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P51793

- CLCN4_HUMAN

UniProt

P51793 - CLCN4_HUMAN

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Protein
H(+)/Cl(-) exchange transporter 4
Gene
CLCN4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei181 – 1811Chloride By similarity
Sitei224 – 2241Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport
Sitei281 – 2811Mediates proton transfer from the protein to the inner aqueous phase
Binding sitei469 – 4691Chloride; via amide nitrogen By similarity
Binding sitei572 – 5721Chloride By similarity
Binding sitei610 – 6101ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi631 – 6333ATP By similarity
Nucleotide bindingi738 – 7414ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. antiporter activity Source: UniProtKB-KW
  3. chloride channel activity Source: MGI
  4. voltage-gated chloride channel activity Source: ProtInc

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. chloride transport Source: MGI
  3. ion transmembrane transport Source: Reactome
  4. regulation of anion transport Source: GOC
  5. transmembrane transport Source: Reactome
  6. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Chloride, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Protein family/group databases

TCDBi2.A.49.2.8. the chloride carrier/channel (clc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
H(+)/Cl(-) exchange transporter 4
Alternative name(s):
Chloride channel protein 4
Short name:
ClC-4
Chloride transporter ClC-4
Gene namesi
Name:CLCN4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:2022. CLCN4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6767Cytoplasmic By similarity
Add
BLAST
Transmembranei68 – 10538Helical; By similarity
Add
BLAST
Transmembranei151 – 17424Helical; By similarity
Add
BLAST
Intramembranei183 – 1908Helical; By similarity
Transmembranei200 – 21819Helical; By similarity
Add
BLAST
Transmembranei224 – 24320Helical; By similarity
Add
BLAST
Intramembranei255 – 26713Helical; By similarity
Add
BLAST
Intramembranei271 – 2799Helical; By similarity
Transmembranei291 – 30919Helical; By similarity
Add
BLAST
Transmembranei333 – 35826Helical; By similarity
Add
BLAST
Transmembranei365 – 38521Helical; By similarity
Add
BLAST
Transmembranei442 – 46221Helical; By similarity
Add
BLAST
Transmembranei467 – 48620Helical; By similarity
Add
BLAST
Intramembranei514 – 52815Helical; By similarity
Add
BLAST
Intramembranei532 – 54312Helical; By similarity
Add
BLAST
Intramembranei544 – 5474Note=Loop between two helices; By similarity
Transmembranei548 – 56619Helical; By similarity
Add
BLAST
Topological domaini567 – 760194Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. early endosome membrane Source: UniProtKB-SubCell
  2. endosome membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. late endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi224 – 2241E → A: Restores chloride translocation, but not proton transport; when associated with A-281. 1 Publication
Mutagenesisi281 – 2811E → A: Abolishes translocation of protons and chloride ions. 1 Publication

Organism-specific databases

PharmGKBiPA26549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 760760H(+)/Cl(-) exchange transporter 4
PRO_0000094443Add
BLAST

Proteomic databases

MaxQBiP51793.
PaxDbiP51793.
PRIDEiP51793.

PTM databases

PhosphoSiteiP51793.

Expressioni

Tissue specificityi

Abundant in skeletal muscle and also detectable in brain and heart.

Gene expression databases

ArrayExpressiP51793.
BgeeiP51793.
CleanExiHS_CLCN4.
GenevestigatoriP51793.

Organism-specific databases

HPAiHPA031313.

Interactioni

Protein-protein interaction databases

MINTiMINT-3019161.
STRINGi9606.ENSP00000370213.

Structurei

3D structure databases

ProteinModelPortaliP51793.
SMRiP51793. Positions 148-572, 592-753.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini600 – 66667CBS 1
Add
BLAST
Domaini697 – 75559CBS 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi180 – 1845Selectivity filter part_1 By similarity
Motifi222 – 2265Selectivity filter part_2 By similarity
Motifi467 – 4715Selectivity filter part_3 By similarity

Sequence similaritiesi

Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0038.
HOGENOMiHOG000164493.
HOVERGENiHBG050984.
InParanoidiP51793.
KOiK05012.
OMAiQDGMTVE.
OrthoDBiEOG7MWGXT.
PhylomeDBiP51793.
TreeFamiTF313867.

