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P51790

- CLCN3_HUMAN

UniProt

P51790 - CLCN3_HUMAN

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Protein

H(+)/Cl(-) exchange transporter 3

Gene
CLCN3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei239 – 2391Chloride By similarity
Sitei282 – 2821Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport By similarity
Sitei339 – 3391Mediates proton transfer from the protein to the inner aqueous phase By similarity
Binding sitei527 – 5271Chloride; via amide nitrogen By similarity
Binding sitei630 – 6301Chloride By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi689 – 6913ATP By similarity
Nucleotide bindingi796 – 7994ATP By similarity

GO - Molecular functioni

  1. antiporter activity Source: UniProtKB-KW
  2. ATP binding Source: UniProtKB-KW
  3. chloride channel activity Source: UniProtKB
  4. PDZ domain binding Source: UniProtKB
  5. protein binding Source: UniProtKB
  6. protein heterodimerization activity Source: UniProtKB
  7. protein homodimerization activity Source: UniProtKB
  8. voltage-gated chloride channel activity Source: ProtInc

GO - Biological processi

  1. chloride transmembrane transport Source: GOC
  2. endosomal lumen acidification Source: UniProtKB
  3. ion transmembrane transport Source: Reactome
  4. regulation of anion transport Source: GOC
  5. regulation of pH Source: UniProtKB
  6. transmembrane transport Source: Reactome
  7. transport Source: ProtInc
Complete GO annotation...

Keywords - Biological processi

Antiport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Chloride, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.

Names & Taxonomyi

Protein namesi
Recommended name:
H(+)/Cl(-) exchange transporter 3
Alternative name(s):
Chloride channel protein 3
Short name:
ClC-3
Chloride transporter ClC-3
Gene namesi
Name:CLCN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:2021. CLCN3.

Subcellular locationi

Isoform 1 : Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesiclesecretory vesicle membrane; Multi-pass membrane protein By similarity
Note: Isoform 1 is localized mainly in early and late endosomes.2 Publications
Isoform 2 : Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Note: Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi.2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 125125Cytoplasmic By similarityAdd
BLAST
Transmembranei126 – 16338Helical; By similarityAdd
BLAST
Transmembranei209 – 23224Helical; By similarityAdd
BLAST
Intramembranei241 – 2488Helical; By similarity
Transmembranei258 – 27619Helical; By similarityAdd
BLAST
Transmembranei282 – 30120Helical; By similarityAdd
BLAST
Intramembranei313 – 32513Helical; By similarityAdd
BLAST
Intramembranei329 – 3379Helical; By similarity
Transmembranei349 – 36719Helical; By similarityAdd
BLAST
Transmembranei391 – 41626Helical; By similarityAdd
BLAST
Transmembranei423 – 44321Helical; By similarityAdd
BLAST
Transmembranei500 – 52021Helical; By similarityAdd
BLAST
Transmembranei525 – 54420Helical; By similarityAdd
BLAST
Intramembranei572 – 58615Helical; By similarityAdd
BLAST
Intramembranei590 – 60112Helical; By similarityAdd
BLAST
Intramembranei602 – 6054Note=Loop between two helices; By similarity
Transmembranei606 – 62419Helical; By similarityAdd
BLAST
Topological domaini625 – 818194Cytoplasmic By similarityAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. cell surface Source: UniProtKB
  3. early endosome Source: UniProtKB
  4. early endosome membrane Source: UniProtKB-SubCell
  5. Golgi apparatus Source: UniProtKB
  6. Golgi membrane Source: UniProtKB-SubCell
  7. integral component of membrane Source: UniProtKB
  8. late endosome Source: UniProtKB
  9. late endosome membrane Source: UniProtKB-SubCell
  10. transport vesicle membrane Source: UniProtKB-SubCell
  11. vesicle membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi280 – 2801G → E: Changes channel selectivity from I(-)>Cl(-) to Cl(-)>I(-). 1 Publication

Organism-specific databases

PharmGKBiPA26548.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 818818H(+)/Cl(-) exchange transporter 3PRO_0000094438Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi177 – 1771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi451 – 4511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi479 – 4791N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.2 Publications

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP51790.
PaxDbiP51790.
PRIDEiP51790.

