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P51790 (CLCN3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 136. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
H(+)/Cl(-) exchange transporter 3
Alternative name(s):
Chloride channel protein 3
Short name=ClC-3
Chloride transporter ClC-3
Gene names
Name:CLCN3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length818 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory. Ref.4

Subunit structure

Homo- or heterodimer. Isoform 2 interacts with GOPC, PDZK1 and SLC9A3R1/EBP50. Ref.4 Ref.11

Subcellular location

Isoform 1: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cytoplasmic vesiclesecretory vesicle membrane; Multi-pass membrane protein By similarity. Note: Isoform 1 is localized mainly in early and late endosomes. Ref.3 Ref.11

Isoform 2: Membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note: Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi. Ref.3 Ref.11

Tissue specificity

Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level). Ref.4 Ref.10 Ref.11

Domain

Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC. Ref.4

Post-translational modification

N-glycosylated. Ref.3 Ref.11

Miscellaneous

The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters By similarity.

Sequence similarities

Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. [View classification]

Contains 2 CBS domains.

Sequence caution

The sequence BAC54560.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA55281.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processAntiport
Ion transport
Transport
   Cellular componentCytoplasmic vesicle
Endosome
Golgi apparatus
Membrane
   Coding sequence diversityAlternative splicing
   DomainCBS domain
Repeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Chloride
Nucleotide-binding
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchloride transmembrane transport

Traceable author statement Ref.11. Source: GOC

endosomal lumen acidification

Traceable author statement Ref.11. Source: UniProtKB

ion transmembrane transport

Traceable author statement. Source: Reactome

regulation of anion transport

Traceable author statement Ref.1. Source: GOC

regulation of pH

Traceable author statement Ref.11. Source: UniProtKB

transmembrane transport

Traceable author statement. Source: Reactome

transport

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentGolgi apparatus

Inferred from direct assay Ref.11. Source: UniProtKB

Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

apical plasma membrane

Inferred from electronic annotation. Source: Ensembl

cell surface

Non-traceable author statement Ref.11. Source: UniProtKB

early endosome

Inferred from direct assay Ref.11. Source: UniProtKB

early endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Traceable author statement Ref.11. Source: UniProtKB

late endosome

Inferred from direct assay Ref.11. Source: UniProtKB

late endosome membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

transport vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

vesicle membrane

Inferred from direct assay Ref.11. Source: UniProtKB

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

PDZ domain binding

Inferred from direct assay Ref.11. Source: UniProtKB

antiporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

chloride channel activity

Traceable author statement Ref.11. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.11. Source: UniProtKB

protein heterodimerization activity

Inferred from direct assay Ref.11. Source: UniProtKB

protein homodimerization activity

Non-traceable author statement Ref.11. Source: UniProtKB

voltage-gated chloride channel activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P51790-1)

Also known as: ClC-3A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P51790-2)

Also known as: ClC-3B;

The sequence of this isoform differs from the canonical sequence as follows:
     790-818: RLLGIITKKDILRHMAQTANQDPASIMFN → IVLGIITKKN...EVYLLNSTTL
Isoform 3 (identifier: P51790-4)

The sequence of this isoform differs from the canonical sequence as follows:
     312-338: Missing.
Isoform 4 (identifier: P51790-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: MESEQLFHRG...DNLLDGDTAV → MVTLQLGESH...ALASQVAEIT
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 818818H(+)/Cl(-) exchange transporter 3
PRO_0000094438

Regions

Topological domain1 – 125125Cytoplasmic By similarity
Transmembrane126 – 16338Helical; By similarity
Transmembrane209 – 23224Helical; By similarity
Intramembrane241 – 2488Helical; By similarity
Transmembrane258 – 27619Helical; By similarity
Transmembrane282 – 30120Helical; By similarity
Intramembrane313 – 32513Helical; By similarity
Intramembrane329 – 3379Helical; By similarity
Transmembrane349 – 36719Helical; By similarity
Transmembrane391 – 41626Helical; By similarity
Transmembrane423 – 44321Helical; By similarity
Transmembrane500 – 52021Helical; By similarity
Transmembrane525 – 54420Helical; By similarity
Intramembrane572 – 58615Helical; By similarity
Intramembrane590 – 60112Helical; By similarity
Intramembrane602 – 6054Note=Loop between two helices; By similarity
Transmembrane606 – 62419Helical; By similarity
Topological domain625 – 818194Cytoplasmic By similarity
Domain658 – 72265CBS 1
Domain755 – 81258CBS 2
Nucleotide binding689 – 6913ATP By similarity
Nucleotide binding796 – 7994ATP By similarity
Motif238 – 2425Selectivity filter part_1 By similarity
Motif280 – 2845Selectivity filter part_2 By similarity
Motif525 – 5295Selectivity filter part_3 By similarity

