080.1 .
AC003666 Genomic DNA. No translation available.
AC121345 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98778.1 .
BC130278 mRNA. Translation: AAI30279.1 .
CCDSi CCDS14137.1. [P51793-1 ]
CCDS59159.1. [P51793-2 ]
PIRi I37242.
RefSeqi NP_001243873.1. NM_001256944.1. [P51793-2 ]
NP_001821.2. NM_001830.3. [P51793-1 ]
UniGenei Hs.495674.

3D structure databases

ProteinModelPortali P51793.
SMRi P51793. Positions 139-572, 592-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-3019161.
STRINGi 9606.ENSP00000370213.

Chemistry

GuidetoPHARMACOLOGYi 703.

Protein family/group databases

TCDBi 2.A.49.2.8. the chloride carrier/channel (clc) family.

PTM databases

PhosphoSitei P51793.

Polymorphism databases

DMDMi 20141247.

Proteomic databases

MaxQBi P51793.
PaxDbi P51793.
PRIDEi P51793.

Protocols and materials databases

DNASUi 1183.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380833 ; ENSP00000370213 ; ENSG00000073464 . [P51793-1 ]
ENST00000421085 ; ENSP00000405754 ; ENSG00000073464 . [P51793-2 ]
GeneIDi 1183.
KEGGi hsa:1183.
UCSCi uc004csy.4. human. [P51793-1 ]

Organism-specific databases

CTDi 1183.
GeneCardsi GC0XP010085.
H-InvDB HIX0056096.
HGNCi HGNC:2022. CLCN4.
HPAi HPA031313.
MIMi 302910. gene.
neXtProti NX_P51793.
PharmGKBi PA26549.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0038.
GeneTreei ENSGT00760000119109.
HOGENOMi HOG000164493.
HOVERGENi HBG050984.
InParanoidi P51793.
KOi K05012.
OMAi QDGMTVE.
OrthoDBi EOG7MWGXT.
PhylomeDBi P51793.
TreeFami TF313867.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi CLCN4. human.
GeneWikii CLCN4.
GenomeRNAii 1183.
NextBioi 4890.
PROi P51793.
SOURCEi Search...

Gene expression databases

Bgeei P51793.
CleanExi HS_CLCN4.
ExpressionAtlasi P51793. baseline and differential.
Genevestigatori P51793.

Family and domain databases

Gene3Di 1.10.3080.10. 3 hits.
InterProi IPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002246. Cl_channel-4.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00654. Voltage_CLC. 1 hit.
[Graphical view ]
PRINTSi PR00762. CLCHANNEL.
PR01115. CLCHANNEL4.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
SUPFAMi SSF81340. SSF81340. 3 hits.
PROSITEi PS51371. CBS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "Identification of an acid-activated Cl- channel from human skeletal muscles."
    Kawasaki M., Fukuma T., Yamauchi K., Sakamoto H., Marumo F., Sasaki S.
    Am. J. Physiol. 277:C948-C954(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  3. "A chloride channel (ClC-4) in human lens epithelium."
    Rae J.L.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lens epithelium.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Cerebellum.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Determinants of anion-proton coupling in mammalian endosomal CLC proteins."
    Zdebik A.A., Zifarelli G., Bergsdorf E.-Y., Soliani P., Scheel O., Jentsch T.J., Pusch M.
    J. Biol. Chem. 283:4219-4227(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLU-224 AND GLU-281.

Entry informationi

Entry nameiCLCN4_HUMAN
AccessioniPrimary (citable) accession number: P51793
Secondary accession number(s): A1L3U1, B7Z5Z4, Q9UBU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 11, 2002
Last modified: October 29, 2014
This is version 134 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3