PTM databases

PhosphoSiteiP51790.

Expressioni

Tissue specificityi

Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).3 Publications

Gene expression databases

ArrayExpressiP51790.
BgeeiP51790.
CleanExiHS_CLCN3.
GenevestigatoriP51790.

Organism-specific databases

HPAiHPA044723.

Interactioni

Subunit structurei

Homo- or heterodimer. Isoform 2 interacts with GOPC, PDZK1 and SLC9A3R1/EBP50.2 Publications

Protein-protein interaction databases

BioGridi107596. 5 interactions.
IntActiP51790. 5 interactions.
MINTiMINT-1783418.
STRINGi9606.ENSP00000261514.

Structurei

3D structure databases

ProteinModelPortaliP51790.
SMRiP51790. Positions 211-811.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini658 – 72265CBS 1Add
BLAST
Domaini755 – 81258CBS 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi238 – 2425Selectivity filter part_1 By similarity
Motifi280 – 2845Selectivity filter part_2 By similarity
Motifi525 – 5295Selectivity filter part_3 By similarity

Domaini

Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC.1 Publication

Sequence similaritiesi

Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0038.
HOGENOMiHOG000164493.
KOiK05012.
OMAiEPLTPPW.
OrthoDBiEOG7MWGXT.
PhylomeDBiP51790.
TreeFamiTF313867.

Family and domain databases

Gene3Di1.10.3080.10. 3 hits.
InterProiIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002245. Cl_channel-3.
[Graphical view]
PfamiPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSiPR00762. CLCHANNEL.
PR01114. CLCHANNEL3.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMiSSF81340. SSF81340. 3 hits.
PROSITEiPS51371. CBS. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P51790-1) [UniParc]FASTAAdd to Basket

Also known as: ClC-3A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD    50
TAVGTHYTMT NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD 100
RERHRRINSK KKESAWEMTK SLYDAWSGWL VVTLTGLASG ALAGLIDIAA 150
DWMTDLKEGI CLSALWYNHE QCCWGSNETT FEERDKCPQW KTWAELIIGQ 200
AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG IPEIKTILSG 250
FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF 300
PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW 350
RSFFAALVAA FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG 400
GLWGAFFIRA NIAWCRRRKS TKFGKYPVLE VIIVAAITAV IAFPNPYTRL 450
NTSELIKELF TDCGPLESSS LCDYRNDMNA SKIVDDIPDR PAGIGVYSAI 500
WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI VGIAVEQLAY 550
YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL 600
TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH 650
TTLAADVMRP RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES 700
QRLVGFALRR DLTIAIESAR KKQEGIVGSS RVCFAQHTPS LPAESPRPLK 750
LRSILDMSPF TVTDHTPMEI VVDIFRKLGL RQCLVTHNGR LLGIITKKDI 800
LRHMAQTANQ DPASIMFN 818
Length:818
Mass (Da):90,966
Last modified:April 14, 2009 - v2
Checksum:i30FF0A6A2D6EF3B8
GO
Isoform 2 (identifier: P51790-2) [UniParc]FASTAAdd to Basket

Also known as: ClC-3B

The sequence of this isoform differs from the canonical sequence as follows:
     790-818: RLLGIITKKDILRHMAQTANQDPASIMFN → IVLGIITKKN...EVYLLNSTTL

Show »
Length:866
Mass (Da):96,733
Checksum:i1B2C8D0CC47CF592
GO
Isoform 3 (identifier: P51790-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     312-338: Missing.

Show »
Length:791
Mass (Da):88,464
Checksum:i3C8F08C71A73D3AF
GO
Isoform 4 (identifier: P51790-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MESEQLFHRG...DNLLDGDTAV → MVTLQLGESH...ALASQVAEIT

Note: No experimental confirmation available.