Sites

Binding site2391Chloride By similarity
Binding site5271Chloride; via amide nitrogen By similarity
Binding site6301Chloride By similarity
Site2821Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transport By similarity
Site3391Mediates proton transfer from the protein to the inner aqueous phase By similarity

Amino acid modifications

Glycosylation1771N-linked (GlcNAc...) Potential
Glycosylation4511N-linked (GlcNAc...) Potential
Glycosylation4791N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 5353MESEQ…GDTAV → MVTLQLGESHYVVQAGLQLL GSSNPPALASQVAEIT in isoform 4.
VSP_054415
Alternative sequence312 – 33827Missing in isoform 3.
VSP_045105
Alternative sequence790 – 81829RLLGI…SIMFN → IVLGIITKKNILEHLEQLKQ HVEPLAPPWHYNKKRYPPAY GPDGKPRPRFNNVQLNLTDE EREETEEEVYLLNSTTL in isoform 2.
VSP_016073

Experimental info

Mutagenesis2801G → E: Changes channel selectivity from I(-)>Cl(-) to Cl(-)>I(-). Ref.3
Sequence conflict2091M → T in BX647119. Ref.5
Sequence conflict5511Y → C in BX647119. Ref.5
Sequence conflict5701T → A in BX647119. Ref.5
Sequence conflict6461E → EEF in CAA55280. Ref.1
Sequence conflict6461E → EEF in CAA55281. Ref.1
Sequence conflict6461E → EEF in BAC54560. Ref.4
Sequence conflict7231Q → R in BX647119. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (ClC-3A) [UniParc].

Last modified April 14, 2009. Version 2.
Checksum: 30FF0A6A2D6EF3B8

FASTA81890,966
        10         20         30         40         50         60 
MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD TAVGTHYTMT 

        70         80         90        100        110        120 
NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD RERHRRINSK KKESAWEMTK 

       130        140        150        160        170        180 
SLYDAWSGWL VVTLTGLASG ALAGLIDIAA DWMTDLKEGI CLSALWYNHE QCCWGSNETT 

       190        200        210        220        230        240 
FEERDKCPQW KTWAELIIGQ AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG 

       250        260        270        280        290        300 
IPEIKTILSG FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF 

       310        320        330        340        350        360 
PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW RSFFAALVAA 

       370        380        390        400        410        420 
FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG GLWGAFFIRA NIAWCRRRKS 

       430        440        450        460        470        480 
TKFGKYPVLE VIIVAAITAV IAFPNPYTRL NTSELIKELF TDCGPLESSS LCDYRNDMNA 

       490        500        510        520        530        540 
SKIVDDIPDR PAGIGVYSAI WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI 

       550        560        570        580        590        600 
VGIAVEQLAY YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL 

       610        620        630        640        650        660 
TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH TTLAADVMRP 

       670        680        690        700        710        720 
RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES QRLVGFALRR DLTIAIESAR 

       730        740        750        760        770        780 
KKQEGIVGSS RVCFAQHTPS LPAESPRPLK LRSILDMSPF TVTDHTPMEI VVDIFRKLGL 

       790        800        810 
RQCLVTHNGR LLGIITKKDI LRHMAQTANQ DPASIMFN 

« Hide

Isoform 2 (ClC-3B) [UniParc].

Checksum: 1B2C8D0CC47CF592
Show »

FASTA86696,733
Isoform 3 [UniParc].

Checksum: 3C8F08C71A73D3AF
Show »

FASTA79188,464
Isoform 4 [UniParc].

Checksum: 2A7951DA858393D4
Show »

