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Protein

Zinc finger protein 157

Gene

ZNF157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147117-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 157
Alternative name(s):
Zinc finger protein HZF22
Gene namesi
Name:ZNF157
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:12942. ZNF157.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147117.
PharmGKBiPA37525.

Polymorphism and mutation databases

BioMutaiZNF157.
DMDMi62299056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474321 – 506Zinc finger protein 157Add BLAST506

Proteomic databases

MaxQBiP51786.
PaxDbiP51786.
PeptideAtlasiP51786.
PRIDEiP51786.

PTM databases

iPTMnetiP51786.
PhosphoSitePlusiP51786.

Expressioni

Gene expression databases

BgeeiENSG00000147117.
CleanExiHS_ZNF157.
GenevisibleiP51786. HS.

Organism-specific databases

HPAiHPA003319.

Interactioni

Protein-protein interaction databases

BioGridi113506. 4 interactors.
STRINGi9606.ENSP00000366273.

Structurei

3D structure databases

ProteinModelPortaliP51786.
SMRiP51786.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 12 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51786.
KOiK09228.
OMAiHIGWSWR.
OrthoDBiEOG091G02KC.
PhylomeDBiP51786.
TreeFamiTF337898.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P51786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT
60 70 80 90 100
MHKDVMLETY SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS
110 120 130 140 150
LSLLCGNGSV GDNALRHDND LLHHQKIQTL DQNVEYNGCR KAFHEKTGFV
160 170 180 190 200
RRKRTPRGDK NFECHECGKA YCRKSNLVEH LRIHTGERPY ECGECAKTFS
210 220 230 240 250
ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH TGERPYECTE
260 270 280 290 300
CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK
310 320 330 340 350
PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR
360 370 380 390 400
THTGEKPYQC NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR
410 420 430 440 450
LIEHQRMHSG EKPYECSECG KIFSMKKSLC QHRRTHTGEK PYECSECGNA
460 470 480 490 500
FYVKVRLIEH QRIHTGERPF ECQECGKAFC RKAHLTEHQR THIGWSWRCT

MKKASH
Length:506
Mass (Da):58,291
Last modified:March 29, 2005 - v2
Checksum:i59E1403E7F0CF944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165H → N in AAA97578 (PubMed:8586441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28687 mRNA. Translation: AAA97578.1.
AL590223 Genomic DNA. Translation: CAC88160.2.
AL591503, AL590223 Genomic DNA. Translation: CAI41199.1.
BC075003 mRNA. Translation: AAH75003.1.
CCDSiCCDS14278.1.
RefSeqiNP_003437.2. NM_003446.3.
UniGeneiHs.89897.

Genome annotation databases

EnsembliENST00000377073; ENSP00000366273; ENSG00000147117.
GeneIDi7712.
KEGGihsa:7712.
UCSCiuc004dhr.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28687 mRNA. Translation: AAA97578.1.
AL590223 Genomic DNA. Translation: CAC88160.2.
AL591503, AL590223 Genomic DNA. Translation: CAI41199.1.
BC075003 mRNA. Translation: AAH75003.1.
CCDSiCCDS14278.1.
RefSeqiNP_003437.2. NM_003446.3.
UniGeneiHs.89897.

3D structure databases

ProteinModelPortaliP51786.
SMRiP51786.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113506. 4 interactors.
STRINGi9606.ENSP00000366273.

PTM databases

iPTMnetiP51786.
PhosphoSitePlusiP51786.

Polymorphism and mutation databases

BioMutaiZNF157.
DMDMi62299056.

Proteomic databases

MaxQBiP51786.
PaxDbiP51786.
PeptideAtlasiP51786.
PRIDEiP51786.

Protocols and materials databases

DNASUi7712.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377073; ENSP00000366273; ENSG00000147117.
GeneIDi7712.
KEGGihsa:7712.
UCSCiuc004dhr.2. human.

Organism-specific databases

CTDi7712.
GeneCardsiZNF157.
HGNCiHGNC:12942. ZNF157.
HPAiHPA003319.
MIMi300024. gene.
neXtProtiNX_P51786.
OpenTargetsiENSG00000147117.
PharmGKBiPA37525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133681.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP51786.
KOiK09228.
OMAiHIGWSWR.
OrthoDBiEOG091G02KC.
PhylomeDBiP51786.
TreeFamiTF337898.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147117-MONOMER.
ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii7712.
PROiP51786.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147117.
CleanExiHS_ZNF157.
GenevisibleiP51786. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 12 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN157_HUMAN
AccessioniPrimary (citable) accession number: P51786
Secondary accession number(s): Q96LE9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.