Show »
Length:801
Mass (Da):88,781
Checksum:i2A7951DA858393D4
GO

Sequence cautioni

The sequence BAC54560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA55281.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353MESEQ…GDTAV → MVTLQLGESHYVVQAGLQLL GSSNPPALASQVAEIT in isoform 4. VSP_054415Add
BLAST
Alternative sequencei312 – 33827Missing in isoform 3. VSP_045105Add
BLAST
Alternative sequencei790 – 81829RLLGI…SIMFN → IVLGIITKKNILEHLEQLKQ HVEPLAPPWHYNKKRYPPAY GPDGKPRPRFNNVQLNLTDE EREETEEEVYLLNSTTL in isoform 2. VSP_016073Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti209 – 2091M → T in BX647119. 1 Publication
Sequence conflicti551 – 5511Y → C in BX647119. 1 Publication
Sequence conflicti570 – 5701T → A in BX647119. 1 Publication
Sequence conflicti646 – 6461E → EEF in CAA55280. 1 Publication
Sequence conflicti646 – 6461E → EEF in CAA55281. 1 Publication
Sequence conflicti646 – 6461E → EEF in BAC54560. 1 Publication
Sequence conflicti723 – 7231Q → R in BX647119. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78520 mRNA. Translation: CAA55280.1.
X78520 mRNA. Translation: CAA55281.1. Different initiation.
AF029346 mRNA. Translation: AAB95161.1.
AF172729 mRNA. Translation: AAD51034.1.
AB019542 mRNA. Translation: BAC54560.1. Different initiation.
AK304362 mRNA. Translation: BAH14168.1.
BX647119 mRNA. No translation available.
AC084724 Genomic DNA. No translation available.
AC106878 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04782.1.
CH471056 Genomic DNA. Translation: EAX04786.1.
BC136510 mRNA. Translation: AAI36511.1.
CCDSiCCDS34100.1. [P51790-2]
CCDS34101.1. [P51790-1]
CCDS58932.1. [P51790-4]
PIRiI37240.
RefSeqiNP_001230301.1. NM_001243372.1. [P51790-4]
NP_001230303.1. NM_001243374.1.
NP_001820.2. NM_001829.3. [P51790-1]
NP_776297.2. NM_173872.3. [P51790-2]
UniGeneiHs.481186.
Hs.736017.

Genome annotation databases

EnsembliENST00000347613; ENSP00000261514; ENSG00000109572. [P51790-2]
ENST00000360642; ENSP00000353857; ENSG00000109572. [P51790-4]
ENST00000504131; ENSP00000424540; ENSG00000109572.
ENST00000513761; ENSP00000424603; ENSG00000109572. [P51790-1]
GeneIDi1182.
KEGGihsa:1182.
UCSCiuc003ish.3. human. [P51790-2]
uc003isi.3. human. [P51790-1]

Polymorphism databases

DMDMi226693513.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78520 mRNA. Translation: CAA55280.1 .
X78520 mRNA. Translation: CAA55281.1 . Different initiation.
AF029346 mRNA. Translation: AAB95161.1 .
AF172729 mRNA. Translation: AAD51034.1 .
AB019542 mRNA. Translation: BAC54560.1 . Different initiation.
AK304362 mRNA. Translation: BAH14168.1 .
BX647119 mRNA. No translation available.
AC084724 Genomic DNA. No translation available.
AC106878 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04782.1 .
CH471056 Genomic DNA. Translation: EAX04786.1 .
BC136510 mRNA. Translation: AAI36511.1 .
CCDSi CCDS34100.1. [P51790-2 ]
CCDS34101.1. [P51790-1 ]
CCDS58932.1. [P51790-4 ]
PIRi I37240.
RefSeqi NP_001230301.1. NM_001243372.1. [P51790-4 ]
NP_001230303.1. NM_001243374.1.
NP_001820.2. NM_001829.3. [P51790-1 ]
NP_776297.2. NM_173872.3. [P51790-2 ]
UniGenei Hs.481186.
Hs.736017.

3D structure databases

ProteinModelPortali P51790.
SMRi P51790. Positions 211-811.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107596. 5 interactions.
IntActi P51790. 5 interactions.
MINTi MINT-1783418.
STRINGi 9606.ENSP00000261514.

Chemistry

ChEMBLi CHEMBL2401603.
GuidetoPHARMACOLOGYi 702.

PTM databases

PhosphoSitei P51790.

Polymorphism databases

DMDMi 226693513.

Proteomic databases

MaxQBi P51790.
PaxDbi P51790.
PRIDEi P51790.

Protocols and materials databases

DNASUi 1182.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000347613 ; ENSP00000261514 ; ENSG00000109572 . [P51790-2 ]
ENST00000360642 ; ENSP00000353857 ; ENSG00000109572 . [P51790-4 ]
ENST00000504131 ; ENSP00000424540 ; ENSG00000109572 .
ENST00000513761 ; ENSP00000424603 ; ENSG00000109572 . [P51790-1 ]
GeneIDi 1182.
KEGGi hsa:1182.
UCSCi uc003ish.3. human. [P51790-2 ]
uc003isi.3. human. [P51790-1 ]

Organism-specific databases

CTDi 1182.
GeneCardsi GC04P170541.
H-InvDB HIX0024545.
HGNCi HGNC:2021. CLCN3.
HPAi HPA044723.
MIMi 600580. gene.
neXtProti NX_P51790.
PharmGKBi PA26548.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0038.
HOGENOMi HOG000164493.
KOi K05012.
OMAi EPLTPPW.
OrthoDBi EOG7MWGXT.
PhylomeDBi P51790.
TreeFami TF313867.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSi CLCN3. human.
GeneWikii CLCN3.
GenomeRNAii 1182.
NextBioi 4884.
PROi P51790.
SOURCEi Search...

Gene expression databases

ArrayExpressi P51790.
Bgeei P51790.
CleanExi HS_CLCN3.
Genevestigatori P51790.

Family and domain databases

Gene3Di 1.10.3080.10. 3 hits.
InterProi IPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002245. Cl_channel-3.
[Graphical view ]
Pfami PF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view ]
PRINTSi PR00762. CLCHANNEL.
PR01114. CLCHANNEL3.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
SUPFAMi SSF81340. SSF81340. 3 hits.
PROSITEi PS51371. CBS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein."
    Borsani G., Rugarli E.I., Taglialatela M., Wong C., Ballabio A.
    Genomics 27:131-141(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "Ion transporters and receptors in cDNA libraries from lens and cornea epithelia."
    Shepard A.R., Rae J.L.
    Curr. Eye Res. 17:708-719(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lens epithelium.
  3. "Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase."
    Huang P., Liu J., Di A., Robinson N.C., Musch M.W., Kaetzel M.A., Nelson D.J.
    J. Biol. Chem. 276:20093-20100(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GLYCOSYLATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-280.
    Tissue: Colon tumor.
  4. "ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC."
    Ogura T., Furukawa T., Toyozaki T., Yamada K., Zheng Y.-J., Katayama Y., Nakaya H., Inagaki N.
    FASEB J. 16:863-865(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SLC9A3R1, DOMAIN, FUNCTION.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon endothelium.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Trachea.
  7. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Testis.
  10. "Expression of CLCN voltage-gated chloride channel genes in human blood vessels."
    Lamb F.S., Clayton G.H., Liu B.-X., Smith R.L., Barna T.J., Schutte B.C.
    J. Mol. Cell. Cardiol. 31:657-666(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Tissue: Aortic endothelium, Fetal lung and Vascular smooth muscle.
  11. "The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins."
    Gentzsch M., Cui L., Mengos A., Chang X.-B., Chen J.-H., Riordan J.R.
    J. Biol. Chem. 278:6440-6449(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH GOPC; PDZK1 AND SLC9A3R1, GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCLCN3_HUMAN
AccessioniPrimary (citable) accession number: P51790
Secondary accession number(s): B7Z932
, B9EGJ9, D3DP34, E9PB97, O14918, Q86Z21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 14, 2009
Last modified: September 3, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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