Family and domain databases

Gene3Di1.10.3080.10. 3 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002246. Cl_channel-4.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01115. CLCHANNEL4.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 3 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51793-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVNAGAMSGS GNLMDFLDEP FPDVGTYEDF HTIDWLREKS RDTDRHRKIT    50
SKSKESIWEF IKSLLDAWSG WVVMLLIGLL AGTLAGVIDL AVDWMTDLKE 100
GVCLSAFWYS HEQCCWTSNE TTFEDRDKCP LWQKWSELLV NQSEGASAYI 150
LNYLMYILWA LLFAFLAVSL VRVFAPYACG SGIPEIKTIL SGFIIRGYLG 200
KWTLLIKTVT LVLVVSSGLS LGKEGPLVHV ACCCGNFFSS LFSKYSKNEG 250
KRREVLSAAA AAGVSVAFGA PIGGVLFSLE EVSYYFPLKT LWRSFFAALV 300
AAFTLRSINP FGNSRLVLFY VEYHTPWYMA ELFPFILLGV FGGLWGTLFI 350
RCNIAWCRRR KTTRLGKYPV LEVIVVTAIT AIIAYPNPYT RQSTSELISE 400
LFNDCGALES SQLCDYINDP NMTRPVDDIP DRPAGVGVYT AMWQLALALI 450
FKIVVTIFTF GMKIPSGLFI PSMAVGAIAG RMVGIGVEQL AYHHHDWIIF 500
RNWCRPGADC VTPGLYAMVG AAACLGGVTR MTVSLVVIMF ELTGGLEYIV 550
PLMAAAVTSK WVADAFGKEG IYEAHIHLNG YPFLDVKDEF THRTLATDVM 600
RPRRGEPPLS VLTQDSMTVE DVETLIKETD YNGFPVVVSR DSERLIGFAQ 650
RRELILAIKN ARQRQEGIVS NSIMYFTEEP PELPANSPHP LKLRRILNLS 700
PFTVTDHTPM ETVVDIFRKL GLRQCLVTRS GRLLGIITKK DVLRHMAQMA 750
NQDPESIMFN 760
Length:760
Mass (Da):84,917
Last modified:February 11, 2002 - v2
Checksum:i3A5A25D1FEF3F217
GO
Isoform 2 (identifier: P51793-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-94: Missing.

Note: No experimental confirmation available.

Show »
Length:666
Mass (Da):74,347
Checksum:i4A8ACB4F7865A5C8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 9494Missing in isoform 2.
VSP_054658Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti178 – 1781A → R in CAA54417. 1 Publication
Sequence conflicti498 – 4992II → YY in CAA54417. 1 Publication
Sequence conflicti659 – 6591K → N in CAA54417. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77197 mRNA. Translation: CAA54417.1.
AB019432 mRNA. Translation: BAA77327.1.
AF170492 mRNA. Translation: AAD50981.1.
AK289564 mRNA. Translation: BAF82253.1.
AK299611 mRNA. Translation: BAH13080.1.
AC003666 Genomic DNA. No translation available.
AC121345 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98778.1.
BC130278 mRNA. Translation: AAI30279.1.
CCDSiCCDS14137.1. [P51793-1]
CCDS59159.1. [P51793-2]
PIRiI37242.
RefSeqiNP_001243873.1. NM_001256944.1. [P51793-2]
NP_001821.2. NM_001830.3. [P51793-1]
UniGeneiHs.495674.

Genome annotation databases

EnsembliENST00000380833; ENSP00000370213; ENSG00000073464.
ENST00000421085; ENSP00000405754; ENSG00000073464.
GeneIDi1183.
KEGGihsa:1183.
UCSCiuc004csy.4. human. [P51793-1]

Polymorphism databases

DMDMi20141247.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77197 mRNA. Translation: CAA54417.1 .
AB019432 mRNA. Translation: BAA77327.1 .
AF170492 mRNA. Translation: AAD50981.1 .
AK289564 mRNA. Translation: BAF82253.1 .
AK299611 mRNA. Translation: BAH13080.1 .
AC003666 Genomic DNA. No translation available.
AC121345 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98778.1 .
BC130278 mRNA. Translation: AAI30279.1 .
CCDSi CCDS14137.1. [P51793-1 ]
CCDS59159.1. [P51793-2 ]
PIRi I37242.
RefSeqi NP_001243873.1. NM_001256944.1. [P51793-2 ]
NP_001821.2. NM_001830.3. [P51793-1 ]
UniGenei Hs.495674.

3D structure databases

ProteinModelPortali P51793.
SMRi P51793. Positions 148-572, 592-753.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-3019161.
STRINGi 9606.ENSP00000370213.

Chemistry

GuidetoPHARMACOLOGYi 703.

Protein family/group databases

TCDBi 2.A.49.2.8. the chloride carrier/channel (clc) family.

PTM databases

PhosphoSitei P51793.

Polymorphism databases

DMDMi 20141247.

Proteomic databases

MaxQBi P51793.
PaxDbi P51793.
PRIDEi P51793.

Protocols and materials databases

DNASUi 1183.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000380833 ; ENSP00000370213 ; ENSG00000073464 .
ENST00000421085 ; ENSP00000405754 ; ENSG00000073464 .
GeneIDi 1183.
KEGGi hsa:1183.
UCSCi uc004csy.4. human. [P51793-1 ]

Organism-specific databases

CTDi 1183.
GeneCardsi GC0XP010085.
H-InvDB HIX0056096.
HGNCi HGNC:2022. CLCN4.
HPAi HPA031313.
MIMi 302910. gene.
neXtProti NX_P51793.
PharmGKBi PA26549.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0038.
HOGENOMi HOG000164493.
HOVERGENi HBG050984.
InParanoidi P51793.
KOi K05012.
OMAi QDGMTVE.
OrthoDBi EOG7MWGXT.
PhylomeDBi P51793.
TreeFami TF313867.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi CLCN4. human.
GeneWikii CLCN4.
GenomeRNAii 1183.
NextBioi 4890.
PROi P51793.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51793.
Bgeei P51793.
CleanExi HS_CLCN4.
Genevestigatori P51793.

Family and domain databases

Gene3Di 1.10.3080.10. 3 hits.
InterProi IPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002246. Cl_channel-4.
[Graphical view ]
Pfami PF00571. CBS. 2 hits.
PF00654. Voltage_CLC. 1 hit.
[Graphical view ]
PRINTSi PR00762. CLCHANNEL.
PR01115. CLCHANNEL4.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
SUPFAMi SSF81340. SSF81340. 3 hits.
PROSITEi PS51371. CBS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "Identification of an acid-activated Cl- channel from human skeletal muscles."
    Kawasaki M., Fukuma T., Yamauchi K., Sakamoto H., Marumo F., Sasaki S.
    Am. J. Physiol. 277:C948-C954(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Skeletal muscle.
  3. "A chloride channel (ClC-4) in human lens epithelium."
    Rae J.L.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lens epithelium.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Cerebellum.
  5. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  8. "Determinants of anion-proton coupling in mammalian endosomal CLC proteins."
    Zdebik A.A., Zifarelli G., Bergsdorf E.-Y., Soliani P., Scheel O., Jentsch T.J., Pusch M.
    J. Biol. Chem. 283:4219-4227(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLU-224 AND GLU-281.

Entry informationi

Entry nameiCLCN4_HUMAN
AccessioniPrimary (citable) accession number: P51793
Secondary accession number(s): A1L3U1, B7Z5Z4, Q9UBU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 11, 2002
Last modified: September 3, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi