Reviewed, UniProtKB/Swiss-Prot P51783 (HXA9_CAVPO)

Names and origin

Protein names

Recommended name:
    Homeobox protein Hox-A9
Alternative name(s):
    Hox-1.7

Gene names

Name:	HOXA9
Synonyms:	HOX-1.7

Organism

Cavia porcellus (Guinea pig)

Taxonomic identifier

10141 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length	162 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro transcription activator activity Inferred from electronic annotation. Source: InterPro transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – 162	›162	Homeobox protein Hox-A9		PRO_0000200080
Regions
	DNA binding	96 – 155	60	Homeobox
Experimental info
	Non-terminal residue	1	1

Sequences

	Sequence		Length	Mass (Da)
	P51783-1 [UniParc]. Last modified October 1, 1996. Version 1. Checksum: B84FA507EC67CF91	FASTA	162	18,661
	10 20 30 40 50 60 NSGTVLLLVS EGGSSRSRSS WCCNLKQLAF AGLAGDPAWR SQLPLGSDSE MCQVDREKQP 70 80 90 100 110 120 NEGAFSENNA ENDSSGDKPP IDPNNPAANW LHARSTRKKR CPYTKHQTLE LEKEFLFNMY 130 140 150 160 LTRDRRYEVA RLLNLTERQV KIWFQNRRMK MKKINKDRAK DE

References

[1]	"Alternatively spliced Hox-1.7 transcripts encode different protein products." Rubin M.R., Nguyen-Huu M.C. DNA Seq. 1:115-124(1990) [PubMed: 1983703] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X13536 mRNA. Translation: CAA31887.1.
PIR	A48428.
3D structure databases
SMR	P51783. Positions 84-160.
ModBase	Search...
Genome annotation databases
Ensembl	ENSCPOT00000027205; ENSCPOP00000015273; ENSCPOG00000011365; Cavia porcellus. [Genome view]
Phylogenomic databases
HOVERGEN	P51783.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017970. Homeobox_CS. IPR020479. Homeobox_region. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. IPR006711. Hox9_act. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
Pfam	PF00046. Homeobox. 1 hit. PF04617. Hox9_act. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA9_CAVPO

Accession

Primary (citable) accession number: P51783

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)