ID   GSTA1_PIG               Reviewed;         222 AA.
AC   P51781;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   16-JUN-2009, entry version 54.
DE   RecName: Full=Glutathione S-transferase alpha M14;
DE            EC=2.5.1.18;
DE   AltName: Full=GST class-alpha;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RA   Hatey F., Tosser G.;
RL   Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Conjugation of reduced glutathione to a wide number of
CC       exogenous and endogenous hydrophobic electrophiles.
CC   -!- CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the GST superfamily. Alpha family.
CC   -!- SIMILARITY: Contains 1 GST C-terminal domain.
CC   -!- SIMILARITY: Contains 1 GST N-terminal domain.
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DR   EMBL; Z69585; CAA93433.1; -; mRNA.
DR   RefSeq; NP_999554.1; -.
DR   UniGene; Ssc.69976; -.
DR   HSSP; P08263; 1K3O.
DR   SMR; P51781; 2-220.
DR   GeneID; 397682; -.
DR   KEGG; ssc:397682; -.
DR   HOVERGEN; P51781; -.
DR   BRENDA; 2.5.1.18; 249.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004364; F:glutathione transferase activity; IEA:EC.
DR   GO; GO:0008152; P:metabolic process; IEA:InterPro.
DR   InterPro; IPR010987; Glutathione-S-Trfase_C-like.
DR   InterPro; IPR004045; Glutathione_S-Trfase_N.
DR   InterPro; IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
DR   InterPro; IPR003080; GST_alpha.
DR   InterPro; IPR004046; GST_C.
DR   InterPro; IPR012335; Thioredoxin_fold.
DR   Gene3D; G3DSA:1.20.1050.10; GST_C_like; 1.
DR   Gene3D; G3DSA:3.40.30.10; Thioredoxin_fold; 1.
DR   PANTHER; PTHR11571:SF4; GST_alpha; 1.
DR   Pfam; PF00043; GST_C; 1.
DR   Pfam; PF02798; GST_N; 1.
DR   PRINTS; PR01266; GSTRNSFRASEA.
DR   PROSITE; PS50405; GST_CTER; 1.
DR   PROSITE; PS50404; GST_NTER; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Transferase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    222       Glutathione S-transferase alpha M14.
FT                                /FTId=PRO_0000185797.
FT   DOMAIN        3     83       GST N-terminal.
FT   DOMAIN       85    208       GST C-terminal.
SQ   SEQUENCE   222 AA;  25281 MW;  8AAF741EEC8DDD4B CRC64;
     MAGKPILHYF NGRGRMECIR WLLAAAGVEF EEKFIKTPED LDKLTNDGSL LFQQVPMVEI
     DGMKLVQTRA ILNYIATKYN LYGKDAKERA LIDMYTEGVA DLGEMILLLP LCPPNEKDAK
     VASIKEKSTN RYLPAFEKVL KSHGQDYLVG NKLSRADIQL VELLYYVEEL DPSLLANFPL
     LKALKTRVSN LPTVKKFLQP GSQRKPPMDA KKIRRSQEYF PD
//