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Protein

Zinc finger protein 157

Gene

ZNF157

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 157
Alternative name(s):
Zinc finger protein HZF22
Gene namesi
Name:ZNF157
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000147117.7
HGNCiHGNC:12942 ZNF157
MIMi300024 gene
neXtProtiNX_P51786

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000147117
PharmGKBiPA37525

Polymorphism and mutation databases

BioMutaiZNF157
DMDMi62299056

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000474321 – 506Zinc finger protein 157Add BLAST506

Proteomic databases

EPDiP51786
MaxQBiP51786
PaxDbiP51786
PeptideAtlasiP51786
PRIDEiP51786

PTM databases

iPTMnetiP51786
PhosphoSitePlusiP51786

Expressioni

Gene expression databases

BgeeiENSG00000147117
CleanExiHS_ZNF157
GenevisibleiP51786 HS

Organism-specific databases

HPAiHPA003319

Interactioni

Protein-protein interaction databases

BioGridi113506, 4 interactors
STRINGi9606.ENSP00000366273

Structurei

3D structure databases

ProteinModelPortaliP51786
SMRiP51786
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 98KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri162 – 184C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri190 – 212C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri218 – 240C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri246 – 268C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri274 – 296C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri302 – 324C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri330 – 352C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri358 – 380C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri386 – 408C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri414 – 436C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri442 – 464C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri470 – 492C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00900000140826
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiP51786
KOiK09228
OMAiDKNFECH
OrthoDBiEOG091G02KC
PhylomeDBiP51786
TreeFamiTF337898

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequencei

Sequence statusi: Complete.

P51786-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPANGTSPQR FPALIPGEPG RSFEGSVSFE DVAVDFTRQE WHRLDPAQRT
60 70 80 90 100
MHKDVMLETY SNLASVGLCV AKPEMIFKLE RGEELWILEE ESSGHGYSGS
110 120 130 140 150
LSLLCGNGSV GDNALRHDND LLHHQKIQTL DQNVEYNGCR KAFHEKTGFV
160 170 180 190 200
RRKRTPRGDK NFECHECGKA YCRKSNLVEH LRIHTGERPY ECGECAKTFS
210 220 230 240 250
ARSYLIAHQK THTGERPFEC NECGKSFGRK SQLILHTRTH TGERPYECTE
260 270 280 290 300
CGKTFSEKAT LTIHQRTHTG EKPYECSECG KTFRVKISLT QHHRTHTGEK
310 320 330 340 350
PYECGECGKN FRAKKSLNQH QRIHTGEKPY ECGECGKFFR MKMTLNNHQR
360 370 380 390 400
THTGEKPYQC NECGKSFRVH SSLGIHQRIH TGEKPYECNE CGNAFYVKAR
410 420 430 440 450
LIEHQRMHSG EKPYECSECG KIFSMKKSLC QHRRTHTGEK PYECSECGNA
460 470 480 490 500
FYVKVRLIEH QRIHTGERPF ECQECGKAFC RKAHLTEHQR THIGWSWRCT

MKKASH
Length:506
Mass (Da):58,291
Last modified:March 29, 2005 - v2
Checksum:i59E1403E7F0CF944
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti165H → N in AAA97578 (PubMed:8586441).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28687 mRNA Translation: AAA97578.1
AL590223 Genomic DNA No translation available.
AL591503 Genomic DNA No translation available.
BC075003 mRNA Translation: AAH75003.1
CCDSiCCDS14278.1
RefSeqiNP_003437.2, NM_003446.3
UniGeneiHs.89897

Genome annotation databases

EnsembliENST00000377073; ENSP00000366273; ENSG00000147117
GeneIDi7712
KEGGihsa:7712
UCSCiuc004dhr.2 human

Similar proteinsi

Entry informationi

Entry nameiZN157_HUMAN
AccessioniPrimary (citable) accession number: P51786
Secondary accession number(s): Q96LE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 29, 2005
Last modified: March 28, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health