FASTA80188,781

References

« Hide 'large scale' references
[1]"Characterization of a human and murine gene (CLCN3) sharing similarities to voltage-gated chloride channels and to a yeast integral membrane protein."
Borsani G., Rugarli E.I., Taglialatela M., Wong C., Ballabio A.
Genomics 27:131-141(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Retina.
[2]"Ion transporters and receptors in cDNA libraries from lens and cornea epithelia."
Shepard A.R., Rae J.L.
Curr. Eye Res. 17:708-719(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Lens epithelium.
[3]"Regulation of human CLC-3 channels by multifunctional Ca2+/calmodulin-dependent protein kinase."
Huang P., Liu J., Di A., Robinson N.C., Musch M.W., Kaetzel M.A., Nelson D.J.
J. Biol. Chem. 276:20093-20100(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), GLYCOSYLATION, SUBCELLULAR LOCATION, MUTAGENESIS OF GLY-280.
Tissue: Colon tumor.
[4]"ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC."
Ogura T., Furukawa T., Toyozaki T., Yamada K., Zheng Y.-J., Katayama Y., Nakaya H., Inagaki N.
FASEB J. 16:863-865(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, INTERACTION WITH SLC9A3R1, DOMAIN, FUNCTION.
[5]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon endothelium.
[6]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Trachea.
[7]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Testis.
[10]"Expression of CLCN voltage-gated chloride channel genes in human blood vessels."
Lamb F.S., Clayton G.H., Liu B.-X., Smith R.L., Barna T.J., Schutte B.C.
J. Mol. Cell. Cardiol. 31:657-666(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
Tissue: Aortic endothelium, Fetal lung and Vascular smooth muscle.
[11]"The PDZ-binding chloride channel ClC-3B localizes to the Golgi and associates with cystic fibrosis transmembrane conductance regulator-interacting PDZ proteins."
Gentzsch M., Cui L., Mengos A., Chang X.-B., Chen J.-H., Riordan J.R.
J. Biol. Chem. 278:6440-6449(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH GOPC; PDZK1 AND SLC9A3R1, GLYCOSYLATION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78520 mRNA. Translation: CAA55280.1.
X78520 mRNA. Translation: CAA55281.1. Different initiation.
AF029346 mRNA. Translation: AAB95161.1.
AF172729 mRNA. Translation: AAD51034.1.
AB019542 mRNA. Translation: BAC54560.1. Different initiation.
AK304362 mRNA. Translation: BAH14168.1.
BX647119 mRNA. No translation available.
AC084724 Genomic DNA. No translation available.
AC106878 Genomic DNA. No translation available.
CH471056 Genomic DNA. Translation: EAX04782.1.
CH471056 Genomic DNA. Translation: EAX04786.1.
BC136510 mRNA. Translation: AAI36511.1.
CCDSCCDS34100.1. [P51790-2]
CCDS34101.1. [P51790-1]
CCDS58932.1. [P51790-4]
PIRI37240.
RefSeqNP_001230301.1. NM_001243372.1. [P51790-4]
NP_001230303.1. NM_001243374.1.
NP_001820.2. NM_001829.3. [P51790-1]
NP_776297.2. NM_173872.3. [P51790-2]
UniGeneHs.481186.
Hs.736017.

3D structure databases

ProteinModelPortalP51790.
SMRP51790. Positions 211-811.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid107596. 5 interactions.
IntActP51790. 5 interactions.
MINTMINT-1783418.
STRING9606.ENSP00000261514.

Chemistry

ChEMBLCHEMBL2401603.
GuidetoPHARMACOLOGY702.

PTM databases

PhosphoSiteP51790.

Polymorphism databases

DMDM226693513.

Proteomic databases

MaxQBP51790.
PaxDbP51790.
PRIDEP51790.

Protocols and materials databases

DNASU1182.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000347613; ENSP00000261514; ENSG00000109572. [P51790-2]
ENST00000360642; ENSP00000353857; ENSG00000109572. [P51790-4]
ENST00000504131; ENSP00000424540; ENSG00000109572.
ENST00000513761; ENSP00000424603; ENSG00000109572. [P51790-1]
GeneID1182.
KEGGhsa:1182.
UCSCuc003ish.3. human. [P51790-2]
uc003isi.3. human. [P51790-1]

Organism-specific databases

CTD1182.
GeneCardsGC04P170541.
H-InvDBHIX0024545.
HGNCHGNC:2021. CLCN3.
HPAHPA044723.
MIM600580. gene.
neXtProtNX_P51790.
PharmGKBPA26548.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0038.
HOGENOMHOG000164493.
KOK05012.
OMAEPLTPPW.
OrthoDBEOG7MWGXT.
PhylomeDBP51790.
TreeFamTF313867.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressP51790.
BgeeP51790.
CleanExHS_CLCN3.
GenevestigatorP51790.

Family and domain databases

Gene3D1.10.3080.10. 3 hits.
InterProIPR000644. CBS_dom.
IPR014743. Cl-channel_core.
IPR001807. Cl-channel_volt-gated.
IPR002245. Cl_channel-3.
[Graphical view]
PfamPF00571. CBS. 1 hit.
PF00654. Voltage_CLC. 1 hit.
[Graphical view]
PRINTSPR00762. CLCHANNEL.
PR01114. CLCHANNEL3.
SMARTSM00116. CBS. 2 hits.
[Graphical view]
SUPFAMSSF81340. SSF81340. 3 hits.
PROSITEPS51371. CBS. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCLCN3. human.
GeneWikiCLCN3.
GenomeRNAi1182.
NextBio4884.
PROP51790.
SOURCESearch...

Entry information

Entry nameCLCN3_HUMAN
AccessionPrimary (citable) accession number: P51790
Secondary accession number(s): B7Z932 expand/collapse secondary AC list , B9EGJ9, D3DP34, E9PB97, O14918, Q86Z21
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 14, 2009
Last modified: July 9, 2014
This is version 136 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM